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Research Output 1993 2020

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2020

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Yamashita, M., Ing, C. E., Yeung, P. S. W., Maneshi, M. M., Pomès, R. & Prakriya, M., Jan 6 2020, In : The Journal of general physiology. 152, 1

Research output: Contribution to journalArticle

Open Access
Ions
Severe Combined Immunodeficiency
Mutation
Molecular Dynamics Simulation
Static Electricity
2019
2 Citations (Scopus)

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

Toth, A. B., Hori, K., Novakovic, M. M., Bernstein, N. G., Lambot, L. & Prakriya, M., May 21 2019, In : Science Signaling. 12, 582, aaw5450.

Research output: Contribution to journalArticle

Astrocytes
Proteinase-Activated Receptors
Pyramidal Cells
Inhibitory Postsynaptic Potentials
Exocytosis
2018
12 Citations (Scopus)

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Yeung, P. S. W., Yamashita, M., Ing, C. E., Pomès, R., Freymann, D. M. & Prakriya, M., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5193-E5202

Research output: Contribution to journalArticle

Mutagenesis
Anatomy
Molecular Dynamics Simulation
Endoplasmic Reticulum
Cysteine
5 Citations (Scopus)

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

Metformin
Air Pollution
Electron Transport
Particulate Matter
Alveolar Macrophages
1 Citation (Scopus)

The exquisitely cooperative nature of Orai1 channel activation

Yeung, P. S. W. & Prakriya, M., Oct 1 2018, In : Journal of General Physiology. 215, 10, p. 1352-1355 4 p.

Research output: Contribution to journalArticle

2017
53 Citations (Scopus)

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S., Mar 15 2017, In : Nature communications. 8, 14714.

Research output: Contribution to journalArticle

T-cells
immunity
entry
Cellular Immunity
calcium
32 Citations (Scopus)

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Yamashita, M., Yeung, P. S. W., Ing, C. E., McNally, B. A., Pomès, R. & Prakriya, M., Feb 21 2017, In : Nature communications. 8, 14512.

Research output: Contribution to journalArticle

helices
Ion Channel Gating
Ions
porosity
Mutation
2016
Calcium Signaling
Calcium Channels
Calcium
Health
Research
19 Citations (Scopus)

Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells

Jairaman, A., Maguire, C. H., Schleimer, R. P. & Prakriya, M., Sep 8 2016, In : Scientific reports. 6, 32311.

Research output: Contribution to journalArticle

Allergens
Epithelial Cells
Cytokines
Calcium
Cockroaches
2015
30 Citations (Scopus)

Conformational changes in the Orai1 C-terminus evoked by STIM1 binding

Tirado-Lee, L., Yamashita, M. & Prakriya, M., Jun 2 2015, In : PloS one. 10, 6, e0128622.

Research output: Contribution to journalArticle

crosslinking
endoplasmic reticulum
Drosophila
calcium
Mutagenesis
27 Citations (Scopus)

Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production

Velmurugan, G. V., Huang, H., Sun, H., Candela, J., Jaiswal, M. K., Beaman, K. D., Yamashita, M., Prakriya, M. & White, C., Dec 15 2015, In : Science Signaling. 8, 407, ra128.

Research output: Contribution to journalArticle

Macrophages
Adipose Tissue
Obesity
Tissue
Cytokines
34 Citations (Scopus)

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

Maus, M., Jairaman, A., Stathopulos, P. B., Muik, M., Fahrner, M., Weidinger, C., Benson, M., Fuchs, S., Ehl, S., Romanin, C., Ikura, M., Prakriya, M. & Feske, S., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6206-6211 6 p.

Research output: Contribution to journalArticle

Missense Mutation
Endoplasmic Reticulum
Mutation
Cell Membrane
Severe Combined Immunodeficiency
24 Citations (Scopus)
PAR-2 Receptor
Epithelial Cells
Cytokines
Dinoprostone
Interleukin-6
364 Citations (Scopus)

Store-operated calcium channels

Prakriya, M. & Lewis, R. S., Sep 23 2015, In : Physiological Reviews. 95, 4, p. 1383-1436 54 p.

