• 4389 Citations
20012023

Research output per year

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Research Output

2020

A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial

Pedrosa, M., Seyedkazemi, S., Francque, S., Sanyal, A., Rinella, M., Charlton, M., Loomba, R., Ratziu, V., Kochuparampil, J., Fischer, L., Vaidyanathan, S. & Anstee, Q. M., Jan 2020, In : Contemporary Clinical Trials. 88, 105889.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

Atrial fibrillation is highly prevalent yet undertreated in patients with biopsy-proven nonalcoholic steatohepatitis

Whitsett, M., Wilcox, J., Yang, A., Zhao, L., Rinella, M. & VanWagner, L. B., May 2019, In : Liver International. 39, 5, p. 933-940 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Defining Improvement in Nonalcoholic Steatohepatitis for Treatment Trial Endpoints: Recommendations From the Liver Forum

on behalf of the Liver Forum Case Definitions Working Group, Nov 1 2019, In : Hepatology. 70, 5, p. 1841-1855 15 p.

Research output: Contribution to journalReview article

11 Scopus citations

Editorial: sarcopenia in liver transplantation-our weakest patients may need the strongest push

Mazumder, N. & Rinella, M., Apr 1 2019, In : Alimentary pharmacology & therapeutics. 49, 8, p. 1100-1101 2 p.

Research output: Contribution to journalEditorial

Open Access

Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges

Samji, N. S., Verma, R., Keri, K. C., Singal, A. K., Ahmed, A., Rinella, M., Bernstein, D., Abdelmalek, M. F. & Satapathy, S. K., Dec 1 2019, In : Digestive diseases and sciences. 64, 12, p. 3413-3430 18 p.

Research output: Contribution to journalReview article

2 Scopus citations

Low Awareness of Nonalcoholic Fatty Liver Disease in a Population-Based Cohort Sample: the CARDIA Study

Cleveland, E. R., Ning, H., Vos, M. B., Lewis, C. E., Rinella, M. E., Carr, J. J., Lloyd-Jones, D. M. & VanWagner, L. B., Dec 1 2019, In : Journal of general internal medicine. 34, 12, p. 2772-2778 7 p.

Research output: Contribution to journalArticle

Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients With Alcohol-Associated Hepatitis

Lee, B. P., Samur, S., Dalgic, O. O., Bethea, E. D., Lucey, M. R., Weinberg, E., Hsu, C., Rinella, M. E., Im, G. Y., Fix, O. K., Therapondos, G., Han, H., Victor, D. W., Voigt, M. D., Eswaran, S., Terrault, N. A. & Chhatwal, J., Aug 2019, In : Gastroenterology. 157, 2, p. 472-480.e5

Research output: Contribution to journalArticle

7 Scopus citations

Nonalcoholic Fatty Liver Disease: Identification and Management of High-Risk Patients

Cheung, A., Figueredo, C. & Rinella, M. E., Apr 1 2019, In : American Journal of Gastroenterology. 114, 4, p. 579-590 12 p.

Research output: Contribution to journalReview article

2 Scopus citations

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

REGENERATE Study Investigators, Dec 14 2019, In : The Lancet. 394, 10215, p. 2184-2196 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

Zemel, M. B., Kolterman, O., Rinella, M., Vuppalanchi, R., Flores, O., Barritt, A. S., Siddiqui, M. & Chalasani, N., Jan 2019, In : Obesity. 27, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Range of Normal Serum Aminotransferase Levels in Liver Transplant Recipients

Siddiqui, M. B., Patel, S., Bhati, C., Reichman, T., Williams, K., Driscoll, C., Liptrap, E., Rinella, M. E., Sterling, R. K. & Siddiqui, M. S., Jul 1 2019, In : Transplantation proceedings. 51, 6, p. 1895-1901 7 p.

