Grants per year
Personal profile
Research Interests
We examine the neural control of movement, focusing on the role of spinal circuitry. We use an interdisciplinary approach in this research, using a combination of behavioral, biomechanical, and neurophysiological techniques. Our current research examines the neural control of internal joint variables, evaluating the hypothesis that the nervous system actively regulates the stresses and strains within joints in order to minimize injury. We examine this issue using biomechanics, characterizing how muscles affect the stresses and strains within joints; using behavioral studies, characterizing how the CNS adapts kinematics and muscle activations to compensate for alterations in joint structures; and using electrophysiological studies, examining the neural systems involved in regulating joint stresses and strains.
We are also developing neuroprostheses for restoring functional movements following spinal cord injury. This is collaborative work with Dr. Lee Miller. Previous work from his lab has shown the potential of cortically controlled FES: using cortical predictions of muscle activation to drive stimulation of paralyzed muscles, thereby restoring natural control of a paralyzed animals’ own limb. We are developing these procedures in a rodent model, examining whether this approach can be used to restore the hindlimb movements underlying locomotion in animals paralyzed by spinal cord injury.
Education/Academic qualification
Neuroscience, PhD, Massachusetts Institute of Technology
… → 1998
Psychology, BA, Wesleyan University
… → 1992
Research interests
- Coordination
- Motor control
- Muscle synergies
- Nervous system
- Neuro-physiological substrates of motor coordination
- Restoration after injury
- Spinal cord
- Synchronization in spinal cord function
Fingerprint
- 1 Similar Profiles
Network
-
NeuroNex: Communication, Coordination, and Control of Neuromechanical Systems (C3NS)
Case Western Reserve University, National Science Foundation
9/1/20 → 8/31/25
Project: Research project
-
Data-Driven Biomechanical Simulation of Eye Movement and Strabismus
George Mason University, National Eye Institute
6/1/19 → 5/31/23
Project: Research project
-
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Disterhoft, J. F., McLean, D., McLean, D., Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., MacIver, M. A., Maccaferri, G., Martina, M., Mazzulli, J., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E. E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 5/12/22
Project: Research project
-
Development of an FES neuroprosthesis for rehabilitation following SCI
Miller, L. E., Tresch, M. C. & Tysseling, V. M.
9/30/15 → 3/31/19
Project: Research project
-
Analyzing Modeled Torque Profiles to Understand Scale-Dependent Active Muscle Responses in the Hip Joint
Young, F. R., Chiel, H. J., Tresch, M. C., Heckman, C. J., Hunt, A. J. & Quinn, R. D., Mar 2022, In: Biomimetics. 7, 1, 17.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Biomechanical and Sensory Feedback Regularize the Behavior of Different Locomotor Central Pattern Generators
Deng, K., Hunt, A. J., Szczecinski, N. S., Tresch, M. C., Chiel, H. J., Heckman, C. J. & Quinn, R. D., Dec 2022, In: Biomimetics. 7, 4, 226.Research output: Contribution to journal › Article › peer-review
Open Access -
Canonical Motor Microcircuit for Control of a Rat Hindlimb
Jackson, C., Nourse, W. R. P., Heckman, C. J., Tresch, M. & Quinn, R. D., 2022, Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings. Hunt, A., Vouloutsi, V., Moses, K., Quinn, R., Mura, A., Prescott, T. & Verschure, P. F. (eds.). Springer Science and Business Media Deutschland GmbH, p. 309-320 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13548 LNAI).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
-
Estimating muscle activation from EMG using deep learning-based dynamical systems models
Wimalasena, L. N., Braun, J. F., Keshtkaran, M. R., Hofmann, D., Gallego, J. Á., Alessandro, C., Tresch, M. C., Miller, L. E. & Pandarinath, C., Jun 2022, In: Journal of Neural Engineering. 19, 3, 036013.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Inhibition of Knee Sensory Receptors Alters Quadriceps Muscle Coordination in the Rat
Alessandro, C. & Tresch, M. C., 2022, Biosystems and Biorobotics. Springer Science and Business Media Deutschland GmbH, p. 519-523 5 p. (Biosystems and Biorobotics; vol. 28).Research output: Chapter in Book/Report/Conference proceeding › Chapter