Morris Kletzel

  • 3757 Citations
1980 …2020

Research output per year

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Personal profile

Research Interests

Stem Cell Transplantation for Pediatric diseases Minimal residual disease in leukemia Neuroblastoma and its treatment Stem Cell differentiation Tumor vaccines.

I have been involved in Clinical research for Neuroblastoma and stem cell transplantation. I have also for the past 26 year have a laboratory that was focused on several projects such as: 1. Minimal Residual Disease in leukemia and neuroblastoma using WT1 gene as a marker. 2. Hematopoietic stem cell differentiation primarily on neural differentiation. 3. The use of RT-PCR to assess chimerism post transplant. 4. Stem cell processing and storage. 5. neuroblastoma tumor stem cell identification and its role in disease development.

My clinical focus has been related to Hematopoietic Stem Cell transplantation both autologous and allogeneic. I have also developed and participate at the national level in the development of therapeutic protocols for neuroblastoma , leukemia and lymphoma at the former Pediatric Oncology group and the Children's Oncology Group. Most recently I have been the Institutional PI for the Pediatric Immune Deficiency consortium developing protocols for the transplant of patients affected with immune deficiency disorders.

Certifications and Licenses

Pediatric Hematology-Oncology

Training Experience

1972Internship, University of Tel Aviv
1977Residency, University of Arkansas Hospital
1980Fellowship, University of Texas/MD Anderson Cancer Center

Education/Academic qualification

MD, Facultad de Medicina de la UNAM

… → 1971

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Pediatrics
  • Stem Cells
  • Transplantation

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Research Output

Veno-occlusive disease after high-dose busulfan–melphalan in neuroblastoma

Schechter, T., Perez-Albuerne, E., Lin, T. F., Irwin, M. S., Essa, M., Desai, A. V., Frangoul, H., Yanik, G., Dupuis, L. L., Jacobsohn, D., Kletzel, M., Ranalli, M., Soni, S., Seif, A. E., Grupp, S. & Dvorak, C. C., Mar 1 2020, In : Bone Marrow Transplantation. 55, 3, p. 531-537 7 p.

Research output: Contribution to journalArticle

  • 4 Scopus citations

    Fecal calprotectin and serum albumin as markers of gastrointestinal graft versus host disease

    Broglie, L., Rademaker, A., Galvin, J., Ray, A., Tse, W. T., Duerst, R., Schneiderman, J., Kletzel, M. & Chaudhury, S., Sep 2018, In : Hematology/ Oncology and Stem Cell Therapy. 11, 3, p. 169-174 6 p.

    Research output: Contribution to journalArticle

  • Gene therapy in patients with transfusion-dependent β-thalassemia

    Thompson, A. A., Walters, M. C., Kwiatkowski, J., Rasko, J. E. J., Ribeil, J. A., Hongeng, S., Magrin, E., Schiller, G. J., Payen, E., Semeraro, M., Moshous, D., Lefrere, F., Puy, H., Bourget, P., Magnani, A., Caccavelli, L., Diana, J. S., Suarez, F., Monpoux, F., Brousse, V. & 27 others, Poirot, C., Brouzes, C., Meritet, J. F., Pondarré, C., Beuzard, Y., Chrétien, S., Lefebvre, T., Teachey, D. T., Anurathapan, U., Ho, P. J., Von Kalle, C., Kletzel, M., Vichinsky, E., Soni, S., Veres, G., Negre, O., Ross, R. W., Davidson, D., Petrusich, A., Sandler, L., Asmal, M., Hermine, O., De Montalembert, M., Hacein-Bey-Abina, S., Blanche, S., Leboulch, P. & Cavazzana, M., Apr 19 2018, In : New England Journal of Medicine. 378, 16, p. 1479-1493 15 p.

    Research output: Contribution to journalArticle

  • 162 Scopus citations
  • 1 Scopus citations

    Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation

    Duncan, C. N., Brazauskas, R., Huang, J., Shaw, B. E., Majhail, N. S., Savani, B. N., Flowers, M. E. D., Battiwalla, M., Beebe, K., Dietz, A. C., Dvorak, C. C., Giller, R., Jacobsohn, D. A., Kletzel, M., Martin, P. L., Nemecek, E. R., Nuechterlein, B., Talano, J. A., Pulsipher, M. A. & Baker, K. S., Oct 1 2018, In : Bone Marrow Transplantation. 53, 10, p. 1278-1287 10 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations