Martha C Bohn

  • 6307 Citations
1971 …2017
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Personal profile

Research Interests

The Bohn lab is developing gene and stem cell therapies for Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)using experimental rodent models of these diseases. Previous studies focused on gene therapy with the neurotrophic factor, glial cell line derived neurotrophic factor (GDNF) which the group has shown slows the progression of dopamine neuron loss in rat models of PD. A phase I clinical trial testing GDNF gene therapy will commence soon. The lab is currently studying viral vector mediated gene silencing of alpha-synuclein, a gene linked to familiar forms of Parkinson’s disease. In addition, the lab is generating neuroprogenitor-like cells and neurospheres from rat and mouse bone marrow and determining whether this interesting source of stem cells can be developed as a novel therapy for PD. Studies of the effects of rat bone marrow derived neurospheres are also being tested for effects on traumatic brain injury. Viral vectors harboring neurotrophic factors are also being made for studies aimed at reversing aging of dopamine neurons in rat hypothalamus and targeting upper motoneurons in mouse models of ALS. The experimental approaches in the lab are multi-faceted and employ techniques ranging from making viral vectors to molecular and morphometric assays to behavioral testing.

Education/Academic qualification

PhD, University of Connecticut

… → 1979

Research interests

  • Gene Therapy
  • Nervous System Diseases
  • Neurology
  • Neuroscience

Fingerprint Dive into the research topics where Martha C Bohn is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Glial Cell Line-Derived Neurotrophic Factor Medicine & Life Sciences
Phenylethanolamine N-Methyltransferase Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Neurons Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Glucocorticoid Receptors Medicine & Life Sciences
Oxidopamine Medicine & Life Sciences

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Research Output 1971 2017

1 Citation (Scopus)
Pulmonary Veins
Adenosine
Atrial Fibrillation
Veins
Databases
4 Citations (Scopus)

Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex

Jara, J. H., Stanford, M. J., Zhu, Y., Tu, M., Hauswirth, W. W., Bohn, M. C., Devries, S. H. & Özdinler, P. H., Mar 1 2016, In : Gene therapy. 23, 3, p. 272-282 11 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Motor Cortex
Motor Neurons
Amyotrophic Lateral Sclerosis
Injections
4 Citations (Scopus)
Conscious Sedation
General Anesthesia
Safety
Electrophysiology
Atrial Fibrillation
34 Citations (Scopus)

Corticospinal motor neurons are susceptible to increased ER stress and display profound degeneration in the absence of UCHL1 function

Jara, J. H., Genç, B., Cox, G. A., Bohn, M. C., Roos, R. P., Macklis, J. D., Ulupinar, E. & Ozdinler, P. H., Jan 1 2015, In : Cerebral Cortex. 25, 11, p. 4259-4272 14 p.

Research output: Contribution to journalArticle

Ubiquitin Thiolesterase
Motor Neurons
Nerve Degeneration
Motor Neuron Disease
Dendrites
40 Citations (Scopus)

Cryoballoon versus radiofrequency catheter ablation for paroxysmal atrial fibrillation

Wasserlauf, J., Pelchovitz, D. J., Rhyner, J., Verma, N., Bohn, M., Li, Z., Arora, R., Chicos, A. B., Goldberger, J. J., Kim, S. S., Lin, A. C., Knight, B. P. & Passman, R. S., Apr 1 2015, In : PACE - Pacing and Clinical Electrophysiology. 38, 4, p. 483-489 7 p.

Research output: Contribution to journalArticle

Catheter Ablation
Atrial Fibrillation
Fluoroscopy
Pulmonary Veins
Atrial Flutter