Mee-Ngan Frances Yap

  • 740 Citations
20002019

Research output per year

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Personal profile

Research Interests

Ribosomes are protein manufacturers that are essential for all cells and viruses. Our lab applies genetic, structural and biochemical principles to understand how ribosome composition and associations, antibiotics and stressors affect the translation of genetic codes and, in turn, give rise to phenotypic variations and differential manifestations of infection. Our focus spans fundamental basic biology and extends to understanding bacterial physiology and human and plant diseases.

Education/Academic qualification

PhD, University of Wisconsin-Madison

… → 2006

Research interests

  • Bacterial Pathogenesis
  • Biochemistry: Nucleic Acid
  • Biochemistry: Proteins
  • Genomics
  • Infectious Diseases: Bacteria
  • Microbiome
  • Molecular Biology
  • Proteins / Macromolecules
  • Sepsis

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Research Output

  • 740 Citations
  • 24 Article
  • 1 Review article

Stress response as implemented by hibernating ribosomes: a structural overview

Matzov, D., Bashan, A., Yap, M. N. F. & Yonath, A., Sep 1 2019, In : FEBS Journal. 286, 18, p. 3558-3565 8 p.

Research output: Contribution to journalArticle

Open Access
  • 2 Scopus citations

    Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management

    Gohara, D. W. & Yap, M-N. F., Aug 1 2018, In : Current Genetics. 64, 4, p. 753-760 8 p.

    Research output: Contribution to journalReview article

    Open Access
  • 17 Scopus citations

    Thermal and nutritional regulation of ribosome hibernation in Staphylococcus aureus

    Basu, A., Shields, K. E., Eickhoff, C. S., Hoft, D. F. & Yap, M-N. F., Dec 1 2018, In : Journal of bacteriology. 200, 24, e00426.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations
    Open Access
  • 14 Scopus citations

    The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus

    Matzov, D., Aibara, S., Basu, A., Zimmerman, E., Bashan, A., Yap, M. N. F., Amunts, A. & Yonath, A. E., Dec 1 2017, In : Nature communications. 8, 1, 723.

    Research output: Contribution to journalArticle

    Open Access
  • 25 Scopus citations