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Personal profile

Research Interests

Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.

Training Experience

1999Postdoctoral Fellowship, Washington University
2004Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, Washington University

… → 1997

Research interests

  • Cell Imaging
  • Cellular Electrophysiology
  • Immunology
  • Ion Channels
  • Neurobiology
  • Pharmacology
  • Physiology
  • Stem Cells

Fingerprint Dive into the research topics where Murali Prakriya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Endoplasmic Reticulum Medicine & Life Sciences
Chromaffin Cells Medicine & Life Sciences
Large-Conductance Calcium-Activated Potassium Channels Medicine & Life Sciences
Calcium Medicine & Life Sciences
Calcium Signaling Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Ions Medicine & Life Sciences

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Grants 2006 2023

Epithelial Cells
Inflammation
Reactive Oxygen Species
Cytokines
Allergens
Astrocytes
Nervous System
Neurotransmitter Agents
Exocytosis
Neurons

Research Output 1993 2019

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.

Research output: Contribution to journalArticle

Astrocytes
Proteinase-Activated Receptors
Pyramidal Cells
Inhibitory Postsynaptic Potentials
Exocytosis

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H. R., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N., Mutlu, G. M. & Budinger, GR. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Metformin
Air Pollution
Electron Transport
Names
Publications

Molecular basis of allosteric Orai1 channel activation by STIM1

Yeung, P. S. W., Yamashita, M. & Prakriya, M., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalReview article

Exocytosis
Dermatoglyphics
Receptor Protein-Tyrosine Kinases
GTP-Binding Proteins
Endoplasmic Reticulum
10 Citations (Scopus)

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

Mutagenesis
Anatomy
Molecular Dynamics Simulation
Endoplasmic Reticulum
Cysteine
1 Citation (Scopus)

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

Metformin
Air Pollution
Electron Transport
Particulate Matter
Alveolar Macrophages