Grants per year
Personal profile
Research Interests
The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.
Training Experience
| 2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
| 2015 | Postdoctoral Fellowship, Whitehead Institute |
Education/Academic qualification
PhD, University Of California-San Diego
… → 2007
Keywords
- Cancer Biology
- Cell Biology
- Energy Metabolism
- Epigenetics
- Gene Regulation
- Genetics
- Genomics
- Systems Biology
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 7 Similar Profiles
DNA Mismatch Repair
Medicine & Life Sciences
Shock
Medicine & Life Sciences
Hot Temperature
Medicine & Life Sciences
Adenosine Triphosphate
Medicine & Life Sciences
DNA
Medicine & Life Sciences
Saccharomyces cerevisiae
Medicine & Life Sciences
Heat-Shock Response
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2016 2021
Harnessing Druggable Synthetic Lethal Interactions in Triple-Negative Breast Cancer with Elevated MYC Expression
Clutter, M., Horiuchi, D., Mendillo, M. L., Vasilopoulos, A. & Santa-Maria, C. A.
U.S. Army Medical Research and Materiel Command
4/1/18 → 3/31/21
Project: Research project
Triple Negative Breast Neoplasms
Neoplasms
Breast Neoplasms
Therapeutics
Mutation
Delineating and exploiting HSF1 activation in highly malignant breast cancers.
Susan G. Komen Breast Cancer Foundation
6/21/17 → 6/20/20
Project: Research project
The role of the proteostasis network in cancer evolution and the response to therapeutics
Sidney Kimmel Foundation for Cancer Research
7/1/16 → 6/30/19
Project: Research project
Neoplasms
Therapeutics
Heat-Shock Response
Tumor Microenvironment
Survival
Elucidating the stress response regulatory networks that enable malignancy
2/11/16 → 1/31/20
Project: Research project
Shock
Hot Temperature
Neoplasms
Phenotype
Biochemistry
Effect of the Cellular Stress Response Network in Sculpting the Therapeutic Response in Human Breast Cancers
Northwestern Memorial Hospital
9/1/16 → 8/31/17
Project: Research project
Breast Neoplasms
Heat-Shock Response
Neoplasms
Cell Biology
Oxidative Stress
Research Output 1999 2017
14
Citations
(Scopus)
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)
Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.Research output: Contribution to journal › Article
Cutaneous T-Cell Lymphoma
T-cells
NF-kappa B
T-Cell Antigen Receptor
T-Lymphocytes
39
Citations
(Scopus)
Luminidependens (LD) is an Arabidopsis protein with prion behavior
Chakrabortee, S., Kayatekin, C., Newby, G. A., Mendillo, M. L., Lancaster, A. & Lindquist, S., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6065-6070 6 p.Research output: Contribution to journal › Article
Prions
Yeasts
Arabidopsis LD protein
Biological Phenomena
Plant Proteins
18
Citations
(Scopus)
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome
Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., Brummelkamp, T. R., Santagata, S. & Lindquist, S., Sep 1 2015, In : eLife. 4, September2015, e08467.Research output: Contribution to journal › Article
Proteasome Endopeptidase Complex
Fluxes
Proteins
Survival
Eukaryota
50
Citations
(Scopus)
HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models
Whitesell, L., Santagata, S., Mendillo, M. L., Lin, N. U., Proia, D. A. & Lindquist, S., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18297-18302 6 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
Breast Neoplasms
Hormone Antagonists
Estrogen Receptors
Heat-Shock Response
11
Citations
(Scopus)
The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection
Filone, C. M., Caballero, I. S., Dower, K., Mendillo, M. L., Cowley, G. S., Santagata, S., Rozelle, D. K., Yen, J., Rubins, K. H., Hacohen, N., Root, D. E., Hensley, L. E. & Connor, J., Jan 1 2014, In : PLoS Pathogens. 10, 2, e1003904.Research output: Contribution to journal › Article
Orthopoxvirus
Heat-Shock Response
Shock
Hot Temperature
Infection