Grants per year
Personal profile
Research Interests
Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.
Training Experience
1999 | Postdoctoral Fellowship, Washington University |
2004 | Postdoctoral Fellowship, Stanford University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Neuroscience, PhD, Washington University
… → 1997
Research interests keywords
- Cell Imaging
- Cellular Electrophysiology
- Immunology
- Ion Channels
- Neurobiology
- Pharmacology
- Physiology
- Stem Cells
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Collaborations and top research areas from the last five years
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SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L., Burridge, P., DeCaen, P. G., Horvath, C. M., Kearney, J. A., Kiskinis, E., McNally, E. M., Miller, R. J., Prakriya, M., Smith, R. S., Surmeier Jr, D. J. & Vanoye, C. G.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Weintraub, S., Allada, R., Bevan, M. D., Caraveo Piso, G., Carvill, G. L., Chan, S., Contractor, A., Disterhoft, J. F., Dombeck, D. A., Dong, H., Ferreira, A. B., Flanagan, M. E., Gefen, T. D., Geula, C., Gratton, C., He, C., Kahnt, T., Kalb, R. G., Kennedy, A., Kessler, J., Kiskinis, E., Klein, W. L., Kozorovitskiy, Y., Krainc, D., Li, L., Mazzulli, J., Mesulam, M., Miller, R. J., Morimoto, R. I., Opal, P., Ozdinler, H., Paller, K., Parisiadou, L., Penzes, P., Pinto, L., Prakriya, M., Reber, P. J., Roberts, A. L., Rogalski, E., Savas, J. N., Surmeier Jr, D. J., Swanson, G. T., Voss, J. L., Zee, P. C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19
Budinger, G. S., Misharin, A., Abdala-Valencia, H., Braun, R. I., Casalino Matsuda, M. S., Horvath, C. M., Lomasney, J. W., Prakriya, M., Wunderink, R. G., Yamashita, M. & Casalino Matsuda, M. S.
National Heart, Lung, and Blood Institute
4/1/22 → 3/31/26
Project: Research project
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Store-operated channels in the nervous system
Prakriya, M., Apkarian, A. & Yamashita, M.
National Institute of Neurological Disorders and Stroke
7/1/21 → 6/30/26
Project: Research project
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Targeting abnormal alveolar immune activation in COVID-19
Budinger, G. S., Chandel, N., Horvath, C. M., Kelleher, N. L., Misharin, A., Prakriya, M., Wunderink, R. G. & Casalino Matsuda, M. S.
Northwestern Memorial Hospital
4/1/21 → 3/31/24
Project: Research project
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A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
Yeung, P. S. W., Yamashita, M. & Prakriya, M., Feb 2023, In: eLife. 12, e82281.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein
Shum, A., Zaichick, S., McElroy, G. S., Alessandro, K. D., Alasady, M. J., Novakovic, M., Peng, W., Grebenik, E. A., Chung, D., Flanagan, M. E., Smith, R., Morales, A., Stumpf, L., McGrath, K., Krainc, D., Mendillo, M. L., Prakriya, M., Chandel, N. S. & Caraveo, G., Apr 25 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, e2217396120.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Regulation of neuropathic pain by microglial Orai1 channels
Tsujikawa, S., DeMeulenaere, K. E., Centeno, M. V., Ghazisaeidi, S., Martin, M. E., Tapies, M. R., Maneshi, M. M., Yamashita, M., Stauderman, K. A., Apkarian, A. V., Salter, M. W. & Prakriya, M., Jan 2023, In: Science Advances. 9, 4, eade7002.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
SOCE as a regulator of neuronal activity
Courjaret, R., Prakriya, M. & Machaca, K., 2023, (Accepted/In press) In: Journal of physiology.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Store-Operated CRAC Channels
Prakriya, M., Jan 1 2023, Textbook of Ion Channels Volume II: Properties, Function, and Pharmacology of the Superfamilies. CRC Press, p. 387-400 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter