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Michael J Avram

  • 4377 Citations
1976 …2023
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Personal profile

Research Interests

Dr. Avram’s research interests include pharmacokinetics (PKs) and pharmacodynamics (PDs) of hypnotics, sedatives, opioids, analgesics, non-depolarizing neuromuscular blockers, chemotherapeutics, etc. His major research focus has been the development and evaluation of detailed PK models of rapidly acting intravanously administered drugs from the moment of injection to serve as the basis for understanding the PK basis of interindividual variability in response to these agents, which often have low clinical margins of safety.

Education/Academic qualification

PhD, Loyola University Chicago

… → 1980

Research interests

  • Aging
  • Anesthesiology
  • Clinical Pharmacology
  • Oncology
  • Pain Management
  • Pharmacokinetics
  • Pharmacology
  • Physiology

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Grants 2006 2023

Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunities

Avram, M. J., Chmiel, J. S., Schleimer, R. P. & Tan, B. K.

National Institute on Deafness and Other Communication Disorders

7/23/18 → 6/30/23

Project: Research project

Smell
Inflammation
Proton-Translocating ATPases
Therapeutics
Ion Pumps

Optimizing Pharmacotherapy for Depression during Pregnancy (OPTI-MOM)

Avram, M. J., Ciolino, J. D., George Jr, A. L., Gollan, J. K., Grobman, W. A., Rasmussen-Torvik, L. J. & Wisner, K. L.

National Institute of Child Health and Human Development

8/1/15 → 6/30/20

Project: Research project

Depression
Drug Therapy
Pregnancy
Postpartum Period
Health Priorities

A Multi Facility Mass Spectrometer for Targeted Quantitation Experiments

Avram, M. J., Bass, J., Habibi Goudarzi, S., Kandela, I., Kelleher, N. L., Kiser, P., Krejcie, T. C., Mazar, A. P., Ott, A. W., Schiltz, G. E., Siddique, T., Thomas, P. M., Tyo, K. E. J., Wainwright, D. A., Watterson, D. M. & Woodruff, T. K.

Office of the Director, National Institutes of Health

7/15/16 → 7/14/18

Project: Research project

Mass spectrometers
Metabolites
Experiments
High pressure liquid chromatography
Ions

High Density Lipoprotein Nanoparticles for siRNA Delivery

Avram, M. J., Thaxton, C. S. & Volpert, O.

National Cancer Institute

7/1/16 → 6/30/18

Project: Research project

Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System

Avram, M. J., Hope, T. J., Kim, J. J., Pavone, M. & Woodruff, T. K.

National Center for Advancing Translational Sciences

9/18/14 → 12/31/17

Project: Research project

Research Output 1976 2020

Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty

Cason, C. A., Kuntz, T. M., Chen, E. B., Wun, K., Nooromid, M. J., Xiong, L., Gottel, N. R., Harris, K. G., Morton, T. C., Avram, M. J., Chang, E. B., Gilbert, J. A. & Ho, K. J., Jan 1 2020, (Accepted/In press) In : Journal of Vascular Surgery.

Research output: Contribution to journal › Article

Microbiota
Angioplasty
Hyperplasia
Inflammation
Balloon Angioplasty

Postoperative Pain and Analgesic Requirements in the First Year after Intraoperative Methadone for Complex Spine and Cardiac Surgery

Murphy, G. S., Avram, M. J., Greenberg, S. B., Shear, T. D., Deshur, M. A., Dickerson, D., Bilimoria, S., Benson, J., Maher, C. E., Trenk, G. J., Teister, K. J. & Szokol, J. W., Feb 1 2020, In : Anesthesiology. 132, 2, p. 330-342 13 p.

Research output: Contribution to journal › Article

Methadone
Postoperative Pain
Thoracic Surgery
Analgesics
Spine

Pre-TKR genicular nerve ablation

Walega, D., Mccormick, Z. & Avram, M., Jan 1 2020, In : Regional anesthesia and pain medicine. 45, 1, p. 91-92 2 p.

Research output: Contribution to journal › Letter

Postoperative Pain
Chronic Pain
Knee
2 Citations (Scopus)

Radiofrequency ablation of genicular nerves prior to total knee replacement has no effect on postoperative pain outcomes: A prospective randomized sham-controlled trial with 6-month follow-up

Walega, D. R., McCormick, Z., Manning, D. W. & Avram, M. J., Jun 1 2019, In : Regional anesthesia and pain medicine. 44, 6, p. 646-651 6 p.

Research output: Contribution to journal › Article

Knee Replacement Arthroplasties
Postoperative Pain
Knee
Randomized Controlled Trials
Opioid Analgesics
8 Citations (Scopus)

A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery

Northwestern High Risk Spine Group, Feb 2018, In : World neurosurgery. 110, p. e572-e579

Research output: Contribution to journal › Article

Tranexamic Acid
Erythrocyte Transfusion
Spine
Randomized Controlled Trials
Placebos