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Personal profile

Research Interests

In the Tetreault Lab, our goal is to better understand the crosstalk between epithelial cells and their surrounding microenvironment (immune cells, fibroblasts, endothelial cells). A particular area of expertise of our laboratory is in defining the role of epithelial inflammatory mediators in esophageal tissue homeostasis and esophageal disease pathogenesis. Our diseases of interest include esophageal cancer, eosinophilic esophagitis, scleroderma esophageal disease and achalasia. Our research program focuses on two key inflammatory pathways: the IKKß/NF¿B and STAT3 pathways. We employ novel three-dimensional culture models (3D organotypic culture, 3D esophageal organoids) and in vivo models (genetically-engineered and chemically induced) and state-of-the-art methodology (single-cell RNA sequencing, bulk RNA sequencing, multiplex ELISA, high parameter flow cytometer) to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. We also use patient-derived specimens with derived clinical data. We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal diseases.

Training Experience

2011Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

PhD, University of Sherbrooke

… → 2007

Research interests

  • Angiogenesis
  • Eosinophilic Esophagitis
  • Fibrosis
  • Gene Regulation
  • Immune Regulation
  • Inflammation
  • Molecular Biology
  • Scleroderma
  • Signal Transduction
  • Translational Research
  • Digestive Cancer (esophagus, stomach, colon, rectum)

Fingerprint Dive into the research topics where Marie-Pier Tetreault is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Epithelial Cells Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Squamous Cell Neoplasms Medicine & Life Sciences
Esophageal Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Stomach Medicine & Life Sciences
Esophagus Medicine & Life Sciences
Esophageal Diseases Medicine & Life Sciences

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Grants 2015 2023

Esophageal Diseases
Deglutition Disorders
Esophagus
Mechanical Phenomena
Eosinophilic Esophagitis

Research Output 2005 2019

  • 476 Citations
  • 17 Article
  • 3 Chapter
  • 3 Review article

Clinical and translational advances in esophageal squamous cell carcinoma

Reichenbach, Z. W., Murray, M. G., Saxena, R., Farkas, D., Karassik, E. G., Klochkova, A., Patel, K., Tice, C., Hall, T. M., Gang, J., Parkman, H. P., Ward, S. J., Tetreault, M-P. & Whelan, K. A., Jan 1 2019, Advances in Cancer Research. Tew, K. D. & Fisher, P. B. (eds.). Academic Press Inc, p. 95-135 41 p. (Advances in Cancer Research; vol. 144).

Research output: Chapter in Book/Report/Conference proceedingChapter

Delayed Diagnosis
Esophageal Squamous Cell Carcinoma
Epidemiology
Therapeutics
Neoplasm Metastasis
Systemic Scleroderma
Esophagus
Esophageal Diseases
Esophageal Motility Disorders
Knockout Mice
4 Citations (Scopus)

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Hall, T. M., Tetreault, M-P., Hamilton, K. E. & Whelan, K. A., Aug 1 2018, In : Current Opinion in Pharmacology. 41, p. 12-19 8 p.

Research output: Contribution to journalReview article

Autophagy
Neoplasms
Esophageal Squamous Cell Carcinoma
Organelles
Homeostasis
6 Citations (Scopus)

Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer

Rosenberg, A. J., Wainwright, D. A., Rademaker, A. W., Galvez, C., Genet, M., Zhai, L., Lauing, K. L., Mulcahy, M. F., Hayes, J. P., Odell, D. D., Horbinski, C. M., Komanduri, S., Tetreault, M-P., Kim, K-Y. A. & Villaflor, V. M., May 1 2018, In : Oncotarget. 9, 34, p. 23482-23493 12 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Esophageal Neoplasms
Survival
Ligands
Squamous Cell Carcinoma
6 Citations (Scopus)

Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis

Tetreault, M-P., Weinblatt, D., Ciolino, J. D., Klein-Szanto, A. J., Sackey, B. K., Twyman-Saint Victor, C., Karakasheva, T., Teal, V. & Katz, J. P., Jun 1 2016, In : Gastroenterology. 150, 7, p. 1609-1619.e11

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Phosphotransferases
Up-Regulation
Tumor Necrosis Factor-alpha
Inflammation