Michael Sean Carroll

  • 348 Citations

Research output per year

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Personal profile

Research Interests

My research is aimed at using computational methods to derive insight from large physiological datasets generated in clinical practice, with particular focus on pediatric autonomic and respiratory disorders, but recently expanding into critical care. My work has included familial dysautonomia, congenital central hypoventilation syndrome (CCHS), rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD), Rett syndrome and other pediatric disorders. My combined fluency with basic science, clinical and mathematical concepts inspires an eclectic and inclusive approach to discovery. Preferred quantitative tools span a wide range from traditional statistics through machine learning, network theory and dynamical system simulation. Nevertheless, these techniques are secondary to the central goal of understanding the physiological phenotype and underlying mechanisms of pediatric disorders, with the ultimate desire to improve patient care. I am also profoundly interested in bringing clinical physiology into the modern computational era by developing analytics and visualization systems that could provide physicians with tools to accelerate research, reduce healthcare costs and save lives. Such systems would be deeply transformative in specialty areas such as sleep medicine, neurophysiology, critical care, and of course, autonomic medicine. I’m currently collaborating with several physicians in critical care at Lurie to secure funding for continued development and further deployment of a visual analytics system to improve clinician situational awareness and patient monitoring in that department. For that project, I will be contributing to the development of physiologically relevant metrics and intuitive visualization techniques to facilitate important clinical decisions.

Education/Academic qualification

PhD, The University of Chicago

… → 2009

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Research Output

Diurnal variation in autonomic regulation among patients with genotyped Rett syndrome

Carroll, M. S., Ramirez, J. M. & Weese-Mayer, D. E., Jan 1 2020, (Accepted/In press) In : Journal of medical genetics.

Research output: Contribution to journalArticle

  • Heart rate variability as a marker of recovery from critical illness in children

    Marsillio, L. E., Manghi, T., Carroll, M. S., Balmert, L. C. & Wainwright, M., May 2019, In : PloS one. 14, 5, e0215930.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Novel methods of imaging and analysis for the thermoregulatory sweat test

    Carroll, M. S., Reed, D. W., Kuntz, N. L. & Weese-Mayer, D. E., Sep 2018, In : Journal of applied physiology. 125, 3, p. 755-762 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Congenital central hypoventilation syndrome: A bedside-to-bench success story for advancing early diagnosis and treatment and improved survival and quality of life

    Weese-Mayer, D. E., Rand, C. M., Zhou, A., Carroll, M. S. & Hunt, C. E., Jan 1 2017, In : Pediatric research. 81, 1-2, p. 192-201 10 p.

    Research output: Contribution to journalReview article

  • 15 Scopus citations

    Congenital central hypoventilation syndrome (CCHS): Circadian temperature variation

    Saiyed, R., Rand, C. M., Carroll, M. S., Koliboski, C. M., Stewart, T. M., Brogadir, C. D., Kenny, A. S., Petersen, E. K. E., Carley, D. W. & Weese-Mayer, D. E., Mar 1 2016, In : Pediatric Pulmonology. 51, 3, p. 300-307 8 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations