Mary Anne Hummel

  • 1862 Citations
1980 …2020

Research output per year

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Personal profile

Research Interests

Cytomegalovirus is a ubiquitous herpesvirus which latently infects the majority of adults. Reactivation of latent virus occurs frequently, and in immunocompromised individuals, such as recipients of solid organ and bone marrow transplants, reactivation of CMV is associated with significant morbidity and mortality. The primary focus of research in our lab is the elucidation of the molecular mechanisms by which cytomegalovirus (CMV) establishes latent infection, in which the DNA is present but no virus is produced, and the mechanisms by which the virus reactivates, starts actively replicating and induces disease in vivo. Using murine CMV as a model system, our studies have shown that the virus establishes latency by shutting down viral gene expression through recruitment of transcriptional repressors to the viral genome. We have developed a unique kidney transplant model for studying reactivation of the virus which closely approximates clinical settings in which reactivation occurs, and we are investigating molecular signaling pathways that lead to transcriptional reactivation of viral gene expression. This may lead to identification of novel targets for therapeutic intervention which could prevent reactivation of CMV and its associated pathologies.

Education/Academic qualification

PhD, The University of Chicago

… → 1982

Research interests

  • Gene Regulation
  • Immunology
  • Molecular Biology
  • Transplantation
  • Virology

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Grants

  • Research Output

    • 1862 Citations
    • 31 Article
    • 3 Review article
    • 1 Chapter
    • 1 Comment/debate
    Open Access
  • 2 Scopus citations

    New Insights into the Molecular Mechanisms and Immune Control of Cytomegalovirus Reactivation

    Heald-Sargent, T. A., Forte, E., Liu, X., Thorp, E. B., Abecassis, M. M., Zhang, Z. J. & Hummel, M. A., Jan 1 2020, (Accepted/In press) In : Transplantation. p. E118-E124

    Research output: Contribution to journalReview article

  • 10 Scopus citations
  • 13 Scopus citations

    Transplant-induced reactivation of murine cytomegalovirus immediate early gene expression is associated with recruitment of NF-kB and AP-1 to the major immediate early promoter

    Liu, X. F., Jie, C., Zhang, Z., Yan, S., Wang, J. J., Wang, X., Kurian, S., Salomon, D. R., Abecassis, M. & Hummel, M., Apr 2016, In : Journal of General Virology. 97, 4, p. 941-954 14 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations