Grants per year
Personal profile
Research Interests
In my lab, we are interested in understanding mechanisms leading to newborn brain injury, especially preterm brain injury. Our research focuses on the impact of hypoxia-ischemia on the development of cells of the oligodendroglial lineage. Our strategy is to genetically manipulate bone morphogenetic protein (BMP) signaling in an attempt to regenerate white matter lost to perinatal hypoxic-ischemic (HI) brain injury. Currently, we are exploring the role of microRNAs in oligodendroglial differentiation. We are particularly interested in how microRNA-21 may modulate BMP signaling. With my clinical colleagues, we are exploring biomarkers for the development of cerebral palsy, including microRNAs. Finally, I am interested in variances in the management of neonatal encephalopathy. Through the Children's Hospital Neonatal Database HI encephalopathy workgroup, we continue to examine intercenter variation in medical management and resource utilization.
I have been an attending neonatologist in the Division of Neonatology since the early 2000s, and have been a proud contributor to the growth of our division, our department and our hospital over the years. I completed my subspecialty training at Northwestern University following general pediatrics training at Boston City Hospital. Although originally a Texan, Chicago is my sweet home.
As Co-Director of our NeuroNICU program, we are working to heighten brain-awareness in the clinical management of our babies, as well as increase opportunities for clinical research that will improve the neurodevelopmental outcomes of our patients in the future.
Certifications and Licenses
| Pediatrics | |
| Neonatal-Perinatal Medicine |
Training Experience
| 1997 | Residency, Boston City Hospital |
| 2002 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
MD, Texas Tech University
… → 1994
Research interests
- Brain Injury
- Cerebral Palsy
- Critical Care
- Neuroscience
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Grants
MicroRNAs in Magnesium-Mediated Neuroprotection
American Academy for Cerebral Palsy and Developmental Medicine
10/1/19 → 12/31/20
Project: Research project
MicroRNAs and Perinatal Hypoxia-Ischemia
Northwestern University, National Institutes of Health
8/1/15 → 4/30/20
Project: Research project
MicroRNAs and Perinatal Hypoxia-Ischemia
Northwestern University, National Institutes of Health
8/1/15 → 4/30/20
Project: Research project
MicroRNAs and Perinatal Hypoxia-Ischemia
Northwestern University, National Institutes of Health
8/1/15 → 4/30/20
Project: Research project
MicroRNAs and Perinatal Hypoxia-Ischemia
Northwestern University, National Institutes of Health
8/1/15 → 4/30/20
Project: Research project
Research Output
Antimicrobial therapy utilization in neonates with hypoxic-ischemic encephalopathy (HIE): a report from the Children’s Hospital Neonatal Database (CHND)
Rao, R., Lee, K. S., Zaniletti, I., Yanowitz, T. D., DiGeronimo, R., Dizon, M. L. V., Hamrick, S. E., Natarajan, G., Peeples, E. S., Murthy, K., Mathur, A. M. & Massaro, A., Jan 1 2020, In : Journal of Perinatology. 40, 1, p. 70-78 9 p.Research output: Contribution to journal › Article
Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs
Dizon, M. L. V., Rao, R., Hamrick, S. E., Zaniletti, I., Digeronimo, R., Natarajan, G., Kaiser, J. R., Flibotte, J., Lee, K. S., Smith, D., Yanowitz, T., Mathur, A. M. & Massaro, A. N., Feb 27 2019, In : BMC Pediatrics. 19, 1, 67.Research output: Contribution to journal › Article
Open Access
Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy
Children's Hospitals Neonatal Consortium (CHNC), Feb 1 2019, In : Pediatric neurology. 91, p. 20-26 7 p.Research output: Contribution to journal › Article
2
Scopus
citations
Bone morphogenetic protein signaling: A promising target for white matter protection in perinatal brain injury
Chang, J., Dettman, R. & Dizon, M. L. V., Jul 1 2018, In : Neural Regeneration Research. 13, 7, p. 1183-1184 2 p.Research output: Contribution to journal › Short survey
Intrauterine growth restriction and hyperoxia as a cause of white matter injury
Chang, J. L., Bashir, M., Santiago, C., Farrow, K., Fung, C., Brown, A. S., Dettman, R. W. & Dizon, M. L. V., Dec 1 2018, In : Developmental Neuroscience. 40, 4, p. 344-357 14 p.Research output: Contribution to journal › Article