Mohammed Javeed I Ansari

  • 2060 Citations
20032019
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Research Output 2003 2019

2019
2 Citations (Scopus)

Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil

Traitanon, O., Mathew, J., Shetty, A. A., Bontha, S. V., Maluf, D. G., El Kassis, Y., Park, S. H., Han, J., Ansari, M. J. I., Leventhal, J. R., Mas, V. & Gallon, L., May 1 2019, In : PloS one. 14, 5, e0216300.

Research output: Contribution to journalArticle

Open Access
tacrolimus
Mycophenolic Acid
kidney transplant
Transplants
Tacrolimus
2018
28 Citations (Scopus)

A Phase i Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Mathew, J. M., H-Voss, J., LeFever, A., Konieczna, I., Stratton, C., He, J., Huang, X., Gallon, L., Skaro, A., Ansari, M. J. & Leventhal, J. R., Dec 1 2018, In : Scientific reports. 8, 1, 7428.

Research output: Contribution to journalArticle

Living Donors
Regulatory T-Lymphocytes
Clinical Trials
Transplants
Kidney
2 Citations (Scopus)

Cellular and functional biomarkers of clinical transplant tolerance

Mathew, J. M., Ansari, M. J., Gallon, L. & Leventhal, J. R., May 2018, In : Human Immunology. 79, 5, p. 322-333 12 p.

Research output: Contribution to journalReview article

Adaptive Immunity
Biomarkers
Transplants
Tissue Donors
Innate Immunity
4 Citations (Scopus)

Heterogeneity of memory B cells

Chong, A. S. & Ansari, M. J., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 779-784 6 p.

Research output: Contribution to journalReview article

Plasma Cells
B-Lymphocytes
Tissue Donors
Transplants
B-Lymphocyte Differentiation Antigens
2015
23 Citations (Scopus)

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus

Gallon, L., Traitanon, O., Sustento-Reodica, N., Leventhal, J., Ansari, M. J., Gehrau, R. C., Ariyamuthu, V., De Serres, S. A., Alvarado, A., Chhabra, D., Mathew, J. M., Najafian, N. & Mas, V., Apr 8 2015, In : Kidney international. 87, 4, p. 828-838 11 p.

Research output: Contribution to journalArticle

Tacrolimus
Sirolimus
Kidney
Transplants
T-Lymphocytes
15 Citations (Scopus)

T-cell exhaustion in allograft rejection and tolerance

Thorp, E. B., Stehlik, C. & Ansari, M. J., Feb 21 2015, In : Current opinion in organ transplantation. 20, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

Transplantation Tolerance
T-Lymphocytes
Virus Diseases
Allografts
Leukocytes
2014

Corrigendum to 'Mechanisms of PDL1-mediated regulation of autoimmune diabetes' [Clin. Immunol. 125 (2007) 16-25]

Guleria, I., Bupp, M. G., Dada, S., Fife, B. T., Tang, Q., Ansari, M. J., Trikudanathan, S., Vadivel, N., Fiorina, P., Yagita, H., Azuma, M., Atkinson, M., Bluestone, J. A. & Sayegh, M. H., Jan 1 2014, In : Clinical Immunology. 150, 1, 1 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
corrigendum
21 Citations (Scopus)

Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection

Sarraj, B., Ye, J., Akl, A. I., Chen, G., Wang, J. J., Zhang, Z. J., Abadja, F., Abecassis, M. M., Miller, S. D., Kansas, G. S. & Ansari, M. J. I., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12145-12150 6 p.

Research output: Contribution to journalArticle

Selectins
Allografts
Leukocytes
T-Lymphocytes
Graft Survival
2013
15 Citations (Scopus)

CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival

D'Addio, F., Ueno, T., Clarkson, M., Zhu, B., Vergani, A., Freeman, G. J., Sayegh, M. H., Ansari, M. J. I., Fiorina, P. & Habicht, A., Apr 4 2013, In : PloS one. 8, 4, e60391.

Research output: Contribution to journalArticle

allografting
T-cells
Allografts
Fusion reactions
T-lymphocytes
10 Citations (Scopus)

Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model

D'Addio, F., Boenisch, O., Magee, C. N., Yeung, M. Y., Yuan, X., Mfarrej, B., Vergani, A., Ansari, M. J. I., Fiorina, P. & Najafian, N., Jan 17 2013, In : PloS one. 8, 1, e53797.

Research output: Contribution to journalArticle

Transplants
Antilymphocyte Serum
thymocytes
globulins
Globulins
2012
111 Citations (Scopus)

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L. & 4 others, Bonertz, A., Beckhove, P., Gounari, F. & Khazaie, K., Dec 12 2012, In : Science translational medicine. 4, 164

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Polyps
Colonic Neoplasms
Interleukin-17
36 Citations (Scopus)

Significance of T helper 17 immunity in transplantation

Abadja, F., Sarraj, B. & Ansari, M. J., Feb 1 2012, In : Current opinion in organ transplantation. 17, 1, p. 8-14 7 p.

Research output: Contribution to journalReview article

Immunity
Transplantation
Autoimmunity
Th17 Cells
Allografts
2011
161 Citations (Scopus)

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., Bere, P., Sarraj, B., Khan, M. W., Pakanati, K. C., Ansari, M. J., O'Flaherty, S., Barrett, T. & Klaenhammer, T. R., Mar 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, SUPPL. 1, p. 4623-4630 8 p.

Research output: Contribution to journalArticle

Lactobacillus acidophilus
Colitis
Dendritic Cells
Dextran Sulfate
Interleukin-12
2010
34 Citations (Scopus)

A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model

D'Addio, F., Yuan, X., Habicht, A., Williams, J., Ruzek, M., Iacomini, J., Turka, L. A., Sayegh, M. H., Najafian, N. & Ansari, M. J. I., Aug 15 2010, In : Transplantation. 90, 3, p. 260-269 10 p.

Research output: Contribution to journalArticle

Antilymphocyte Serum
T-Lymphocytes
Transplants
Sirolimus
Organ Transplantation
56 Citations (Scopus)

A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice

Vergani, A., D'Addio, F., Jurewicz, M., Petrelli, A., Watanabe, T., Liu, K., Law, K., Schuetz, C., Carvello, M., Orsenigo, E., Deng, S., Rodig, S. J., Ansari, J. M., Staudacher, C., Abdi, R., Williams, J., Markmann, J., Atkinson, M., Sayegh, M. H. & Fiorina, P., Sep 2010, In : Diabetes. 59, 9, p. 2253-2264 12 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Autoimmunity
Islets of Langerhans Transplantation
Obese Mice
Type 1 Diabetes Mellitus

Novel Diagnostics in Transplantation

Ansari, MJ. & Strom, TB., 2010, Chronic Kidney Disease, Dialysis and Transplantation. Himmelfarb, J. & Sayegh, MH. (eds.). Philadelphia: Elsevier, p. 609

Research output: Chapter in Book/Report/Conference proceedingChapter

2009
53 Citations (Scopus)

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

Yuan, X., Ansari, M. J. I., D'Addio, F., Paez-Cortez, J., Schmitt, I., Donnarumma, M., Boenisch, O., Zhao, X., Popoola, J., Clarkson, M. R., Yagita, H., Akiba, H., Freeman, G. J., Iacomini, J., Turka, L. A., Glimcher, L. H. & Sayegh, M. H., Jun 30 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 26, p. 10734-10739 6 p.

Research output: Contribution to journalArticle

Transplantation Tolerance
Interleukin-17
T-Lymphocytes
Mucin-1
Allografts
2008
225 Citations (Scopus)

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

Yuan, X., Paez-Cortez, J., Schmitt-Knosalla, I., D'Addio, F., Mfarrej, B., Donnarumma, M., Habicht, A., Clarkson, M. R., Iacomini, J., Glimcher, L. H., Sayegh, M. H. & Javeed Ansari, M., Dec 22 2008, In : Journal of Experimental Medicine. 205, 13, p. 3133-3144 12 p.

Research output: Contribution to journalArticle

Th17 Cells
Allografts
Interleukin-17
Cytokines
T-Lymphocytes

Complement dances with T cells

Ansari, M. J. & Sayegh, M. H., Sep 1 2008, In : Blood. 112, 5, p. 1551-1552 2 p.

Research output: Contribution to journalShort survey

T-cells
61 Citations (Scopus)

Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy

Yang, J., Popoola, J., Khandwala, S., Vadivel, N., Vanguri, V., Yuan, X., Dada, S., Guleria, I., Tian, C., Ansari, M. J., Shin, T., Yagita, H., Azuma, M., Sayegh, M. H. & Chandraker, A., Feb 5 2008, In : Circulation. 117, 5, p. 660-669 10 p.

