Marilyn L G Lamm

  • 936 Citations
1988 …2015
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Personal profile

Research Interests

I have been interested in understanding the intricate signaling interactions among cancer cells, stromal cells, and the extracellular matrix environment that contribute to cancer progression, metastasis and the development of drug resistance. Our research has investigated reciprocal cross-talk in bone metastatic tumor development. We hypothesize a role for the Sonic hedgehog - Gli pathway in paracrine interactions between cancer cells and bone cells. Sonic hedgehog (Shh) is a member of the hedgehog family of ligands that activate an intracellular signaling cascade upon binding to transmembrane receptors (Patched) leading to transcriptional regulation of specific target genes by the Gli family of transcription factors. We have demonstrated that paracrine Shh-Gli signaling between prostate cancer cells and osteoblasts promote osteoblast differentiation, a hallmark of prostate cancer metastasis in bone. We have provided evidence that osteoblasts elaborate a different kind of collagen extracellular matrix in the presence of Shh-expressing prostate cancer cells. The structural properties of collagen matrix in bone microenvironment impact cancer cell functions. Knowledge from our research can inform our understanding of the role of the tumor fibrillar microenvironment, cancer cells and host stromal cells in carcinogenesis and metastasis.

Education/Academic qualification

PhD, University of Illinois - Urbana

… → 1988

Research interests

  • Cell Adhesion Mechanisms
  • Cell Biology
  • Developmental Biology
  • Prostate Cancer
  • Signal Transduction

Fingerprint Dive into the research topics where Marilyn L G Lamm is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
LH Receptors Medicine & Life Sciences
Prostate Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Chorionic Gonadotropin Medicine & Life Sciences
Swine Medicine & Life Sciences
Relaxin Medicine & Life Sciences
Corpus Luteum Medicine & Life Sciences
Hedgehogs Medicine & Life Sciences

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Research Output 1988 2015

p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

Yoon, JW., Lamm, M., Iannccone, S., Higashiyama, N., Leong, KF., Iannaccone, P. & Walterhouse, D., Oct 2015, In : DNA Repair. 34, p. 9-17 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

P53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

Yoon, J. W., Lamm, M. L. G., Iannaccone, S., Higashiyama, N., Leong, K. F., Iannaccone, P. M. & Walterhouse, D. O., Oct 1 2015, In : DNA Repair. 34, p. 9-17 9 p.

Research output: Contribution to journalArticle

TATA-Binding Protein Associated Factors
Oncogenes
Cells
Point Mutation
Transcriptional Activation
23 Citations (Scopus)

Noncanonical regulation of the hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma

Yoon, J. W., Gallant, M., Lamm, M. L. G., Iannaccone, S., Vieux, K. F., Proytcheva, M., Hyjek, E., Iannaccone, P. M. & Walterhouse, D. O., Jun 1 2013, In : Molecular Cancer Research. 11, 6, p. 604-615 12 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Apoptosis
Cell Line
Genetic Translocation
Cilia
12 Citations (Scopus)
Hedgehogs
Osteoblasts
Prostatic Neoplasms
Up-Regulation
Collagen
31 Citations (Scopus)

Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation

Zunich, S. M., Douglas, T., Valdovinos, M., Chang, T., Bushman, W., Walterhouse, D. O., Iannaccone, P. M. & Lamm, M. L. G., Mar 2 2009, In : Molecular Cancer. 8, 12.

Research output: Contribution to journalArticle

Hedgehogs
Osteoblasts
Prostatic Neoplasms
Prostate
Neoplasm Metastasis