• 30814 Citations
1987 …2018
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Personal profile

Research Interests

Signaling of death receptors with emphasis on Fas. The role of microRNA in tumor progression.

Research Interests

The lab of Dr. Marcus E. Peter studies various forms of cell death including apoptosis, which is a fundamental process to regulate homeostasis of all tissues and to eliminate unwanted cells specifically in the immune system. Another interest lies in the study of RNA interference and based on toxic RNAs to development a novel form of cancer treatment. The laboratory is located within the Robert H. Lurie Cancer Center at Northwestern University.

Education/Academic qualification

PhD, University of Bayreuth, Germany

… → 1988


  • MicroRNA
  • Cancer: Female Reproductive System (ovary / cervix / uterus)
  • Liver Cancer
  • Apoptosis

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Research Output 1987 2018

1 Citations

CD95/Fas ligand mRNA is toxic to cells

Putzbach, W., Haluck-Kangas, A., Gao, Q. Q., Sarshad, A. A., Bartom, E. T., Stults, A., Qadir, A. S., Hafner, M. & Peter, M. E., Oct 16 2018, In : eLife. 7

Research output: Contribution to journalArticle

Fas Ligand Protein
Messenger RNA
RNA-Induced Silencing Complex
Death Domain Receptors

DISE: A Seed-Dependent RNAi Off-Target Effect That Kills Cancer Cells

Putzbach, W., Gao, Q. Q., Patel, M., Haluck-Kangas, A., Murmann, A. E. & Peter, M. E., Jan 1 2018, In : Trends in Cancer. 4, 1, p. 10-19 10 p.

Research output: Contribution to journalReview article

RNA Interference
Small Interfering RNA
3 Citations

Identification of DISE-inducing shRNAs by monitoring cellular responses

Patel, M. & Peter, M. E., Feb 16 2018, In : Cell Cycle. 17, 4, p. 506-514 9 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Gene Targeting
87 Citations

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 149 othersBlomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chandel, N., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K. M., Deberardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., García-Sáez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H. U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. & Kroemer, G., Mar 1 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalReview article

Cell Death
Cell Aging
4 Citations

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

Murmann, A. E., Gao, Q. Q., Putzbach, W. E., Patel, M., Bartom, E. T., Law, C. Y., Bridgeman, B., Chen, S., Mcmahon, K. M., Thaxton, C. S. & Peter, M. E., Mar 1 2018, In : EMBO Reports. 19, 3, e45336.

Research output: Contribution to journalArticle

Trinucleotide Repeats
Small Interfering RNA
Trinucleotide Repeat Expansion