Michael Markl

  • 10073 Citations
1998 …2024
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Personal profile

Research Interests

Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl has been on faculty at Northwestern since 2011 during which time he has been the Director of Cardiovascular Imaging Research and led Cardiovascular MR research in the Center for Translational Imaging, a Northwestern University core facility housed in Radiology. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system. To date, his accomplishments include a total of >280 peer-reviewed publications, 600+ conference abstracts, 10 book chapters, 10 patents, and >140 invited presentations. In addition, Dr. Markl has a track-record of external funding with over 20 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 75 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry. Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is a Member of the Editorial Boards of the ‘European Heart Journal - Cardiovascular Imaging’, 'JCMR', and 'Radiology - Cardiothoracic Imaging, a Fellow of the ISMRM and SCMR, a member of the Board of Trustees of the SCMR, and the President-of the Society for Magnetic Resonance Angiography (SMRA).

A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system.

Training Experience

2003Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, University of Freiburg

… → 2000

Keywords

  • Cardiovascular Diseases
  • Cardiovascular Imaging
  • Radiology
  • Bioengineering

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Grants 2011 2024

Catheters
Hemodynamics
Congenital Heart Defects
Aortic Valve
Aorta
Catheters
Hemodynamics
Databases
Bicuspid Aortic Valve
Pressure
Muscular Diseases
Atrial Fibrillation
Epidemiology
Stroke
Cardiac Electrophysiology

Research Output 1998 2019

Tetralogy of Fallot
Biomarkers
Magnetic Resonance Imaging
Pulmonary Artery
Heart Ventricles

4-D flow MRI aortic 3-D hemodynamics and wall shear stress remain stable over short-term follow-up in pediatric and young adult patients with bicuspid aortic valve

Rose, M. J., Rigsby, C. K., Berhane, H., Bollache, E., Jarvis, K., Barker, A. J., Schnell, S., Allen, B. D., Robinson, J. D. & Markl, M., Jan 10 2019, In : Pediatric radiology. 49, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

Young Adult
Hemodynamics
Pediatrics
Growth
Aortic Rupture

Aortic 4D flow MRI in 2 minutes using compressed sensing, respiratory controlled adaptive k-space reordering, and inline reconstruction

Ma, L. E., Markl, M., Chow, K., Huh, H., Forman, C., Vali, A., Greiser, A., Carr, J., Schnell, S., Barker, A. J. & Jin, N., Jun 1 2019, In : Magnetic resonance in medicine. 81, 6, p. 3675-3690 16 p.

Research output: Contribution to journalArticle

Volunteers
Thoracic Aorta
Healthy Volunteers
Hemodynamics
Pulsatile Flow
3 Citations (Scopus)

Aortic stenosis exacerbates flow aberrations related to the bicuspid aortic valve fusion pattern and the aortopathy phenotype

Shan, Y., Li, J., Wang, Y., Wu, B., Barker, A. J., Markl, M., Wang, C., Wang, X. & Shu, X., Mar 1 2019, In : European Journal of Cardio-thoracic Surgery. 55, 3, p. 534-542 9 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Phenotype
Dilatation
Aorta
Bicuspid Aortic Valve

Autocalibrated multiband CAIPIRINHA with through-time encoding: Proof of principle and application to cardiac tissue phase mapping

Ferrazzi, G., Bassenge, J. P., Wink, C., Ruh, A., Markl, M., Moeller, S., Metzger, G. J., Ittermann, B. & Schmitter, S., Feb 1 2019, In : Magnetic resonance in medicine. 81, 2, p. 1016-1030 15 p.

Research output: Contribution to journalArticle

Myocardium
Workflow
Calibration
Pulse