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2020

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : Journal of General Physiology. 152, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

15 Scopus citations

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

12 Scopus citations

The exquisitely cooperative nature of Orai1 channel activation

Yeung, P. S. W. & Prakriya, M., Oct 1 2018, In : Journal of General Physiology. 215, 10, p. 1352-1355 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S., Mar 15 2017, In : Nature communications. 8, 14714.

Research output: Contribution to journalArticle

60 Scopus citations

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Yamashita, M., Yeung, P. S. W., Ing, C. E., McNally, B. A., Pomès, R. & Prakriya, M., Feb 21 2017, In : Nature communications. 8, 14512.

Research output: Contribution to journalArticle

36 Scopus citations

Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells

Jairaman, A., Maguire, C. H., Schleimer, R. P. & Prakriya, M., Sep 8 2016, In : Scientific reports. 6, 32311.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Conformational changes in the Orai1 C-terminus evoked by STIM1 binding

Tirado-Lee, L., Yamashita, M. & Prakriya, M., Jun 2 2015, In : PloS one. 10, 6, e0128622.

Research output: Contribution to journalArticle

31 Scopus citations

Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production

Velmurugan, G. V., Huang, H., Sun, H., Candela, J., Jaiswal, M. K., Beaman, K. D., Yamashita, M., Prakriya, M. & White, C., Dec 15 2015, In : Science Signaling. 8, 407, ra128.

Research output: Contribution to journalArticle

30 Scopus citations

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

Maus, M., Jairaman, A., Stathopulos, P. B., Muik, M., Fahrner, M., Weidinger, C., Benson, M., Fuchs, S., Ehl, S., Romanin, C., Ikura, M., Prakriya, M. & Feske, S., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6206-6211 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
24 Scopus citations

Store-operated calcium channels

Prakriya, M. & Lewis, R. S., Sep 23 2015, In : Physiological Reviews. 95, 4, p. 1383-1436 54 p.

Research output: Contribution to journalArticle

431 Scopus citations
2014

Calcium release-activated calcium (CRAC) channels mediate the β2-adrenergic regulation of Na,K-ATPase

Keller, M. J., Lecuona, E., Prakriya, M., Cheng, Y., Soberanes, S., Budinger, G. R. S. & Sznajder, J. I., Dec 20 2014, In : FEBS Letters. 588, 24, p. 4686-4693 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
27 Scopus citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M., 2014, In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

71 Scopus citations
2013

Conformational dynamics of STIM1 activation

Feske, S. & Prakriya, M., Aug 1 2013, In : Nature Structural and Molecular Biology. 20, 8, p. 918-919 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C. R., Schumacker, P. T., Licht, J. D., Perlman, H., Bryce, P. J. & Chandel, N. S., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

458 Scopus citations

Molecular pharmacology of store-operated CRAC channels

Jairaman, A. & Prakriya, M., Sep 1 2013, In : Channels. 7, 5, p. 402-414 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

Mcnally, B. A., Somasundaram, A., Jairaman, A., Yamashita, M. & Prakriya, M., Jun 1 2013, In : Journal of Physiology. 591, 11, p. 2833-2850 18 p.

Research output: Contribution to journalArticle

73 Scopus citations
2012

Gated regulation of CRAC channel ion selectivity by STIM1

McNally, B. A., Somasundaram, A., Yamashita, M. & Prakriya, M., Feb 9 2012, In : Nature. 482, 7384, p. 241-245 5 p.

Research output: Contribution to journalArticle

145 Scopus citations
2011

Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate

Yamashita, M., Somasundaram, A. & Prakriya, M., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9429-9442 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Hypoxia leads to Na,K-ATPase downregulation via Ca 2+ release-activated Ca 2+ channels and AMPK activation

Gusarova, G. A., Trejo, H. E., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M. & Sznajder, J. I., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3546-3556 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K. & Schumacker, P. T., Sep 2011, In : Molecular and cellular biology. 31, 17, p. 3531-3545 15 p.

Research output: Contribution to journalArticle

218 Scopus citations

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Hobbs, R. P., Amargo, E. V., Somasundaram, A., Simpson, C. L., Prakriya, M., Denning, M. F. & Green, K. J., Mar 1 2011, In : FASEB Journal. 25, 3, p. 990-1001 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection

McCarl, C. A., Khalil, S., Ma, J., Oh-Hora, M., Yamashita, M., Roether, J., Kawasaki, T., Jairaman, A., Sasaki, Y., Prakriya, M. & Feske, S., Nov 15 2010, In : Journal of Immunology. 185, 10, p. 5845-5858 14 p.

Research output: Contribution to journalArticle

93 Scopus citations
2009

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M. & Penzes, P., Oct 1 2009, In : Nature Neuroscience. 12, 10, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Structural determinants of ion permeation in CRAC channels

McNally, B. A., Yamashita, M., Engh, A. & Prakriya, M., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22516-22521 6 p.

Research output: Contribution to journalArticle

115 Scopus citations
2008

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Oh-hora, M., Yamashita, M., Hogan, P. G., Sharma, S., Lamperti, E., Chung, W., Prakriya, M., Feske, S. & Rao, A., Apr 1 2008, In : Nature Immunology. 9, 4, p. 432-443 12 p.

Research output: Contribution to journalArticle

412 Scopus citations

Hair loss and defective T- and B-cell function in mice lacking ORAI1

Gwack, Y., Srikanth, S., Oh-hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K. & Rao, A., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5209-5222 14 p.

Research output: Contribution to journalArticle

217 Scopus citations

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Luik, R. M., Wang, B., Prakriya, M., Wu, M. M. & Lewis, R. S., Jul 24 2008, In : Nature. 454, 7203, p. 538-542 5 p.

Research output: Contribution to journalArticle

379 Scopus citations

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

Navarro-Borelly, L., Somasundaram, A., Yamashita, M., Ren, D., Miller, R. J. & Prakriya, M., Nov 15 2008, In : Journal of Physiology. 586, 22, p. 5383-5401 19 p.

Research output: Contribution to journalArticle

159 Scopus citations
2007

Orai1 mutations alter ion permeation and Ca2+-dependent fast inactivation of CRAC channels: Evidence for coupling of permeation and gating

Yamashita, M., Navarro-Borelly, L., McNally, B. A. & Prakriya, M., Nov 1 2007, In : Journal of General Physiology. 130, 5, p. 525-540 16 p.

Research output: Contribution to journalArticle

102 Scopus citations
2006

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S. H., Tanasa, B., Hogan, P. G., Lewis, R. S., Daly, M. & Rao, A., May 11 2006, In : Nature. 441, 7090, p. 179-185 7 p.

Research output: Contribution to journalArticle

1591 Scopus citations

Orai1 is an essential pore subunit of the CRAC channel

Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A. & Hogan, P. G., Sep 14 2006, In : Nature. 443, 7108, p. 230-233 4 p.

Research output: Contribution to journalArticle

967 Scopus citations

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

Prakriya, M. & Lewis, R. S., Sep 1 2006, In : Journal of General Physiology. 128, 3, p. 373-386 14 p.

Research output: Contribution to journalArticle

101 Scopus citations
2005

Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC

Chen, X. K., Wang, L. C., Zhou, Y., Cai, Q., Prakriya, M., Duan, K. L., Sheng, Z. H., Lingle, C. & Zhou, Z., Sep 1 2005, In : Nature neuroscience. 8, 9, p. 1160-1168 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

Feske, S., Prakriya, M., Rao, A. & Lewis, R. S., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 651-662 12 p.

Research output: Contribution to journalArticle

179 Scopus citations
2002

Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels

Prakriya, M. & Lewis, R. S., May 27 2002, In : Journal of General Physiology. 119, 5, p. 487-507 21 p.

Research output: Contribution to journalArticle

246 Scopus citations
2001
396 Scopus citations
2000

Activation of BK channels in rat chromaffin cells requires summation of Ca2+ influx from multiple Ca2+ channels

Prakriya, M. & Lingle, C. J., 2000, In : Journal of neurophysiology. 84, 3, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Selective depression of low-release probability excitatory synapses by sodium channel blockers

Prakriya, M. & Mennerick, S., Jan 1 2000, In : Neuron. 26, 3, p. 671-682 12 p.

Research output: Contribution to journalArticle

85 Scopus citations
1999

BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells

Prakriya, M. & Lingle, C. J., Jan 1 1999, In : Journal of neurophysiology. 81, 5, p. 2267-2278 12 p.

Research output: Contribution to journalArticle

76 Scopus citations
1998

Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks γ-aminobutyric acid-modulatory activity

Todorovic, S. M., Prakriya, M., Nakashima, Y. M., Nilsson, K. R., Han, M., Zorumski, C. F., Covery, D. F. & Lingle, C. J., Nov 1998, In : Molecular Pharmacology. 54, 5, p. 918-927 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
1996

[Ca2+](i) elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells

Prakriya, M., Solaro, C. R. & Lingle, C. J., Jul 15 1996, In : Journal of Neuroscience. 16, 14, p. 4344-4359 16 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations
1995

Inactivating and noninactivating Ca2+- and voltage-dependent K+ current in rat adrenal chromaffin cells

Solaro, C. R., Prakriya, M., Ding, J. P. & Lingle, C. J., Jan 1 1995, In : Journal of Neuroscience. 15, 9, p. 6110-6123 14 p.

Research output: Contribution to journalArticle

105 Scopus citations
1993

A computerized grid walking system for evaluating the accuracy of locomotion in rats

Prakriya, M., McCabe, P. M. & Holets, V. R., Jun 1993, In : Journal of Neuroscience Methods. 48, 1-2, p. 15-25 11 p.

Research output: Contribution to journalArticle

16 Scopus citations