Grants per year
Personal profile
Research Interests
As part of the Auditory Physiology Laboratory, Mary Ann Cheatham has engaged in the study of cochlear nonlinearities and their origins. This investigation provides a foundation for further studies using the mouse in auditory research. Given that mice and humans carry several homologous genes for hereditary deafness, mice provide an important animal model for studying hearing loss of genetic origin, which affects at least 1 in 2000 births. In order to investigate the effect of targeted mutations on the development and maintenance of auditory function, procedures were devised for use with small animals. Because of the several mutagenesis programs now established worldwide, the numbers of genes associated with the inner ear will increase rapidly, thereby providing a genetic approach to the study of cochlear physiology. Our current focus is on the processes underlying cochlear amplification and how they are modulated by the central nervous system via efferent innervation from the medial superior olivary complex.
Education/Academic qualification
Audiology, PhD, Northwestern University
Speech Pathology and Audiology, BA, University of Kansas
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Collaborations and top research areas from the last five years
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Development of Cochlear Innervation
Garcia-Anoveros, J. (PD/PI), Cheatham, M. A. (Co-Investigator), Duggan, A. (Co-Investigator) & Garcia Gomez, I. (Co-Investigator)
National Institute on Deafness and Other Communication Disorders
12/1/24 → 11/30/29
Project: Research project
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Enhancing Cochlear Proteome Fidelity to Prevent Noise-Induced Hearing Loss
Savas, J. N. (PD/PI), Cheatham, M. A. (Co-Investigator) & Welty, L. J. (Co-Investigator)
U.S. Army Medical Research and Materiel Command
9/1/22 → 8/31/25
Project: Research project
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Outer and Inner Hair Cell Development
Garcia-Anoveros, J. (PD/PI), Garcia-Anoveros, J. (PD/PI), Cheatham, M. A. (Co-Investigator), Cheatham, M. A. (Co-Investigator), Duggan, A. (Co-Investigator), Duggan, A. (Co-Investigator), Homma, K. (Co-Investigator) & Homma, K. (Co-Investigator)
National Institute on Deafness and Other Communication Disorders
8/1/22 → 7/31/27
Project: Research project
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Transdifferentiation in the Cochlea
Garcia-Anoveros, J. (PD/PI), Garcia-Anoveros, J. (PD/PI), Cheatham, M. A. (Co-Investigator), Cheatham, M. A. (Co-Investigator), Duggan, A. (Co-Investigator), Duggan, A. (Co-Investigator), Garcia Gomez, I. (Co-Investigator), Garcia Gomez, I. (Co-Investigator), Homma, K. (Co-Investigator) & Homma, K. (Co-Investigator)
National Institute on Deafness and Other Communication Disorders
4/2/21 → 6/30/26
Project: Research project
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Modulating the Cochlear Proteostasis Network to Prevent Hidden Hearing Loss
Savas, J. N. (PD/PI), Cheatham, M. A. (Co-Investigator), Kim, K.-Y. A. (Co-Investigator) & Welty, L. J. (Co-Investigator)
U.S. Army Medical Research and Materiel Command
9/1/19 → 8/31/22
Project: Research project
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The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss
Takahashi, S., Zhou, Y., Cheatham, M. A. & Homma, K., Mar 15 2024, In: Journal of physiology. 602, 6, p. 1199-1210 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Distortion Product Otoacoustic Emissions in Mice Above and Below the Eliciting Primaries
Cheatham, M. A., Aug 2023, In: JARO - Journal of the Association for Research in Otolaryngology. 24, 4, p. 413-428 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Prestin’s fast motor kinetics is essential for mammalian cochlear amplification
Takahashi, S., Zhou, Y., Kojima, T., Cheatham, M. A. & Homma, K., Mar 10 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 11, e2217891120.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Editorial: Hair cells: From molecules to function, volume II
Cheatham, M. A., Fritzsch, B., He, D. Z. & Walters, B. J., Oct 13 2022, In: Frontiers in Cellular Neuroscience. 16, 1046646.Research output: Contribution to journal › Editorial › peer-review
Open Access -
How much prestin motor activity is required for normal hearing?
Homma, K., Takahashi, S. & Cheatham, M. A., Sep 15 2022, In: Hearing research. 423, 108376.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
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The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity
Zhou, Y. (Contributor), Takahashi, S. (Contributor), Homma, K. (Creator), Duan, C. (Contributor), Zheng, J. (Creator), Cheatham, M. A. (Creator) & Zheng, J. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4242956, https://springernature.figshare.com/collections/The_susceptibility_of_cochlear_outer_hair_cells_to_cyclodextrin_is_not_related_to_their_electromotile_activity/4242956
Dataset