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Marc Laurence Mendillo

  • 1559 Citations
19992021

Research output per year

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Personal profile

Research Interests

The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.

Training Experience

2008Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA
2015Postdoctoral Fellowship, Whitehead Institute

Education/Academic qualification

PhD, University of California, San Diego

… → 2007

Research interests

  • Cancer Biology
  • Cell Biology
  • Energy Metabolism
  • Epigenetics
  • Gene Regulation
  • Genetics
  • Genomics
  • Systems Biology

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Grants

Harnessing Druggable Synthetic Lethal Interactions in Triple-Negative Breast Cancer with Elevated MYC Expression

Clutter, M., Horiuchi, D., Mendillo, M. L., Vasilopoulos, A. & Santa-Maria, C. A.

U.S. Army Medical Research and Materiel Command

4/1/18 → 3/31/21

Project: Research project

    • Delineating and exploiting HSF1 activation in highly malignant breast cancers.

    Mendillo, M. L.

    Susan G. Komen Breast Cancer Foundation

    6/21/17 → 6/20/20

    Project: Research project

    Effect of the Cellular Stress Response Network in Sculpting the Therapeutic Response in Human Breast Cancers

    Mendillo, M. L.

    Northwestern Memorial Hospital

    9/1/16 → 8/31/17

    Project: Research project

    • The role of the proteostasis network in cancer evolution and the response to therapeutics

    Mendillo, M. L.

    Sidney Kimmel Foundation for Cancer Research

    7/1/16 → 6/30/19

    Project: Research project

    • Elucidating the stress response regulatory networks that enable malignancy

    Mendillo, M. L.

    National Cancer Institute

    2/11/16 → 1/31/20

    Project: Research project

    • Research Output

    • 1559 Citations
    • 19 Article
    • 1 Comment/debate

    Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

    Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.

    Research output: Contribution to journal › Article

    • 27 Scopus citations

    Luminidependens (LD) is an Arabidopsis protein with prion behavior

    Chakrabortee, S., Kayatekin, C., Newby, G. A., Mendillo, M. L., Lancaster, A. & Lindquist, S., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6065-6070 6 p.

    Research output: Contribution to journal › Article

    • 55 Scopus citations

    Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

    Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., Brummelkamp, T. R., Santagata, S. & Lindquist, S., Sep 1 2015, In : eLife. 4, September2015, e08467.

    Research output: Contribution to journal › Article

    • 26 Scopus citations

    HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

    Whitesell, L., Santagata, S., Mendillo, M. L., Lin, N. U., Proia, D. A. & Lindquist, S., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18297-18302 6 p.

    Research output: Contribution to journal › Article

    • 58 Scopus citations

    The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

    Filone, C. M., Caballero, I. S., Dower, K., Mendillo, M. L., Cowley, G. S., Santagata, S., Rozelle, D. K., Yen, J., Rubins, K. H., Hacohen, N., Root, D. E., Hensley, L. E. & Connor, J., Feb 2014, In : PLoS pathogens. 10, 2, e1003904.

    Research output: Contribution to journal › Article

    • 15 Scopus citations