Mingchen Jiang

  • 663 Citations
1996 …2024
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Personal profile

Research Interests

My research focuses on spinal motor-system. I am interested in the interaction between pre-motor interneurons and motoneurons; the synaptic plasticity of motoneurons for peripheral and brainstem descending pathways; and the mechanisms of amyotrophic lateral sclerosis (ALS). Using a root recording system I developed for mouse spinal cord study, I have demonstrated the existence of two forms of short-term plasticity in the spinal motoneurons in response to different source of synaptic inputs. Further studies in this direction will move toward the cellular level to understand their pre- and post-synaptic mechanisms. In an animal model of ALS (mSOD1 mouse), I have found that NMDA receptors in the spinal interneurons might be an important component contributing to motoneurons' excitotoxicity. Further studies will apply intracellular recording and calcium image techniques to answer that through what ions, channels and/or receptors the interneurons interact with motoneurons in mSOD1 mouse in order to determine new therapeutic targets for this disease.

Education/Academic qualification

PhD, University of Iowa

… → 1998

MD, Jiwaji University

… → 1982

Research interests

  • Aging
  • Electrophysiology
  • Nanotechnology
  • Nervous System Diseases
  • Neuroscience
  • Physiology

Fingerprint Dive into the research topics where Mingchen Jiang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Motor Neurons Medicine & Life Sciences
Pelvic Pain Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Chronic Pain Medicine & Life Sciences
Spinal Cord Medicine & Life Sciences
Neurons Medicine & Life Sciences
Hyperalgesia Medicine & Life Sciences
Spinal Nerve Roots Medicine & Life Sciences

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Grants 2004 2024

Research Output 1996 2018

  • 663 Citations
  • 20 Article
  • 1 Review article
2 Citations (Scopus)

Acyloxyacyl hydrolase modulates pelvic pain severity

Yang, W., Yaggie, R. E., Jiang, M., Rudick, C. N., Done, J., Heckman, C., Rosen, J. M., Schaeffer, A. J. & Klumpp, D., Mar 1 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 3, p. R353-R365

Research output: Contribution to journalArticle

Pelvic Pain
Urinary Bladder
Suid Herpesvirus 1
Hyperalgesia
Chronic Pain

Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP network study

MAPP Research Network & MAPP Research Network Study Group, Dec 1 2018, In : PloS one. 13, 12, e0206807.

Research output: Contribution to journalArticle

Open Access
Pelvic Pain
Anisotropy
Chronic Pain
pain
Brain
7 Citations (Scopus)

Hyperexcitability in synaptic and firing activities of spinal motoneurons in an adult mouse model of amyotrophic lateral sclerosis

Jiang, M., Adimula, A., Birch, D. & Heckman, C., Oct 24 2017, In : Neuroscience. 362, p. 33-46 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Excitatory Postsynaptic Potentials
Spinal Nerve Roots
Action Potentials
2 Citations (Scopus)

The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis

Mao, Y., Kuo, S. W., Chen, L., Heckman, C. & Jiang, M., Mar 1 2017, In : PloS one. 12, 3, e0172246.

Research output: Contribution to journalArticle

Protein Interaction Maps
Amyotrophic Lateral Sclerosis
protein-protein interactions
Electric network analysis
Proteins
2 Citations (Scopus)

The regulatory effect of electro-acupuncture on the expression of NMDA receptors in a SCI rat model

Tu, W. Z., Chen, W. C., Xia, W., He, R., Hu, J., Jiang, M. & Jiang, S. H., May 15 2017, In : Life Sciences. 177, p. 8-14 7 p.

Research output: Contribution to journalArticle

Electroacupuncture
Acupuncture
N-Methyl-D-Aspartate Receptors
Spinal Cord Injuries
Rats