Research Output per year
Research Output per year
Personal profile
Research Interests
Primary focus of my research has been on host defense response during nosocomial infections and lung injury repair, specifically the role of Notch1 signaling in the bacterial clearance and resolution of inflammatory lung injury. I will test the hypothesis that interaction of Notch1 receptor on neutrophils with its ligand, Jag1 on endothelial cells is required for neutrophils sequestration into lungs and thereby bacterial clearance.
1. Role of endothelial Jag1 in Notch1 activation in bacterial clearance and resolution of lung injury during Pseudomonas infection. Percent effort: 60. 2. Role of nitrative stress in the peribronchiolar and perivascular fibrosis in Caveolin-1 deficient mice. Percent effort: 30. 3. Development of Lab Animal protocols. Percent effort:10.
Education/Academic qualification
PhD, Osmania University
… → 1993
Immunology, PhD, Osmania University
… → 1993
Research interests
- Lung Injury
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Research Output
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Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice
Tamatam, C. M., Reddy, N. M., Potteti, H. R., Ankireddy, A., Noone, P. M., Yamamoto, M., Kensler, T. W. & Reddy, S. P., Dec 1 2020, In: Scientific reports. 10, 1, 19034.Research output: Contribution to journal › Article › peer-review
Open Access -
Endothelial and smooth muscle cell interaction via FoxM1 signaling mediates vascular remodeling and pulmonary hypertension
Dai, Z., Zhu, M. M., Peng, Y., Jin, H., Machireddy, N., Qian, Z., Zhang, X. & Zhao, Y. Y., Sep 15 2018, In: American journal of respiratory and critical care medicine. 198, 6, p. 788-802 15 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
FOSL1 promotes Kras-induced lung cancer through amphiregulin and cell survival gene regulation
Elangovan, I. M., Vaz, M., Tamatam, C. R., Potteti, H. R., Reddy, N. M. & Reddy, S. P., May 1 2018, In: American journal of respiratory cell and molecular biology. 58, 5, p. 625-635 11 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor
Dai, Z., Zhu, M. M., Peng, Y., Machireddy, N., Evans, C. E., Machado, R., Zhang, X. & Zhao, Y-Y., Jun 20 2018, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Natarajan, V., Ha, A. W., Dong, Y., Reddy, N. M., Ebenezer, D. L., Kanteti, P., Reddy, S. P., Usha Raj, J., Lei, Z., Maienschein-Cline, M., Arbieva, Z. & Harijith, A., Aug 29 2017, In: BMC Genomics. 18, 1, 664.Research output: Contribution to journal › Article › peer-review
9 Scopus citations