Grants per year
Personal profile
Research Interests
Our research uses advanced imaging techniques to assess the interaction of neural activity and vascular physiology in healthy brains and neurological disease. This involves the design and implementation of tools to stimulate or monitor human physiology during MRI scanning, and the development of specialized MRI acquisition methods to characterize neurovascular function. In combination with bespoke signal processing pipelines developed in our lab, we aim to produce robust quantitative imaging biomarkers for studying Multiple Sclerosis, fatigue, migraine, stroke, dementia, spinal cord injury, and the response of individual patients to personalised therapeutic interventions.
Research Interests
Following a B.S. in physics from MIT, Dr. Bright received her D.Phil. from the University of Oxford as part of a collaboration with the US National Institutes of Health, working with Peter Jezzard at the Oxford Centre for Functional MRI of the Brain (FMRIB) and Jeff Duyn in the Advanced MRI group of NINDS. She completed post-doctoral training at the Cardiff University Brain Research Imaging Centre (CUBRIC), incorporating new physiological stimuli, additional imaging modalities, and advanced fMRI processing techniques to her research. She then moved to Nottingham as an independent Anne McLaren Fellow, to develop ultra-high-field MR imaging methods for studying cerebral physiology in neurological diseases at the world-leading Sir Peter Mansfield Imaging Centre, the birthplace of MRI. In 2018, she returned home to America to lead the Applied Neuro-Vascular Imaging Lab (ANVIL) at Northwestern University.
The Applied Neuro-Vascular Imaging Lab focuses on advanced MRI techniques to assess the interaction of neural activity and vascular physiology in healthy brains and neurological disease or impairment. This involves the design and implementation of tools to stimulate or monitor human physiology during MRI scanning, and the development of specialized MRI acquisition methods to characterize neuro-vascular function. In combination with bespoke signal processing pipelines developed in our lab, we aim to produce robust quantitative imaging biomarkers for studying stroke, Cerebral Palsy, Spinal Cord Injury, Parkinson's Disease, and the response of individual patients to personalized therapeutic interventions. This work is in collaboration with Physical Therapy and Human Movement Sciences, Biomedical Engineering, Neurology, Radiology, the Center for Translational Imaging, the Northwestern University Interdepartmental Neuroscience program, and the Shirley Ryan Ability Lab.
Training Experience
2014 | Postdoctoral Fellowship, Cardiff University |
2017 | Postdoctoral Fellowship, University of Nottingham, UK |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Neurosciences, DPhil, Clinical Neurosciences, University of Oxford
… → 2011
Physics, BS, Massachusetts Institute of Technology
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Network
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Probing silent cerebral infarct pathogenesis in sickle cell disease with cerebrovascular MRI - F31 for Kristina Marie Zvolanek
1/15/23 → 1/14/24
Project: Research project
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Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
Bright, M., Chen, Y. J., Parrish, T. B. & Sorond, F. A.
National Institute of Neurological Disorders and Stroke
12/15/21 → 11/30/23
Project: Research project
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Neurovascular Mechanisms of Intermittent Hypoxia Induced Neural Plasticity
7/31/19 → 7/30/23
Project: Research project
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Comparing end-tidal CO2, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with breath-hold task BOLD fMRI
Zvolanek, K. M., Moia, S., Dean, J. N., Stickland, R. C., Caballero-Gaudes, C. & Bright, M. G., May 15 2023, In: Neuroimage. 272, 120038.Research output: Contribution to journal › Article › peer-review
Open Access -
Hemodynamic timing in resting-state and breathing-task BOLD fMRI
Gong, J., Stickland, R. C. & Bright, M. G., Jul 1 2023, In: Neuroimage. 274, 120120.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of variability in manually contoured spinal cord masks on fMRI co-registration and interpretation
Hoggarth, M. A., Wang, M. C., Hemmerling, K. J., Vigotsky, A. D., Smith, Z. A., Parrish, T. B., Weber, K. A. & Bright, M. G., Oct 20 2022, In: Frontiers in Neurology. 13, 907581.Research output: Contribution to journal › Article › peer-review
Open Access -
Lag-Optimized Blood Oxygenation Level Dependent Cerebrovascular Reactivity Estimates Derived From Breathing Task Data Have a Stronger Relationship With Baseline Cerebral Blood Flow
Stickland, R. C., Zvolanek, K. M., Moia, S., Caballero-Gaudes, C. & Bright, M. G., Jun 15 2022, In: Frontiers in Neuroscience. 16, 910025.Research output: Contribution to journal › Article › peer-review
Open Access -
A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function
Stickland, R. C., Zvolanek, K. M., Moia, S., Ayyagari, A., Caballero-Gaudes, C. & Bright, M. G., Oct 1 2021, In: Neuroimage. 239, 118306.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Datasets
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physiopy/phys2bids: BIDS formatting of physiological recordings
Alcalá, D. (Creator), Ayyagari, A. (Creator), Bottenhorn, K. (Creator), Bright, M. (Creator), Caballero-Gaudes, C. (Creator), Chavarría, I. (Creator), Ferrer, V. (Creator), Hayashi, S. (Creator), Iacovella, V. (Creator), Lespinasse, F. (Creator), Markello, R. (Creator), Moia, S. (Creator), Oostenveld, R. (Creator), Salo, T. (Creator), Stickland, R. (Creator), Uruñuela, E. (Creator), Thiel, M. V. D. (Creator) & Zvolanek, K. (Creator), ZENODO, 2022
DOI: 10.5281/zenodo.6836077, https://zenodo.org/record/6836077
Dataset
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physiopy/phys2bids: BIDS formatting of physiological recordings
Alcalá, D. (Creator), Ayyagari, A. (Creator), Bottenhorn, K. (Creator), Bright, M. (Creator), Caballero-Gaudes, C. (Creator), Chavarría, I. (Creator), Ferrer, V. (Creator), Hayashi, S. (Creator), Iacovella, V. (Creator), Lespinasse, F. (Creator), Markello, R. (Creator), Moia, S. (Creator), Oostenveld, R. (Creator), Salo, T. (Creator), Stickland, R. (Creator), Uruñuela, E. (Creator), Thiel, M. V. D. (Creator) & Zvolanek, K. (Creator), ZENODO, 2022
DOI: 10.5281/zenodo.6837855, https://zenodo.org/record/6837855
Dataset