Research output: Contribution to journalArticle

REGENERATE: Design of a pivotal, randomised, phase 3 study evaluating the safety and efficacy of obeticholic acid in patients with fibrosis due to nonalcoholic steatohepatitis

Ratziu, V., Sanyal, A. J., Loomba, R., Rinella, M., Harrison, S., Anstee, Q. M., Goodman, Z., Bedossa, P., MacConell, L., Shringarpure, R., Shah, A. & Younossi, Z., Sep 2019, In : Contemporary Clinical Trials. 84, 105803.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD

the participants of the AASLD/EASL Workshop, Oct 2019, In : Journal of Hepatology. 71, 4, p. 823-833 11 p.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD

on behalf of the participants of the AASLD/EASL Workshop, Oct 1 2019, In : Hepatology. 70, 4, p. 1424-1436 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis

Rinella, M. E., Trotter, J. F., Abdelmalek, M. F., Paredes, A. H., Connelly, M. A., Jaros, M. J., Ling, L., Rossi, S. J., DePaoli, A. M. & Harrison, S. A., Apr 2019, In : Journal of Hepatology. 70, 4, p. 735-744 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sex Hormone-Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Coronary Artery Risk Development in Young Adults (CARDIA) Cohort, May 1 2019, In : The American journal of gastroenterology. 114, 5, p. 758-763 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Body mass index trajectories in young adulthood predict non-alcoholic fatty liver disease in middle age: The CARDIA cohort study

VanWagner, L. B., Khan, S. S., Ning, H., Siddique, J., Lewis, C. E., Carr, J. J., Vos, M. B., Speliotes, E., Terrault, N. A., Rinella, M. E., Lloyd-Jones, D. M. & Allen, N. B., Apr 2018, In : Liver International. 38, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Younossi, Z. M., Loomba, R., Rinella, M. E., Bugianesi, E., Marchesini, G., Neuschwander-Tetri, B. A., Serfaty, L., Negro, F., Caldwell, S. H., Ratziu, V., Corey, K. E., Friedman, S. L., Abdelmalek, M. F., Harrison, S. A., Sanyal, A. J., Lavine, J. E., Mathurin, P., Charlton, M. R., Chalasani, N. P., Anstee, Q. M. & 4 others, Kowdley, K. V., George, J., Goodman, Z. D. & Lindor, K., Jul 2018, In : Hepatology. 68, 1, p. 361-371 11 p.

Research output: Contribution to journalReview article

90 Scopus citations

Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

Younossi, Z. M., Loomba, R., Anstee, Q. M., Rinella, M. E., Bugianesi, E., Marchesini, G., Neuschwander-Tetri, B. A., Serfaty, L., Negro, F., Caldwell, S. H., Ratziu, V., Corey, K. E., Friedman, S. L., Abdelmalek, M. F., Harrison, S. A., Sanyal, A. J., Lavine, J. E., Mathurin, P., Charlton, M. R., Goodman, Z. D. & 4 others, Chalasani, N. P., Kowdley, K. V., George, J. & Lindor, K., Jul 2018, In : Hepatology. 68, 1, p. 349-360 12 p.

Research output: Contribution to journalReview article

85 Scopus citations

International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients

Charlton, M., Levitsky, J., Aqel, B., O'Grady, J., Hemibach, J., Rinella, M., Fung, J., Ghabril, M., Thomason, R., Burra, P., Little, E. C., Berenguer, M., Shaked, A., Trotter, J., Roberts, J., Rodriguez-Davalos, M., Rela, M., Pomfret, E., Heyrend, C., Gallegos-Orozco, J. & 1 others, Saliba, F., May 1 2018, In : Transplantation. 102, 5, p. 727-743 17 p.

Research output: Contribution to journalReview article

16 Scopus citations

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M. E. & Sanyal, A. J., Jul 1 2018, In : Nature Medicine. 24, 7, p. 908-922 15 p.

Research output: Contribution to journalReview article

220 Scopus citations

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Harrison, S. A., Rinella, M. E., Abdelmalek, M. F., Trotter, J. F., Paredes, A. H., Arnold, H. L., Kugelmas, M., Bashir, M. R., Jaros, M. J., Ling, L., Rossi, S. J., DePaoli, A. M. & Loomba, R., Mar 24 2018, In : The Lancet. 391, 10126, p. 1174-1185 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis

Lee, B. P., Mehta, N., Platt, L., Gurakar, A., Rice, J. P., Lucey, M. R., Im, G. Y., Therapondos, G., Han, H., Victor, D. W., Fix, O. K., Dinges, L., Dronamraju, D., Hsu, C., Voigt, M. D., Rinella, M. E., Maddur, H., Eswaran, S., Hause, J., Foley, D. & 4 others, Ghobrial, R. M., Dodge, J. L., Li, Z. & Terrault, N. A., Aug 2018, In : Gastroenterology. 155, 2, p. 422-430.e1

Research output: Contribution to journalArticle

65 Scopus citations

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani, N., Vuppalanchi, R., Rinella, M., Middleton, M. S., Siddiqui, M. S., Barritt, A. S., Kolterman, O., Flores, O., Alonso, C., Iruarrizaga-Lejarreta, M., Gil-Redondo, R., Sirlin, C. B. & Zemel, M. B., Jun 2018, In : Alimentary Pharmacology and Therapeutics. 47, 12, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases

Stine, J. G., Wentworth, B. J., Zimmet, A., Rinella, M. E., Loomba, R., Caldwell, S. H. & Argo, C. K., Oct 2018, In : Alimentary Pharmacology and Therapeutics. 48, 7, p. 696-703 8 p.

Research output: Contribution to journalReview article

31 Scopus citations

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M. & Sanyal, A. J., Jan 2018, In : Hepatology. 67, 1, p. 328-357 30 p.

Research output: Contribution to journalArticle

810 Scopus citations

Twenty-five-year trajectories of insulin resistance and pancreatic β-cell response and diabetes risk in nonalcoholic fatty liver disease

Vanwagner, L. B., Ning, H., Allen, N. B., Siddique, J., Carson, A. P., Bancks, M. P., Lewis, C. E., Carr, J. J., Speliotes, E., Terrault, N. A., Rinella, M. E., Vos, M. B. & Lloyd-Jones, D. M., Nov 2018, In : Liver International. 38, 11, p. 2069-2081 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management

ASGE EndoVators Task Force & Reprint requests: Kenneth R. McQuaid, MD, FASGE, San Francisco VA Healthcare System, University of California San Francisco., Nov 2017, In : Gastrointestinal endoscopy. 86, 5, p. 757-767 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management

Ryou, M., McQuaid, K. R., Thompson, C. C., Edmundowicz, S., Mergener, K., Dayyeh, B. A., Apovian, C., Burke, C., Chand, B., Chandraker, A., Deas, T., Dietz, W., Dunkin, B., Ernest, O., Faigel, D., Garber, S., Hamdy, O., Kaplan, L., Kumar, N., Kushner, R. & 16 others, Larsen, M. C., Lerner, H., Littenberg, G., Mantzoros, C., Mattar, S., Moore, R., Rinella, M., Rothstein, R., Schillinger, D., Spring, B., Sullivan, S., Tice, J., Vargo, J., Wilson, E., Woods, K. & Zundel, N., Nov 2017, In : Surgery for Obesity and Related Diseases. 13, 11, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Everolimus Is Associated with Less Weight Gain Than Tacrolimus 2 Years after Liver Transplantation: Results of a Randomized Multicenter Study

Charlton, M., Rinella, M., Patel, D., McCague, K., Heimbach, J. & Watt, K., Dec 1 2017, In : Transplantation. 101, 12, p. 2873-2882 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Medical and Obstetric Complications among Pregnant Women with Liver Cirrhosis

Palatnik, A. & Rinella, M. E., Jun 1 2017, In : Obstetrics and gynecology. 129, 6, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Sarkar, M., Wellons, M., Cedars, M. I., VanWagner, L., Gunderson, E. P., Ajmera, V., Torchen, L., Siscovick, D., Carr, J. J., Terry, J. G., Rinella, M., Lewis, C. E. & Terrault, N., May 1 2017, In : American Journal of Gastroenterology. 112, 5, p. 755-762 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Management of NAFLD: A stage-based approach

Rinella, M. E. & Sanyal, A. J., Apr 1 2016, In : Nature Reviews Gastroenterology and Hepatology. 13, 4, p. 196-205 10 p.

