Grants per year
Personal profile
Research Interests
Matthew Feinstein, MD MSc is a cardiologist at Northwestern Medicine and an assistant professor at the Northwestern University Feinberg School of Medicine with a dual appointment in the Department of Medicine and Department of Preventive Medicine Dr. Feinstein is a physician-scientist with expertise in immune and inflammatory triggers of cardiovascular diseases. Much of Dr. Feinstein's work has analyzed human immunodeficiency virus (HIV) as a model of chronic immune dysregulation leading to cardiovascular disease. Dr. Feinstein is an elected Fellow of the American Heart Association (AHA), served as writing chair of the AHA Scientific Statement on HIV and cardiovascular disease (https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000000695?af=R), and is actively involved as an elected investigator and faculty contributor on several AHA committees. He also serves as an investigator for the AIDS Clinical Trials Group End-Organ Disease and Inflammation Transformative Science Group as well as the Pediatric HIV/AIDS Cohort Study Metabolic Working Group. Dr. Feinstein was awarded an American Society of Clincial Investigation (ASCI) Young Investigator Award, and was voted a finalist for the AHA Stamler Award for New Investigators and the ACC Young Investigator Award Competition. He was a recipient of the prestigious AHA Fellow-to-Faculty Transition Award and has also received grant funding for his work from the National Institutes of Health. He and his work have been featured nationally on ABC World News Tonight, CBS, Time Magazine, Fox News, the Chicago Tribune, and NPR, as well as internationally on Voice of America, the Economic Times, African Medical Digest, and the Gulf Times. Dr. Feinstein received his bachelor of arts in sociology from Princeton University. He received his MD and MS in clinical investigation from Northwestern University Feinberg School of Medicine. He completed his internship and residency in internal medicine at Northwestern University and completed his fellowship in cardiovascular medicine at Northwestern University.
Certifications and Licenses
| Internal Medicine | |
| Cardiology |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, Northwestern University Feinberg School of Medicine
… → 2011
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Collaborations and top research areas from the last five years
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Element B + Subcontracts
Becker, S. (PD/PI), D'Aquila, R. T. (PD/PI), Yancy, C. W. (PD/PI), Alshurafa, N. (Other), Ameer, G. A. (Other), Beidas, R. S. (Other), Blanco, I. (Other), Bradley, C. D. (Other), Brawley, C. (Other), Brown, O. E. (Other), Brown, C. H. (Other), Cameron, K. A. (Other), Carnethon, M. R. (Other), Cooper, L. A. D. (Other), Feinstein, M. J. (Other), Franklin, P. D. (Other), Helseth, S. A. (Other), Hill, V. B. (Other), Holmes, K. (Other), Kalhan, R. (Other), Khan, S. S. (Other), Kho, A. N. (Other), Li, D. H. (Other), Liebovitz, D. M. (Other), Luo, Y. (Other), Macapagal, K. (Other), O'Brien, M. J. (Other), Passman, R. S. (Other), Perreault, E. (Other), Peters, A. T. (Other), Pickens, C. I. (Other), Rasmussen-Torvik, L. J. (Other), Rivnay, J. (Other), Rosenberg, S. R. (Other), Schauer, J. M. (Other), Scott, K. (Other), Scott, E. A. (Other), Simon, M. A. (Other), Skolarus, L. E. (Other), Spring, B. (Other), Starren, J. (Other), Tandon, D. (Other), Walunas, T. L. (Other), Welty, L. J. (Other), Woitowich, N. C. (Other) & Wolf, M. (Other)
National Center for Advancing Translational Sciences
9/1/24 → 7/31/31
Project: Research project
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Integrated epidemiology of systemic and plaque-specific immunologic features of human atherosclerosis
Feinstein, M. J. (PD/PI), Thorp, E. B. (PD/PI), Alexandria, S. J. (Co-Investigator), Lloyd-Jones, D. M. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Rasmussen-Torvik, L. J. (Co-Investigator) & Glinton, K. E. (Other)
National Heart, Lung, and Blood Institute
8/1/24 → 5/31/28
Project: Research project
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Role of dynamic stressors in inflammation and early HFpEF risk
Feinstein, M. J. (PD/PI), Kershaw, K. N. (PD/PI), Kershaw, K. N. (Co-PD/PI), Alexandria, S. J. (Co-Investigator), Khan, S. S. (Co-Investigator) & Patel, R. B. (Co-Investigator)
4/1/24 → 3/31/28
Project: Research project
