• 3661 Citations
19992020

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2019

Cancer therapy-induced cardiovascular toxicity: Old/new problems and old drugs

Beyer, A. M., Bonini, M. G. & Moslehi, J., Jun 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 1, p. H164-H167

Research output: Contribution to journalArticle

2 Scopus citations

Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors

Bonds, J. A., Shetti, A., Bheri, A., Chen, Z., Disouky, A., Tai, L., Mao, M., Head, B. P., Bonini, M. G., Haus, J. M., Minshall, R. D. & Lazarov, O., Oct 23 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 43, p. 8576-8583 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

Lee, J., Yesilkanal, A. E., Wynne, J. P., Frankenberger, C., Liu, J., Yan, J., Elbaz, M., Rabe, D. C., Rustandy, F. D., Tiwari, P., Grossman, E. A., Hart, P. C., Kang, C., Sanderson, S. M., Andrade, J., Nomura, D. K., Bonini, M. G., Locasale, J. W. & Rosner, M. R., Apr 11 2019, In : Nature. 568, 7751, p. 254-258 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension

Oliveira, S. D. S., Chen, J., Castellon, M., Mao, M., Raj, J. U., Comhair, S., Erzurum, S., Silva, C. L. M., Machado, R. F., Bonini, M. G. & Minshall, R. D., Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1191-1202 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D., Dec 1 2019, In : Nature communications. 10, 1, 2399.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice

Gerber, T. J., Fehr, V. C. O., Oliveira, S. D. S., Hu, G., Dull, R., Bonini, M. G., Beck-Schimmer, B. & Minshall, R. D., Dec 1 2019, In : Anesthesiology. 131, 6, p. 1301-1315 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

He, C., Danes, J. M., Hart, P. C., Zhu, Y., Huang, Y., de Abreu, A. L., O’Brien, J., Mathison, A. J., Tang, B., Frasor, J. M., Wakefield, L. M., Ganini, D., Stauder, E., Zielonka, J., Gantner, B. N., Urrutia, R. A., Gius, D. & Bonini, M. G., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23534-23541 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle

Mey, J. T., Blackburn, B. K., Miranda, E. R., Chaves, A. B., Briller, J., Bonini, M. G. & Haus, J. M., Feb 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 2, p. R181-R190

Research output: Contribution to journalArticle

10 Scopus citations

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

Chen, Z., Oliveira, S. D. S., Zimnicka, A. M., Jiang, Y., Sharma, T., Chen, S., Lazarov, O., Bonini, M. G., Haus, J. M. & Minshall, R. D., May 15 2018, In : Molecular biology of the cell. 29, 10, p. 1190-1202 13 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice

Ganini, D., Santos, J. H., Bonini, M. G. & Mason, R. P., Apr 19 2018, In : Cell Chemical Biology. 25, 4, p. 413-425.e6

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2017

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin

Ekoue, D. N., Bera, S., Ansong, E., Hart, P. C., Zaichick, S., Domann, F. E., Bonini, M. G. & Diamond, A. M., Jun 3 2017, In : Free Radical Research. 51, 6, p. 582-590 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling

Oliveira, S. D. S., Castellon, M., Chen, J., Bonini, M. G., Gu, X., Elliott, M. H., Machado, R. F. & Minshall, R. D., May 4 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 5, p. L760-L771

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Mitochondria targeting by environmental stressors: Implications for redox cellular signaling

Blajszczak, C. & Bonini, M. G., Nov 1 2017, In : Toxicology. 391, p. 84-89 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production

Potje, S. R., Chen, Z., Oliveira, S. D. A. S., Bendhack, L. M., da Silva, R. S., Bonini, M. G., Antoniali, C. & Minshall, R. D., Nov 2017, In : Free Radical Biology and Medicine. 112, p. 587-596 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities

Rauscher, G. H., Silva, A., Pauls, H., Frasor, J., Bonini, M. G. & Hoskins, K., Jun 1 2017, In : Breast Cancer Research and Treatment. 163, 2, p. 321-330 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

Kenny, T. T., Hart, P., Ragazzi, M., Sersinghe, M., Chipuk, J., Sagar, M. A. K., Eliceiri, K. K., LaFramboise, T., Grandhi, S., Santos, J., Riar, A. A., Papa, L., D'Aurello, M., Manfredi, G., Bonini, M. M. & Germain, D., Aug 1 2017, In : Oncogene. 36, 31, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P)

Ekoue, D. N., Zaichick, S., Valyi-Nagy, K., Picklo, M., Lacher, C., Hoskins, K., Warso, M. A., Bonini, M. G. & Diamond, A. M., Jan 1 2017, In : Journal of Trace Elements in Medicine and Biology. 39, p. 227-233 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion

de Abreu, A. L. P., Malaguti, N., Souza, R. P., Uchimura, N. S., Ferreira, É. C., Pereira, M. W., Carvalho, M. D. B., Pelloso, S. M., Bonini, M. G., Gimenes, F. & Consolaro, M. E. L., Jan 1 2016, In : American Journal of Cancer Research. 6, 6, p. 1371-1383 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis

Hart, P. C., Ratti, B. A., Mao, M., Ansenberger-Fricano, K., Shajahan-Haq, A. N., Tyner, A. L., Minshall, R. D. & Bonini, M. G., 2016, In : Oncotarget. 7, 1, p. 308-322 15 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Fettiplace, M. R., Kowal, K., Ripper, R., Young, A., Lis, K., Rubinstein, I., Bonini, M., Minshall, R. & Weinberg, G., Feb 1 2016, In : Anesthesiology. 124, 2, p. 428-442 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

Tang, H., Chen, J., Fraidenburg, D. R., Song, S., Sysol, J. R., Drennan, A. R., Offermanns, S., Ye, R. D., Bonini, M. G., Minshall, R. D., Garcia, J. G. N., Machado, R. F., Makino, A. & Yuan, J. X. J., Jan 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 2, p. L208-L220

Research output: Contribution to journalArticle

33 Scopus citations

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

Hart, P. C., Mao, M., De Abreu, A. L. P., Ansenberger-Fricano, K., Ekoue, D. N., Ganini, D., Kajdacsy-Balla, A., Diamond, A. M., Minshall, R. D., Consolaro, M. E. L., Santos, J. H. & Bonini, M. G., Feb 2015, In : Nature communications. 6, 6053.

Research output: Contribution to journalArticle

Open Access
114 Scopus citations

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

Baig, M. S., Zaichick, S. V., Mao, M., de Abreu, A. L., Bakhshi, F. R., Hart, P. C., Saqib, U., Deng, J., Chatterjee, S., Block, M. L., Vogel, S. M., Malik, A. B., Consolaro, M. E. L., Christman, J. W., Minshall, R. D., Gantner, B. N. & Bonini, M. G., Sep 21 2015, In : Journal of Experimental Medicine. 212, 10, p. 1725-1738 14 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

Propofol increases morbidity and mortality in a rat model of sepsis

Schläpfer, M., Piegeler, T., Dull, R. O., Schwartz, D. E., Mao, M., Bonini, M. G., Z'Graggen, B. R., Beck-Schimmer, B. & Minshall, R. D., Feb 19 2015, In : Critical Care. 19, 1, 45.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Redox regulation of NF-κB p50 and M1 polarization in microglia

Taetzsch, T., Levesque, S., Mcgraw, C., Brookins, S., Luqa, R., Bonini, M. G., Mason, R. P., Oh, U. & Block, M. L., Mar 1 2015, In : Glia. 63, 3, p. 423-440 18 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating csrc tyrosine kinase

Yang, K. C., Rutledge, C. A., Mao, M., Bakhshi, F. R., Xie, A., Liu, H., Bonini, M. G., Patel, H. H., Minshall, R. D. & Dudley, S. C., Aug 1 2014, In : Circulation: Arrhythmia and Electrophysiology. 7, 4, p. 701-710 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for Endothelial cell Apoptosis

Hecquet, C. M., Zhang, M., Mittal, M., Vogel, S. M., Di, A., Gao, X., Bonini, M. G. & Malik, A. B., Jan 31 2014, In : Circulation research. 114, 3, p. 469-479 11 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Endothelial barrier protection by local anesthetics: Ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation

Piegeler, T., Votta-Velis, E. G., Bakhshi, F. R., Mao, M., Carnegie, G., Bonini, M. G., Schwartz, D. E., Borgeat, A., Beck-Schimmer, B. & Minshall, R. D., Jun 2014, In : Anesthesiology. 120, 6, p. 1414-1428 15 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function

Bera, S., Weinberg, F., Ekoue, D. N., Ansenberger-Fricano, K., Mao, M., Bonini, M. G. & Diamond, A. M., Jul 21 2014, In : Cancer Research. 74, 18, p. 5118-5126 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Nitroglycerin tolerance in caveolin-1 deficient mice

Mao, M., Varadarajan, S., Fukai, T., Bakhshi, F. R., Chernaya, O., Dudley, S. C., Minshall, R. D. & Bonini, M. G., Aug 26 2014, In : PloS one. 9, 8, e104101.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Regulating the regulator of ROS production

Bonini, M. G. & Malik, A. B., Aug 2014, In : Cell Research. 24, 8, p. 908-909 2 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Sensitive simultaneous detection of seven sexually transmitted agents in Semen by multiplex-PCR and of HPV by single PCR

Gimenes, F., Medina, F. S., De Abreu, A. L. P., Irie, M. M. T., Esquica̧ti, I. B., Malagutti, N., Vasconcellos, V. R. B., Discacciati, M. G., Bonini, M. G., Maria-Engler, S. S. & Consolaro, M. E. L., Jun 12 2014, In : PloS one. 9, 6, e98862.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2013

Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin

Sieracki, N. A., Gantner, B. N., Mao, M., Horner, J. H., Ye, R. D., Malik, A. B., Newcomb, M. E. & Bonini, M. G., Apr 25 2013, In : Free Radical Biology and Medicine. 61, p. 40-50 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

Schmidt, T. T., Tauseef, M., Yue, L., Bonini, M. G., Gothert, J., Shen, T. L., Guan, J. L., Predescu, S., Sadikot, R. & Mehta, D., May 8 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 305, 4, p. L291-L300

Research output: Contribution to journalArticle

31 Scopus citations

Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women

Souza, R. P., Gimenes, F., De Abreu, A. L. P., Rocha-Brischiliari, S. C., De Carvalho, M. D. B., Ferreira, É. C., Bonini, M. G., Pelloso, S. M. & Consolaro, M. E. L., Oct 9 2013, In : Infectious Agents and Cancer. 8, 1, 38.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Glutathiolated Ras: Characterization and implications for Ras activation

Hobbs, G. A., Bonini, M. G., Gunawardena, H. P., Chen, X. & Campbell, S. L., Apr 1 2013, In : Free Radical Biology and Medicine. 57, p. 221-229 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis

Towner, R. A., Smith, N., Saunders, D., Lupu, F., Silasi-Mansat, R., West, M., Ramirez, D. C., Gomez-Mejiba, S. E., Bonini, M. G., Mason, R. P., Ehrenshaft, M. & Hensley, K., Jan 1 2013, In : Free Radical Biology and Medicine. 63, p. 351-360 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Microglial activation decreases retention of the protease inhibitor saquinavir: Implications for HIV treatment

Dallas, S., Block, M. L., Thompson, D. M., Bonini, M. G., Ronaldson, P. T., Bendayan, R. & Miller, D. S., May 4 2013, In : Journal of neuroinflammation. 10, 822.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death

Sovari, A. A., Rutledge, C. A., Jeong, E. M., Dolmatova, E., Arasu, D., Liu, H., Vahdani, N., Gu, L., Zandieh, S., Xiao, L., Bonini, M. G., Duffy, H. S. & Dudley, S. C., Jun 1 2013, In : Circulation: Arrhythmia and Electrophysiology. 6, 3, p. 623-631 9 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

