Grants per year
Personal profile
Research Interests
We examine the neural control of movement, focusing on the role of spinal circuitry. We use an interdisciplinary approach in this research, using a combination of behavioral, biomechanical, and neurophysiological techniques. Our current research examines the neural control of internal joint variables, evaluating the hypothesis that the nervous system actively regulates the stresses and strains within joints in order to minimize injury. We examine this issue using biomechanics, characterizing how muscles affect the stresses and strains within joints; using behavioral studies, characterizing how the CNS adapts kinematics and muscle activations to compensate for alterations in joint structures; and using electrophysiological studies, examining the neural systems involved in regulating joint stresses and strains.
We are also developing neuroprostheses for restoring functional movements following spinal cord injury. This is collaborative work with Dr. Lee Miller. Previous work from his lab has shown the potential of cortically controlled FES: using cortical predictions of muscle activation to drive stimulation of paralyzed muscles, thereby restoring natural control of a paralyzed animals’ own limb. We are developing these procedures in a rodent model, examining whether this approach can be used to restore the hindlimb movements underlying locomotion in animals paralyzed by spinal cord injury.
Education/Academic qualification
Neuroscience, PhD, Massachusetts Institute of Technology
… → 1998
Psychology, BA, Wesleyan University
… → 1992
Research interests
- Coordination
- Motor control
- Muscle synergies
- Nervous system
- Neuro-physiological substrates of motor coordination
- Restoration after injury
- Spinal cord
- Synchronization in spinal cord function
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Grants
Data-Driven Biomechanical Simulation of Eye Movement and Strabismus
George Mason University, Kennedy Institute - National Eye Clinic
6/1/19 → 5/31/23
Project: Research project
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
The Neural Control of Internal Joint State
Sandercock, T. G. & Tresch, M. C.
National Institute of Neurological Disorders and Stroke
9/1/14 → 7/31/20
Project: Research project
Research Output
Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury
Thaweerattanasinp, T., Birch, D., Jiang, M. C., Tresch, M. C., Bennett, D. J., Heckman, C. J. & Tysseling, V. M., May 1 2020, In : Journal of neurophysiology. 123, 5, p. 1657-1670 14 p.Research output: Contribution to journal › Article
1
Scopus
citations
Coordination amongst quadriceps muscles suggests neural regulation of internal joint stresses, not simplification of task performance
Alessandro, C., Barroso, F. O., Prashara, A., Tentler, D. P., Yeh, H. Y. & Tresch, M. C., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8135-8142 8 p.Research output: Contribution to journal › Article
Adaptation of muscle activation after patellar loading demonstrates neural control of joint variables
Barroso, F. O., Alessandro, C. & Tresch, M. C., Dec 1 2019, In : Scientific reports. 9, 1, 20370.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats
Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Decoding neural activity to predict rat locomotion using intracortical and epidural arrays
Barroso, F. O., Yoder, B., Tentler, D., Wallner, J. J., Kinkhabwala, A. A., Jantz, M. K., Flint, R. D., Tostado, P. M., Pei, E., Satish, A. D. R., Brodnick, S. K., Suminski, A. J., Williams, J. C., Miller, L. E. & Tresch, M. C., Jan 1 2019, In : Journal of Neural Engineering. 16, 3, 036005.Research output: Contribution to journal › Article