Grants per year
Personal profile
Research Interests
The cellular protein homeostasis network guards the proteome from diverse endogenous and environmental insults to maintain the fitness of the organism. Ironically, this pro-survival network can act to the detriment of the host to enable tumor cells accommodate to the myriad stresses associated with malignancy. Our long-term goals are to identify and characterize the systems that promote protein homeostasis, understand how these systems are co-opted and perturbed in malignancy, and ultimately identify means to manipulate them for therapeutic benefit. To accomplish these goals our group bridges biochemical, genetic and chemical biology approaches with systematic high-throughput and genomic methods.
Training Experience
| 2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
| 2015 | Postdoctoral Fellowship, Whitehead Institute |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Sciences, PhD, University of California at San Diego
… → 2007
Biomedical Sciences, PhD, University of California at San Diego
… → 2007
Research interests keywords
- Cancer Biology
- Cell Biology
- Energy Metabolism
- Epigenetics
- Gene Regulation
- Genetics
- Genomics
- Systems Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Regulation and interplay of Heat Shock Factors in growth-associated proteotoxic stresses
Mendillo, M. L. & Mendillo, M. L.
National Institute of General Medical Sciences
9/1/22 → 8/31/27
Project: Research project
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Phenotypic marker-guided development of selective antimetastasis therapeutic leads
Huang, S., Huang, S., Ji, Z., Ji, Z., Mendillo, M. L., Mendillo, M. L., Qiang, W. & Qiang, W.
7/1/22 → 6/30/27
Project: Research project
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Role of C16orf72 in Response to Complex and Multifactorial Cancer-Associated Molecular Stresses
Mendillo, M. L., Mendillo, M. L., Kiyokawa, H. & Kiyokawa, H.
4/1/22 → 3/31/26
Project: Research project
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Leveraging Systematic Chemical-Genetic Profiling as a Path to Expand Precision Medicine in Breast Cancer
Mendillo, M. L., Cristofanilli, M. & Horiuchi, D.
U.S. Army Medical Research and Materiel Command
1/15/22 → 1/14/24
Project: Research project
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Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors
Klein, A. T. & Mendillo, M. L., Nov 16 2023, In: Cell Chemical Biology. 30, 11, p. 1334-1336 3 p.Research output: Contribution to journal › Comment/debate › peer-review
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Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer
Hua, X., Li, Y., Pentaparthi, S. R., McGrail, D. J., Zou, R., Guo, L., Shrawat, A., Cirillo, K. M., Li, Q., Bhat, A., Xu, M., Qi, D., Singh, A., McGrath, F., Andrews, S., Aung, K. L., Das, J., Zhou, Y., Lodi, A., Mills, G. B., & 7 others, Jan 1 2023, In: Cancer Research. 83, 1, p. 59-73 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein
Shum, A., Zaichick, S., McElroy, G. S., Alessandro, K. D., Alasady, M. J., Novakovic, M., Peng, W., Grebenik, E. A., Chung, D., Flanagan, M. E., Smith, R., Morales, A., Stumpf, L., McGrath, K., Krainc, D., Mendillo, M. L., Prakriya, M., Chandel, N. S. & Caraveo, G., Apr 25 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, e2217396120.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
Amici, D. R., Cingoz, H., Alasady, M. J., Alhayek, S., Phoumyvong, C. M., Sahni, N., Yi, S. S. & Mendillo, M. L., Dec 2023, In: Nature communications. 14, 1, 152.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins
McGrail, D. J., Li, Y., Smith, R. S., Feng, B., Dai, H., Hu, L., Dennehey, B., Awasthi, S., Mendillo, M. L., Sood, A. K., Mills, G. B., Lin, S. Y., Yi, S. S. & Sahni, N., Nov 21 2023, In: Cell Reports Medicine. 4, 11, 101255.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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QMAP-Seq: quantitative and multiplexed chemical-genetic phenotyping in mammalian cells
Brockway, S. (Creator), Wang, G. (Creator), Jackson, J. M. (Creator), Amici, D. R. (Creator), Takagishi, S. R. (Contributor), Clutter, M. R. (Creator), Bartom, E. T. (Creator), Mendillo, M. L. (Creator) & Bartom, E. T. (Creator), Code Ocean, 2020
DOI: 10.24433/co.6760903.v1, https://codeocean.com/capsule/3022355/tree/v1
Dataset
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QMAP-Seq bioinformatic analysis pipeline
Brockway, S. (Contributor), Wang, G. (Contributor), Jackson, J. M. (Contributor), Amici, D. R. (Contributor), Takagishi, S. R. (Contributor), Clutter, M. R. (Contributor), Bartom, E. T. (Contributor) & Mendillo, M. L. (Contributor), ZENODO, Oct 5 2020
DOI: 10.5281/zenodo.4067236, https://zenodo.org/record/4067236
Dataset