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Personal profile

Research Interests

Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.

Training Experience

1999Postdoctoral Fellowship, Washington University
2004Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, Washington University

… → 1997

Research interests

  • Cell Imaging
  • Cellular Electrophysiology
  • Immunology
  • Ion Channels
  • Neurobiology
  • Pharmacology
  • Physiology
  • Stem Cells

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Grants

  • Research Output

    The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

    Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : The Journal of general physiology. 152, 1

    Research output: Contribution to journalArticle

    Open Access
  • CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

    Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

    Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

    Research output: Contribution to journalComment/debate

  • 1 Scopus citations

    Molecular basis of allosteric Orai1 channel activation by STIM1

    Yeung, P. S. W., Yamashita, M. & Prakriya, M., Jan 1 2019, In : Journal of Physiology.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

    Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

    Research output: Contribution to journalArticle

  • 12 Scopus citations