Michael Markl

  • 12023 Citations
19982020

Research output per year

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Personal profile

Research Interests

Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl has been on faculty at Northwestern since 2011 during which time he has been the Director of Cardiovascular Imaging Research and led Cardiovascular MR research in the Center for Translational Imaging, a Northwestern University core facility housed in Radiology. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system. To date, his accomplishments include a total of >280 peer-reviewed publications, 600+ conference abstracts, 10 book chapters, 10 patents, and >140 invited presentations. In addition, Dr. Markl has a track-record of external funding with over 20 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 75 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry. Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is a Member of the Editorial Boards of the ‘European Heart Journal - Cardiovascular Imaging’, 'JCMR', and 'Radiology - Cardiothoracic Imaging, a Fellow of the ISMRM and SCMR, a member of the Board of Trustees of the SCMR, and the President-of the Society for Magnetic Resonance Angiography (SMRA).

A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system.

Training Experience

2003Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, University of Freiburg

… → 2000

Research interests

  • Cardiovascular Diseases
  • Cardiovascular Imaging
  • Radiology
  • Bioengineering

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Grants

Research Output

4D Flow MRI Pressure Estimation Using Velocity Measurement-Error-Based Weighted Least-Squares

Zhang, J., Brindise, M. C., Rothenberger, S., Schnell, S., Markl, M., Saloner, D., Rayz, V. L. & Vlachos, P. P., May 2020, In : IEEE Transactions on Medical Imaging. 39, 5, p. 1668-1680 13 p., 8908717.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    4D Flow with MRI

    Soulat, G., McCarthy, P. & Markl, M., Jun 4 2020, In : Annual Review of Biomedical Engineering. 22, p. 103-126 24 p.

    Research output: Contribution to journalReview article

    Open Access
  • Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy

    Li, A., Ruh, A., Berhane, H., Robinson, J. D., Markl, M. & Rigsby, C. K., Feb 1 2020, In : Pediatric radiology. 50, 2, p. 168-179 12 p.

    Research output: Contribution to journalArticle

  • Cardiac MRI Myocardial Functional and Tissue Characterization Detects Early Cardiac Dysfunction in a Mouse Model of Chemotherapy-Induced Cardiotoxicity

    Naresh, N. K., Misener, S., Zhang, Z., Yang, C., Ruh, A., Bertolino, N., Epstein, F. H., Collins, J. D., Markl, M., Procissi, D., Carr, J. C. & Allen, B. A., 2020, (Accepted/In press) In : NMR in Biomedicine. 33, 9, e4327.

    Research output: Contribution to journalArticle

  • Detecting Aortic Valve-Induced Abnormal Flow with Seismocardiography and Cardiac MRI

    Johnson, E. M. I., Heller, J. A., Garcia Vicente, F., Sarnari, R., Gordon, D., McCarthy, P. M., Barker, A. J., Etemadi, M. & Markl, M., Jun 1 2020, In : Annals of Biomedical Engineering. 48, 6, p. 1779-1792 14 p.

    Research output: Contribution to journalArticle