Narsa Reddy Machireddy

  • 1449 Citations
20002018

Research output per year

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Personal profile

Research Interests

Primary focus of my research has been on host defense response during nosocomial infections and lung injury repair, specifically the role of Notch1 signaling in the bacterial clearance and resolution of inflammatory lung injury. I will test the hypothesis that interaction of Notch1 receptor on neutrophils with its ligand, Jag1 on endothelial cells is required for neutrophils sequestration into lungs and thereby bacterial clearance.

1. Role of endothelial Jag1 in Notch1 activation in bacterial clearance and resolution of lung injury during Pseudomonas infection. Percent effort: 60. 2. Role of nitrative stress in the peribronchiolar and perivascular fibrosis in Caveolin-1 deficient mice. Percent effort: 30. 3. Development of Lab Animal protocols. Percent effort:10.

Education/Academic qualification

PhD, Osmania University

… → 1993

Research interests

  • Lung Injury

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Research Output

  • 1449 Citations
  • 35 Article
  • 1 Short survey

Endothelial and smooth muscle cell interaction via FoxM1 signaling mediates vascular remodeling and pulmonary hypertension

Dai, Z., Zhu, M. M., Peng, Y., Jin, H., Machireddy, N., Qian, Z., Zhang, X. & Zhao, Y. Y., Sep 15 2018, In : American journal of respiratory and critical care medicine. 198, 6, p. 788-802 15 p.

Research output: Contribution to journalArticle

  • 19 Scopus citations

    FOSL1 promotes Kras-induced lung cancer through amphiregulin and cell survival gene regulation

    Elangovan, I. M., Vaz, M., Tamatam, C. R., Potteti, H. R., Reddy, N. M. & Reddy, S. P., May 1 2018, In : American journal of respiratory cell and molecular biology. 58, 5, p. 625-635 11 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor

    Dai, Z., Zhu, M. M., Peng, Y., Machireddy, N., Evans, C. E., Machado, R., Zhang, X. & Zhao, Y-Y., Jun 20 2018, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

    Natarajan, V., Ha, A. W., Dong, Y., Reddy, N. M., Ebenezer, D. L., Kanteti, P., Reddy, S. P., Usha Raj, J., Lei, Z., Maienschein-Cline, M., Arbieva, Z. & Harijith, A., Aug 29 2017, In : BMC Genomics. 18, 1, 664.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer

    Bikkavilli, R. K., Zerayesus, S. A., Van Scoyk, M., Wilson, L., Wu, P. Y., Baskaran, A., Tang, K., Raheem, S., Samuelson, B. A., Reddy, N. M., Reddy, S. P., Cool, C. D., Kosmider, B., Avasarala, S. & Winn, R. A., May 5 2017, In : Journal of Biological Chemistry. 292, 18, p. 7423-7434 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations