Martha C Bohn

  • 6421 Citations
1971 …2017

Research output per year

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Personal profile

Research Interests

The Bohn lab is developing gene and stem cell therapies for Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)using experimental rodent models of these diseases. Previous studies focused on gene therapy with the neurotrophic factor, glial cell line derived neurotrophic factor (GDNF) which the group has shown slows the progression of dopamine neuron loss in rat models of PD. A phase I clinical trial testing GDNF gene therapy will commence soon. The lab is currently studying viral vector mediated gene silencing of alpha-synuclein, a gene linked to familiar forms of Parkinson’s disease. In addition, the lab is generating neuroprogenitor-like cells and neurospheres from rat and mouse bone marrow and determining whether this interesting source of stem cells can be developed as a novel therapy for PD. Studies of the effects of rat bone marrow derived neurospheres are also being tested for effects on traumatic brain injury. Viral vectors harboring neurotrophic factors are also being made for studies aimed at reversing aging of dopamine neurons in rat hypothalamus and targeting upper motoneurons in mouse models of ALS. The experimental approaches in the lab are multi-faceted and employ techniques ranging from making viral vectors to molecular and morphometric assays to behavioral testing.

Education/Academic qualification

PhD, University of Connecticut

… → 1979

Research interests

  • Gene Therapy
  • Nervous System Diseases
  • Neurology
  • Neuroscience

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Research Output

  • 1 Scopus citations

    Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex

    Jara, J. H., Stanford, M. J., Zhu, Y., Tu, M., Hauswirth, W. W., Bohn, M. C., Devries, S. H. & Özdinler, P. H., Mar 1 2016, In : Gene therapy. 23, 3, p. 272-282 11 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations
  • 7 Scopus citations

    Corticospinal motor neurons are susceptible to increased ER stress and display profound degeneration in the absence of UCHL1 function

    Jara, J. H., Genç, B., Cox, G. A., Bohn, M. C., Roos, R. P., Macklis, J. D., Ulupinar, E. & Özdinler, P. H., Jan 1 2015, In : Cerebral Cortex. 25, 11, p. 4259-4272 14 p.

    Research output: Contribution to journalArticle

  • 39 Scopus citations

    Cryoballoon versus radiofrequency catheter ablation for paroxysmal atrial fibrillation

    Wasserlauf, J., Pelchovitz, D. J., Rhyner, J., Verma, N., Bohn, M., Li, Z., Arora, R., Chicos, A. B., Goldberger, J. J., Kim, S. S., Lin, A. C., Knight, B. P. & Passman, R. S., Apr 1 2015, In : PACE - Pacing and Clinical Electrophysiology. 38, 4, p. 483-489 7 p.

    Research output: Contribution to journalArticle

  • 48 Scopus citations