• 3010 Citations
1993 …2022
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Personal profile

Research Interests

We examine the neural control of movement, focusing on the role of spinal circuitry.  We use an interdisciplinary approach in this research, using a combination of behavioral, biomechanical, and neurophysiological techniques.  Our current research examines the neural control of internal joint variables, evaluating the hypothesis that the nervous system actively regulates the stresses and strains within joints in order to minimize injury. We examine this issue using biomechanics, characterizing how muscles affect the stresses and strains within joints; using behavioral studies, characterizing how the CNS adapts kinematics and muscle activations to compensate for alterations in joint structures; and using electrophysiological studies, examining the neural systems involved in regulating joint stresses and strains.

We are also developing neuroprostheses for restoring functional movements following spinal cord injury. This is collaborative work with Dr. Lee Miller.  Previous work from his lab has shown the potential of cortically controlled FES: using cortical predictions of muscle activation to drive stimulation of paralyzed muscles, thereby restoring natural control of a paralyzed animals’ own limb.  We are developing these procedures in a rodent model, examining whether this approach can be used to restore the hindlimb movements underlying locomotion in animals paralyzed by spinal cord injury.

Training Experience

1998 - 2000Postdoctoral fellow at University of Copenhagen

Education/Academic qualification

Neuroscience, PhD, Massachusetts Institute of Technology

… → 1998

Psychology, BA, Wesleyan University

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Grants 2007 2022

Spinal Cord Injuries
Rehabilitation
Primates
Electrodes
Research
Joints
Muscles
Quadriceps Muscle
Torque
Task Performance and Analysis

Research Output 1993 2019

Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats

Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V. M., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

Patient rehabilitation
Restoration
Rats
Muscle
Electrodes

Adaptation after vastus lateralis denervation in rats demonstrates neural regulation of joint stresses and strains

Alessandro, C., Rellinger, B. A., Barroso, F. O. & Tresch, M. C., Jan 1 2018, In : eLife. 7, e38215.

Research output: Contribution to journalArticle

Quadriceps Muscle
Denervation
Muscle
Rats
Joints
1 Citations
Rats
Muscle
Uncertainty
Animals
Chemical activation
1 Citations
Patella
Quadriceps Muscle
Tibia
Muscle
Rats

Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

Quinlan, K. A., Kajtaz, E., Ciolino, J. D., Imhoff-Manuel, R. D., Tresch, M. C., Heckman, C. & Tysseling, V. M., Aug 1 2017, In : Journal of Physiology. 595, 15, p. 5387-5400 14 p.

Research output: Contribution to journalArticle

Electromyography
Running
Muscles
Locomotion
Amyotrophic Lateral Sclerosis