Bakhshi, F. R., Mao, M., Shajahan, A. N., Piegeler, T., Chen, Z., Chernaya, O., Sharma, T., Elliott, W. M., Szulcek, R., Bogaard, H. J., Comhair, S., Erzurum, S., Van Nieuw Amerongen, G. P., Bonini, M. G. & Minshall, R. D., Dec 2013, In : Pulmonary Circulation. 3, 4, p. 816-830 15 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Short report: Simultaneous detection of seven sexually transmitted agents in human immunodeficiency virus-infected Brazilian women by multiplex polymerase chain reaction

Souza, R. P., De Abreu, A. L. P., Ferreira, É. C., Rocha-Brischiliari, S. C., De Carvalho, M. D. B., Pelloso, S. M., Bonini, M. G., Gimenes, F. & Consolaro, M. E. L., Dec 1 2013, In : American Journal of Tropical Medicine and Hygiene. 89, 6, p. 1199-1202 4 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

The peroxidase activity of mitochondrial superoxide dismutase

Ansenberger-Fricano, K., Ganini, D., Mao, M., Chatterjee, S., Dallas, S., Mason, R. P., Stadler, K., Santos, J. H. & Bonini, M. G., Jan 1 2013, In : Free Radical Biology and Medicine. 54, p. 116-124 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Detection of Ras GTPase protein radicals through immuno-spin trapping

Davis, M. F., Zhou, L., Ehrenshaft, M., Ranguelova, K., Gunawardena, H. P., Chen, X., Bonini, M. G., Mason, R. P. & Campbell, S. L., Sep 15 2012, In : Free Radical Biology and Medicine. 53, 6, p. 1339-1345 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model

Towner, R. A., Smith, N., Saunders, D., Henderson, M., Downum, K., Lupu, F., Silasi-Mansat, R., Ramirez, D. C., Gomez-Mejiba, S. E., Bonini, M. G., Ehrenshaft, M. & Mason, R. P., Oct 2012, In : Diabetes. 61, 10, p. 2405-2413 9 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate

Ranguelova, K., Ganini, D., Bonini, M. G., London, R. E. & Mason, R. P., Aug 1 2012, In : Free Radical Biology and Medicine. 53, 3, p. 589-594 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Chen, Z., Bakhshi, F. R., Shajahan, A. N., Sharma, T., Mao, Trane, A., Bernatchez, P., Van Nieuw Amerongen, G. P., Bonini, M. G., Skidgel, R. A., Malik, A. B. & Minshall, R. D., Apr 1 2012, In : Molecular biology of the cell. 23, 7, p. 1388-1398 11 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway

Mao, M., Sudhahar, V., Ansenberger-Fricano, K., Fernandes, D. C., Tanaka, L. Y., Fukai, T., Laurindo, F. R. M., Mason, R. P., Vasquez-Vivar, J., Minshall, R. D., Stadler, K. & Bonini, M. G., Jan 15 2012, In : Free Radical Biology and Medicine. 52, 2, p. 427-435 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation

Kadiiska, M. B., Bonini, M. G., Ruggiero, C., Cleland, E., Wicks, S. & Stadler, K., Mar 1 2012, In : Diabetes. 61, 3, p. 586-596 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2011

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death

Sovari, A. A., Iravanian, S., Dolmatova, E., Jiao, Z., Liu, H., Zandieh, S., Kumar, V., Wang, K., Bernstein, K. E., Bonini, M. G., Duffy, H. S. & Dudley, S. C., Nov 22 2011, In : Journal of the American College of Cardiology. 58, 22, p. 2332-2339 8 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury

Toya, S. P., Li, F., Bonini, M. G., Gomez, I., Mao, M., Bachmaier, K. W. & Malik, A. B., Jan 2011, In : American Journal of Pathology. 178, 1, p. 313-324 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations