Mee-Ngan Frances Yap

  • 715 Citations
20002019
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Personal profile

Research Interests

Ribosomes are protein manufacturers that are essential for all cells and viruses. Our lab applies genetic, structural and biochemical principles to understand how ribosome composition and associations, antibiotics and stressors affect the translation of genetic codes and, in turn, give rise to phenotypic variations and differential manifestations of infection. Our focus spans fundamental basic biology and extends to understanding bacterial physiology and human and plant diseases.

Education/Academic qualification

PhD, University of Wisconsin-Madison

… → 2006

Research interests

  • Bacterial Pathogenesis
  • Biochemistry: Nucleic Acid
  • Biochemistry: Proteins
  • Genomics
  • Infectious Diseases: Bacteria
  • Microbiome
  • Molecular Biology
  • Proteins / Macromolecules
  • Sepsis

Fingerprint Dive into the research topics where Mee-Ngan Frances Yap is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Ribosomes Medicine & Life Sciences
Pectobacterium chrysanthemi Medicine & Life Sciences
Ipomoea batatas Medicine & Life Sciences
Hibernation Medicine & Life Sciences
Proteins Medicine & Life Sciences
Staphylococcus aureus Medicine & Life Sciences
sweet potatoes Agriculture & Biology
Virulence Medicine & Life Sciences

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Research Output 2000 2019

  • 715 Citations
  • 24 Article
  • 1 Review article

Stress response as implemented by hibernating ribosomes: a structural overview

Matzov, D., Bashan, A., Yap, M. N. F. & Yonath, A., Sep 1 2019, In : FEBS Journal. 286, 18, p. 3558-3565 8 p.

Research output: Contribution to journalArticle

Open Access
Dimerization
Ribosomes
Bacteria
Proteins
Dimers
13 Citations (Scopus)

Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management

Gohara, D. W. & Yap, M-N. F., Aug 1 2018, In : Current Genetics. 64, 4, p. 753-760 8 p.

Research output: Contribution to journalReview article

Open Access
Ribosomes
Hibernation
Dimerization
Bacteria
Food
2 Citations (Scopus)

Thermal and nutritional regulation of ribosome hibernation in Staphylococcus aureus

Basu, A., Shields, K. E., Eickhoff, C. S., Hoft, D. F. & Yap, M-N. F., Dec 1 2018, In : Journal of bacteriology. 200, 24, e00426.

Research output: Contribution to journalArticle

Open Access
Hibernation
Ribosomes
Staphylococcus aureus
Hot Temperature
Gammaproteobacteria
12 Citations (Scopus)
Open Access
GTP Phosphohydrolases
Ribosomes
Staphylococcus aureus
Hibernation
Guanosine
22 Citations (Scopus)

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus

Matzov, D., Aibara, S., Basu, A., Zimmerman, E., Bashan, A., Yap, M. N. F., Amunts, A. & Yonath, A. E., Dec 1 2017, In : Nature communications. 8, 1, 723.

Research output: Contribution to journalArticle

Open Access
ribosomes
staphylococcus
Ribosomes
Dimers
Staphylococcus aureus