Megumi Yamashita

  • 1831 Citations
19982023
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Personal profile

Training Experience

2008Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Kyushu University

… → 2000

DDS, Kyushu University

… → 1995

Fingerprint Dive into the research topics where Megumi Yamashita is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Endoplasmic Reticulum Medicine & Life Sciences
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Ions Medicine & Life Sciences
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GABA-A Receptors Medicine & Life Sciences
Neurons Medicine & Life Sciences
gamma-Aminobutyric Acid Medicine & Life Sciences
Macrophages Chemical Compounds

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Grants 2001 2023

Epithelial Cells
Inflammation
Reactive Oxygen Species
Cytokines
Allergens
Astrocytes
Nervous System
Neurotransmitter Agents
Exocytosis
Neurons
Calcium Channels
Ions
Protein Engineering
Severe Combined Immunodeficiency
Electrophysiology

Research Output 1998 2020

  • 1831 Citations
  • 28 Article
  • 2 Review article

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : The Journal of general physiology. 152, 1

Research output: Contribution to journalArticle

Open Access
Ions
Severe Combined Immunodeficiency
Mutation
Molecular Dynamics Simulation
Static Electricity
1 Citation (Scopus)

Molecular basis of allosteric Orai1 channel activation by STIM1

Yeung, P. S. W., Yamashita, M. & Prakriya, M., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalReview article

Exocytosis
Dermatoglyphics
Receptor Protein-Tyrosine Kinases
GTP-Binding Proteins
Endoplasmic Reticulum
12 Citations (Scopus)

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

Mutagenesis
Anatomy
Molecular Dynamics Simulation
Endoplasmic Reticulum
Cysteine
53 Citations (Scopus)

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S., Mar 15 2017, In : Nature communications. 8, 14714.

Research output: Contribution to journalArticle

T-cells
immunity
entry
Cellular Immunity
calcium
20 Citations (Scopus)

Pore opening mechanism of CRAC channels

Yeung, P. S. W., Yamashita, M. & Prakriya, M., May 2017, In : Cell Calcium. 63, p. 14-19 6 p.

Research output: Contribution to journalReview article

Calcium
Endoplasmic Reticulum
Muscle Contraction
Publications
Immunity