Research output: Contribution to journalArticle

Calcium Channels
Endoplasmic Reticulum
Cell Membrane
Calcium
Proteins
2014
5 Citations (Scopus)

Calcium release-activated calcium (CRAC) channels mediate the β2-adrenergic regulation of Na,K-ATPase

Keller, M. J., Lecuona, E., Prakriya, M., Cheng, Y., Soberanes, S., Budinger, G. R. S. & Sznajder, J. I., Dec 20 2014, In : FEBS Letters. 588, 24, p. 4686-4693 8 p.

Research output: Contribution to journalArticle

Calcium Channels
Adrenergic Agents
Adenosine Triphosphatases
Calcium
Cell membranes
26 Citations (Scopus)
Noise
Ions
Endoplasmic Reticulum
Binding Sites
2-aminoethoxydiphenyl borate
65 Citations (Scopus)

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M., Jan 1 2014, In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

Stem Cells
Neurogenesis
Gene Expression
NFATC Transcription Factors
Neural Stem Cells
2013
22 Citations (Scopus)

Conformational dynamics of STIM1 activation

Feske, S. & Prakriya, M., Aug 1 2013, In : Nature Structural and Molecular Biology. 20, 8, p. 918-919 2 p.

Research output: Contribution to journalArticle

Protein Conformation
Molecular Models
Calcium Signaling
Membrane Glycoproteins
Calcium Channels
398 Citations (Scopus)

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C-R., Schumacker, P. T., Licht, J. D., Perlman, H. R., Bryce, P. J. & Chandel, N., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

CD27 Antigens
Reactive Oxygen Species
Mitochondria
T-Lymphocytes
Interleukin-2
40 Citations (Scopus)

Molecular pharmacology of store-operated CRAC channels

Jairaman, A. & Prakriya, M., Sep 1 2013, In : Channels. 7, 5, p. 402-414 13 p.

Research output: Contribution to journalArticle

Pharmacology
Exocytosis
Cell proliferation
Gene expression
Modulators
69 Citations (Scopus)

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

Mcnally, B. A., Somasundaram, A., Jairaman, A., Yamashita, M. & Prakriya, M., Jun 1 2013, In : Journal of Physiology. 591, 11, p. 2833-2850 18 p.

Research output: Contribution to journalArticle

Binding Sites
Endoplasmic Reticulum
Ions
Stromal Interaction Molecule 1
Cell Membrane
2012
139 Citations (Scopus)

Gated regulation of CRAC channel ion selectivity by STIM1

McNally, B. A., Somasundaram, A., Yamashita, M. & Prakriya, M., Feb 9 2012, In : Nature. 482, 7384, p. 241-245 5 p.

Research output: Contribution to journalArticle

Ion Channels
Ion Channel Gating
Ions
Stromal Interaction Molecule 1
Eukaryotic Cells
2011
37 Citations (Scopus)

Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate

Yamashita, M., Somasundaram, A. & Prakriya, M., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9429-9442 14 p.

Research output: Contribution to journalArticle

Borates
Modulation
Chemical activation
Endoplasmic Reticulum
Pharmacology
75 Citations (Scopus)

Hypoxia leads to Na,K-ATPase downregulation via Ca 2+ release-activated Ca 2+ channels and AMPK activation

Gusarova, G. A., Trejo, H. E., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M. & Sznajder, J. I., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3546-3556 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Down-Regulation
Reactive Oxygen Species
Endoplasmic Reticulum
Calcium
205 Citations (Scopus)

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K. & Schumacker, P. T., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3531-3545 15 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Reactive Oxygen Species
Calcium
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Adenosine Monophosphate
43 Citations (Scopus)

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Hobbs, R. P., Amargo, E. V., Somasundaram, A., Simpson, C. L., Prakriya, M., Denning, M. F. & Green, K. J., Mar 1 2011, In : FASEB Journal. 25, 3, p. 990-1001 12 p.

