Matthias Dominikus Hofer

  • 3765 Citations
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Personal profile

Research Interests

I am an Assistant Professor of Urology at Northwestern University Feinberg School of Medicine. I graduated magna cum laude from the University of Ulm in Ulm, Germany with both an M.D and Ph.D. I went on to complete his residency training at Northwestern University Feinberg School of Medicine. I subsequently completed a fellowship at UT Southwestern in Dallas, TX specializing in reconstruction, trauma, and prosthetics. My clinical interests include the treatment of stress urinary incontinence, which often occurs following surgery for prostate cancer. I am also an expert in the treatment of benign prostatic hyperplasia (BPH). There are a wide range of short-term and long-term treatment options that I believe can help improve the patient’s quality of life. I spent time during a postdoctoral fellowship at Harvard focusing on biomarkers of prostate cancer progression and metastasis. This included experience in clinical research, both patient-based and tissue-based, all of which I continue to implement in my research endeavors. My research efforts also include benign prostatic hyperplasia, reconstruction, and urethral wound healing.

Analyzing urethral wound healing and promoting and inhibiting factors for it has been the focus of my research for several years. We have established a rat model of urethroplasty surgery that allowed the analysis of urethral healing. Briefly, urethral healing recapitulates dermal healing with its phases yet with a prolongation of the phases, specifically the inflammatory phase. An increased peri-urethral inflammatory response such as can be elicited by androgen supplementation in an androgen deprived (castrate levels) system will delay the healing process by not only prolonging the inflammatory phase but also by extending the regenerative phase that is furthermore characterized by increased proliferation of myofibroblasts and scar formation. This in turn can foster the development of urethral strictures. Given the implications that strictures can have on the patient and also on the healthcare system I believe that strategies decreasing stricture development after urethral surgery or the rate of stricture recurrence is of paramount importance in reconstructive urology.

Training Experience

1993Internship, Northwestern University, McGaw Medical Center
2015Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
2016Fellowship, UT Southwestern

Education/Academic qualification

MD, PhD, University of Ulm

… → 2002

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Prostatic Neoplasms Medicine & Life Sciences
Urethral Stricture Medicine & Life Sciences
Artificial Urinary Sphincter Medicine & Life Sciences
Neoplasm Metastasis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Penile Prosthesis Medicine & Life Sciences
Androgens Medicine & Life Sciences
Prostatectomy Medicine & Life Sciences

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Grants 2016 2019

Research Output 2003 2019

Antibiotic prophylaxis after urethroplasty may offer no benefit

Manjunath, A., Chen, L., Welty, L. J., Wong, V. J., Amarasekera, C., Gonzalez, C. M. & Hofer, M. D., Jan 1 2019, In : World journal of urology.

Research output: Contribution to journalArticle

Antibiotic Prophylaxis
Pathologic Constriction
Wounds and Injuries

Author Reply

Hofer, M. D., Mar 1 2019, In : Urology. 125, 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma

Chirieac, L. R., Hung, Y. P., Foo, W. C., Hofer, M. D., VanderLaan, P. A., Richards, W. G., Sugarbaker, D. J. & Bueno, R., Dec 1 2019, In : Cancer. 125, 23, p. 4164-4171 8 p.

Research output: Contribution to journalArticle

Malignant Mesothelioma
Large-Core Needle Biopsy

Editorial Comment

Hofer, M. D., May 1 2019, In : The Journal of urology. 201, 5, 1 p.

Research output: Contribution to journalComment/debate


Hofer, M. D., Aug 1 2019, In : Urology. 130, 1 p.

Research output: Contribution to journalComment/debate