Mingchen Jiang

  • 690 Citations

Research output per year

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Personal profile

Research Interests

My research focuses on spinal motor-system. I am interested in the interaction between pre-motor interneurons and motoneurons; the synaptic plasticity of motoneurons for peripheral and brainstem descending pathways; and the mechanisms of amyotrophic lateral sclerosis (ALS). Using a root recording system I developed for mouse spinal cord study, I have demonstrated the existence of two forms of short-term plasticity in the spinal motoneurons in response to different source of synaptic inputs. Further studies in this direction will move toward the cellular level to understand their pre- and post-synaptic mechanisms. In an animal model of ALS (mSOD1 mouse), I have found that NMDA receptors in the spinal interneurons might be an important component contributing to motoneurons' excitotoxicity. Further studies will apply intracellular recording and calcium image techniques to answer that through what ions, channels and/or receptors the interneurons interact with motoneurons in mSOD1 mouse in order to determine new therapeutic targets for this disease.

Education/Academic qualification

PhD, University of Iowa

… → 1998

MD, Jiwaji University

… → 1982

Research interests

  • Aging
  • Electrophysiology
  • Nanotechnology
  • Nervous System Diseases
  • Neuroscience
  • Physiology

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Research Output

  • 690 Citations
  • 22 Article
  • 1 Review article

Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury

Thaweerattanasinp, T., Birch, D., Jiang, M. C., Tresch, M. C., Bennett, D. J., Heckman, C. J. & Tysseling, V. M., May 1 2020, In : Journal of neurophysiology. 123, 5, p. 1657-1670 14 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Multicomponent diffusion analysis reveals microstructural alterations in spinal cord of a mouse model of amyotrophic lateral sclerosis ex vivo

    Gao, J., Jiang, M., Magin, R. L., Gatto, R. G., Morfini, G., Larson, A. C. & Li, W., Apr 2020, In : PloS one. 15, 4, e0231598.

    Research output: Contribution to journalArticle

    Open Access
  • Acyloxyacyl hydrolase modulates pelvic pain severity

    Yang, W., Yaggie, R. E., Jiang, M. C., Rudick, C. N., Done, J., Heckman, C. J., Rosen, J. M., Schaeffer, A. J. & Klumpp, D. J., Mar 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 3, p. R353-R365

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP network study

    MAPP Research Network & MAPP Research Network Study Group, Dec 2018, In : PloS one. 13, 12, e0206807.

    Research output: Contribution to journalArticle

    Open Access
  • Hyperexcitability in synaptic and firing activities of spinal motoneurons in an adult mouse model of amyotrophic lateral sclerosis

    Jiang, M. C., Adimula, A., Birch, D. & Heckman, C. J., Oct 24 2017, In : Neuroscience. 362, p. 33-46 14 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations