Michael J Avram

  • 4207 Citations
1976 …2023
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Personal profile

Research Interests

Dr. Avram’s research interests include pharmacokinetics (PKs) and pharmacodynamics (PDs) of hypnotics, sedatives, opioids, analgesics, non-depolarizing neuromuscular blockers, chemotherapeutics, etc. His major research focus has been the development and evaluation of detailed PK models of rapidly acting intravanously administered drugs from the moment of injection to serve as the basis for understanding the PK basis of interindividual variability in response to these agents, which often have low clinical margins of safety.

Education/Academic qualification

PhD, Loyola University-Chicago

… → 1980

Research interests

  • Aging
  • Anesthesiology
  • Clinical Pharmacology
  • Oncology
  • Pain Management
  • Pharmacokinetics
  • Pharmacology
  • Physiology

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Grants 2006 2023

Research Output 1976 2019

Knee Replacement Arthroplasties
Postoperative Pain
Knee
Randomized Controlled Trials
Opioid Analgesics
6 Citations (Scopus)

A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery

Northwestern High Risk Spine Group, Feb 1 2018, In : World Neurosurgery. 110, p. e572-e579

Research output: Contribution to journalArticle

Tranexamic Acid
Erythrocyte Transfusion
Spine
Randomized Controlled Trials
Placebos

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

Henthorn, T. K., Avram, M. J., Dahan, A., Gustafsson, L. L., Persson, J., Krejcie, T. C. & Olofsen, E., Aug 1 2018, In : Anesthesiology. 129, 2, p. 260-270 11 p.

Research output: Contribution to journalArticle

Ketamine
Pharmacokinetics
Arm
Pharmaceutical Preparations
Population
1 Citation (Scopus)

Comparison of the TOFscan and the TOF-Watch SX during recovery of neuromuscular function

Murphy, G. S., Szokol, J. W., Avram, M. J., Greenberg, S. B., Shear, T. D., Deshur, M., Benson, J., Newmark, R. L. & Maher, C. E., Jan 1 2018, In : Anesthesiology. 129, 5, p. 880-888 9 p.

Research output: Contribution to journalArticle

Recovery of Function
Neuromuscular Blockade
Equipment and Supplies
Calibration
Neuromuscular Monitoring

In Reply

Murphy, G. S., Szokol, J. W. & Avram, M. J., Aug 1 2018, In : Anesthesiology. 129, 2, p. 384-385 2 p.

Research output: Contribution to journalComment/debate

Neostigmine
Muscle Weakness
Legendary Creatures