• 4410 Citations
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2020

A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial

Pedrosa, M., Seyedkazemi, S., Francque, S., Sanyal, A., Rinella, M., Charlton, M., Loomba, R., Ratziu, V., Kochuparampil, J., Fischer, L., Vaidyanathan, S. & Anstee, Q. M., Jan 2020, In : Contemporary Clinical Trials. 88, 105889.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

Atrial fibrillation is highly prevalent yet undertreated in patients with biopsy-proven nonalcoholic steatohepatitis

Whitsett, M., Wilcox, J., Yang, A., Zhao, L., Rinella, M. & VanWagner, L. B., May 2019, In : Liver International. 39, 5, p. 933-940 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Low Awareness of Nonalcoholic Fatty Liver Disease in a Population-Based Cohort Sample: the CARDIA Study

Cleveland, E. R., Ning, H., Vos, M. B., Lewis, C. E., Rinella, M. E., Carr, J. J., Lloyd-Jones, D. M. & VanWagner, L. B., Dec 1 2019, In : Journal of general internal medicine. 34, 12, p. 2772-2778 7 p.

Research output: Contribution to journalArticle

Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients With Alcohol-Associated Hepatitis

Lee, B. P., Samur, S., Dalgic, O. O., Bethea, E. D., Lucey, M. R., Weinberg, E., Hsu, C., Rinella, M. E., Im, G. Y., Fix, O. K., Therapondos, G., Han, H., Victor, D. W., Voigt, M. D., Eswaran, S., Terrault, N. A. & Chhatwal, J., Aug 2019, In : Gastroenterology. 157, 2, p. 472-480.e5

Research output: Contribution to journalArticle

7 Scopus citations

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

REGENERATE Study Investigators, Dec 14 2019, In : The Lancet. 394, 10215, p. 2184-2196 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

Zemel, M. B., Kolterman, O., Rinella, M., Vuppalanchi, R., Flores, O., Barritt, A. S., Siddiqui, M. & Chalasani, N., Jan 2019, In : Obesity. 27, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Range of Normal Serum Aminotransferase Levels in Liver Transplant Recipients

Siddiqui, M. B., Patel, S., Bhati, C., Reichman, T., Williams, K., Driscoll, C., Liptrap, E., Rinella, M. E., Sterling, R. K. & Siddiqui, M. S., Jul 1 2019, In : Transplantation proceedings. 51, 6, p. 1895-1901 7 p.

Research output: Contribution to journalArticle

REGENERATE: Design of a pivotal, randomised, phase 3 study evaluating the safety and efficacy of obeticholic acid in patients with fibrosis due to nonalcoholic steatohepatitis

Ratziu, V., Sanyal, A. J., Loomba, R., Rinella, M., Harrison, S., Anstee, Q. M., Goodman, Z., Bedossa, P., MacConell, L., Shringarpure, R., Shah, A. & Younossi, Z., Sep 2019, In : Contemporary Clinical Trials. 84, 105803.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD

on behalf of the participants of the AASLD/EASL Workshop, Oct 1 2019, In : Hepatology. 70, 4, p. 1424-1436 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis

Rinella, M. E., Trotter, J. F., Abdelmalek, M. F., Paredes, A. H., Connelly, M. A., Jaros, M. J., Ling, L., Rossi, S. J., DePaoli, A. M. & Harrison, S. A., Apr 2019, In : Journal of Hepatology. 70, 4, p. 735-744 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sex Hormone-Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Coronary Artery Risk Development in Young Adults (CARDIA) Cohort, May 1 2019, In : The American journal of gastroenterology. 114, 5, p. 758-763 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Body mass index trajectories in young adulthood predict non-alcoholic fatty liver disease in middle age: The CARDIA cohort study

VanWagner, L. B., Khan, S. S., Ning, H., Siddique, J., Lewis, C. E., Carr, J. J., Vos, M. B., Speliotes, E., Terrault, N. A., Rinella, M. E., Lloyd-Jones, D. M. & Allen, N. B., Apr 2018, In : Liver International. 38, 4, p. 706-714 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Harrison, S. A., Rinella, M. E., Abdelmalek, M. F., Trotter, J. F., Paredes, A. H., Arnold, H. L., Kugelmas, M., Bashir, M. R., Jaros, M. J., Ling, L., Rossi, S. J., DePaoli, A. M. & Loomba, R., Mar 24 2018, In : The Lancet. 391, 10126, p. 1174-1185 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis

Lee, B. P., Mehta, N., Platt, L., Gurakar, A., Rice, J. P., Lucey, M. R., Im, G. Y., Therapondos, G., Han, H., Victor, D. W., Fix, O. K., Dinges, L., Dronamraju, D., Hsu, C., Voigt, M. D., Rinella, M. E., Maddur, H., Eswaran, S., Hause, J., Foley, D. & 4 others, Ghobrial, R. M., Dodge, J. L., Li, Z. & Terrault, N. A., Aug 2018, In : Gastroenterology. 155, 2, p. 422-430.e1

Research output: Contribution to journalArticle

66 Scopus citations

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani, N., Vuppalanchi, R., Rinella, M., Middleton, M. S., Siddiqui, M. S., Barritt, A. S., Kolterman, O., Flores, O., Alonso, C., Iruarrizaga-Lejarreta, M., Gil-Redondo, R., Sirlin, C. B. & Zemel, M. B., Jun 2018, In : Alimentary Pharmacology and Therapeutics. 47, 12, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M. & Sanyal, A. J., Jan 2018, In : Hepatology. 67, 1, p. 328-357 30 p.

Research output: Contribution to journalArticle

818 Scopus citations

Twenty-five-year trajectories of insulin resistance and pancreatic β-cell response and diabetes risk in nonalcoholic fatty liver disease

Vanwagner, L. B., Ning, H., Allen, N. B., Siddique, J., Carson, A. P., Bancks, M. P., Lewis, C. E., Carr, J. J., Speliotes, E., Terrault, N. A., Rinella, M. E., Vos, M. B. & Lloyd-Jones, D. M., Nov 2018, In : Liver International. 38, 11, p. 2069-2081 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management

ASGE EndoVators Task Force & Reprint requests: Kenneth R. McQuaid, MD, FASGE, San Francisco VA Healthcare System, University of California San Francisco., Nov 2017, In : Gastrointestinal endoscopy. 86, 5, p. 757-767 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management

Ryou, M., McQuaid, K. R., Thompson, C. C., Edmundowicz, S., Mergener, K., Dayyeh, B. A., Apovian, C., Burke, C., Chand, B., Chandraker, A., Deas, T., Dietz, W., Dunkin, B., Ernest, O., Faigel, D., Garber, S., Hamdy, O., Kaplan, L., Kumar, N., Kushner, R. & 16 others, Larsen, M. C., Lerner, H., Littenberg, G., Mantzoros, C., Mattar, S., Moore, R., Rinella, M., Rothstein, R., Schillinger, D., Spring, B., Sullivan, S., Tice, J., Vargo, J., Wilson, E., Woods, K. & Zundel, N., Nov 2017, In : Surgery for Obesity and Related Diseases. 13, 11, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Everolimus Is Associated with Less Weight Gain Than Tacrolimus 2 Years after Liver Transplantation: Results of a Randomized Multicenter Study

Charlton, M., Rinella, M., Patel, D., McCague, K., Heimbach, J. & Watt, K., Dec 1 2017, In : Transplantation. 101, 12, p. 2873-2882 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Medical and Obstetric Complications among Pregnant Women with Liver Cirrhosis

Palatnik, A. & Rinella, M. E., Jun 1 2017, In : Obstetrics and gynecology. 129, 6, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Sarkar, M., Wellons, M., Cedars, M. I., VanWagner, L., Gunderson, E. P., Ajmera, V., Torchen, L., Siscovick, D., Carr, J. J., Terry, J. G., Rinella, M., Lewis, C. E. & Terrault, N., May 1 2017, In : American Journal of Gastroenterology. 112, 5, p. 755-762 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Practice patterns in NAFLD and NASH: Real life differs from published guidelines

Rinella, M. E., Lominadze, Z., Loomba, R., Charlton, M., Neuschwander Tetri, B. A., Caldwell, S. H., Kowdley, K. & Harrison, S. A., Jan 2016, In : Therapeutic Advances in Gastroenterology. 9, 1, p. 4-12 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

Association of nonalcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: A population-based study

Vanwagner, L. B., Wilcox, J. E., Colangelo, L. A., Lloyd-Jones, D. M., Carr, J. J., Lima, J. A., Lewis, C. E., Rinella, M. E. & Shah, S. J., Sep 1 2015, In : Hepatology. 62, 3, p. 773-783 11 p.

Research output: Contribution to journalArticle

93 Scopus citations
30 Scopus citations

Nonalcoholic fatty liver disease

Brunt, E. M., Wong, V. W. S., Nobili, V., Day, C. P., Sookoian, S., Maher, J. J., Bugianesi, E., Sirlin, C. B., Neuschwander-Tetri, B. A. & Rinella, M. E., Dec 17 2015, In : Nature Reviews Disease Primers. 1, 15080.

Research output: Contribution to journalArticle

170 Scopus citations

The "dose" of exercise and its effects beyond weight loss

Rinella, M. E., Apr 1 2015, In : Hepatology. 61, 4, p. 1115-1117 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Controversies in the diagnosis and management of NAFLD and NASH

Rinella, M. E., Loomba, R., Caldwell, S. H., Kowdley, K., Charlton, M., Tetri, B. & Harrison, S. A., Jan 1 2014, In : Gastroenterology and Hepatology. 10, 4, p. 219-227 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Liraglutide-induced autoimmune hepatitis

Kern, E., Van Wagner, L. B., Yang, G. Y. & Rinella, M. E., Jun 2014, In : JAMA internal medicine. 174, 6, p. 984-987 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Amelioration of hepatic inflammation in a mouse model of NASH using a dithiocarbamate derivative

Schwartz, J. J., Emerson, L., Hillas, E., Phan, A., Thiesset, H., Firpo, M., Sorensen, J., Kennedy, T. & Rinella, M., Jun 1 2013, In : Hepatology International. 7, 2, p. 600-609 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Interpretation and management of hepatic abnormalities in pregnancy

Kia, L. & Rinella, M. E., Nov 1 2013, In : Clinical Gastroenterology and Hepatology. 11, 11, p. 1392-1398 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

VanWagner, L. B., Bhave, M., Te, H. S., Feinglass, J. M., Alvarez, L. & Rinella, M. E., Nov 1 2012, In : Hepatology. 56, 5, p. 1741-1750 10 p.

Research output: Contribution to journalArticle

106 Scopus citations

The Role of Diet and Nutrient Composition in Nonalcoholic Fatty Liver Disease

McCarthy, E. M. & Rinella, M. E., Mar 2012, In : Journal of the Academy of Nutrition and Dietetics. 112, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

83 Scopus citations
2011

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

Rinella, M. E., Siddiqui, M. S., Gardikiotes, K., Gottstein, J., Elias, M. & Green, R. M., Nov 1 2011, In : Hepatology. 54, 5, p. 1600-1609 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice

Henkel, A. S., Kavesh, M. H., Kriss, M. S., Dewey, A. M., Rinella, M. E. & Green, R. M., Oct 2011, In : Gastroenterology. 141, 4, p. 1404-1411.e2

Research output: Contribution to journalArticle

8 Scopus citations

Pentoxifylline for the treatment of non-alcoholic steatohepatitis: A randomized controlled trial

van Wagner, L. B., Koppe, S. W. P., Brunt, E. M., Gottstein, J., Gardikiotes, K., Green, R. M. & Rinella, M. E., Jul 1 2011, In : Annals of Hepatology. 10, 3, p. 277-286 10 p.

Research output: Contribution to journalArticle

101 Scopus citations
2010

Factors associated with sustained virological response in liver transplant recipients with recurrent hepatitis C

Pillai, A. A., Lee, V. S., Wang, E., Rinella, M. E. & Levitsky, J., Nov 1 2010, In : Transplantation proceedings. 42, 9, p. 3647-3651 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

Rinella, M. E., Elias, M. S., Smolak, R. R., Fu, T., Borensztajn, J. & Green, R. M., May 1 2008, In : Journal of lipid research. 49, 5, p. 1068-1076 9 p.

Research output: Contribution to journalArticle

256 Scopus citations
2006

Primary biliary cirrhosis

Rinella, M. E., Sep 28 2006, In : Annals of Hepatology. 5, 3, p. 198-200 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2005
29 Scopus citations
2004
261 Scopus citations
2003

Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation

Rinella, M. E., McCarthy, R., Thakrar, K., Finn, J. P., Musunuri, S. R., Koffron, A. J., Abecassis, M. M. & Blei, A. T., Aug 1 2003, In : Liver Transplantation. 9, 8, p. 851-856 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Fundal variceal bleeding after correction of portal hypertension in patients with cirrhosis

Rinella, M. E., Shah, D., Vogelzang, R. L., Blei, A. T. & Flamm, S. L., Jul 1 2003, In : Gastrointestinal endoscopy. 58, 1, p. 122-127 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2002

Liver biopsy in living donors

Rinella, M. E. & Abecassis, M. M., Dec 1 2002, In : Liver Transplantation. 8, 12, p. 1123-1125 3 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

Body mass index as as a predictor of hepatic steatosis in living liver donors

Rinella, M. E., Alonso, E. M., Musunuri, S. R., Whitington, P. F., Fryer, J. P., Abecassis, M. M., Superina, R. A., Flamm, S. L. & Blei, A. T., Jan 1 2001, In : Liver Transplantation. 7, 5, p. 409-414 6 p.

Research output: Contribution to journalArticle

193 Scopus citations