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Dynamic Inflammatory Determinants of Heart Failure with Preserved Ejection Fraction
Feinstein, M. J. (PD/PI), Carnethon, M. R. (Co-Investigator), Fourati, S. (Co-Investigator), Lloyd-Jones, D. M. (Co-Investigator) & Walunas, T. L. (Co-Investigator)
4/1/24 → 3/31/28
Project: Research project
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Clinical Project II Monocyte inflammatory priming in human HFpEF
Feinstein, M. J. (PD/PI), Shah, S. J. (Co-PD/PI) & Fourati, S. (Co-Investigator)
4/1/24 → 3/31/28
Project: Research project
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CITE-Seq Analysis Reveals a Differential Natural Killer Cell SPON2 Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and Diabetes
Armstrong, S. S., Chen, D. G., Kumar, S., Heath, J. R., Feinstein, M. J., Greenland, J. R., Calabrese, D. R., Lanier, L. L., Ley, K. & Shemesh, A., Feb 2025, In: International journal of molecular sciences. 26, 3, 1369.Research output: Contribution to journal › Article › peer-review
Open Access -
Cumulative HIV viral load and lower CD4+ cell count are associated with incident venous thromboembolism in people with HIV
Ruderman, S. A., Nance, R. M., Crane, H. M., Cachay, E., Kitahata, M. M., Napravnik, S., Whitney, B. M., Heckbert, S. R., Attia, E. F., Longenecker, C. T., Hoffmann, A. P., Budoff, M. J., Ma, J., Christopoulos, K., Hunt, P. W., Moore, R. D., Keruly, J. C., Burkholder, G., Bamford, L. & Willig, A. L. & 6 others, , Apr 1 2025, In: AIDS. 39, 5, p. 579-583 5 p.Research output: Contribution to journal › Article › peer-review
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Immune Dysregulation in Ischemic Heart Disease Among Individuals with Human Immunodeficiency Virus
Shi, M. & Feinstein, M. J., Apr 2025, In: Heart Failure Clinics. 21, 2, p. 227-239 13 p.Research output: Contribution to journal › Review article › peer-review
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Multicenter study of heart failure phenotypes and physician-adjudicated etiologies in people with HIV
Beydoun, N., Nance, R. M., Durstenfeld, M. S., Hoffmann, A. P., Whitney, B. M., Burkholder, G. A., Health, S., Hsue, P. Y., Saag, M., Delaney, J. A. C., Longenecker, C. T., Crane, H. M. & Feinstein, M. J., 2025, (Accepted/In press) In: AIDS. 10.1097/QAD.0000000000004182.Research output: Contribution to journal › Article › peer-review
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Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
Filipp, M., Ge, Z.-D., DeBerge, M. P., Lantz, C., Glinton, K., Gao, P., Smolgovsky, S., Dai, J., Zhao, Y., Yvan-Charvet, L., Alcaide, P., Weinberg, S. E., Schiattarella, G. G., Hill, J. A., Feinstein, M. J., Shah, S. J. & Thorp, E. B., 2025, (Accepted/In press) In: Circulation.Research output: Contribution to journal › Article › peer-review
Datasets
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Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
Delaney, J. A. C. (Creator), Olson, N. C. (Creator), Sitlani, C. M. (Creator), Fohner, A. E. (Creator), Huber, S. A. (Creator), Landay, A. L. (Creator), Heckbert, S. R. (Creator), Tracy, R. P. (Creator), Psaty, B. M. (Creator), Feinstein, M. (Creator) & Doyle, M. F. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5279213, https://springernature.figshare.com/collections/Natural_killer_cells_gamma_delta_T_cells_and_classical_monocytes_are_associated_with_systolic_blood_pressure_in_the_multi-ethnic_study_of_atherosclerosis_MESA_/5279213
Dataset
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Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS)
Feinstein, M. J. (Creator), Nance, R. M. (Creator), Delaney, J. A. C. (Contributor), Heckbert, S. R. (Creator), Budoff, M. J. (Creator), Drozd, D. R. (Creator), Burkholder, G. A. (Creator), Willig, J. H. (Creator), Mugavero, M. J. (Creator), Mathews, W. C. (Creator), Moore, R. D. (Creator), Eron, J. J. (Creator), Napravnik, S. (Creator), Hunt, P. W. (Creator), Geng, E. (Creator), Hsue, P. (Creator), Peter, I. (Creator), Lober, W. B. (Creator), Crothers, K. (Creator), Grunfeld, C. (Creator), Saag, M. S. (Creator), Kitahata, M. M. (Creator), Lloyd-Jones, D. M. (Creator) & Crane, H. M. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4601540, https://springernature.figshare.com/collections/Mortality_following_myocardial_infarction_among_HIV-infected_persons_the_Center_for_AIDS_Research_Network_Of_Integrated_Clinical_Systems_CNICS_/4601540
Dataset