Grants per year
Personal profile
Research Interests
Stem Cell Transplantation for Pediatric diseases Minimal residual disease in leukemia Neuroblastoma and its treatment Stem Cell differentiation Tumor vaccines.
I have been involved in Clinical research for Neuroblastoma and stem cell transplantation. I have also for the past 26 year have a laboratory that was focused on several projects such as: 1. Minimal Residual Disease in leukemia and neuroblastoma using WT1 gene as a marker. 2. Hematopoietic stem cell differentiation primarily on neural differentiation. 3. The use of RT-PCR to assess chimerism post transplant. 4. Stem cell processing and storage. 5. neuroblastoma tumor stem cell identification and its role in disease development.
My clinical focus has been related to Hematopoietic Stem Cell transplantation both autologous and allogeneic. I have also developed and participate at the national level in the development of therapeutic protocols for neuroblastoma , leukemia and lymphoma at the former Pediatric Oncology group and the Children's Oncology Group. Most recently I have been the Institutional PI for the Pediatric Immune Deficiency consortium developing protocols for the transplant of patients affected with immune deficiency disorders.
Certifications and Licenses
| Pediatric Hematology-Oncology | |
| Pediatrics |
Training Experience
| 1972 | Internship, University of Tel Aviv |
| 1977 | Residency, University of Arkansas Hospital |
| 1980 | Fellowship, University of Texas/MD Anderson Cancer Center |
Education/Academic qualification
MD, Facultad de Medicina de la UNAM
… → 1971
Keywords
- Blood Cancer (leukemia and lymphomas)
- Pediatrics
- Stem Cells
- Transplantation
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- 18 Similar Profiles
Transplants
Medicine & Life Sciences
Pediatrics
Medicine & Life Sciences
Hematopoietic Stem Cell Transplantation
Medicine & Life Sciences
Neuroblastoma
Medicine & Life Sciences
Hematopoietic Stem Cells
Medicine & Life Sciences
Stem Cells
Medicine & Life Sciences
Stem Cell Transplantation
Medicine & Life Sciences
Wilms Tumor
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2017
- 5 Finished
SCT 0914: 13-TLEC Natural HIstory & Biology of Long-Term Late Effects Following HCT for Childhood Malignancies
National Marrow Donor Program, National Institutes of Health
12/16/14 → 12/15/17
Project: Research project
4 protocols:#6901-A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders#6902-Primary Immune Deficiency Treatment Consortium: Protocol #6902: A Retrospective
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/14 → 8/31/17
Project: Research project
Primary Immune Deficiency Treatment Consortium
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/13 → 8/31/14
Project: Research project
Primary Immune Deficiency Treatment Consortium: Protocols #6901 and #6902
Fuleihan, R. L., Kletzel, M. & Tse, W. T.
University of California at San Francisco, National Institute of Allergy and Infectious Diseases
9/1/11 → 8/31/14
Project: Research project
Research Output 1980 2018
Fecal calprotectin and serum albumin as markers of gastrointestinal graft versus host disease
Broglie, L., Rademaker, A. W., Galvin, J., Ray, A., Tse, W. T., Duerst, R. E., Schneiderman, J., Kletzel, M. & Chaudhury, S., Sep 1 2018, In : Hematology/ Oncology and Stem Cell Therapy. 11, 3, p. 169-174 6 p.Research output: Contribution to journal › Article
Leukocyte L1 Antigen Complex
Graft vs Host Disease
Serum Albumin
Albumins
Hematopoietic Stem Cell Transplantation
74
Citations
(Scopus)
Gene therapy in patients with transfusion-dependent β-thalassemia
Thompson, A. A., Walters, M. C., Kwiatkowski, J., Rasko, J. E. J., Ribeil, J. A., Hongeng, S., Magrin, E., Schiller, G. J., Payen, E., Semeraro, M., Moshous, D., Lefrere, F., Puy, H., Bourget, P., Magnani, A., Caccavelli, L., Diana, J. S., Suarez, F., Monpoux, F., Brousse, V. & 27 others, Apr 19 2018, In : New England Journal of Medicine. 378, 16, p. 1479-1493 15 p.Research output: Contribution to journal › Article
Thalassemia
Genetic Therapy
Hemoglobins
Genotype
Busulfan
High-dose chemotherapy and autologous hematopoietic stem-cell rescue for treatment of relapsed and refractory Wilms tumor: Re-evaluating outcomes
Rossoff, J., Tse, W. T., Duerst, R. E., Schneiderman, J., Morgan, E. R., Kletzel, M. & Chaudhury, S., Aug 18 2018, In : Pediatric Hematology and Oncology. 35, 5-6, p. 316-321 6 p.Research output: Contribution to journal › Article
Wilms Tumor
Hematopoietic Stem Cells
Salvage Therapy
Drug Therapy
Disease-Free Survival
2
Citations
(Scopus)
Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation
Duncan, C. N., Brazauskas, R., Huang, J., Shaw, B. E., Majhail, N. S., Savani, B. N., Flowers, M. E. D., Battiwalla, M., Beebe, K., Dietz, A. C., Dvorak, C. C., Giller, R., Jacobsohn, D. A., Kletzel, M., Martin, P. L., Nemecek, E. R., Nuechterlein, B., Talano, J. A., Pulsipher, M. A. & Baker, K. S., Oct 1 2018, In : Bone Marrow Transplantation. 53, 10, p. 1278-1287 10 p.Research output: Contribution to journal › Article
Cell Transplantation
Dyslipidemias
Survivors
Anthracyclines
Pediatrics
3
Citations
(Scopus)
Late Effects in Pediatric High-risk Neuroblastoma Survivors after Intensive Induction Chemotherapy Followed by Myeloablative Consolidation Chemotherapy and Triple Autologous Stem Cell Transplants
Armstrong, A. E., Danner-Koptik, K., Golden, S., Schneiderman, J., Kletzel, M., Reichek, J. & Gosiengfiao, Y., Jan 1 2018, In : Journal of pediatric hematology/oncology. 40, 1, p. 31-35 5 p.Research output: Contribution to journal › Article
Consolidation Chemotherapy
Induction Chemotherapy
Neuroblastoma
Survivors
Stem Cells