Grants per year
Personal profile
Research Interests
The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.
Training Experience
2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
2015 | Postdoctoral Fellowship, Whitehead Institute |
Education/Academic qualification
Biomedical Sciences, PhD, University of California at San Diego
… → 2007
PhD, University of California, San Diego
… → 2007
Research interests
- Cancer Biology
- Cell Biology
- Energy Metabolism
- Epigenetics
- Gene Regulation
- Genetics
- Genomics
- Systems Biology
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Network
Grants
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The role of nucleoli in human genome organization in normal and disease states
Foltz, D. R., Mendillo, M. L. & Huang, S.
University of Massachusetts Medical School, National Cancer Institute
9/21/20 → 8/31/25
Project: Research project
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Harnessing Druggable Synthetic Lethal Interactions in Triple-Negative Breast Cancer with Elevated MYC Expression
Horiuchi, D., Mendillo, M. L., Santa-Maria, C. A. & Vasilopoulos, A.
U.S. Army Medical Research and Materiel Command
4/1/18 → 3/31/21
Project: Research project
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Delineating and exploiting HSF1 activation in highly malignant breast cancers.
Susan G. Komen Breast Cancer Foundation
6/21/17 → 12/20/20
Project: Research project
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Effect of the Cellular Stress Response Network in Sculpting the Therapeutic Response in Human Breast Cancers
Northwestern Memorial Hospital
9/1/16 → 8/31/17
Project: Research project
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The role of the proteostasis network in cancer evolution and the response to therapeutics
Sidney Kimmel Foundation for Cancer Research
7/1/16 → 6/30/19
Project: Research project
Research Output
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Preface: dedication to susan lindquist
Mendillo, M. L., Scherz-Shouval, R. & Pincus, D., 2020, In: Advances in experimental medicine and biology. 1243, p. v-viResearch output: Contribution to journal › Editorial › peer-review
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Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq
Brockway, S., Wang, G., Jackson, J. M., Amici, D. R., Takagishi, S. R., Clutter, M. R., Bartom, E. T. & Mendillo, M. L., Dec 2020, In: Nature communications. 11, 1, 5722.Research output: Contribution to journal › Article › peer-review
Open Access -
The Multifaceted Role of HSF1 in Tumorigenesis
Alasady, M. J. & Mendillo, M. L., 2020, Advances in Experimental Medicine and Biology. Springer, p. 69-85 17 p. (Advances in Experimental Medicine and Biology; vol. 1243).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)
Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In: Blood. 130, 12, p. 1430-1440 11 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Luminidependens (LD) is an Arabidopsis protein with prion behavior
Chakrabortee, S., Kayatekin, C., Newby, G. A., Mendillo, M. L., Lancaster, A. & Lindquist, S., May 24 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6065-6070 6 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations