Personal profile

Research Interests

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).

Keywords

  • Cancer: Lung/Chest
  • Immune System
  • Lung Cancer / Chest Cancer

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 28 Similar Profiles
Anoxia Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences

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Research Output 1993 2017

1 Citations

Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI

Dutta, R. K., Kondeti, V. K., Sharma, I., Chandel, N. S., Quaggin, S. E. & Kanwar, Y. S. May 1 2017 In : Journal of the American Society of Nephrology : JASN. 28, 5, p. 1421-1436 16 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Cisplatin
Reactive Oxygen Species
In Vitro Techniques
Small Interfering RNA

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E. , Chalastanis, A. , Wu, Y. , Hurley, L. A. , Kouri, F. M. , Bi, Y. , Kachman, M. , May, J. L. , Bartom, E. , Hua, Y. , Mishra, R. K. , Schiltz, G. E. , Dubrovskyi, O. , Mazar, A. P. , Peter, M. E. , Zheng, H. , James, C. D. , Burant, C. F. , Chandel, N. S. , Davuluri, R. V. & 2 others Horbinski, C. & Stegh, A. H. May 30 2017 In : Cell Reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Mutation
Neoplasms
Erythrasma
Isocitrate Dehydrogenase

Metabolism and skeletal muscle homeostasis in lung disease

Ceco, E., Weinberg, S. E., Chandel, N. S. & Sznajder, J. I. Jul 1 2017 In : American Journal of Respiratory Cell and Molecular Biology. 57, 1, p. 28-34 7 p.

Research output: Contribution to journalReview article

Lung Diseases
Skeletal Muscle
Homeostasis
Aldehyde Oxidoreductases
Muscles

Mitochondria control acute and chronic responses to hypoxia

McElroy, G. S. & Chandel, N. S. Mar 4 2017 In : Experimental Cell Research.

Research output: Contribution to journalArticle

Mitochondria
Anoxia
Carotid Body
Muscle Contraction
Erythropoietin
2 Citations

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Liu, X., Zhang, Y., Ni, M., Cao, H., Signer, R. A. J., Li, D., Li, M., Gu, Z., Hu, Z., Dickerson, K. E., Weinberg, S. E., Chandel, N. S., Deberardinis, R. J., Zhou, F., Shao, Z. & Xu, J. May 31 2017 In : Nature Cell Biology. 19, 6, p. 626-638 13 p.

Research output: Contribution to journalArticle

Mitochondrial Turnover
Erythropoiesis
Protein Biosynthesis
Mitochondria
Hematopoietic Stem Cells