• 1440 Citations
19992021
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Personal profile

Research Interests

The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.

Training Experience

2008Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA
2015Postdoctoral Fellowship, Whitehead Institute

Education/Academic qualification

PhD, University Of California-San Diego

… → 2007

Research interests

  • Cancer Biology
  • Cell Biology
  • Energy Metabolism
  • Epigenetics
  • Gene Regulation
  • Genetics
  • Genomics
  • Systems Biology

Fingerprint Dive into the research topics where Marc Laurence Mendillo is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
DNA Mismatch Repair Medicine & Life Sciences
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Hot Temperature Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
DNA Medicine & Life Sciences
Saccharomyces cerevisiae Medicine & Life Sciences
Heat-Shock Response Medicine & Life Sciences
Mutation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2016 2021

Triple Negative Breast Neoplasms
Neoplasms
Breast Neoplasms
Therapeutics
Mutation
Shock
Hot Temperature
Neoplasms
Phenotype
Biochemistry
Breast Neoplasms
Heat-Shock Response
Neoplasms
Cell Biology
Oxidative Stress
Neoplasms
Therapeutics
Heat-Shock Response
Tumor Microenvironment
Survival

Research Output 1999 2017

  • 1440 Citations
  • 19 Article
  • 1 Comment/debate
22 Citations (Scopus)

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Cutaneous T-Cell Lymphoma
T-cells
NF-kappa B
T-Cell Antigen Receptor
T-Lymphocytes
45 Citations (Scopus)

Luminidependens (LD) is an Arabidopsis protein with prion behavior

Chakrabortee, S., Kayatekin, C., Newby, G. A., Mendillo, M. L., Lancaster, A. & Lindquist, S., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6065-6070 6 p.

Research output: Contribution to journalArticle

Prions
Yeasts
Arabidopsis LD protein
Biological Phenomena
Plant Proteins
20 Citations (Scopus)

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., Brummelkamp, T. R., Santagata, S. & Lindquist, S., Sep 1 2015, In : eLife. 4, September2015, e08467.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Fluxes
Proteins
Survival
Eukaryota
51 Citations (Scopus)

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

Whitesell, L., Santagata, S., Mendillo, M. L., Lin, N. U., Proia, D. A. & Lindquist, S., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18297-18302 6 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Breast Neoplasms
Hormone Antagonists
Estrogen Receptors
Heat-Shock Response
14 Citations (Scopus)

The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

Filone, C. M., Caballero, I. S., Dower, K., Mendillo, M. L., Cowley, G. S., Santagata, S., Rozelle, D. K., Yen, J., Rubins, K. H., Hacohen, N., Root, D. E., Hensley, L. E. & Connor, J., Jan 1 2014, In : PLoS pathogens. 10, 2, e1003904.

Research output: Contribution to journalArticle

Orthopoxvirus
Heat-Shock Response
Shock
Hot Temperature
Infection