Grants per year
Personal profile
Research Interests
Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl has been on faculty at Northwestern since 2011 during which time he has been the Director of Cardiovascular Imaging Research and led Cardiovascular MR research in the Center for Translational Imaging, a Northwestern University core facility housed in Radiology. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system. To date, his accomplishments include a total of >280 peer-reviewed publications, 600+ conference abstracts, 10 book chapters, 10 patents, and >140 invited presentations. In addition, Dr. Markl has a track-record of external funding with over 20 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 75 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry. Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is a Member of the Editorial Boards of the ‘European Heart Journal - Cardiovascular Imaging’, 'JCMR', and 'Radiology - Cardiothoracic Imaging, a Fellow of the ISMRM and SCMR, a member of the Board of Trustees of the SCMR, and the President-of the Society for Magnetic Resonance Angiography (SMRA).
A central objective of Dr. Markl's research program is to develop multi-parametric imaging techniques than can afford a better understanding of the underlying physiologic mechanisms of heart disease and stroke as well as the impact of therapy. The work of his research group has been instrumental in establishing '4D Flow MRI' for the comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Further accomplishments include the development, validation, and application of novel imaging tools for the evaluation of structure and function of the heart. Clinical applications have provided new insights into the specific links between pathology, therapy, intervention and functional changes within the heart and cardiovascular system.
Training Experience
2003 | Postdoctoral Fellowship, Stanford University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Freiburg
… → 2000
Research interests keywords
- Cardiovascular Diseases
- Cardiovascular Imaging
- Radiology
- Bioengineering
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Collaborations and top research areas from the last five years
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Graduate Training Program for Magnetic Resonance Imaging
Markl, M. (PD/PI)
National Institute of Biomedical Imaging and Bioengineering
9/1/24 → 8/31/29
Project: Research project
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4D virtual Catheter (4D vCath) for multi-factorial hemodynamics in pulmonary hypertension
Elbaz, M. (PD/PI), Allen, B. D. (Co-Investigator), Freed, B. H. (Co-Investigator), Markl, M. (Co-Investigator), Ragin, A. (Co-Investigator) & Raza, Y. (Co-Investigator)
National Heart, Lung, and Blood Institute
8/1/24 → 5/31/29
Project: Research project
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AI Driven 4D Flow MRI for Improved Risk Assessment in Bicuspid Valve Disease
Markl, M. (PD/PI) & Ragin, A. (Co-Investigator)
Northwestern Memorial Hospital
7/1/24 → 8/31/27
Project: Research project
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AI Driven Point-of-Care Seismocardiography in Bicuspid Aortic Valve Disease
Markl, M. (PD/PI), Bagci, U. (Co-Investigator) & Ragin, A. (Co-Investigator)
7/1/24 → 6/30/27
Project: Research project
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Safe and Effective MRI for Pediatric Patients with a Cardiac Implantable Electronic Device
Golestani Rad, L. (PD/PI), Kim, D. (PD/PI) & Markl, M. (Co-Investigator)
National Heart, Lung, and Blood Institute
3/1/24 → 2/29/28
Project: Research project
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4D flow MRI velocity uncertainty quantification
Rothenberger, S. M., Zhang, J., Markl, M., Craig, B. A., Vlachos, P. P. & Rayz, V. L., Jan 2025, In: Magnetic resonance in medicine. 93, 1, p. 397-410 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
MRI Investigation of the Association of Left Atrial and Left Atrial Appendage Hemodynamics with Silent Brain Infarction
Pradella, M., Baraboo, J. J., Prabhakaran, S., Zhao, L., Hijaz, T., McComb, E. N., Naidich, M. J., Heckbert, S. R., Nasrallah, I. M., Bryan, R. N., Passman, R. S., Markl, M. & Greenland, P., Jan 2025, In: Journal of Magnetic Resonance Imaging. 61, 1, p. 276-286 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
3D Vortex-Energetics in the Left Pulmonary Artery for Differentiating Pulmonary Arterial Hypertension and Pulmonary Venous Hypertension Groups Using 4D Flow MRI
Elbaz, M. S. M., Shafeghat, M., Freed, B. H., Sarnari, R., Zilber, Z., Avery, R., Markl, M., Allen, B. D. & Carr, J., 2024, (Accepted/In press) In: Journal of Magnetic Resonance Imaging.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Aortic velocity measurements derived from phase-contrast MRI are influenced by a cardiac implantable electronic device in both adult and pediatric human subjects
Yang, H., Aboyewa, O. B., Webster, R. G., Shah, D., Golestanirad, L., Baraboo, J. J., Markl, M., Collins, J. D., Knight, B. P., Hong, K., Patel, A. R., Lee, D. C. & Kim, D., 2024, (Accepted/In press) In: Magnetic resonance in medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Associations between 3D-based Left Atrial Volumetric and Blood Flow Parameters in a Single-Site Cohort of the Multi-Ethnic Study of Atherosclerosis
Pradella, M., Baraboo, J. J., Maroun, A., Liu, S. Z., Dicarlo, A. L., Chu, S. H., Hwang, J. M., Collins, M. A., Passman, R., Heckbert, S. R., Greenland, P. & Markl, M., Apr 2024, In: Radiology: Cardiothoracic Imaging. 6, 2, e230148.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations