If you made any changes in Pure these will be visible here soon.

Research Output

2020

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : The Journal of general physiology. 152, 1

Research output: Contribution to journalArticle

Open Access
2019

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.

Research output: Contribution to journalArticle

2 Scopus citations

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Molecular basis of allosteric Orai1 channel activation by STIM1

Yeung, P. S. W., Yamashita, M. & Prakriya, M., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

12 Scopus citations

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

8 Scopus citations

The exquisitely cooperative nature of Orai1 channel activation

Yeung, P. S. W. & Prakriya, M., Oct 1 2018, In : Journal of General Physiology. 215, 10, p. 1352-1355 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S., Mar 15 2017, In : Nature communications. 8, 14714.

Research output: Contribution to journalArticle

54 Scopus citations

Pore opening mechanism of CRAC channels

Yeung, P. S. W., Yamashita, M. & Prakriya, M., May 2017, In : Cell Calcium. 63, p. 14-19 6 p.

Research output: Contribution to journalReview article

21 Scopus citations

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Yamashita, M., Yeung, P. S. W., Ing, C. E., McNally, B. A., Pomès, R. & Prakriya, M., Feb 21 2017, In : Nature communications. 8, 14512.

Research output: Contribution to journalArticle

32 Scopus citations
2016

Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells

Jairaman, A., Maguire, C. H., Schleimer, R. P. & Prakriya, M., Sep 8 2016, In : Scientific reports. 6, 32311.

Research output: Contribution to journalArticle

20 Scopus citations

Regulation of neurogenesis by calcium signaling

Toth, A. B., Shum, A. K. & Prakriya, M., Mar 1 2016, In : Cell Calcium. 59, 2-3, p. 124-134 11 p.

Research output: Contribution to journalReview article

49 Scopus citations
2015

Conformational changes in the Orai1 C-terminus evoked by STIM1 binding

Tirado-Lee, L., Yamashita, M. & Prakriya, M., Jun 2 2015, In : PloS one. 10, 6, e0128622.

Research output: Contribution to journalArticle

30 Scopus citations

Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production

Velmurugan, G. V., Huang, H., Sun, H., Candela, J., Jaiswal, M. K., Beaman, K. D., Yamashita, M., Prakriya, M. & White, C., Dec 15 2015, In : Science Signaling. 8, 407, ra128.

Research output: Contribution to journalArticle

28 Scopus citations

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

Maus, M., Jairaman, A., Stathopulos, P. B., Muik, M., Fahrner, M., Weidinger, C., Benson, M., Fuchs, S., Ehl, S., Romanin, C., Ikura, M., Prakriya, M. & Feske, S., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6206-6211 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
24 Scopus citations

Store-operated calcium channels

Prakriya, M. & Lewis, R. S., Sep 23 2015, In : Physiological Reviews. 95, 4, p. 1383-1436 54 p.

Research output: Contribution to journalArticle

379 Scopus citations

Structural and functional mechanisms of CRAC channel regulation

Shim, A. H. R., Tirado-Lee, L. & Prakriya, M., Jan 16 2015, In : Journal of Molecular Biology. 427, 1, p. 77-93 17 p.

Research output: Contribution to journalReview article

62 Scopus citations
2014

Calcium release-activated calcium (CRAC) channels mediate the β2-adrenergic regulation of Na,K-ATPase

Keller, M. J., Lecuona, E., Prakriya, M., Cheng, Y., Soberanes, S., Budinger, G. R. S. & Sznajder, J. I., Dec 20 2014, In : FEBS Letters. 588, 24, p. 4686-4693 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
26 Scopus citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M., Jan 1 2014, In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

66 Scopus citations
2013

Conformational dynamics of STIM1 activation

Feske, S. & Prakriya, M., Aug 1 2013, In : Nature Structural and Molecular Biology. 20, 8, p. 918-919 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C. R., Schumacker, P. T., Licht, J. D., Perlman, H., Bryce, P. J. & Chandel, N. S., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

410 Scopus citations

Molecular pharmacology of store-operated CRAC channels

Jairaman, A. & Prakriya, M., Sep 1 2013, In : Channels. 7, 5, p. 402-414 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Preface

Prakriya, M., Aug 1 2013, In : Current Topics in Membranes. 71

Research output: Contribution to journalEditorial

Preface

Prakriya, M., Aug 1 2013, In : Current topics in membranes. 71

Research output: Contribution to journalEditorial

2 Scopus citations

Store-Operated Orai Channels: Structure and Function

Prakriya, M., 2013, Current Topics in Membranes. Academic Press Inc, p. 1-32 32 p. (Current Topics in Membranes; vol. 71).

Research output: Chapter in Book/Report/Conference proceedingChapter

43 Scopus citations

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

Mcnally, B. A., Somasundaram, A., Jairaman, A., Yamashita, M. & Prakriya, M., Jun 1 2013, In : Journal of Physiology. 591, 11, p. 2833-2850 18 p.

Research output: Contribution to journalArticle

69 Scopus citations
2012

Gated regulation of CRAC channel ion selectivity by STIM1

McNally, B. A., Somasundaram, A., Yamashita, M. & Prakriya, M., Feb 9 2012, In : Nature. 482, 7384, p. 241-245 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Ion channels and transporters in lymphocyte function and immunity

Feske, S., Skolnik, E. Y. & Prakriya, M., Jul 1 2012, In : Nature Reviews Immunology. 12, 7, p. 532-547 16 p.

Research output: Contribution to journalReview article

222 Scopus citations

Permeation, selectivity and gating in store-operated CRAC channels

McNally, B. A. & Prakriya, M., Sep 1 2012, In : Journal of Physiology. 590, 17, p. 4179-4191 13 p.

Research output: Contribution to journalReview article

41 Scopus citations

Permeation and gating mechanisms in store-operated CRAC channels

Engh, A., Somasundaram, A. & Prakriya, M., Jan 1 2012, In : Frontiers in Bioscience. 17, 5, p. 1613-1626 14 p.

Research output: Contribution to journalReview article

13 Scopus citations
2011

Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate

Yamashita, M., Somasundaram, A. & Prakriya, M., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9429-9442 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Hypoxia leads to Na,K-ATPase downregulation via Ca 2+ release-activated Ca 2+ channels and AMPK activation

Gusarova, G. A., Trejo, H. E., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M. & Sznajder, J. I., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3546-3556 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K. & Schumacker, P. T., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3531-3545 15 p.

Research output: Contribution to journalArticle

207 Scopus citations

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Hobbs, R. P., Amargo, E. V., Somasundaram, A., Simpson, C. L., Prakriya, M., Denning, M. F. & Green, K. J., Mar 1 2011, In : FASEB Journal. 25, 3, p. 990-1001 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection

McCarl, C. A., Khalil, S., Ma, J., Oh-Hora, M., Yamashita, M., Roether, J., Kawasaki, T., Jairaman, A., Sasaki, Y., Prakriya, M. & Feske, S., Nov 15 2010, In : Journal of Immunology. 185, 10, p. 5845-5858 14 p.

Research output: Contribution to journalArticle

86 Scopus citations
2009

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M. & Penzes, P., Oct 1 2009, In : Nature Neuroscience. 12, 10, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Structural determinants of ion permeation in CRAC channels

McNally, B. A., Yamashita, M., Engh, A. & Prakriya, M., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22516-22521 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

The molecular physiology of CRAC channels

Prakriya, M., Sep 1 2009, In : Immunological Reviews. 231, 1, p. 88-98 11 p.

Research output: Contribution to journalReview article

84 Scopus citations
2008

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Oh-hora, M., Yamashita, M., Hogan, P. G., Sharma, S., Lamperti, E., Chung, W., Prakriya, M., Feske, S. & Rao, A., Apr 1 2008, In : Nature Immunology. 9, 4, p. 432-443 12 p.

Research output: Contribution to journalArticle

401 Scopus citations

Hair loss and defective T- and B-cell function in mice lacking ORAI1

Gwack, Y., Srikanth, S., Oh-hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K. & Rao, A., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5209-5222 14 p.

Research output: Contribution to journalArticle

214 Scopus citations

Neuronal and Glial signaling

Prakriya, M. & Miller, RJ., 2008, Neuroimmune Pharmacology.. Tsuneya, I. & Gendelman, H. (eds.). New York: Springer, p. 105-121

Research output: Chapter in Book/Report/Conference proceedingChapter

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Luik, R. M., Wang, B., Prakriya, M., Wu, M. M. & Lewis, R. S., Jul 24 2008, In : Nature. 454, 7203, p. 538-542 5 p.

Research output: Contribution to journalArticle

368 Scopus citations

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

Navarro-Borelly, L., Somasundaram, A., Yamashita, M., Ren, D., Miller, R. J. & Prakriya, M., Nov 15 2008, In : Journal of Physiology. 586, 22, p. 5383-5401 19 p.

Research output: Contribution to journalArticle

156 Scopus citations
2007

Orai1 mutations alter ion permeation and Ca2+-dependent fast inactivation of CRAC channels: Evidence for coupling of permeation and gating

Yamashita, M., Navarro-Borelly, L., McNally, B. A. & Prakriya, M., Nov 1 2007, In : Journal of General Physiology. 130, 5, p. 525-540 16 p.

Research output: Contribution to journalArticle

100 Scopus citations
2006

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S. H., Tanasa, B., Hogan, P. G., Lewis, R. S., Daly, M. & Rao, A., May 11 2006, In : Nature. 441, 7090, p. 179-185 7 p.

Research output: Contribution to journalArticle

1551 Scopus citations

Orai1 is an essential pore subunit of the CRAC channel

Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A. & Hogan, P. G., Sep 14 2006, In : Nature. 443, 7108, p. 230-233 4 p.

Research output: Contribution to journalArticle

941 Scopus citations