Grants per year
Personal profile
Research Interests
In the Tetreault Lab, our goal is to better understand the crosstalk between epithelial cells and their surrounding microenvironment (immune cells, fibroblasts, endothelial cells). A particular area of expertise of our laboratory is in defining the role of epithelial inflammatory mediators in esophageal tissue homeostasis and esophageal disease pathogenesis. Our diseases of interest include esophageal cancer, eosinophilic esophagitis, scleroderma esophageal disease and achalasia. Our research program focuses on two key inflammatory pathways: the IKKß/NF¿B and STAT3 pathways. We employ novel three-dimensional culture models (3D organotypic culture, 3D esophageal organoids) and in vivo models (genetically-engineered and chemically induced) and state-of-the-art methodology (single-cell RNA sequencing, bulk RNA sequencing, multiplex ELISA, high parameter flow cytometer) to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. We also use patient-derived specimens with derived clinical data. We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal diseases.
Training Experience
2011 | Postdoctoral Fellowship, University of Pennsylvania |
Education/Academic qualification
PhD, University of Sherbrooke
… → 2007
Research interests
- Angiogenesis
- Eosinophilic Esophagitis
- Fibrosis
- Gene Regulation
- Immune Regulation
- Inflammation
- Molecular Biology
- Scleroderma
- Signal Transduction
- Translational Research
- Digestive Cancer (esophagus, stomach, colon, rectum)
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Grants
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Molecular profiling of scleroderma esophageal disease
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/20 → 6/30/21
Project: Research project
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Project 1: Measurement & Molecular Mechanisms of Altered Esophageal Distensibility
National Institute of Diabetes and Digestive and Kidney Diseases
7/15/18 → 6/30/23
Project: Research project
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Disordered Tissue Biomechanics as a Driver of Esophageal Disease
Budinger, G. S., Carlson, D. A., Ciolino, J. D., Espinosa, H. D., Gonsalves, N. P., Hinchcliff, M. E., Hirano, I., Kahrilas, P. J., Pandolfino, J. E., Passman, R. S., Patankar, N. A., Taft, T. N., Tetreault, M. & Yang, G.
National Institute of Diabetes and Digestive and Kidney Diseases
7/15/18 → 6/30/23
Project: Research project
Research Output
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Clinical and translational advances in esophageal squamous cell carcinoma
Reichenbach, Z. W., Murray, M. G., Saxena, R., Farkas, D., Karassik, E. G., Klochkova, A., Patel, K., Tice, C., Hall, T. M., Gang, J., Parkman, H. P., Ward, S. J., Tétreault, M. P. & Whelan, K. A., 2019, Advances in Cancer Research. Tew, K. D. & Fisher, P. B. (eds.). Academic Press Inc, p. 95-135 41 p. (Advances in Cancer Research; vol. 144).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
GI Manifestations With a Focus on the Esophagus: Recent Progress in Understanding Pathogenesis
Tétreault, M. P. & Kahrilas, P., Aug 1 2019, In: Current rheumatology reports. 21, 8, 42.Research output: Contribution to journal › Review article › peer-review
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Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma
Hall, T. M., Tétreault, M. P., Hamilton, K. E. & Whelan, K. A., Aug 2018, In: Current Opinion in Pharmacology. 41, p. 12-19 8 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer
Rosenberg, A. J., Wainwright, D. A., Rademaker, A., Galvez, C., Genet, M., Zhai, L., Lauing, K. L., Mulcahy, M. F., Hayes, J. P., Odell, D. D., Horbinski, C., Komanduri, S., Tetreault, M. P., Kim, K. Y. A. & Villaflor, V. M., May 1 2018, In: Oncotarget. 9, 34, p. 23482-23493 12 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis
Tétreault, M. P., Weinblatt, D., Ciolino, J. D., Klein-Szanto, A. J., Sackey, B. K., Twyman-Saint Victor, C., Karakasheva, T., Teal, V. & Katz, J. P., Jun 1 2016, In: Gastroenterology. 150, 7, p. 1609-1619.e11Research output: Contribution to journal › Article › peer-review
8 Scopus citations