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2015

A structure-activity relationship of non-peptide macrocyclic histone deacetylase inhibitors and their anti-proliferative and anti-inflammatory activities

Tapadar, S., Fathi, S., Raji, I., Omesiete, W., Kornacki, J. R., Mwakwari, S. C., Miyata, M., Mitsutake, K., Li, J. D., Mrksich, M. & Oyelere, A. K., Dec 15 2015, In : Bioorganic and Medicinal Chemistry. 23, 24, p. 7543-7564 22 p.

Research output: Contribution to journalArticle

9 Scopus citations

Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids

Sodji, Q. H., Kornacki, J. R., McDonald, J. F., Mrksich, M. & Oyelere, A. K., May 26 2015, In : European Journal of Medicinal Chemistry. 96, p. 340-359 20 p.

Research output: Contribution to journalArticle

19 Scopus citations

Discovery of SIRT3 inhibitors using SAMDI mass spectrometry

Patel, K., Sherrill, J., Mrksich, M. & Scholle, M. D., Aug 25 2015, In : Journal of Biomolecular Screening. 20, 7, p. 842-848 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

Brennand, K., Savas, J. N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K. G., Kim, H. J., Topol, A., Ladran, I., Abdelrahim, M., Matikainen-Ankney, B., Chao, S. H., Mrksich, M., Rakic, P., Fang, G., Zhang, B., Yates, J. R. & Gage, F. H., Mar 12 2015, In : Molecular Psychiatry. 20, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

204 Scopus citations

SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction

Diagne, A. B., Li, S., Perkowski, G. A., Mrksich, M. & Thomson, R. J., Nov 1 2015, In : ACS Combinatorial Science. 17, 11, p. 658-662 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites

Abouelfetouh, A., Kuhn, M. L., Hu, L. I., Scholle, M. D., Sorensen, D. J., Sahu, A. K., Becher, D., Antelmann, H., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Feb 1 2015, In : MicrobiologyOpen. 4, 1, p. 66-83 18 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Geometric control of vimentin intermediate filaments

Shabbir, S. H., Cleland, M. M., Goldman, R. & Mrksich, M., Feb 1 2014, In : Biomaterials. 35, 5, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Self-assembled monolayer facilitates epithelial-Mesenchymal interactions mimicking odontogenesis

Muni, T., Mrksich, M. & George, A., Jan 1 2014, In : Connective tissue research. 55, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

Kuhn, M. L., Zemaitaitis, B., Hu, L. I., Sahu, A., Sorensen, D., Minasov, G., Lima, B. P., Scholle, M., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Apr 22 2014, In : PloS one. 9, 4, e94816.

Research output: Contribution to journalArticle

140 Scopus citations

The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors

Sodji, Q., Patil, V., Jain, S., Kornacki, J. R., Mrksich, M., Tekwani, B. L. & Oyelere, A. K., Oct 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 20, p. 4826-4830 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

3-Hydroxypyridin-2-thione as Novel Zinc Binding Group for Selective Histone Deacetylase Inhibition

Patil, V., Sodji, Q. H., Kornacki, J. R., Mrksich, M. & Oyelere, A. K., May 9 2013, In : Journal of Medicinal Chemistry. 56, 9, p. 3492-3506 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen

Hudalla, G. A., Modica, J. A., Tian, Y. F., Rudra, J. S., Chong, A. S., Sun, T., Mrksich, M. & Collier, J. H., Aug 2013, In : Advanced Healthcare Materials. 2, 8, p. 1114-1119 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

Bien, C., Affinati, A. H., Ramsey, K. M., Kuo, H. Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., Levine, D. C., Bacsik, D. J., Gius, D. R., Newgard, C. B., Goetzman, E., Chandel, N., Denu, J. M., Mrksich, M. & Bass, J., 2013, In : Science. 342, 6158, 1243417.

Research output: Contribution to journalArticle

347 Scopus citations

Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization

Cabrera-Pardo, J. R., Chai, D. I., Liu, S., Mrksich, M. & Kozmin, S. A., Mar 24 2013, In : Nature chemistry. 5, 5, p. 423-427 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

Nanopatterned substrates increase surface sensitivity for real-time biosensing

Lin, J. Y., Stuparu, A. D., Huntington, M. D., Mrksich, M. & Odom, T. W., Mar 14 2013, In : Journal of Physical Chemistry C. 117, 10, p. 5286-5292 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Plectin-containing, centrally localized focal adhesions exert traction forces in primary lung epithelial cells

Eisenberg, J. L., Beaumont, K. G., Takawira, D., Hopkinson, S. B., Mrksich, M., Scott Budinger, G. R. & Jones, J. C. R., 2013, In : Journal of cell science. 126, 16, p. 3746-3755 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Steady-state of an enzymatic reaction is dependent on the density of reactant

Li, S., Liao, X. & Mrksich, M., Jan 8 2013, In : Langmuir. 29, 1, p. 294-298 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and structure-activity relationship of 3-hydroxypyridine-2- thione-based histone deacetylase inhibitors

Sodji, Q. H., Patil, V., Kornacki, J. R., Mrksich, M. & Oyelere, A. K., Dec 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9969-9981 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

Cancer prognostics by direct detection of p53-antibodies on gold surfaces by impedance measurements

Prats-Alfonso, E., Sisquella, X., Zine, N., Gabriel, G., Guimerà, A., Del Campo, F. J., Villa, R., Eisenberg, A. H., Mrksich, M., Errachid, A., Aguiló, J. & Albericio, F., Jul 9 2012, In : Small. 8, 13, p. 2106-2115 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
115 Scopus citations

Discovery of glycosyltransferases using carbohydrate arrays and mass spectrometry

Ban, L., Pettit, N., Li, L., Stuparu, A. D., Cai, L., Chen, W., Guan, W., Han, W., Wang, P. G. & Mrksich, M., Sep 2012, In : Nature Chemical Biology. 8, 9, p. 769-773 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

Modular Assembly of Protein Building Blocks To Create Precisely Defined Megamolecules

Modica, J. A., Skarpathiotis, S. & Mrksich, M., Nov 5 2012, In : ChemBioChem. 13, 16, p. 2331-2334 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

The mechanostability of isolated focal adhesions is strongly dependent on pH

Beaumont, K. G. & Mrksich, M., Jun 22 2012, In : Chemistry and Biology. 19, 6, p. 711-720 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers

Montavon, T. J., Li, J., Cabrera-Pardo, J. R., Mrksich, M. & Kozmin, S. A., Jan 2012, In : Nature chemistry. 4, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

A conformation- and ion-sensitive plasmonic biosensor

Hall, W. P., Modica, J., Anker, J., Lin, Y., Mrksich, M. & Van Duyne, R. P., Mar 9 2011, In : Nano letters. 11, 3, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

A spatially propagating biochemical reaction

Liao, X., Petty, R. T. & Mrksich, M., Jan 17 2011, In : Angewandte Chemie - International Edition. 50, 3, p. 706-708 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase LgtA

Guan, W., Ban, L., Cai, L., Li, L., Chen, W., Liu, X., Mrksich, M. & Wang, P. G., Sep 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 17, p. 5025-5028 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

De novo motif for kinase mediated signaling across the cell membrane

Petty, R. T. & Mrksich, M., Aug 1 2011, In : Integrative Biology. 3, 8, p. 816-822 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Enzymatic synthesis and properties of uridine-5′-O-(2-thiodiphospho)- N-acetylglucosamine

Cai, L., Ban, L., Guan, W., Mrksich, M. & Wang, P. G., Sep 6 2011, In : Carbohydrate Research. 346, 12, p. 1576-1580 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

High-throughput screening of small molecule libraries using SAMDI mass spectrometry

Gurard-Levin, Z. A., Scholle, M. D., Eisenberg, A. H. & Mrksich, M., Jul 11 2011, In : ACS Combinatorial Science. 13, 4, p. 347-350 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Using self-assembled monolayers to understand α8β1-mediated cell adhesion to RGD and FEI motifs in nephronectin

Sánchez-Cortés, J. & Mrksich, M., Oct 21 2011, In : ACS chemical biology. 6, 10, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2010

An inhibitor of a cell adhesion receptor stimulates cell migration

Shabbir, S. H., Eisenberg, J. L. & Mrksich, M., Oct 11 2010, In : Angewandte Chemie - International Edition. 49, 42, p. 7706-7709 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cell adhesion to unnatural ligands mediated by a bifunctional protein

Sánchez-Cortés, J., Bähr, K. & Mrksich, M., Jul 21 2010, In : Journal of the American Chemical Society. 132, 28, p. 9733-9737 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Detection of differentially expressed basal cell proteins by mass spectrometry

Todorović, V., Desai, B. V., Eigenheer, R. A., Yin, T., Amargo, E. V., Mrksich, M., Green, K. J. & Patterson, M. J. S., Feb 2010, In : Molecular and Cellular Proteomics. 9, 2, p. 351-361 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Geometric cues for directing the differentiation of mesenchymal stem cells

Kilian, K. A., Bugarija, B., Lahn, B. T. & Mrksich, M., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4872-4877 6 p.

Research output: Contribution to journalArticle

1152 Scopus citations

Micropatterned dynamically adhesive substrates for cell migration

Sriraghavan, V., Desai, R. A., Kwon, Y., Mrksich, M. & Chen, C. S., Nov 16 2010, In : Langmuir. 26, 22, p. 17733-17738 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton

Mwakwari, S. C., Guerrant, W., Patil, V., Khan, S. I., Tekwani, B. L., Gurard-Levin, Z. A., Mrksich, M. & Oyelere, A. K., Aug 26 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 6100-6111 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Peptide arrays identify isoform-selective substrates for profiling endogenous lysine deacetylase activity

Gurard-Levin, Z. A., Kilian, K. A., Kim, J., Bähr, K. & Mrksich, M., Sep 17 2010, In : ACS chemical biology. 5, 9, p. 863-873 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

Rate enhancement of an interfacial biochemical reaction through localization of substrate and enzyme by an adaptor domain

Li, J., Nayak, S. & Mrksich, M., Nov 25 2010, In : Journal of Physical Chemistry B. 114, 46, p. 15113-15118 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Using the angle-dependent resonances of molded plasmonic crystals to improve the sensitivities of biosensors

Gao, H., Yang, J. C., Lin, J. Y., Stuparu, A. D., Lee, M. H., Mrksich, M. & Odom, T. W., Jul 14 2010, In : Nano letters. 10, 7, p. 2549-2554 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
2009

An adaptor domain-mediated autocatalytic interfacial kinase reaction

Liao, X., Su, J. & Mrksich, M., Dec 4 2009, In : Chemistry - A European Journal. 15, 45, p. 12303-12309 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Combining mass spectrometry and peptide arrays to profile the specificities of histone deacetylases

Gurard-Levin, Z. A., Kim, J. & Mrksich, M., Sep 4 2009, In : ChemBioChem. 10, 13, p. 2159-2161 3 p.

Research output: Contribution to journalArticle

46 Scopus citations

Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

Anker, J. N., Hall, W. P., Lambert, M. P., Velasco, P. T., Mrksich, M., Klein, W. L. & Van Duyne, R. P., Apr 16 2009, In : Journal of Physical Chemistry C. 113, 15, p. 5891-5894 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Profiling the selectivity of DNA ligases in an array format with mass spectrometry

Kim, J. & Mrksich, M., Oct 23 2009, In : Nucleic acids research. 38, 1, p. e2-e2 gkp827.

Research output: Contribution to journalArticle

23 Scopus citations

The Platelet Integrin αIIbβ3 Binds to the RGD and AGD Motifs in Fibrinogen

Sánchez-Cortés, J. & Mrksich, M., Sep 25 2009, In : Chemistry and Biology. 16, 9, p. 990-1000 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Using Self-assembled monolayers to model cell adhesion to the 9th and 10th type III domains of fibronectin

Eisenberg, J. L., Piper, J. L. & Mrksich, M., Dec 15 2009, In : Langmuir. 25, 24, p. 13942-13951 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

A bio-mechanical model for coupling cell contractility with focal adhesion formation

Deshpande, V. S., Mrksich, M., McMeeking, R. M. & Evans, A. G., Apr 1 2008, In : Journal of the Mechanics and Physics of Solids. 56, 4, p. 1484-1510 27 p.

Research output: Contribution to journalArticle

110 Scopus citations

A calcium-modulated plasmonic switch

Hall, W. P., Anker, J. N., Lin, Y., Modica, J., Mrksich, M. & Van Duyne, R. P., May 7 2008, In : Journal of the American Chemical Society. 130, 18, p. 5836-5837 2 p.

Research output: Contribution to journalArticle

80 Scopus citations

Biochemical assays of immobilized oligonucleotides with mass spectrometry

Tsubery, H. & Mrksich, M., May 20 2008, In : Langmuir. 24, 10, p. 5433-5438 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

On-chip synthesis and label-free assays of oligosaccharide arrays

Ban, L. & Mrksich, M., Apr 21 2008, In : Angewandte Chemie - International Edition. 47, 18, p. 3396-3399 4 p.

Research output: Contribution to journalArticle

83 Scopus citations