Grants per year
Personal profile
Research Interests
The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.
Training Experience
| 2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
| 2015 | Postdoctoral Fellowship, Whitehead Institute |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Sciences, PhD, University of California at San Diego
… → 2007
Biomedical Sciences, PhD, University of California at San Diego
… → 2007
Research interests keywords
- Cancer Biology
- Cell Biology
- Energy Metabolism
- Epigenetics
- Gene Regulation
- Genetics
- Genomics
- Systems Biology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Regulation and interplay of Heat Shock Factors in growth-associated proteotoxic stresses
Mendillo, M. L. (PD/PI) & Mendillo, M. L. (PD/PI)
National Institute of General Medical Sciences
9/1/22 → 8/31/27
Project: Research project
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Phenotypic marker-guided development of selective antimetastasis therapeutic leads
Huang, S. (PD/PI), Huang, S. (PD/PI), Ji, Z. (Co-Investigator), Ji, Z. (Co-Investigator), Mendillo, M. L. (Co-Investigator), Mendillo, M. L. (Co-Investigator), Qiang, W. (Co-Investigator) & Qiang, W. (Co-Investigator)
7/1/22 → 6/30/27
Project: Research project
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Role of C16orf72 in Response to Complex and Multifactorial Cancer-Associated Molecular Stresses
Mendillo, M. L. (PD/PI), Mendillo, M. L. (PD/PI), Kiyokawa, H. (Co-Investigator) & Kiyokawa, H. (Co-Investigator)
4/1/22 → 3/31/26
Project: Research project
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Investigating Rational Combination Therapies for Triple-Negative Breast Cancer
Horiuchi, D. (PD/PI), Horiuchi, D. (PD/PI), Horiuchi, D. (PD/PI), Mendillo, M. L. (PD/PI), Cristofanilli, M. (Co-Investigator), Cristofanilli, M. (Co-Investigator), Vasilopoulos, A. (Co-Investigator) & Vasilopoulos, A. (Co-Investigator)
1/1/22 → 12/31/26
Project: Research project
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The role of nucleoli in human genome organization in normal and disease states
Foltz, D. R. (PD/PI), Foltz, D. R. (PD/PI), Huang, S. (PD/PI), Huang, S. (PD/PI), Mendillo, M. L. (Co-Investigator), Mendillo, M. L. (Co-Investigator) & Huang, S. (Other)
University of Massachusetts Medical School, National Cancer Institute
9/21/20 → 2/28/27
Project: Research project
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Investigating the Aggregation and Prionogenic Properties of Human Cancer-Related Proteins
Goncharoff, D., Du, Z., Venkatesan, S., Cho, B., Zhao, J., Alasady, M. J., Huey, D., Ma, H., Rosenthal, J., Turenitsa, A., Feldman, C., Halfmann, R., Mendillo, M. L. & Li, L., 2025, In: Molecular and cellular biology. 45, 4, p. 154-168 15 p.Research output: Contribution to journal › Article › peer-review
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An HSF1–JMJD6–HSP feedback circuit promotes cell adaptation to proteotoxic stress
Alasady, M. J., Koeva, M., Takagishi, S. R., Segal, D., Amici, D. R., Smith, R. S., Ansel, D. J., Lindquist, S., Whitesell, L., Bartom, E. T., Taipale, M. & Mendillo, M. L., Jul 16 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 29, e2313370121.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Stress biology: Complexity and multifariousness in health and disease
Mayer, M. P., Blair, L., Blatch, G. L., Borges, T. J., Chadli, A., Chiosis, G., de Thonel, A., Dinkova-Kostova, A., Ecroyd, H., Edkins, A. L., Eguchi, T., Fleshner, M., Foley, K. P., Fragkostefanakis, S., Gestwicki, J., Goloubinoff, P., Heritz, J. A., Heske, C. M., Hibshman, J. D. & Joutsen, J. & 18 others, , Feb 2024, In: Cell Stress and Chaperones. 29, 1, p. 143-157 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The heat shock factor code: Specifying a diversity of transcriptional regulatory programs broadly promoting stress resilience
Alasady, M. J. & Mendillo, M. L., Dec 2024, In: Cell Stress and Chaperones. 29, 6, p. 735-749 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
Amici, D. R., Alhayek, S., Klein, A. T., Wang, Y. Z., Wilen, A. P., Song, W., Zhu, P., Thakkar, A., King, M. A., Steffeck, A. W. T., Alasady, M. J., Peek, C., Savas, J. N. & Mendillo, M. L., May 2024, In: Life science alliance. 7, 5, e202302370.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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QMAP-Seq bioinformatic analysis pipeline
Brockway, S. (Contributor), Wang, G. (Contributor), Jackson, J. M. (Contributor), Amici, D. R. (Contributor), Takagishi, S. R. (Contributor), Clutter, M. R. (Contributor), Bartom, E. T. (Contributor) & Mendillo, M. L. (Contributor), ZENODO, Oct 5 2020
DOI: 10.5281/zenodo.4067236, https://zenodo.org/records/4067236
Dataset
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QMAP-Seq: quantitative and multiplexed chemical-genetic phenotyping in mammalian cells
Brockway, S. (Creator), Wang, G. (Creator), Jackson, J. M. (Creator), Amici, D. R. (Creator), Takagishi, S. R. (Contributor), Clutter, M. R. (Creator), Bartom, E. T. (Creator) & Mendillo, M. L. (Creator), Code Ocean, 2020
DOI: 10.24433/co.6760903.v1, https://codeocean.com/capsule/3022355/tree/v1
Dataset