• 1559 Citations
19992021

Research output per year

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Personal profile

Research Interests

The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.

Training Experience

2008Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA
2015Postdoctoral Fellowship, Whitehead Institute

Education/Academic qualification

PhD, University of California, San Diego

… → 2007

Research interests

  • Cancer Biology
  • Cell Biology
  • Energy Metabolism
  • Epigenetics
  • Gene Regulation
  • Genetics
  • Genomics
  • Systems Biology

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Grants

  • Research Output

    • 1559 Citations
    • 19 Article
    • 1 Comment/debate

    Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

    Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.

    Research output: Contribution to journalArticle

  • 27 Scopus citations

    Luminidependens (LD) is an Arabidopsis protein with prion behavior

    Chakrabortee, S., Kayatekin, C., Newby, G. A., Mendillo, M. L., Lancaster, A. & Lindquist, S., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6065-6070 6 p.

    Research output: Contribution to journalArticle

  • 55 Scopus citations

    Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

    Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., Brummelkamp, T. R., Santagata, S. & Lindquist, S., Sep 1 2015, In : eLife. 4, September2015, e08467.

    Research output: Contribution to journalArticle

  • 26 Scopus citations

    HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

    Whitesell, L., Santagata, S., Mendillo, M. L., Lin, N. U., Proia, D. A. & Lindquist, S., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18297-18302 6 p.

    Research output: Contribution to journalArticle

  • 58 Scopus citations

    The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

    Filone, C. M., Caballero, I. S., Dower, K., Mendillo, M. L., Cowley, G. S., Santagata, S., Rozelle, D. K., Yen, J., Rubins, K. H., Hacohen, N., Root, D. E., Hensley, L. E. & Connor, J., Feb 2014, In : PLoS pathogens. 10, 2, e1003904.

    Research output: Contribution to journalArticle

  • 15 Scopus citations