Research output: Contribution to journalArticle

Allografts
Tissue Donors
Ligands
T-Lymphocytes
Graft Survival
70 Citations (Scopus)

Mechanisms underlying blockade of allograft acceptance by TLR ligands

Porrett, P. M., Yuan, X., LaRosa, D. F., Walsh, P. T., Yang, J., Gao, W., Li, P., Zhang, J., Ansari, J. M., Hancock, W. W., Sayegh, M. H., Koulmanda, M., Strom, T. B. & Turka, L. A., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 1692-1699 8 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Allografts
Ligands
Transplants
Interleukin-6

Renal Transplantation: Clinical Management

Magee, C., Ansari, MJ. & Milford, E., 2008, The Kidney. Brenner & Rector (eds.). Philadelphia: Elsevier, p. 2138

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Citations (Scopus)

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

Ansari, M. J. I., Fiorina, P., Dada, S., Guleria, I., Ueno, T., Yuan, X., Trikudanathan, S., Smith, R. N., Freeman, G. & Sayegh, M. H., Feb 1 2008, In : Clinical Immunology. 126, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Autoimmunity
Allografts
Islets of Langerhans Transplantation
Graft Survival
82 Citations (Scopus)

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

Ueno, T., Habicht, A., Clarkson, M. R., Albin, M. J., Yamaura, K., Boenisch, O., Popoola, J., Wang, Y., Yagita, H., Akiba, H., Ansari, M. J., Yang, J., Turka, L. A., Rothstein, D. M., Padera, R. F., Najafian, N. & Sayegh, M. H., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 742-751 10 p.

Research output: Contribution to journalArticle

Mucin-1
T-Lymphocytes
Transplants
Allografts
Antibodies
2007
21 Citations (Scopus)

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy

Tian, C., Ansari, M. J. I., Paez-Cortez, J., Bagley, J., Godwin, J., Donnarumma, M., Sayegh, M. H. & Iacomini, J., Nov 15 2007, In : Journal of Immunology. 179, 10, p. 6762-6769 8 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Type 1 Diabetes Mellitus
Genetic Therapy
Inbred NOD Mouse
Viruses
77 Citations (Scopus)

Mechanisms of PDL1-mediated regulation of autoimmune diabetes

Guleria, I., Gubbels Bupp, M., Dada, S., Fife, B., Tang, Q., Ansari, M. J., Trikudanathan, S., Vadivel, N., Fiorina, P., Yagita, H., Azuma, M., Atkinson, M., Bluestone, J. A. & Sayegh, M. H., Oct 1 2007, In : Clinical Immunology. 125, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
T-Lymphocytes
Inbred NOD Mouse
Transgenic Mice
Lymph Nodes
4 Citations (Scopus)

The arduous road to achieving an immunosuppression-free state in kidney transplant recipients

Ansari, M. J. & Sayegh, M. H., Sep 1 2007, In : Nature Clinical Practice Nephrology. 3, 9, p. 464-465 2 p.

Research output: Contribution to journalShort survey

Graft Rejection
Immunosuppressive Agents
Kidney Transplantation
Immunosuppression
Kidney
2006
18 Citations (Scopus)

Costimulation and autoimmune diabetes in BB rats

Beaudette-Zlatanova, B. C., Whalen, B., Zipris, D., Yagita, H., Rozing, J., Groen, H., Benjamin, C. D., Hunig, T., Drexhage, H. A., Ansari, M. J., Leif, J., Mordes, J. P., Greiner, D. L., Sayegh, M. H. & Rossini, A. A., May 1 2006, In : American Journal of Transplantation. 6, 5 I, p. 894-902 9 p.

Research output: Contribution to journalArticle

Inbred BB Rats
Type 1 Diabetes Mellitus
Monoclonal Antibodies
Poly I-C
Regulatory T-Lymphocytes
13 Citations (Scopus)

Costimulation couture: A designer approach to regulating autoimmunity

Ansari, M. J. & Sayegh, M. H., Aug 1 2006, In : Journal of Clinical Investigation. 116, 8, p. 2080-2083 4 p.

Research output: Contribution to journalReview article

Autoimmunity
Autoimmune Diseases
Peripheral Tolerance
T-Lymphocytes
Inbred NOD Mouse
57 Citations (Scopus)

Role of CXC chemokine receptor 3 pathway in renal ischemic injury

Fiorina, P., Ansari, M. J., Jurewicz, M., Barry, M., Ricchiuti, V., Smith, R. N., Shea, S., Means, T. K., Auchincloss, H., Luster, A. D., Sayegh, M. H. & Abdi, R., Mar 1 2006, In : Journal of the American Society of Nephrology. 17, 3, p. 716-723 8 p.

Research output: Contribution to journalArticle

CXCR3 Receptors
Reperfusion Injury
Kidney
Wounds and Injuries
Ischemia
3 Citations (Scopus)
Enteric-Coated Tablets
Drug Substitution
Mycophenolic Acid
Generic Drugs
Evidence-Based Medicine
1 Citation (Scopus)

Tolerance is the achievable 'Holy Grail' in transplantation

Yuan, X., Ansari, M. J. & Sayegh, M. H., Feb 1 2006, In : Current opinion in organ transplantation. 11, 1, p. 24-29 6 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Transplantation
Transplantation Tolerance
Organ Transplantation
Cell- and Tissue-Based Therapy
2005
256 Citations (Scopus)

A critical role for the programmed death ligand 1 in fetomaternal tolerance

Guleria, I., Khosroshahi, A., Ansari, M. J., Habicht, A., Azuma, M., Yagita, H., Noelle, R. J., Coyle, A., Mellor, A. L., Khoury, S. J. & Sayegh, M. H., Jul 18 2005, In : Journal of Experimental Medicine. 202, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Ligands
Isoantigens
Pregnancy
B-Lymphocytes
T-Lymphocytes
4 Citations (Scopus)

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection [4] (multiple letters)

Hilbrands, L., Hoitsma, A., Wetzels, J., Ansari, M. J., Tinckam, K., Chandraker, A., Dragun, D., Fritsche, L. & Luft, F. C., May 12 2005, In : New England Journal of Medicine. 352, 19, p. 2027-2028 2 p.

Research output: Contribution to journalLetter

Malignant Hypertension
Angiotensin Type 1 Receptor
Hemolytic-Uremic Syndrome
Graft Rejection
Acute Disease
2004
22 Citations (Scopus)

Clinical transplantation tolerance: The promise and challenges

Ansari, M. J. I. & Sayegh, M. H., May 2004, In : Kidney international. 65, 5, p. 1560-1563 4 p.

Research output: Contribution to journalArticle

Transplantation Tolerance
Transplants
Drug Tolerance
Organ Transplantation
Immunosuppressive Agents
2003
29 Citations (Scopus)

Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice

Makhlouf, L., Yamada, A., Ito, T., Abdi, R., Ansari, M. J. I., Khuong, C. Q., Winn, H. J., Auchincloss, H. & Sayegh, M. H., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2168-2175 8 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Allografts
T-Lymphocytes
Autoimmunity
Inbred C57BL Mouse
8 Citations (Scopus)

Emerging immunomodulatory therapies targeting the co-stimulatory pathways for the prevention of transplant rejection

Ansari, M. J. I. & Abdi, R., Oct 1 2003, In : IDrugs. 6, 10, p. 964-969 6 p.

Research output: Contribution to journalReview article

Transplantation Tolerance
Immunomodulation
Graft Rejection
Immunosuppressive Agents
Monoclonal Antibodies
2 Citations (Scopus)

Erratum: (The Journal of Experimemal Medicine (July 7, 2003) 198:1 (71-78))

Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J. I., Akiba, H., Tushima, F., Azuma, M., Yagita, H., Sayegh, M. H. & Khoury, S. J., Aug 18 2003, In : Journal of Experimental Medicine. 198, 4, 1 p.

Research output: Contribution to journalComment/debate

Medicine
491 Citations (Scopus)

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

Ansari, M. J. I., Salama, A. D., Chitnis, T., Smith, R. N., Yagita, H., Akiba, H., Yamazaki, T., Azuma, M., Iwai, H., Khoury, S. J., Auchincloss, H. & Sayegh, M. H., Jul 7 2003, In : Journal of Experimental Medicine. 198, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Type 1 Diabetes Mellitus
CTLA-4 Antigen
Peripheral Tolerance
Congenic Mice