• 3661 Citations
19992020

Research output per year

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Research Output

2020

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal about a Key Cellular Redox Switch

Palma, F. R., He, C., Danes, J. M., Paviani, V., Coelho, D. R., Gantner, B. N. & Bonini, M. G., Apr 1 2020, In : Antioxidants and Redox Signaling. 32, 10, p. 701-714 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

Nitric oxide in cellular adaptation and disease

Gantner, B. N., LaFond, K. M. & Bonini, M. G., Jul 2020, In : Redox Biology. 34, 101550.

Research output: Contribution to journalReview article

Open Access
2019

Cancer therapy-induced cardiovascular toxicity: Old/new problems and old drugs

Beyer, A. M., Bonini, M. G. & Moslehi, J., Jun 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 1, p. H164-H167

Research output: Contribution to journalArticle

2 Scopus citations

Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors

Bonds, J. A., Shetti, A., Bheri, A., Chen, Z., Disouky, A., Tai, L., Mao, M., Head, B. P., Bonini, M. G., Haus, J. M., Minshall, R. D. & Lazarov, O., Oct 23 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 43, p. 8576-8583 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

Lee, J., Yesilkanal, A. E., Wynne, J. P., Frankenberger, C., Liu, J., Yan, J., Elbaz, M., Rabe, D. C., Rustandy, F. D., Tiwari, P., Grossman, E. A., Hart, P. C., Kang, C., Sanderson, S. M., Andrade, J., Nomura, D. K., Bonini, M. G., Locasale, J. W. & Rosner, M. R., Apr 11 2019, In : Nature. 568, 7751, p. 254-258 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension

Oliveira, S. D. S., Chen, J., Castellon, M., Mao, M., Raj, J. U., Comhair, S., Erzurum, S., Silva, C. L. M., Machado, R. F., Bonini, M. G. & Minshall, R. D., Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1191-1202 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D., Dec 1 2019, In : Nature communications. 10, 1, 2399.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice

Gerber, T. J., Fehr, V. C. O., Oliveira, S. D. S., Hu, G., Dull, R., Bonini, M. G., Beck-Schimmer, B. & Minshall, R. D., Dec 1 2019, In : Anesthesiology. 131, 6, p. 1301-1315 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

He, C., Danes, J. M., Hart, P. C., Zhu, Y., Huang, Y., de Abreu, A. L., O’Brien, J., Mathison, A. J., Tang, B., Frasor, J. M., Wakefield, L. M., Ganini, D., Stauder, E., Zielonka, J., Gantner, B. N., Urrutia, R. A., Gius, D. & Bonini, M. G., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23534-23541 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle

Mey, J. T., Blackburn, B. K., Miranda, E. R., Chaves, A. B., Briller, J., Bonini, M. G. & Haus, J. M., Feb 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 2, p. R181-R190

Research output: Contribution to journalArticle

10 Scopus citations

Environmental toxicant exposures and type 2 diabetes mellitus: Two interrelated public health problems on the rise

Bonini, M. G. & Sargis, R. M., Feb 2018, In : Current Opinion in Toxicology. 7, p. 52-59 8 p.

Research output: Contribution to journalReview article

12 Scopus citations

Feeding During Phases of Altered Mitochondrial Activity: A Theory

McKeever, L., Bonini, M. & Braunschweig, C., Jul 2018, In : Journal of Parenteral and Enteral Nutrition. 42, 5, p. 855-863 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

Chen, Z., Oliveira, S. D. S., Zimnicka, A. M., Jiang, Y., Sharma, T., Chen, S., Lazarov, O., Bonini, M. G., Haus, J. M. & Minshall, R. D., May 15 2018, In : Molecular biology of the cell. 29, 10, p. 1190-1202 13 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice

Ganini, D., Santos, J. H., Bonini, M. G. & Mason, R. P., Apr 19 2018, In : Cell Chemical Biology. 25, 4, p. 413-425.e6

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2017

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin

Ekoue, D. N., Bera, S., Ansong, E., Hart, P. C., Zaichick, S., Domann, F. E., Bonini, M. G. & Diamond, A. M., Jun 3 2017, In : Free Radical Research. 51, 6, p. 582-590 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling

Oliveira, S. D. S., Castellon, M., Chen, J., Bonini, M. G., Gu, X., Elliott, M. H., Machado, R. F. & Minshall, R. D., May 4 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 5, p. L760-L771

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Zou, X., Ratti, B. A., O’Brien, J. G., Lautenschlager, S. O., Gius, D. R., Bonini, M. G. & Zhu, Y., Aug 1 2017, In : Journal of Bioenergetics and Biomembranes. 49, 4, p. 325-333 9 p.

Research output: Contribution to journalReview article

38 Scopus citations
Open Access
21 Scopus citations

Mitochondria targeting by environmental stressors: Implications for redox cellular signaling

Blajszczak, C. & Bonini, M. G., Nov 1 2017, In : Toxicology. 391, p. 84-89 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production

Potje, S. R., Chen, Z., Oliveira, S. D. A. S., Bendhack, L. M., da Silva, R. S., Bonini, M. G., Antoniali, C. & Minshall, R. D., Nov 2017, In : Free Radical Biology and Medicine. 112, p. 587-596 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities

Rauscher, G. H., Silva, A., Pauls, H., Frasor, J., Bonini, M. G. & Hoskins, K., Jun 1 2017, In : Breast Cancer Research and Treatment. 163, 2, p. 321-330 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

Kenny, T. T., Hart, P., Ragazzi, M., Sersinghe, M., Chipuk, J., Sagar, M. A. K., Eliceiri, K. K., LaFramboise, T., Grandhi, S., Santos, J., Riar, A. A., Papa, L., D'Aurello, M., Manfredi, G., Bonini, M. M. & Germain, D., Aug 1 2017, In : Oncogene. 36, 31, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P)

Ekoue, D. N., Zaichick, S., Valyi-Nagy, K., Picklo, M., Lacher, C., Hoskins, K., Warso, M. A., Bonini, M. G. & Diamond, A. M., Jan 1 2017, In : Journal of Trace Elements in Medicine and Biology. 39, p. 227-233 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion

de Abreu, A. L. P., Malaguti, N., Souza, R. P., Uchimura, N. S., Ferreira, É. C., Pereira, M. W., Carvalho, M. D. B., Pelloso, S. M., Bonini, M. G., Gimenes, F. & Consolaro, M. E. L., Jan 1 2016, In : American Journal of Cancer Research. 6, 6, p. 1371-1383 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis

Hart, P. C., Ratti, B. A., Mao, M., Ansenberger-Fricano, K., Shajahan-Haq, A. N., Tyner, A. L., Minshall, R. D. & Bonini, M. G., 2016, In : Oncotarget. 7, 1, p. 308-322 15 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Fettiplace, M. R., Kowal, K., Ripper, R., Young, A., Lis, K., Rubinstein, I., Bonini, M., Minshall, R. & Weinberg, G., Feb 1 2016, In : Anesthesiology. 124, 2, p. 428-442 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions

He, C., Hart, P. C., Germain, D. & Bonini, M. G., Jul 1 2016, In : Trends in Biochemical Sciences. 41, 7, p. 568-577 10 p.

Research output: Contribution to journalReview article

Open Access
15 Scopus citations

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease

Bonds, J. A., Hart, P. C., Minshall, R. D., Lazarov, O., Haus, J. M. & Bonini, M. G., Jan 1 2016, Genes, Environment and Alzheimer's Disease. Elsevier Inc, p. 387-413 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

Tang, H., Chen, J., Fraidenburg, D. R., Song, S., Sysol, J. R., Drennan, A. R., Offermanns, S., Ye, R. D., Bonini, M. G., Minshall, R. D., Garcia, J. G. N., Machado, R. F., Makino, A. & Yuan, J. X. J., Jan 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 2, p. L208-L220

Research output: Contribution to journalArticle

33 Scopus citations

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

Hart, P. C., Mao, M., De Abreu, A. L. P., Ansenberger-Fricano, K., Ekoue, D. N., Ganini, D., Kajdacsy-Balla, A., Diamond, A. M., Minshall, R. D., Consolaro, M. E. L., Santos, J. H. & Bonini, M. G., Feb 2015, In : Nature communications. 6, 6053.

Research output: Contribution to journalArticle

Open Access
114 Scopus citations

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

Baig, M. S., Zaichick, S. V., Mao, M., de Abreu, A. L., Bakhshi, F. R., Hart, P. C., Saqib, U., Deng, J., Chatterjee, S., Block, M. L., Vogel, S. M., Malik, A. B., Consolaro, M. E. L., Christman, J. W., Minshall, R. D., Gantner, B. N. & Bonini, M. G., Sep 21 2015, In : Journal of Experimental Medicine. 212, 10, p. 1725-1738 14 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

Propofol increases morbidity and mortality in a rat model of sepsis

Schläpfer, M., Piegeler, T., Dull, R. O., Schwartz, D. E., Mao, M., Bonini, M. G., Z'Graggen, B. R., Beck-Schimmer, B. & Minshall, R. D., Feb 19 2015, In : Critical Care. 19, 1, 45.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Redox regulation of NF-κB p50 and M1 polarization in microglia

Taetzsch, T., Levesque, S., Mcgraw, C., Brookins, S., Luqa, R., Bonini, M. G., Mason, R. P., Oh, U. & Block, M. L., Mar 1 2015, In : Glia. 63, 3, p. 423-440 18 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating csrc tyrosine kinase

Yang, K. C., Rutledge, C. A., Mao, M., Bakhshi, F. R., Xie, A., Liu, H., Bonini, M. G., Patel, H. H., Minshall, R. D. & Dudley, S. C., Aug 1 2014, In : Circulation: Arrhythmia and Electrophysiology. 7, 4, p. 701-710 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for Endothelial cell Apoptosis

Hecquet, C. M., Zhang, M., Mittal, M., Vogel, S. M., Di, A., Gao, X., Bonini, M. G. & Malik, A. B., Jan 31 2014, In : Circulation research. 114, 3, p. 469-479 11 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Endothelial barrier protection by local anesthetics: Ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation

Piegeler, T., Votta-Velis, E. G., Bakhshi, F. R., Mao, M., Carnegie, G., Bonini, M. G., Schwartz, D. E., Borgeat, A., Beck-Schimmer, B. & Minshall, R. D., Jun 2014, In : Anesthesiology. 120, 6, p. 1414-1428 15 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker?

Gimenes, F., Teixeira, J. J. V., de Abreu, A. L. P., Souza, R. P., Pereira, M. W., da Silva, V. R. S., BÔer, C. G., Maria-Engler, S. S., Bonini, M. G., Borelli, S. D. & Consolaro, M. E. L., Dec 1 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1846, 2, p. 576-589 14 p.

Research output: Contribution to journalReview article

21 Scopus citations

Male infertility: A public health issue caused by sexually transmitted pathogens

Gimenes, F., Souza, R. P., Bento, J. C., Teixeira, J. J. V., Maria-Engler, S. S., Bonini, M. G. & Consolaro, M. E. L., Dec 11 2014, In : Nature Reviews Urology. 11, 12, p. 672-687 16 p.

Research output: Contribution to journalReview article

90 Scopus citations

Mitochondria and arrhythmias

Yang, K. C., Bonini, M. G. & Dudley, S. C., Jun 2014, In : Free Radical Biology and Medicine. 71, p. 351-361 11 p.

Research output: Contribution to journalReview article

45 Scopus citations

Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function

Bera, S., Weinberg, F., Ekoue, D. N., Ansenberger-Fricano, K., Mao, M., Bonini, M. G. & Diamond, A. M., Jul 21 2014, In : Cancer Research. 74, 18, p. 5118-5126 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Nitroglycerin tolerance in caveolin-1 deficient mice

Mao, M., Varadarajan, S., Fukai, T., Bakhshi, F. R., Chernaya, O., Dudley, S. C., Minshall, R. D. & Bonini, M. G., Aug 26 2014, In : PloS one. 9, 8, e104101.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Redox control of enzymatic functions: The electronics of life's circuitry

Bonini, M. G., Consolaro, M. E. L., Hart, P. C., Mao, M., De Abreu, A. L. P. & Master, A. M., Mar 2014, In : IUBMB Life. 66, 3, p. 167-181 15 p.

Research output: Contribution to journalReview article

13 Scopus citations

Regulating the regulator of ROS production

Bonini, M. G. & Malik, A. B., Aug 2014, In : Cell Research. 24, 8, p. 908-909 2 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Sensitive simultaneous detection of seven sexually transmitted agents in Semen by multiplex-PCR and of HPV by single PCR

Gimenes, F., Medina, F. S., De Abreu, A. L. P., Irie, M. M. T., Esquica̧ti, I. B., Malagutti, N., Vasconcellos, V. R. B., Discacciati, M. G., Bonini, M. G., Maria-Engler, S. S. & Consolaro, M. E. L., Jun 12 2014, In : PloS one. 9, 6, e98862.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2013

Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin

Sieracki, N. A., Gantner, B. N., Mao, M., Horner, J. H., Ye, R. D., Malik, A. B., Newcomb, M. E. & Bonini, M. G., Apr 25 2013, In : Free Radical Biology and Medicine. 61, p. 40-50 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

Schmidt, T. T., Tauseef, M., Yue, L., Bonini, M. G., Gothert, J., Shen, T. L., Guan, J. L., Predescu, S., Sadikot, R. & Mehta, D., May 8 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 305, 4, p. L291-L300

Research output: Contribution to journalArticle

31 Scopus citations

Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women

Souza, R. P., Gimenes, F., De Abreu, A. L. P., Rocha-Brischiliari, S. C., De Carvalho, M. D. B., Ferreira, É. C., Bonini, M. G., Pelloso, S. M. & Consolaro, M. E. L., Oct 9 2013, In : Infectious Agents and Cancer. 8, 1, 38.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Glutathiolated Ras: Characterization and implications for Ras activation

Hobbs, G. A., Bonini, M. G., Gunawardena, H. P., Chen, X. & Campbell, S. L., Apr 1 2013, In : Free Radical Biology and Medicine. 57, p. 221-229 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis

Towner, R. A., Smith, N., Saunders, D., Lupu, F., Silasi-Mansat, R., West, M., Ramirez, D. C., Gomez-Mejiba, S. E., Bonini, M. G., Mason, R. P., Ehrenshaft, M. & Hensley, K., Jan 1 2013, In : Free Radical Biology and Medicine. 63, p. 351-360 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Microglial activation decreases retention of the protease inhibitor saquinavir: Implications for HIV treatment

Dallas, S., Block, M. L., Thompson, D. M., Bonini, M. G., Ronaldson, P. T., Bendayan, R. & Miller, D. S., May 4 2013, In : Journal of neuroinflammation. 10, 822.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations