If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.

Training Experience

1999Postdoctoral Fellowship, Washington University
2004Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, Washington University

… → 1997

Keywords

  • Cell Imaging
  • Cellular Electrophysiology
  • Immunology
  • Ion Channels
  • Neurobiology
  • Pharmacology
  • Physiology
  • Stem Cells

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Endoplasmic Reticulum Medicine & Life Sciences
Chromaffin Cells Medicine & Life Sciences
Large-Conductance Calcium-Activated Potassium Channels Medicine & Life Sciences
Calcium Medicine & Life Sciences
Calcium Signaling Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Ions Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2006 2022

Astrocytes
Nervous System
Neurotransmitter Agents
Exocytosis
Neurons
Calcium Channels
Ions
Protein Engineering
Severe Combined Immunodeficiency
Electrophysiology

Research Output 1993 2019

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 othersJain, M., Perlman, H. R., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Metformin
Air Pollution
Electron Transport
Names
Publications
9 Citations (Scopus)

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

Mutagenesis
Anatomy
Molecular Dynamics Simulation
Endoplasmic Reticulum
Cysteine
1 Citation (Scopus)

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 othersJain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

Metformin
Air Pollution
Electron Transport
Particulate Matter
Alveolar Macrophages
1 Citation (Scopus)

The exquisitely cooperative nature of Orai1 channel activation

Yeung, P. S. W. & Prakriya, M., Oct 1 2018, In : Journal of General Physiology. 215, 10, p. 1352-1355 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S., Mar 15 2017, In : Nature communications. 8, 14714.

Research output: Contribution to journalArticle

T-cells
immunity
entry
Cellular Immunity
calcium