Grants per year
Personal profile
Research Interests
Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.
Training Experience
| 1999 | Postdoctoral Fellowship, Washington University |
| 2004 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
Neuroscience, PhD, Washington University
… → 1997
Research interests keywords
- Cell Imaging
- Cellular Electrophysiology
- Immunology
- Ion Channels
- Neurobiology
- Pharmacology
- Physiology
- Stem Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The Physiology of Store-Operated Channels in the Nervous System
Prakriya, M. (PD/PI), Swanson, G. T. (Co-Investigator) & Yamashita, M. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
5/1/23 → 4/30/31
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19
Budinger, G. S. (PD/PI), Budinger, G. S. (PD/PI), Misharin, A. (PD/PI), Misharin, A. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Abdala-Valencia, H. (Co-Investigator), Agrawal, A. (Co-Investigator), Braun, R. I. (Co-Investigator), Braun, R. I. (Co-Investigator), Casalino Matsuda, M. S. (Co-Investigator), Casalino Matsuda, M. S. (Co-Investigator), Horvath, C. M. (Co-Investigator), Horvath, C. M. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Prakriya, M. (Co-Investigator), Prakriya, M. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Yamashita, M. (Co-Investigator), Yamashita, M. (Co-Investigator), Casalino Matsuda, M. S. (Other) & Casalino Matsuda, M. S. (Other)
National Heart, Lung, and Blood Institute
4/1/22 → 3/31/26
Project: Research project
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SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L. (PD/PI), Burridge, P. (Other), DeCaen, P. G. (Other), Horvath, C. M. (Other), Kearney, J. A. (Other), Kiskinis, E. (Other), McNally, E. M. (Other), Miller, R. J. (Other), Prakriya, M. (Other), Smith, R. S. (Other), Surmeier Jr, D. J. (Other) & Vanoye, C. G. (Other)
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Kinetic Imaging Plate Reader for Drug Discovery and Biology
George, A. L. (PD/PI), Arispe, L. (Other), Bass, J. (Other), Burridge, P. (Other), DeCaen, P. G. (Other), Gianneschi, N. (Other), Horvath, C. M. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Moskal, J. R. (Other), Penzes, P. (Other), Prakriya, M. (Other), Scheidt, K. A. (Other), Surmeier Jr, D. J. (Other) & Vafabakhsh, R. (Other)
Office of the Director, National Institutes of Health
9/1/21 → 8/31/23
Project: Research project
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Calcium signaling at the interface between astrocytes and brain inflammation
Novakovic, M. M. & Prakriya, M., Feb 2025, In: Current opinion in neurobiology. 90, 102940.Research output: Contribution to journal › Review article › peer-review
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Store-Operated Calcium Channels in the Nervous System
Korshunov, K. S. & Prakriya, M., Feb 10 2025, In: Annual review of physiology. 87, 1, p. 173-199 27 p.Research output: Contribution to journal › Review article › peer-review
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Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease
Jairaman, A. & Prakriya, M., Apr 1 2024, In: Arteriosclerosis, thrombosis, and vascular biology. 44, 4, p. 772-783 12 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
Genetic evidence against involvement of TRPC proteins in SOCE, ROCE, and CRAC channel function
Susperreguy, S., Yamashita, M., Choi, C. I., Liao, Y., Burch, L. H., Blankenship, T. L., Hayes, E., Sliwa, T., Zhang, Y., Grenet, D., Walker, M., Plummer, N. W., Abramowitz, J., Kinet, J. P., Formoso, K., Johnson, B. E., Fleig, A., Hazlehurst, L., Penner, R. & Freichel, M. & 3 others, , Dec 3 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 49, e2411389121.Research output: Contribution to journal › Article › peer-review
Open Access -
SOCE as a regulator of neuronal activity
Courjaret, R., Prakriya, M. & Machaca, K., Apr 15 2024, In: Journal of physiology. 602, 8, p. 1449-1462 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations