Grants per year
Personal profile
Research Interests
Stem Cell Transplantation for Pediatric diseases Minimal residual disease in leukemia Neuroblastoma and its treatment Stem Cell differentiation Tumor vaccines.
I have been involved in Clinical research for Neuroblastoma and stem cell transplantation. I have also for the past 26 year have a laboratory that was focused on several projects such as: 1. Minimal Residual Disease in leukemia and neuroblastoma using WT1 gene as a marker. 2. Hematopoietic stem cell differentiation primarily on neural differentiation. 3. The use of RT-PCR to assess chimerism post transplant. 4. Stem cell processing and storage. 5. neuroblastoma tumor stem cell identification and its role in disease development.
My clinical focus has been related to Hematopoietic Stem Cell transplantation both autologous and allogeneic. I have also developed and participate at the national level in the development of therapeutic protocols for neuroblastoma , leukemia and lymphoma at the former Pediatric Oncology group and the Children's Oncology Group. Most recently I have been the Institutional PI for the Pediatric Immune Deficiency consortium developing protocols for the transplant of patients affected with immune deficiency disorders.
Certifications and Licenses
| Pediatrics | |
| Pediatric Hematology-Oncology |
Training Experience
| 1972 | Internship, University of Tel Aviv |
| 1977 | Residency, University of Arkansas Hospital |
| 1980 | Fellowship, University of Texas/MD Anderson Cancer Center |
Education/Academic qualification
MD, Facultad de Medicina de la UNAM
… → 1971
Research interests
- Blood Cancer (leukemia and lymphomas)
- Pediatrics
- Stem Cells
- Transplantation
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Grants
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GVHD002: Safety Follow-Up Through 180 Days of Treatment with Remestemcel-L in Study MSB-GVHD001 in Pediatric Patients who have Failed to Respond to Steroid Treatment for acute GVHD.
Duerst, R. E., Kletzel, M., Tse, W. T. & Chaudhury, S.
10/19/15 → 8/31/50
Project: Research project
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SCT 0914: 13-TLEC Natural HIstory & Biology of Long-Term Late Effects Following HCT for Childhood Malignancies
National Marrow Donor Program, National Institutes of Health
12/16/14 → 12/15/17
Project: Research project
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4 protocols:#6901-A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders#6902-Primary Immune Deficiency Treatment Consortium: Protocol #6902: A Retrospective
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/14 → 8/31/19
Project: Research project
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4 protocols:#6901-A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders#6902-Primary Immune Deficiency Treatment Consortium: Protocol #6902: A Retrospective
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/14 → 8/31/19
Project: Research project
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4 protocols:#6901-A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders#6902-Primary Immune Deficiency Treatment Consortium: Protocol #6902: A Retrospective
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/14 → 8/31/19
Project: Research project
Research Output
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Veno-occlusive disease after high-dose busulfan–melphalan in neuroblastoma
Schechter, T., Perez-Albuerne, E., Lin, T. F., Irwin, M. S., Essa, M., Desai, A. V., Frangoul, H., Yanik, G., Dupuis, L. L., Jacobsohn, D., Kletzel, M., Ranalli, M., Soni, S., Seif, A. E., Grupp, S. & Dvorak, C. C., Mar 1 2020, In: Bone Marrow Transplantation. 55, 3, p. 531-537 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Fecal calprotectin and serum albumin as markers of gastrointestinal graft versus host disease
Broglie, L., Rademaker, A., Galvin, J., Ray, A., Tse, W. T., Duerst, R., Schneiderman, J., Kletzel, M. & Chaudhury, S., Sep 2018, In: Hematology/ Oncology and Stem Cell Therapy. 11, 3, p. 169-174 6 p.Research output: Contribution to journal › Article › peer-review
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Gene therapy in patients with transfusion-dependent β-thalassemia
Thompson, A. A., Walters, M. C., Kwiatkowski, J., Rasko, J. E. J., Ribeil, J. A., Hongeng, S., Magrin, E., Schiller, G. J., Payen, E., Semeraro, M., Moshous, D., Lefrere, F., Puy, H., Bourget, P., Magnani, A., Caccavelli, L., Diana, J. S., Suarez, F., Monpoux, F., Brousse, V. & 27 others, , Apr 19 2018, In: New England Journal of Medicine. 378, 16, p. 1479-1493 15 p.Research output: Contribution to journal › Article › peer-review
194 Scopus citations -
High-dose chemotherapy and autologous hematopoietic stem-cell rescue for treatment of relapsed and refractory Wilms tumor: Re-evaluating outcomes
Rossoff, J., Tse, W. T., Duerst, R. E., Schneiderman, J., Morgan, E., Kletzel, M. & Chaudhury, S., Aug 18 2018, In: Pediatric Hematology and Oncology. 35, 5-6, p. 316-321 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation
Duncan, C. N., Brazauskas, R., Huang, J., Shaw, B. E., Majhail, N. S., Savani, B. N., Flowers, M. E. D., Battiwalla, M., Beebe, K., Dietz, A. C., Dvorak, C. C., Giller, R., Jacobsohn, D. A., Kletzel, M., Martin, P. L., Nemecek, E. R., Nuechterlein, B., Talano, J. A., Pulsipher, M. A. & Baker, K. S., Oct 1 2018, In: Bone Marrow Transplantation. 53, 10, p. 1278-1287 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations