Grants per year
Personal profile
Research Interests
In the Tetreault Lab, our goal is to better understand the crosstalk between epithelial cells and their surrounding microenvironment (immune cells, fibroblasts, endothelial cells). A particular area of expertise of our laboratory is in defining the role of epithelial inflammatory mediators in esophageal tissue homeostasis and esophageal disease pathogenesis. Our diseases of interest include esophageal cancer, eosinophilic esophagitis, scleroderma esophageal disease and achalasia. Our research program focuses on two key inflammatory pathways: the IKKß/NF¿B and STAT3 pathways. We employ novel three-dimensional culture models (3D organotypic culture, 3D esophageal organoids) and in vivo models (genetically-engineered and chemically induced) and state-of-the-art methodology (single-cell RNA sequencing, bulk RNA sequencing, multiplex ELISA, high parameter flow cytometer) to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. We also use patient-derived specimens with derived clinical data. We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal diseases.
Training Experience
2011 | Postdoctoral Fellowship, University of Pennsylvania |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cell Biology, University of Sherbrooke
… → 2007
Research interests keywords
- Angiogenesis
- Eosinophilic Esophagitis
- Fibrosis
- Gene Regulation
- Immune Regulation
- Inflammation
- Molecular Biology
- Scleroderma
- Signal Transduction
- Translational Research
- Digestive Cancer (esophagus, stomach, colon, rectum)
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Collaborations and top research areas from the last five years
Grants
- 5 Finished
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Molecular profiling of scleroderma esophageal disease
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/20 → 6/30/21
Project: Research project
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5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD Biosciences
Perlman, H. R., Abecassis, M. M., Bharat, A., Budinger, G. S., D'Aquila, R. T., Hope, T. J., Kato, A., Le Poole, I. C., Lesniak, M. S., Luo, X., Misharin, A., Schleimer, R. P., Singer, B., Swaminathan, S., Sznajder, J. I., Tetreault, M., Thorp, E. B. & Wunderink, R. G.
Office of the Director, National Institutes of Health
8/8/19 → 8/7/20
Project: Research project
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Molecular mechanisms involved in early eosinophilic esophagitis pathogenesis
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/19 → 6/30/20
Project: Research project
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Molecular mechanisms of inflammation and fibrosis in eosinophilic esophagitis
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/18 → 6/30/20
Project: Research project
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The role of microenvironment in esophageal epithelial homeostasis
National Institute of Diabetes and Digestive and Kidney Diseases
8/6/15 → 7/31/18
Project: Research project
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A PhysioMechanical Model of Esophageal Function in Eosinophilic Esophagitis
Carlson, D. A., Hirano, I., Gonsalves, N., Kahrilas, P. J., Araujo, I. K., Yang, M., Tetreault, M. P. & Pandolfino, J. E., 2023, (Accepted/In press) In: Gastroenterology.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The Severity of Reduced Esophageal Distensibility Parallels Eosinophilic Esophagitis Disease Duration
Araujo, I. K., Shehata, C., Hirano, I., Gonsalves, N. P., Kahrilas, P. J., Tetreault, M. P., Schauer, J. M., Farina, D., Peterson, S., Kou, W., Pandolfino, J. E. & Carlson, D. A., 2023, (Accepted/In press) In: Clinical Gastroenterology and Hepatology.Research output: Contribution to journal › Article › peer-review
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Aging is associated with a systemic length-associated transcriptome imbalance
Stoeger, T., Grant, R. A., McQuattie-Pimentel, A. C., Anekalla, K. R., Liu, S. S., Tejedor-Navarro, H., Singer, B. D., Abdala-Valencia, H., Schwake, M., Tetreault, M. P., Perlman, H., Balch, W. E., Chandel, N. S., Ridge, K. M., Sznajder, J. I., Morimoto, R. I., Misharin, A. V., Budinger, G. R. S. & Nunes Amaral, L. A., Dec 2022, In: Nature Aging. 2, 12, p. 1191-1206 16 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC
Wiles, K. N., Tsikretsis, L. E., Alioto, C. M., De Viveiros, P. A. H., Villaflor, V. M. & Tétreault, M. P., Sep 1 2022, In: Carcinogenesis. 43, 9, p. 908-918 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Heterogeneity of primary and secondary peristalsis in systemic sclerosis: A new model of “scleroderma esophagus”
Carlson, D. A., Prescott, J. E., Germond, E., Brenner, D., Carns, M., Correia, C. S., Tetreault, M. P., McMahan, Z. H., Hinchcliff, M., Kou, W., Kahrilas, P. J., Perlman, H. R. & Pandolfino, J. E., Jul 2022, In: Neurogastroenterology and Motility. 34, 7, e14284.Research output: Contribution to journal › Article › peer-review
3 Scopus citations