• 458 Citations
20052023
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Personal profile

Research Interests

In the Tetreault Lab, our goal is to better understand the crosstalk between epithelial cells and their surrounding microenvironment (immune cells, fibroblasts, endothelial cells). A particular area of expertise of our laboratory is in defining the role of epithelial inflammatory mediators in esophageal tissue homeostasis and esophageal disease pathogenesis. Our diseases of interest include esophageal cancer, eosinophilic esophagitis, scleroderma esophageal disease and achalasia. Our research program focuses on two key inflammatory pathways: the IKKß/NF¿B and STAT3 pathways. We employ novel three-dimensional culture models (3D organotypic culture, 3D esophageal organoids) and in vivo models (genetically-engineered and chemically induced) and state-of-the-art methodology (single-cell RNA sequencing, bulk RNA sequencing, multiplex ELISA, high parameter flow cytometer) to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. We also use patient-derived specimens with derived clinical data. We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal diseases.

Training Experience

2011Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

PhD, University of Sherbrooke

… → 2007

Research interests

  • Angiogenesis
  • Eosinophilic Esophagitis
  • Fibrosis
  • Gene Regulation
  • Inflammation
  • Molecular Biology
  • Signal Transduction
  • Digestive Cancer (esophagus, stomach, colon, rectum)
  • Immune Regulation
  • Scleroderma
  • Translational Research

Fingerprint Dive into the research topics where Marie-Pier Tetreault is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
Epithelial Cells Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Squamous Cell Neoplasms Medicine & Life Sciences
Esophageal Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Stomach Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Monolayers Chemical Compounds

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Grants 2015 2023

Esophageal Diseases
Deglutition Disorders
Esophagus
Mechanical Phenomena
Eosinophilic Esophagitis
4-Nitroquinoline-1-oxide
Esophageal Diseases
Epithelial Cells
Inflammation
Transgenic Mice
Eosinophilic Esophagitis
Fibrosis
Inflammation
Epithelial Cells
Inflammation Mediators
Esophageal Diseases
Homeostasis
Organized Financing
Epithelial Cells
Cellular Microenvironment

Research Output 2005 2019

  • 458 Citations
  • 17 Article
  • 3 Chapter
  • 2 Review article
Delayed Diagnosis
Esophageal Squamous Cell Carcinoma
Epidemiology
Therapeutics
Neoplasm Metastasis
2 Citations (Scopus)
Autophagy
Neoplasms
Esophageal Squamous Cell Carcinoma
Organelles
Homeostasis
4 Citations (Scopus)
Indoleamine-Pyrrole 2,3,-Dioxygenase
Esophageal Neoplasms
Survival
Ligands
Squamous Cell Carcinoma
6 Citations (Scopus)
Granulocyte-Macrophage Colony-Stimulating Factor
Phosphotransferases
Up-Regulation
Tumor Necrosis Factor-alpha
Inflammation
7 Citations (Scopus)

KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification

Tetreault, M-P., Weinblatt, D., Shaverdashvili, K., Yang, Y. & Katz, J. P., May 17 2016, In : Scientific Reports. 6, 26130.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Zinc Fingers
Keratinocytes
Neoplasms
Homeostasis