Mary Anne Hummel

  • 1786 Citations
1980 …2020
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Personal profile

Research Interests

Cytomegalovirus is a ubiquitous herpesvirus which latently infects the majority of adults. Reactivation of latent virus occurs frequently, and in immunocompromised individuals, such as recipients of solid organ and bone marrow transplants, reactivation of CMV is associated with significant morbidity and mortality. The primary focus of research in our lab is the elucidation of the molecular mechanisms by which cytomegalovirus (CMV) establishes latent infection, in which the DNA is present but no virus is produced, and the mechanisms by which the virus reactivates, starts actively replicating and induces disease in vivo. Using murine CMV as a model system, our studies have shown that the virus establishes latency by shutting down viral gene expression through recruitment of transcriptional repressors to the viral genome. We have developed a unique kidney transplant model for studying reactivation of the virus which closely approximates clinical settings in which reactivation occurs, and we are investigating molecular signaling pathways that lead to transcriptional reactivation of viral gene expression. This may lead to identification of novel targets for therapeutic intervention which could prevent reactivation of CMV and its associated pathologies.

Education/Academic qualification

PhD, University of Chicago

… → 1982

Research interests

  • Gene Regulation
  • Immunology
  • Molecular Biology
  • Transplantation
  • Virology

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  • 4 Similar Profiles
Muromegalovirus Medicine & Life Sciences
Human Herpesvirus 4 Medicine & Life Sciences
Cytomegalovirus Medicine & Life Sciences
Human herpesvirus 4 Agriculture & Biology
Gene Expression Medicine & Life Sciences
Immediate-Early Genes Medicine & Life Sciences
RNA Medicine & Life Sciences
Tumor Necrosis Factor-alpha Medicine & Life Sciences

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Grants 2008 2020

Research Output 1980 2019

  • 1786 Citations
  • 31 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
2 Citations (Scopus)
Muromegalovirus
Cytomegalovirus
Immunosuppression
Transplants
Kidney
6 Citations (Scopus)
Myeloid Cells
Cytomegalovirus
Cell Differentiation
Tumor Necrosis Factor-alpha
Gene Expression
4 Citations (Scopus)

Transplant-induced reactivation of murine cytomegalovirus immediate early gene expression is associated with recruitment of NF-kB and AP-1 to the major immediate early promoter

Liu, X., Jie, C., Zhang, Z. J., Yan, S., Wang, J. J., Wang, X., Kurian, S., Salomon, D. R., Abecassis, M. M. & Hummel, M. A., Apr 1 2016, In : Journal of General Virology. 97, 4, p. 941-954 14 p.

Research output: Contribution to journalArticle

Muromegalovirus
Immediate-Early Genes
NF-kappa B
Transcription Factor AP-1
Transplantation
26 Citations (Scopus)

Epigenetic control of cytomegalovirus latency and reactivation

Liu, X. F., Wang, X., Yan, S., Zhang, Z., Abecassis, M. & Hummel, M., May 22 2013, In : Viruses. 5, 5, p. 1325-1345 21 p.

Research output: Contribution to journalArticle

Viral Genome
Cytomegalovirus
Epigenomics
Chromatin
Muromegalovirus
6 Citations (Scopus)

A mouse model of CMV transmission following kidney transplantation

Li, Z., Wang, X., Yan, S., Zhang, Z. J., Jie, C., Sustento-Reodica, N., Hummel, M. A. & Abecassis, M. M., Apr 1 2012, In : American Journal of Transplantation. 12, 4, p. 1024-1028 5 p.

Research output: Contribution to journalArticle

Muromegalovirus
Kidney Transplantation
Animal Models
Transplantation
Viruses