Grants per year
Personal profile
Research Interests
Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell Physiology, PhD, The University of Chicago
… → 1997
Research interests keywords
- Immune System
- Lung Cancer / Chest Cancer
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Collaborations and top research areas from the last five years
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AFAR fellowship (PD23106)
Glenn Foundation for Medical Research
7/1/23 → 6/30/24
Project: Research project
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Targeting Metabolic Adaptation to Treat TP53-mutated Lethal Prostate Cancer
Yoo, Y. A., Abdulkadir, S. A. & Chandel, N.
11/15/22 → 11/14/25
Project: Research project
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Targeting abnormal alveolar immune activation in COVID-19
Budinger, G. S., Chandel, N., Horvath, C. M., Kelleher, N. L., Misharin, A., Prakriya, M., Wunderink, R. G. & Casalino Matsuda, M. S.
Northwestern Memorial Hospital
4/1/21 → 3/31/24
Project: Research project
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Project 2: Modulating mitochondrial function to promote proteostasis in the aging lung
Chandel, N., Chandel, N., Singer, B. & Singer, B.
6/1/20 → 3/31/25
Project: Research project
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Regulation of de novo purine synthesis by the MAPK/ERK pathway
Ben-Sahra, I., Ben-Sahra, I., Chandel, N. & Chandel, N.
National Institute of General Medical Sciences
1/1/20 → 12/31/24
Project: Research project
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ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia
Phu, T. A., Vu, N. K., Ng, M., Gao, A. S., Stoolman, J. S., Chandel, N. S. & Raffai, R. L., Oct 31 2023, In: Cell reports. 42, 10, 113206.Research output: Contribution to journal › Article › peer-review
Open Access -
Challenges and opportunities in targeting metabolism
Birsoy, K., Chandel, N. S., Fendt, S. M., Green, D. R., Li, X. & Muoio, D. M., Sep 21 2023, In: Cell Chemical Biology. 30, 9, p. 999-1001 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs
Robertson, G. L., Riffle, S., Patel, M., Bodnya, C., Marshall, A., Beasley, H. K., Garza-Lopez, E., Shao, J., Vue, Z., Hinton, A., Stoll, M. S., de Wet, S., Theart, R. P., Chakrabarty, R. P., Loos, B., Chandel, N. S., Mears, J. A. & Gama, V., Feb 2023, In: Journal of cell science. 136, 3, jcs260370.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis
Takata, N., Miska, J. M., Morgan, M. A., Patel, P., Billingham, L. K., Joshi, N., Schipma, M. J., Dumar, Z. J., Joshi, N. R., Misharin, A. V., Embry, R. B., Fiore, L., Gao, P., Diebold, L. P., McElroy, G. S., Shilatifard, A., Chandel, N. S. & Oliver, G., Dec 2023, In: Nature communications. 14, 1, 4129.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial integrated stress response controls lung epithelial cell fate
Han, S. H., Lee, M., Shin, Y., Giovanni, R., Chakrabarty, R. P., Herrerias, M. M., Dada, L. A., Flozak, A. S., Reyfman, P. A., Khuder, B., Reczek, C. R., Gao, L., Lopéz-Barneo, J., Gottardi, C. J., Budinger, G. R. S. & Chandel, N. S., Aug 24 2023, In: Nature. 620, 7975, p. 890-897 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Genome wide RNA Sequencing of whole C. elegans RNA
Schieber, M. (Contributor) & Chandel, N. (Contributor), Gene Expression Omnibus, Aug 27 2014
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE60825
Dataset
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman-Lucero, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. (Contributor), Schumacker, P. T. (Contributor) & Surmeier Jr, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/record/6949450
Dataset