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Mark Johnson

  • 4078 Citations
1980 …2020

Research output per year

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Personal profile

Research Interests

Professor Johnson is internationally known for his work on ocular biomechanics, particular with regards to the pathogenesis of glaucoma and age-related macular degeneration. Studies in his group currently involve a bioengineering approach that utilize perfusion studies, atomic force microscopy and theoretical analysis in combination with use of high-resolution morphometry and finite element modeling.

Education/Academic qualification

Mechanical Engineering, PhD, Massachusetts Institute of Technology

… → 1987

Interdisciplinary Engineering, BS, Purdue University

… → 1975

Mechanical Engineering, MS, Massachusetts Institute of Technology

Mathematics, Purdue University

Research interests

  • Age-Related Macular Degeneration
  • Biomedical transport phenomena
  • Chaos
  • Connective tissue mechanics
  • Fluid Dynamics
  • Glaucoma

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Grants

Small molecular compounds for glaucoma therapy

Johnson, M.

Harvard University, BrightFocus Foundation

7/1/19 → 6/30/21

Project: Research project

    • The Mechanical Basis of Primary Open Angle Glaucoma

    Johnson, M.

    Kennedy Institute - National Eye Clinic

    7/1/15 → 6/30/21

    Project: Research project

    • Regulation and Function of Intermediate Filaments in Cell Mechanics

    Adam, S. A., Gelfand, V. I., Goldman, R., Johnson, M., Kuczmarski, E. R., Ridge, K. M. & Shumaker, D. K.

    National Institute of General Medical Sciences

    6/15/11 → 7/31/22

    Project: Research project

    • Role of non-coding RNAs in glaucomatous outflow resistance dysregulation

    Johnson, M.

    Universität Regensburg, BrightFocus Foundation

    7/1/16 → 6/30/19

    Project: Research project

    Early Detection of Biomechanical Changes in Glaucoma

    Johnson, M. & Tanna, A. P.

    Northwestern Memorial Hospital

    1/1/16 → 12/31/17

    Project: Research project

    • Research Output

    In vivo imaging of Schlemm’s canal and limbal vascular network in mouse using visible-light OCT

    Zhang, X., Beckmann, L., Miller, D. A., Shao, G., Cai, Z., Sun, C., Sheibani, N., Liu, X., Schuman, J., Johnson, M., Kume, T. & Zhang, H. F., Feb 2020, In : Investigative Ophthalmology and Visual Science. 61, 2, 2761682.

    Research output: Contribution to journal › Article

    Open Access

    • Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes

    Vahabikashi, A., Gelman, A., Dong, B., Gong, L., Cha, E. D. K., Schimmel, M., Tamm, E. R., Perkumas, K., Stamer, W. D., Sun, C., Zhang, H. F., Gong, H. & Johnson, M., Dec 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26555-26563 9 p.

    Research output: Contribution to journal › Article

    • Isolation and characterization of inner wall endothelial cells of the schlemm’s canal using a citrate-based polymer

    Ramachandra, S., Vahabikashi, A., Johnson, M. & Ameer, G. A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    • Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

    Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R. D., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles

    Stack, T., Vahabikashi, A., Johnson, M. & Scott, E., Jul 2018, In : Journal of Biomedical Materials Research - Part A. 106, 7, p. 1771-1779 9 p.

    Research output: Contribution to journal › Article

    • 5 Scopus citations