Research output: Contribution to journalReview article

96 Scopus citations

Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis

Corey, K. E. & Rinella, M. E., May 1 2016, In : Digestive diseases and sciences. 61, 5, p. 1387-1397 11 p.

Research output: Contribution to journalReview article

14 Scopus citations

Moderate exercise for nonalcoholic fatty liver disease

Prenner, S. & Rinella, M. E., Aug 2016, In : JAMA internal medicine. 176, 8, p. 1083-1084 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Practice patterns in NAFLD and NASH: Real life differs from published guidelines

Rinella, M. E., Lominadze, Z., Loomba, R., Charlton, M., Neuschwander Tetri, B. A., Caldwell, S. H., Kowdley, K. & Harrison, S. A., Jan 2016, In : Therapeutic Advances in Gastroenterology. 9, 1, p. 4-12 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
1 Scopus citations

The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health

Rinella, M. & Charlton, M., Jul 1 2016, In : Hepatology. 64, 1, p. 19-22 4 p.

Research output: Contribution to journalEditorial

59 Scopus citations
2015

Association of nonalcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: A population-based study

Vanwagner, L. B., Wilcox, J. E., Colangelo, L. A., Lloyd-Jones, D. M., Carr, J. J., Lima, J. A., Lewis, C. E., Rinella, M. E. & Shah, S. J., Sep 1 2015, In : Hepatology. 62, 3, p. 773-783 11 p.

Research output: Contribution to journalArticle

92 Scopus citations
30 Scopus citations

NAFLD in 2014: Genetics, diagnostics and therapeutic advances in NAFLD

Rinella, M. E. & Sanyal, A. J., Jan 1 2015, In : Nature Reviews Gastroenterology and Hepatology. 12, 2, p. 65-66 2 p.

Research output: Contribution to journalReview article

36 Scopus citations

Nonalcoholic fatty liver disease

Brunt, E. M., Wong, V. W. S., Nobili, V., Day, C. P., Sookoian, S., Maher, J. J., Bugianesi, E., Sirlin, C. B., Neuschwander-Tetri, B. A. & Rinella, M. E., Dec 17 2015, In : Nature Reviews Disease Primers. 1, 15080.

Research output: Contribution to journalArticle

170 Scopus citations

Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

Noureddin, M. & Rinella, M. E., May 1 2015, In : Clinics in liver disease. 19, 2, p. 361-379 19 p.

Research output: Contribution to journalReview article

74 Scopus citations

Nonalcoholic fatty liver disease a systematic review

Rinella, M. E., Jun 9 2015, In : JAMA - Journal of the American Medical Association. 313, 22, p. 2263-2273 11 p.

Research output: Contribution to journalReview article

812 Scopus citations

The "dose" of exercise and its effects beyond weight loss

Rinella, M. E., Apr 1 2015, In : Hepatology. 61, 4, p. 1115-1117 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Controversies in the diagnosis and management of NAFLD and NASH

Rinella, M. E., Loomba, R., Caldwell, S. H., Kowdley, K., Charlton, M., Tetri, B. & Harrison, S. A., Jan 1 2014, In : Gastroenterology and Hepatology. 10, 4, p. 219-227 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Liraglutide-induced autoimmune hepatitis

Kern, E., Van Wagner, L. B., Yang, G. Y. & Rinella, M. E., Jun 2014, In : JAMA internal medicine. 174, 6, p. 984-987 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

NAFLD and cardiovascular disease: Can the real association be determined?

Trivedi, I. & Rinella, M. E., Jan 1 2014, In : Current Hepatitis Reports. 13, 2, p. 130-141 12 p.

Research output: Contribution to journalReview article

6 Scopus citations
2013

Amelioration of hepatic inflammation in a mouse model of NASH using a dithiocarbamate derivative

Schwartz, J. J., Emerson, L., Hillas, E., Phan, A., Thiesset, H., Firpo, M., Sorensen, J., Kennedy, T. & Rinella, M., Jun 1 2013, In : Hepatology International. 7, 2, p. 600-609 10 p.

Research output: Contribution to journalArticle

3 Scopus citations