Grants per year
Personal profile
Research Interests
Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.
Training Experience
1999 | Postdoctoral Fellowship, Washington University |
2004 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
Neuroscience, PhD, Washington University
… → 1997
PhD, Washington University St. Louis
… → 1997
Research interests
- Cell Imaging
- Cellular Electrophysiology
- Immunology
- Ion Channels
- Neurobiology
- Pharmacology
- Physiology
- Stem Cells
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Grants
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Regulation of synaptic plasticity and cognitive functions by store-operated Orai1 channels
National Institute of Neurological Disorders and Stroke
9/1/20 → 6/30/25
Project: Research project
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Regulation of airway epithelial cell-mediated inflammation by CRAC channels
Berdnikovs, S., Prakriya, M. & Yamashita, M.
National Heart, Lung, and Blood Institute
7/1/19 → 6/30/23
Project: Research project
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Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Dombeck, D. A., Elliott, J. M., Feng, Y., Gallio, M., Garcia-Anoveros, J., George Jr., A. L., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Nusslock, R., Opal, P., Ozdinler, P. H., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E. E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S., Wright, B. A., Geula, C., Mussa-Ivaldi, F., Ferreira, A. B., Heckman, C., Larson, C., Disterhoft, J. F., Siddique, T., Paller, K., Solla, S. A., Surmeier Jr, D. J., Apkarian, A. & Miller, R. J.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
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Store-Operated Channels in the Nervous System
Prakriya, M., Silinsky, E. M., Silinsky, E. M., Swanson, G. T. & Yamashita, M.
National Institute of Neurological Disorders and Stroke
1/1/17 → 6/30/21
Project: Research project
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Store-operated channels in the nervous system
National Institute of Neurological Disorders and Stroke
1/1/16 → 12/31/16
Project: Research project
Research Output
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An open pore structure of the Orai channel, finally
Prakriya, M., Yeung, P. S. W. & Yamashita, M., Mar 2021, In: Cell Calcium. 94, 102366.Research output: Contribution to journal › Comment/debate › peer-review
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A sulfur-aromatic gate latch is essential for opening of the orai1 channel pore
Yeung, P. S. W., Ing, C. E., Yamashita, M., Pomès, R. & Prakriya, M., Oct 2020, In: eLife. 9, p. 1-18 18 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Calcium and cell function
Prakriya, M., May 1 2020, In: Journal of Physiology. 598, 9, p. 1647-1648 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Scopus citations -
MCU meets cardiolipin: Calcium and disease follow form
Yeung, P. S. W. & Prakriya, M., Dec 2020, In: Cell Calcium. 92, 102287.Research output: Contribution to journal › Comment/debate › peer-review
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Molecular basis of allosteric Orai1 channel activation by STIM1
Yeung, P. S. W., Yamashita, M. & Prakriya, M., May 1 2020, In: Journal of Physiology. 598, 9, p. 1707-1723 17 p.Research output: Contribution to journal › Review article › peer-review
15 Scopus citations