Grants per year
Personal profile
Research Interests
My group’s interests overlap chemistry, biology and engineering, with an emphasis on the design and synthesis of materials that are biologically active and in applications of the materials to relevant problems in the biological and medical sciences. Much of our work uses self-assembled monolayers of alkanethiolates on gold to prepare model surfaces that are structurally defined, yet that can have complex compositions and present the ligands in spatially-organized patterns. We pioneered the design of ‘dynamic substrates’ that present ligands whose activities can be switched on and off in response to electrical or optical signals, particularly for studies that address the responses of adherent cells to changes in the extracellular matrix. These mimics of the extracellular matrix have led the way to the discovery of novel ligands that mediate cell adhesion. We have also developed robust surface chemistries for preparing biochip arrays and that are compatible with new analytical methods for analyzing the arrays. For example, we have developed the SAMDI method, which uses mass spectrometry to analyze the arrays, and we have extended this method to the first label-free approach for high throughput screening, to the functional annotation of recently sequenced genes and towards an understanding of the networks that regulate protein acetylation. Finally, a recent program is creating defined systems for exploring biochemical reactions to understand the role that localization of enzymes and substrates play in controlling reaction networks.
Education/Academic qualification
Chemical Biology, PhD, California Institute of Technology
… → 1994
Chemistry, BS, University of Illinois at Urbana-Champaign
… → 1989
Research interests
- Bio-inspired nanostructured materials and biochips
- Biomaterials and interfaces
- Cell adhesion and migration
- Electroactive interfaces
- Physical organic chemistry of interfacial reactions
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Grants
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Acquisition of a K2 Camera for Soft Matter Transmission Electron Microscopy
Mirkin, C. A., Dravid, V. P., Stupp, S., Meade, T. J., Farha, O. K., Joester, D., Mrksich, M., Scott, E. A., Dichtel, W., Gianneschi, N. & Weiss, E. A.
Office of the Director, National Institutes of Health
8/12/19 → 8/11/24
Project: Research project
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The Robert H. Lurie Comprehensive Cancer Center
Mondragon, A., Benson III, A. B., Rademaker, A. W., Gordon, L. I., Green, K. J., Rosenzweig, A. C., Perlman, H. R., Cella, D., Hahn, E. A., Chandel, N., Munshi, H. G., Khan, S. A., Eklund, E. A., LaBonne, C., Carthew, R. W., Backman, V., Woloschak, G. E., Meade, T. J., Platanias, L. C., Scheidt, K. A., Weiss, E. L., Awatramani, R., Spring, B., Chakravarti, D., Simon, M. A., Butt, Z., Hitsman, B. L., Wei, J., Arvanitis, C., Kelleher, N. L., Peter, M. E., Wignall, S., Mrksich, M., James, C. D., Shilatifard, A., Horbinski, C. M., Cristofanilli, M., Matei, D. E., Kocherginsky, M., Sosman, J. A., Hussain, M., Rini, C., Bonini, M., Obeng, R., Kumthekar, P. U., Horvath, C. M., Frankfurt, O., Murphy, A. B. & Zhang, Z.
8/10/18 → 7/31/23
Project: Research project
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Supplement Funding for Stimuli-Responsive Control of Protein-Based Molecular Structure
7/30/18 → 7/29/23
Project: Research project
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Stimuli-Responsive Control of Protein-Based Molecular Structure
7/30/18 → 7/29/23
Project: Research project
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SERS Nanosensors for in vivo Glucose Sensing
U.S. Army Medical Research and Materiel Command
9/1/16 → 8/31/21
Project: Research project
Research Output
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Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3
Anderson, S. E., Longbotham, J. E., O'Kane, P. T., Ugur, F. S., Fujimori, D. G. & Mrksich, M., Jan 15 2021, In: ACS chemical biology. 16, 1, p. 205-213 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules
Metcalf, K. J., Kimmel, B. R., Sykora, D. J., Modica, J. A., Parker, K. A., Berens, E., Dai, R., Dravid, V. P., Werb, Z. & Mrksich, M., Jan 20 2021, In: Bioconjugate Chemistry. 32, 1, p. 143-152 10 p.Research output: Contribution to journal › Article › peer-review
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A high-throughput SAMDI-mass spectrometry assay for isocitrate dehydrogenase 1
Anderson, S. E., Fahey, N. S., Park, J., O'Kane, P. T., Mirkin, C. A. & Mrksich, M., Jun 7 2020, In: Analyst. 145, 11, p. 3899-3908 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
Schumann, B., Malaker, S. A., Wisnovsky, S. P., Debets, M. F., Agbay, A. J., Fernandez, D., Wagner, L. J. S., Lin, L., Li, Z., Choi, J., Fox, D. M., Peh, J., Gray, M. A., Pedram, K., Kohler, J. J., Mrksich, M. & Bertozzi, C. R., Jun 4 2020, In: Molecular cell. 78, 5, p. 824-834.e15Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Computational planning of the synthesis of complex natural products
Mikulak-Klucznik, B., Gołębiowska, P., Bayly, A. A., Popik, O., Klucznik, T., Szymkuć, S., Gajewska, E. P., Dittwald, P., Staszewska-Krajewska, O., Beker, W., Badowski, T., Scheidt, K. A., Molga, K., Mlynarski, J., Mrksich, M. & Grzybowski, B. A., Dec 3 2020, In: Nature. 588, 7836, p. 83-88 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations