Mohammed Javeed I Ansari

  • 2128 Citations
20032019

Research output per year

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Research Output

2019

Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil

Traitanon, O., Mathew, J. M., Shetty, A., Bontha, S. V., Maluf, D. G., El Kassis, Y., Park, S. H., Han, J., Ansari, M. J., Leventhal, J. R., Mas, V. & Gallon, L., May 2019, In : PloS one. 14, 5, e0216300.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

A Phase i Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Mathew, J. M., H-Voss, J., LeFever, A., Konieczna, I., Stratton, C., He, J., Huang, X., Gallon, L., Skaro, A. I., Ansari, M. J. & Leventhal, J. R., Dec 1 2018, In : Scientific reports. 8, 1, 7428.

Research output: Contribution to journalArticle

37 Scopus citations

Cellular and functional biomarkers of clinical transplant tolerance

Mathew, J. M., Ansari, M. J., Gallon, L. & Leventhal, J. R., May 2018, In : Human Immunology. 79, 5, p. 322-333 12 p.

Research output: Contribution to journalReview article

3 Scopus citations

Heterogeneity of memory B cells

Chong, A. S. & Ansari, M. J., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 779-784 6 p.

Research output: Contribution to journalReview article

10 Scopus citations
2015

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus

Gallon, L., Traitanon, O., Sustento-Reodica, N., Leventhal, J., Ansari, M. J., Gehrau, R. C., Ariyamuthu, V., De Serres, S. A., Alvarado, A., Chhabra, D., Mathew, J. M., Najafian, N. & Mas, V., Apr 8 2015, In : Kidney international. 87, 4, p. 828-838 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

T-cell exhaustion in allograft rejection and tolerance

Thorp, E. B., Stehlik, C. & Ansari, M. J., Feb 21 2015, In : Current opinion in organ transplantation. 20, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

17 Scopus citations
2014

Corrigendum to 'Mechanisms of PDL1-mediated regulation of autoimmune diabetes' [Clin. Immunol. 125 (2007) 16-25]

Guleria, I., Bupp, M. G., Dada, S., Fife, B. T., Tang, Q., Ansari, M. J., Trikudanathan, S., Vadivel, N., Fiorina, P., Yagita, H., Azuma, M., Atkinson, M., Bluestone, J. A. & Sayegh, M. H., Jan 1 2014, In : Clinical Immunology. 150, 1, 1 p.

Research output: Contribution to journalComment/debate

Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection

Sarraj, B., Ye, J., Akl, A. I., Chen, G., Wang, J. J., Zhang, Z. J., Abadja, F., Abecassis, M. M., Miller, S. D., Kansas, G. S. & Ansari, M. J. I., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12145-12150 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival

D'Addio, F., Ueno, T., Clarkson, M., Zhu, B., Vergani, A., Freeman, G. J., Sayegh, M. H., Ansari, M. J. I., Fiorina, P. & Habicht, A., Apr 4 2013, In : PloS one. 8, 4, e60391.

Research output: Contribution to journalArticle

15 Scopus citations

Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model

D'Addio, F., Boenisch, O., Magee, C. N., Yeung, M. Y., Yuan, X., Mfarrej, B., Vergani, A., Ansari, M. J. I., Fiorina, P. & Najafian, N., Jan 17 2013, In : PloS one. 8, 1, e53797.

Research output: Contribution to journalArticle

10 Scopus citations
2012

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L. & 4 others, Bonertz, A., Beckhove, P., Gounari, F. & Khazaie, K., Dec 12 2012, In : Science translational medicine. 4, 164

Research output: Contribution to journalArticle

114 Scopus citations

Significance of T helper 17 immunity in transplantation

Abadja, F., Sarraj, B. & Ansari, M. J., Feb 1 2012, In : Current opinion in organ transplantation. 17, 1, p. 8-14 7 p.

Research output: Contribution to journalReview article

38 Scopus citations
2011

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., Bere, P., Sarraj, B., Khan, M. W., Pakanati, K. C., Ansari, M. J., O'Flaherty, S., Barrett, T. & Klaenhammer, T. R., Mar 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, SUPPL. 1, p. 4623-4630 8 p.

Research output: Contribution to journalArticle

165 Scopus citations
2010

A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model

D'Addio, F., Yuan, X., Habicht, A., Williams, J., Ruzek, M., Iacomini, J., Turka, L. A., Sayegh, M. H., Najafian, N. & Ansari, M. J. I., Aug 15 2010, In : Transplantation. 90, 3, p. 260-269 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice

Vergani, A., D'Addio, F., Jurewicz, M., Petrelli, A., Watanabe, T., Liu, K., Law, K., Schuetz, C., Carvello, M., Orsenigo, E., Deng, S., Rodig, S. J., Ansari, J. M., Staudacher, C., Abdi, R., Williams, J., Markmann, J., Atkinson, M., Sayegh, M. H. & Fiorina, P., Sep 2010, In : Diabetes. 59, 9, p. 2253-2264 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Novel Diagnostics in Transplantation

Ansari, MJ. & Strom, TB., 2010, Chronic Kidney Disease, Dialysis and Transplantation. Himmelfarb, J. & Sayegh, MH. (eds.). Philadelphia: Elsevier, p. 609

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2009

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

Yuan, X., Ansari, M. J. I., D'Addio, F., Paez-Cortez, J., Schmitt, I., Donnarumma, M., Boenisch, O., Zhao, X., Popoola, J., Clarkson, M. R., Yagita, H., Akiba, H., Freeman, G. J., Iacomini, J., Turka, L. A., Glimcher, L. H. & Sayegh, M. H., Jun 30 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 26, p. 10734-10739 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
2008

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

Yuan, X., Paez-Cortez, J., Schmitt-Knosalla, I., D'Addio, F., Mfarrej, B., Donnarumma, M., Habicht, A., Clarkson, M. R., Iacomini, J., Glimcher, L. H., Sayegh, M. H. & Javeed Ansari, M., Dec 22 2008, In : Journal of Experimental Medicine. 205, 13, p. 3133-3144 12 p.

Research output: Contribution to journalArticle

227 Scopus citations

Complement dances with T cells

Ansari, M. J. & Sayegh, M. H., Sep 1 2008, In : Blood. 112, 5, p. 1551-1552 2 p.

Research output: Contribution to journalShort survey

Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy

Yang, J., Popoola, J., Khandwala, S., Vadivel, N., Vanguri, V., Yuan, X., Dada, S., Guleria, I., Tian, C., Ansari, M. J., Shin, T., Yagita, H., Azuma, M., Sayegh, M. H. & Chandraker, A., Feb 5 2008, In : Circulation. 117, 5, p. 660-669 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Mechanisms underlying blockade of allograft acceptance by TLR ligands

Porrett, P. M., Yuan, X., LaRosa, D. F., Walsh, P. T., Yang, J., Gao, W., Li, P., Zhang, J., Ansari, J. M., Hancock, W. W., Sayegh, M. H., Koulmanda, M., Strom, T. B. & Turka, L. A., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 1692-1699 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Renal Transplantation: Clinical Management

Magee, C., Ansari, MJ. & Milford, E., 2008, The Kidney. Brenner & Rector (eds.). Philadelphia: Elsevier, p. 2138

Research output: Chapter in Book/Report/Conference proceedingChapter

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

Ansari, M. J. I., Fiorina, P., Dada, S., Guleria, I., Ueno, T., Yuan, X., Trikudanathan, S., Smith, R. N., Freeman, G. & Sayegh, M. H., Feb 1 2008, In : Clinical Immunology. 126, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

Ueno, T., Habicht, A., Clarkson, M. R., Albin, M. J., Yamaura, K., Boenisch, O., Popoola, J., Wang, Y., Yagita, H., Akiba, H., Ansari, M. J., Yang, J., Turka, L. A., Rothstein, D. M., Padera, R. F., Najafian, N. & Sayegh, M. H., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 742-751 10 p.

Research output: Contribution to journalArticle

84 Scopus citations
2007

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy

Tian, C., Ansari, M. J. I., Paez-Cortez, J., Bagley, J., Godwin, J., Donnarumma, M., Sayegh, M. H. & Iacomini, J., Nov 15 2007, In : Journal of Immunology. 179, 10, p. 6762-6769 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanisms of PDL1-mediated regulation of autoimmune diabetes

Guleria, I., Gubbels Bupp, M., Dada, S., Fife, B., Tang, Q., Ansari, M. J., Trikudanathan, S., Vadivel, N., Fiorina, P., Yagita, H., Azuma, M., Atkinson, M., Bluestone, J. A. & Sayegh, M. H., Oct 1 2007, In : Clinical Immunology. 125, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

The arduous road to achieving an immunosuppression-free state in kidney transplant recipients

Ansari, M. J. & Sayegh, M. H., Sep 1 2007, In : Nature Clinical Practice Nephrology. 3, 9, p. 464-465 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations
2006

Costimulation and autoimmune diabetes in BB rats

Beaudette-Zlatanova, B. C., Whalen, B., Zipris, D., Yagita, H., Rozing, J., Groen, H., Benjamin, C. D., Hunig, T., Drexhage, H. A., Ansari, M. J., Leif, J., Mordes, J. P., Greiner, D. L., Sayegh, M. H. & Rossini, A. A., May 1 2006, In : American Journal of Transplantation. 6, 5 I, p. 894-902 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Costimulation couture: A designer approach to regulating autoimmunity

Ansari, M. J. & Sayegh, M. H., Aug 1 2006, In : Journal of Clinical Investigation. 116, 8, p. 2080-2083 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Role of CXC chemokine receptor 3 pathway in renal ischemic injury

Fiorina, P., Ansari, M. J., Jurewicz, M., Barry, M., Ricchiuti, V., Smith, R. N., Shea, S., Means, T. K., Auchincloss, H., Luster, A. D., Sayegh, M. H. & Abdi, R., Mar 1 2006, In : Journal of the American Society of Nephrology. 17, 3, p. 716-723 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Tolerance is the achievable 'Holy Grail' in transplantation

Yuan, X., Ansari, M. J. & Sayegh, M. H., Feb 1 2006, In : Current opinion in organ transplantation. 11, 1, p. 24-29 6 p.

Research output: Contribution to journalReview article

1 Scopus citations
2005

A critical role for the programmed death ligand 1 in fetomaternal tolerance

Guleria, I., Khosroshahi, A., Ansari, M. J., Habicht, A., Azuma, M., Yagita, H., Noelle, R. J., Coyle, A., Mellor, A. L., Khoury, S. J. & Sayegh, M. H., Jul 18 2005, In : Journal of Experimental Medicine. 202, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

270 Scopus citations

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection [4] (multiple letters)

Hilbrands, L., Hoitsma, A., Wetzels, J., Ansari, M. J., Tinckam, K., Chandraker, A., Dragun, D., Fritsche, L. & Luft, F. C., May 12 2005, In : New England Journal of Medicine. 352, 19, p. 2027-2028 2 p.

Research output: Contribution to journalLetter

4 Scopus citations
2004

Clinical transplantation tolerance: The promise and challenges

Ansari, M. J. I. & Sayegh, M. H., May 2004, In : Kidney international. 65, 5, p. 1560-1563 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
2003

Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice

Makhlouf, L., Yamada, A., Ito, T., Abdi, R., Ansari, M. J. I., Khuong, C. Q., Winn, H. J., Auchincloss, H. & Sayegh, M. H., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2168-2175 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Emerging immunomodulatory therapies targeting the co-stimulatory pathways for the prevention of transplant rejection

Ansari, M. J. I. & Abdi, R., Oct 1 2003, In : IDrugs. 6, 10, p. 964-969 6 p.

Research output: Contribution to journalReview article

8 Scopus citations

Erratum: (The Journal of Experimemal Medicine (July 7, 2003) 198:1 (71-78))

Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J. I., Akiba, H., Tushima, F., Azuma, M., Yagita, H., Sayegh, M. H. & Khoury, S. J., Aug 18 2003, In : Journal of Experimental Medicine. 198, 4, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

Ansari, M. J. I., Salama, A. D., Chitnis, T., Smith, R. N., Yagita, H., Akiba, H., Yamazaki, T., Azuma, M., Iwai, H., Khoury, S. J., Auchincloss, H. & Sayegh, M. H., Jul 7 2003, In : Journal of Experimental Medicine. 198, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

506 Scopus citations