Mesut Eren

  • 1414 Citations
1989 …2022

Research output per year

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Research Output

  • 1414 Citations
  • 36 Article
  • 2 Review article
2019

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

Research output: Contribution to journalArticle

Open Access

PAI-1 contributes to homocysteine-induced cellular senescence

Sun, T., Ghosh, A. K., Eren, M., Miyata, T. & Vaughan, D. E., Dec 2019, In : Cellular Signalling. 64, 109394.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A null mutation in SERPINE1 protects against biological aging in humans

Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., Miyata, T., Gupta, S., Shapiro, A. D. & Vaughan, D. E., Jan 1 2017, In : Science Advances. 3, 11, eaao1617.

Research output: Contribution to journalArticle

27 Scopus citations

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
14 Scopus citations

PAI-1 is a critical regulator of FGF23 homeostasis

Eren, M., Place, A. T., Thomas, P. M., Flevaris, P., Miyata, T. & Vaughan, D. E., Jan 1 2017, In : Science Advances. 3, 9, 1603259.

Research output: Contribution to journalArticle

9 Scopus citations

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Vaughan, D. E., Rai, R., Khan, S. S., Eren, M. & Ghosh, A. K., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1446-1452 7 p.

Research output: Contribution to journalReview article

41 Scopus citations

Plasminogen activator inhibitor type I controls cardiomyocyte transforming growth factor-β and cardiac fibrosis

Flevaris, P., Khan, S. S., Eren, M., Schuldt, A. J. T., Shah, S. J., Lee, D. C., Gupta, S., Shapiro, A. D., Burridge, P. W., Ghosh, A. K. & Vaughan, D. E., Aug 1 2017, In : Circulation. 136, 7, p. 664-679 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

Yahata, T., Ibrahim, A. A., Muguruma, Y., Eren, M., Shaffer, A. M., Watanabe, N., Kaneko, S., Nakabayashi, T., Dan, T., Hirayama, N., Vaughan, D. E., Miyata, T. & Ando, K., Nov 23 2017, In : Blood. 130, 21, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Archer, A. M., Saber, R., Rose, S., Shaffer, A., Misharin, A. V., Tsai, F. N., Haines, G. K., Dominguez, S., Eren, M., Vaughan, D. E., Cuda, C. M. & Perlman, H., Jun 10 2016, In : Journal of Translational Medicine. 14, 1, 170.

Research output: Contribution to journalArticle

4 Scopus citations

A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis

Ghosh, A. K., Rai, R., Park, K. E., Eren, M., Miyata, T., Wilsbacher, L. D. & Vaughan, D. E., Oct 6 2016, In : Oncotarget. 7, 45, p. 72443-72457 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

Nitric oxide prevents alveolar senescence and emphysema in a mouse model

Boe, A. E., Eren, M., Morales-Nebreda, L., Murphy, S. B., Scott Budinger, G. R., Mutlu, G. M., Miyata, T. & Vaughan, D. E., Mar 1 2015, In : PloS one. 10, 3, e0116504.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Functionally stable plasminogen activator inhibitor-1 in a family with cardiovascular disease and vitiligo

Agirbasli, M., Eren, M., Yasar, S., Delil, K., Goktay, F., Oner, E. T. & Vaughan, D. E., Jul 2014, In : Journal of thrombosis and thrombolysis. 38, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., Urich, D., Quaggin, S. E., Scott Budinger, G. R., Mutlu, G. M., Miyata, T. & Vaughan, D. E., May 13 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 19, p. 7090-7095 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Role of plasminogen activator inhibitor-1 in senescence and aging

Eren, M., Boe, A. E., Klyachko, E. A. & Vaughan, D. E., Sep 1 2014, In : Seminars in thrombosis and hemostasis. 40, 6, p. 645-651 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis

Rose, S., Eren, M., Murphy, S., Zhang, H., Thaxton, C. S., Chowaniec, J., Waters, E. A., Meade, T. J., Vaughan, D. E. & Perlman, H., Jan 1 2013, In : Annals of the Rheumatic Diseases. 72, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-Nitro-L-Arginine methyl ester-induced hypertension and vascular senescence

Boe, A. E., Eren, M., Murphy, S. B., Kamide, C. E., Ichimura, A., Terry, D., McAnally, D., Smith, L. H., Miyata, T. & Vaughan, D. E., Nov 19 2013, In : Circulation. 128, 21, p. 2318-2324 7 p.

Research output: Contribution to journalArticle

62 Scopus citations
2012
29 Scopus citations
2011

Enhanced functional stability of plasminogen activator inhibitor-1 in patients with livedoid vasculopathy

Agirbasli, M., Eren, M., Eren, F., Murphy, S. B., Serdar, Z. A., Seckin, D., Zara, T., Mat, M. C., Demirkesen, C. & Vaughan, D. E., Jul 1 2011, In : Journal of thrombosis and thrombolysis. 32, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008

Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein

Khoo, M. S. C., Grueter, C. E., Eren, M., Yang, J., Zhang, R., Bass, M. A., Lwin, S. T., Mendes, L. A., Vaughan, D. E., Colbran, R. J. & Anderson, M. E., Feb 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 2, p. 405-410 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2007

Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: A potential prothrombotic mechanism of drug-eluting stents

Muldowney, J. A. S., Stringham, J. R., Levy, S. E., Gleaves, L. A., Eren, M., Piana, R. N. & Vaughan, D. E., Feb 1 2007, In : Arteriosclerosis, thrombosis, and vascular biology. 27, 2, p. 400-406 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

PAI-1 antagonists: Predictable indications and unconventional applications

Vaughan, D. E., De Taeye, B. M. & Eren, M., Sep 1 2007, In : Current Drug Targets. 8, 9, p. 962-970 9 p.

Research output: Contribution to journalReview article

32 Scopus citations

Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice

Eren, M., Gleaves, L. A., Atkinson, J. B., King, L. E., Declerck, P. J. & Vaughan, D. E., Jul 1 2007, In : Journal of Thrombosis and Haemostasis. 5, 7, p. 1500-1508 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice

Devin, J. K., Johnson, J. E., Eren, M., Gleaves, L. A., Bradham, W. S., Bloodworth, J. R. & Vaughan, D. E., Jul 1 2007, In : Journal of Molecular Endocrinology. 39, 1-2, p. 9-16 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization

Nordstrom, S. M., Carleton, S. M., Carson, W. L., Eren, M., Phillips, C. L. & Vaughan, D. E., Dec 1 2007, In : Bone. 41, 6, p. 995-1004 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo

Yang, Y., Zhu, W. Z., Joiner, M. L., Zhang, R., Oddis, C. V., Hou, Y., Yang, J., Price, E. E., Gleaves, L., Eren, M., Ni, G., Vaughan, D. E., Xiao, R. P. & Anderson, M. E., Dec 18 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 6, p. H3065-H3075

Research output: Contribution to journalArticle

106 Scopus citations

Foxc2 is a common mediator of insulin and transforming growth factor β signaling to regulate plasminogen activator inhibitor type I gene expression

Fujita, H., Kang, M., Eren, M., Gleaves, L. A., Vaughan, D. E. & Kume, T., Mar 1 2006, In : Circulation research. 98, 5, p. 626-634 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis

Smith, L. H., Dixon, J. D., Stringham, J. R., Eren, M., Elokdah, H., Crandall, D. L., Washington, K. & Vaughan, D. E., Jan 1 2006, In : Blood. 107, 1, p. 132-134 3 p.

Research output: Contribution to journalArticle

49 Scopus citations
2004

Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor α and estrogen receptor β in endothelial cells

Smith, L. H., Coats, S. R., Qin, H., Petrie, M. S., Covington, J. W., Su, M., Eren, M. & Vaughan, D. E., Aug 6 2004, In : Circulation research. 95, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tumor Necrosis Factor α Activates the Human Plasminogen Activator Inhibitor-1 Gene through a Distal Nuclear Factor κB Site

Hou, B., Eren, M., Painter, C. A., Covington, J. W., Dixon, J. D., Schoenhard, J. A. & Vaughan, D. E., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18127-18136 10 p.

Research output: Contribution to journalArticle

97 Scopus citations
2003

Regulation of the PAI-1 promoter by circadian clock components: Differential activation by BMAL1 and BMAL2

Schoenhard, J. A., Smith, L. H., Painter, C. A., Eren, M., Johnson, C. H. & Vaughan, D. E., May 1 2003, In : Journal of Molecular and Cellular Cardiology. 35, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

118 Scopus citations

Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice

Eren, M., Painter, C. A., Gleaves, L. A., Choenhard, J. A., Atkinson, J. B., Brown, N. J. & Vaughan, D. E., Nov 1 2003, In : Journal of Thrombosis and Haemostasis. 1, 11, p. 2389-2396 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2002

Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1

Eren, M., Painter, C. A., Atkinson, J. B., Declerck, P. J. & Vaughan, D. E., Jul 23 2002, In : Circulation. 106, 4, p. 491-496 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Alternative splicing yields novel BMAL2 variants: Tissue distribution and functional characterization

Schoenhard, J. A., Eren, M., Johnson, C. H. & Vaughan, D. E., Jul 3 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1

Research output: Contribution to journalArticle

42 Scopus citations
2000

SSeCKS gene expression in vascular smooth muscle cells: Regulation by angiotensin II and a potential role in the regulation of PAI-1 gene expression

Coats, S. R., Covington, J. W., Su, M., Pabón-Peña, L. M., Eren, M., Hao, Q. & Vaughan, D. E., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 12, p. 2207-2219 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
1997

Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: The role of conformation changes

Ludwig, M. L., Pattridge, K. A., Metzger, A. L., Dixon, M. M., Eren, M., Feng, Y. & Swenson, R. P., Feb 11 1997, In : Biochemistry. 36, 6, p. 1259-1280 22 p.

Research output: Contribution to journalArticle

145 Scopus citations
1993

Synthesis, cloning and expression of a synthetic gene for high potential iron protein from chromatium vinosum

Agarwal, A., Tan, J., Eren, M., Tevelev, A., Lui, S. M. & Cowan, J. A., Dec 30 1993, In : Biochemical and Biophysical Research Communications. 197, 3, p. 1357-1362 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
1989

Chemical synthesis and expression of a synthetic gene for the flavodoxin from Clostridium MP

Eren, M. & Swenson, R. P., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 14874-14879 6 p.

Research output: Contribution to journalArticle

14 Scopus citations