Research output: Contribution to journalArticle

Desmoplakins
Reticulum
Calcium-Transporting ATPases
Adhesives
Protein Kinase C
2010
86 Citations (Scopus)

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection

McCarl, C. A., Khalil, S., Ma, J., Oh-Hora, M., Yamashita, M., Roether, J., Kawasaki, T., Jairaman, A., Sasaki, Y., Prakriya, M. & Feske, S., Nov 15 2010, In : Journal of Immunology. 185, 10, p. 5845-5858 14 p.

Research output: Contribution to journalArticle

Autoimmunity
Allografts
T-Lymphocytes
Lymphocytes
Th17 Cells
2009
114 Citations (Scopus)

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M. & Penzes, P., Oct 1 2009, In : Nature Neuroscience. 12, 10, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Synapses
Spine
Depression
Guanine Nucleotide Exchange Factors
Dopamine D1 Receptors
113 Citations (Scopus)

Structural determinants of ion permeation in CRAC channels

McNally, B. A., Yamashita, M., Engh, A. & Prakriya, M., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22516-22521 6 p.

Research output: Contribution to journalArticle

Ions
Cysteine
Calcium Release Activated Calcium Channels
Permeability
2008
397 Citations (Scopus)

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Oh-hora, M., Yamashita, M., Hogan, P. G., Sharma, S., Lamperti, E., Chung, W., Prakriya, M., Feske, S. & Rao, A., Apr 1 2008, In : Nature Immunology. 9, 4, p. 432-443 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Calcium
T-Lymphocytes
Regulatory T-Lymphocytes
Fibroblasts
213 Citations (Scopus)

Hair loss and defective T- and B-cell function in mice lacking ORAI1

Gwack, Y., Srikanth, S., Oh-hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K. & Rao, A., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5209-5222 14 p.

Research output: Contribution to journalArticle

Alopecia
B-Lymphocytes
T-Lymphocytes
Severe Combined Immunodeficiency
Inbred ICR Mouse
364 Citations (Scopus)

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Luik, R. M., Wang, B., Prakriya, M., Wu, M. M. & Lewis, R. S., Jul 24 2008, In : Nature. 454, 7203, p. 538-542 5 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Calcium
Tacrolimus Binding Proteins
Sirolimus
Stromal Interaction Molecule 1
156 Citations (Scopus)

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

Navarro-Borelly, L., Somasundaram, A., Yamashita, M., Ren, D., Miller, R. J. & Prakriya, M., Nov 15 2008, In : Journal of Physiology. 586, 22, p. 5383-5401 19 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Microscopy
Stromal Interaction Molecule 1
Exocytosis
Gene Expression
2007
100 Citations (Scopus)

Orai1 mutations alter ion permeation and Ca2+-dependent fast inactivation of CRAC channels: Evidence for coupling of permeation and gating

Yamashita, M., Navarro-Borelly, L., McNally, B. A. & Prakriya, M., Nov 1 2007, In : Journal of General Physiology. 130, 5, p. 525-540 16 p.

Research output: Contribution to journalArticle

Ion Channel Gating
Ions
Acidic Amino Acids
Mutation
Lymphocyte Activation
2006
1546 Citations (Scopus)

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S. H., Tanasa, B., Hogan, P. G., Lewis, R. S., Daly, M. & Rao, A., May 11 2006, In : Nature. 441, 7090, p. 179-185 7 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Mutation
Activating Transcription Factors
Cell Nucleus Active Transport
Missense Mutation
935 Citations (Scopus)

Orai1 is an essential pore subunit of the CRAC channel

Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A. & Hogan, P. G., Sep 14 2006, In : Nature. 443, 7108, p. 230-233 4 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Drosophila
EF Hand Motifs
Monovalent Cations
99 Citations (Scopus)

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

Prakriya, M. & Lewis, R. S., Sep 1 2006, In : Journal of General Physiology. 128, 3, p. 373-386 14 p.

Research output: Contribution to journalArticle

Personnel Selection
Monovalent Cations
Long-Term Synaptic Depression
Divalent Cations
Noise
2005
76 Citations (Scopus)

Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC

Chen, X. K., Wang, L. C., Zhou, Y., Cai, Q., Prakriya, M., Duan, K. L., Sheng, Z. H., Lingle, C. & Zhou, Z., Sep 1 2005, In : Nature Neuroscience. 8, 9, p. 1160-1168 9 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Protein Kinase C
Adenosine Triphosphate
Purinergic P2 Receptors
Pertussis Toxin
176 Citations (Scopus)

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

Feske, S., Prakriya, M., Rao, A. & Lewis, R. S., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 651-662 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Gene Expression
Ion Channels
Molecular Biology
Lymphocytes
2002
243 Citations (Scopus)

Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels

Prakriya, M. & Lewis, R. S., May 27 2002, In : Journal of General Physiology. 119, 5, p. 487-507 21 p.

Research output: Contribution to journalArticle

Cations
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Calcium Release Activated Calcium Channels
Monovalent Cations
Divalent Cations
2001
391 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Borates
B-Lymphocytes
2000
50 Citations (Scopus)

Activation of BK channels in rat chromaffin cells requires summation of Ca2+ influx from multiple Ca2+ channels

Prakriya, M. & Lingle, C. J., Sep 23 2000, In : Journal of Neurophysiology. 84, 3, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Chromaffin Cells
Egtazic Acid
82 Citations (Scopus)

Selective depression of low-release probability excitatory synapses by sodium channel blockers

Prakriya, M. & Mennerick, S., Jan 1 2000, In : Neuron. 26, 3, p. 671-682 12 p.

Research output: Contribution to journalArticle

Sodium Channel Blockers
Synapses
Glutamic Acid
Excitatory Postsynaptic Potentials
Action Potentials
1999
75 Citations (Scopus)

BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells

Prakriya, M. & Lingle, C. J., Jan 1 1999, In : Journal of neurophysiology. 81, 5, p. 2267-2278 12 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Chromaffin Cells
Action Potentials
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Nifedipine
1998
45 Citations (Scopus)

Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks γ-aminobutyric acid-modulatory activity

Todorovic, S. M., Prakriya, M., Nakashima, Y. M., Nilsson, K. R., Han, M., Zorumski, C. F., Covery, D. F. & Lingle, C. J., Nov 1998, In : Molecular Pharmacology. 54, 5, p. 918-927 10 p.

Research output: Contribution to journalArticle

Aminobutyrates
Sensory Receptor Cells
Steroids
Inhibitory Concentration 50
Minor Planets
1996
50 Citations (Scopus)

[Ca2+](i) elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells

Prakriya, M., Solaro, C. R. & Lingle, C. J., Jul 15 1996, In : Journal of Neuroscience. 16, 14, p. 4344-4359 16 p.

Research output: Contribution to journalArticle

Muscarine
Large-Conductance Calcium-Activated Potassium Channels
Chromaffin Cells
Dialysis
Calcium-Activated Potassium Channels
1995
104 Citations (Scopus)

Inactivating and noninactivating Ca2+- and voltage-dependent K+ current in rat adrenal chromaffin cells

Solaro, C. R., Prakriya, M., Ding, J. P. & Lingle, C. J., Jan 1 1995, In : Journal of Neuroscience. 15, 9, p. 6110-6123 14 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Large-Conductance Calcium-Activated Potassium Channels
Membrane Potentials
Charybdotoxin
Action Potentials
1993
15 Citations (Scopus)

A computerized grid walking system for evaluating the accuracy of locomotion in rats

Prakriya, M., McCabe, P. M. & Holets, V. R., Jun 1993, In : Journal of Neuroscience Methods. 48, 1-2, p. 15-25 11 p.

Research output: Contribution to journalArticle

Locomotion
Walking
Videotape Recording
Microcomputers
Information Systems