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Personal profile

Research Interests

My research focuses on the basal ganglia, a group of subcortical brain nuclei that are critical for voluntary movement and associative learning and are the primary sites of dysfunction in Parkinson’s disease, Huntington’s disease, obsessive-compulsive disorder and addiction. My objectives are to define the principles underlying the normal and pathological operation of the basal ganglia. My hope is that this information will provide the foundation for the rational development of corrective or neuroprotective therapies.

Education/Academic qualification

PhD, University of Manchester

… → 1993

Research interests

  • Nervous System Diseases
  • Neuroscience
  • Pharmacology
  • Physiology

Fingerprint Dive into the research topics where Mark D Bevan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
Subthalamic Nucleus Medicine & Life Sciences
Globus Pallidus Medicine & Life Sciences
Neurons Medicine & Life Sciences
Basal Ganglia Medicine & Life Sciences
Entopeduncular Nucleus Medicine & Life Sciences
Action Potentials Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences

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Grants 2003 2023

trainee
training program
Disease
interdisciplinary research
clubs
Huntington Disease
Down-Regulation
Apamin
Phenotype
Neurons
Subthalamic Nucleus
Neuronal Plasticity
Synaptic Transmission
Parkinson Disease
Parkinsonian Disorders
Subthalamic Nucleus
National Institute of Neurological Disorders and Stroke
Isradipine
Phase III Clinical Trials
Globus Pallidus

Research Output 1990 2019

Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons

McIver, E. L., Atherton, J. F., Chu, H. Y., Cosgrove, K. E., Kondapalli, J., Wokosin, D. L., Surmeier Jr, D. J. & Bevan, M. D., Jul 23 2019, In : Cell reports. 28, 4, p. 992-1002.e4

Research output: Contribution to journalArticle

Open Access
Subthalamic Nucleus
Dopaminergic Neurons
Mesencephalon
Neurons
Dopamine
19 Citations (Scopus)

Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons

Chu, H., McIver, E. L., Kovaleski, R. F., Atherton, J. F. & Bevan, M. D., Sep 13 2017, In : Neuron. 95, 6, p. 1306-1318.e5

Research output: Contribution to journalArticle

Subthalamic Nucleus
Dopaminergic Neurons
Mesencephalon
N-Methyl-D-Aspartate Receptors
Parkinson Disease
8 Citations (Scopus)

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of huntington’s disease

Atherton, J. F., McIver, E. L., Mullen, M. R. M., Wokosin, D. L., Surmeier Jr, D. J. & Bevan, M. D., Dec 20 2016, In : eLife. 5, DECEMBER2016, e21616.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Huntington Disease
N-Methyl-D-Aspartate Receptors
Neurons
KATP Channels
1 Citation (Scopus)

The Subthalamic Nucleus

Bevan, M. D., Jan 1 2016, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 277-291 15 p. (Handbook of Behavioral Neuroscience; vol. 24).

Research output: Chapter in Book/Report/Conference proceedingChapter

Subthalamic Nucleus
Basal Ganglia
Neurons
Disruptive, Impulse Control, and Conduct Disorders
Globus Pallidus
38 Citations (Scopus)
Subthalamic Nucleus
Globus Pallidus
Motor Cortex
N-Methyl-D-Aspartate Receptors
GABA-A Receptors