• 522 Citations
20052019

Research output per year

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Personal profile

Research Interests

In the Tetreault Lab, our goal is to better understand the crosstalk between epithelial cells and their surrounding microenvironment (immune cells, fibroblasts, endothelial cells). A particular area of expertise of our laboratory is in defining the role of epithelial inflammatory mediators in esophageal tissue homeostasis and esophageal disease pathogenesis. Our diseases of interest include esophageal cancer, eosinophilic esophagitis, scleroderma esophageal disease and achalasia. Our research program focuses on two key inflammatory pathways: the IKKß/NF¿B and STAT3 pathways. We employ novel three-dimensional culture models (3D organotypic culture, 3D esophageal organoids) and in vivo models (genetically-engineered and chemically induced) and state-of-the-art methodology (single-cell RNA sequencing, bulk RNA sequencing, multiplex ELISA, high parameter flow cytometer) to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. We also use patient-derived specimens with derived clinical data. We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal diseases.

Training Experience

2011Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

PhD, University of Sherbrooke

… → 2007

Research interests

  • Angiogenesis
  • Eosinophilic Esophagitis
  • Fibrosis
  • Gene Regulation
  • Immune Regulation
  • Inflammation
  • Molecular Biology
  • Scleroderma
  • Signal Transduction
  • Translational Research
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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Grants

  • Research Output

    • 522 Citations
    • 17 Article
    • 3 Review article
    • 2 Chapter
  • Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

    Hall, T. M., Tétreault, M. P., Hamilton, K. E. & Whelan, K. A., Aug 2018, In : Current Opinion in Pharmacology. 41, p. 12-19 8 p.

    Research output: Contribution to journalReview article

  • 8 Scopus citations

    Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer

    Rosenberg, A. J., Wainwright, D. A., Rademaker, A., Galvez, C., Genet, M., Zhai, L., Lauing, K. L., Mulcahy, M. F., Hayes, J. P., Odell, D. D., Horbinski, C., Komanduri, S., Tetreault, M. P., Kim, K. Y. A. & Villaflor, V. M., May 1 2018, In : Oncotarget. 9, 34, p. 23482-23493 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis

    Tétreault, M. P., Weinblatt, D., Ciolino, J. D., Klein-Szanto, A. J., Sackey, B. K., Twyman-Saint Victor, C., Karakasheva, T., Teal, V. & Katz, J. P., Jun 1 2016, In : Gastroenterology. 150, 7, p. 1609-1619.e11

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification

    Tetreault, M. P., Weinblatt, D., Shaverdashvili, K., Yang, Y. & Katz, J. P., May 17 2016, In : Scientific reports. 6, 26130.

    Research output: Contribution to journalArticle

  • 10 Scopus citations