Grants per year
Personal profile
Research Interests
Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from devastating immunodeficiencies, muscle weakness, and a spectrum of defects in the brain, airways, and numerous other tissues, underscoring their vital importance for human health. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, effector cell responses, and brain function.
Training Experience
| 1999 | Postdoctoral Fellowship, Washington University |
| 2004 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
PhD, Washington University
… → 1997
Research interests
- Cell Imaging
- Cellular Electrophysiology
- Immunology
- Ion Channels
- Neurobiology
- Pharmacology
- Physiology
- Stem Cells
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Grants
Regulation of airway epithelial cell-mediated inflammation by CRAC channels
Prakriya, M., Berdnikovs, S. & Yamashita, M.
National Heart, Lung, and Blood Institute
7/1/19 → 6/30/23
Project: Research project
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
Store-Operated Channels in the Nervous System
Prakriya, M., Silinsky, E. M., Silinsky, E. M., Swanson, G. T. & Yamashita, M.
National Institute of Neurological Disorders and Stroke
1/1/17 → 12/31/20
Project: Research project
Store-operated channels in the nervous system
National Institute of Neurological Disorders and Stroke
1/1/16 → 12/31/16
Project: Research project
Regulation of neural progenitor cell migration by store-operated CRAC channels
Miller, R. J., Miller, R. J., Prakriya, M. & Yamashita, M.
National Institute of Neurological Disorders and Stroke
8/1/15 → 4/30/19
Project: Research project
Research Output
The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate
Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : The Journal of general physiology. 152, 1Research output: Contribution to journal › Article
Open Access
CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission
Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.Research output: Contribution to journal › Article
2
Scopus
citations
Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))
Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, , Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.Research output: Contribution to journal › Comment/debate
1
Scopus
citations
Molecular basis of allosteric Orai1 channel activation by STIM1
Yeung, P. S. W., Yamashita, M. & Prakriya, M., Jan 1 2019, In : Journal of Physiology.Research output: Contribution to journal › Review article
1
Scopus
citations
Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating
Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202Research output: Contribution to journal › Article
12
Scopus
citations