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Navdeep Chandel

  • 25543 Citations
1993 …2023
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Personal profile

Research Interests

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).

Education/Academic qualification

PhD, University of Chicago

… → 1997

Keywords

  • Immune System
  • Lung Cancer / Chest Cancer

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Reactive Oxygen Species Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Hypoxia-Inducible Factor 1 Medicine & Life Sciences
Alveolar Epithelial Cells Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Cell death Chemical Compounds

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Grants 2001 2023

The Robert H. Lurie Comprehensive Cancer Center

Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L. & Woloschak, G. E.

National Cancer Institute

8/10/18 → 7/31/23

Project: Research project

Neoplasms
Medicine
Research
Population

Mitochondrial respiration in CD8 T cell mediated immune responses to solid tumors

Chandel, N.

Cancer Research Institute

10/1/17 → 9/30/20

Project: Research project

Allergy and Immunology
Respiration
T-Lymphocytes
Research
Neoplasms

Mitochondrial metabolism and ROS regulate cancer

Budinger, G. S., Chandel, N. & Cheng, C.

National Cancer Institute

6/1/16 → 5/31/23

Project: Research project

Reactive Oxygen Species
Neoplasms
Mitochondria
Antioxidants
Metformin

Pathophysiology of Acute Lung Injury

Budinger, G. S., Chandel, N., Dada, L., Goldman, R., Horvath, C. M., Lecuona, E., Perlman, H. R., Ridge, K. M., Stehlik, C., Sznajder, J. I. & Wunderink, R. G.

National Heart, Lung, and Blood Institute

9/1/15 → 6/30/20

Project: Research project

Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza
Vimentin

Project 3 - Metabolic Regulation of Acute Lung Injury

Budinger, G. S., Chandel, N. & Horvath, C. M.

National Heart, Lung, and Blood Institute

9/1/15 → 6/30/20

Project: Research project

Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza
Vimentin

Research Output 1993 2019

2 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journal › Article

Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 othersJain, M., Perlman, H. R., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journal › Comment/debate

Metformin
Air Pollution
Electron Transport
Names
Publications

Hepatic HKDC1 expression contributes to liver metabolism

Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., Giancola, N., Pervaiz, H., Smith, E. D., Ding, X., Harrison, S., Chandel, N., Becker, T. C., Hay, N., Ardehali, H., Cordoba-Chacon, J. & Layden, B. T., Jan 1 2019, In : Endocrinology. 160, 2, p. 313-330 18 p.

Research output: Contribution to journal › Article

Liver
Hexokinase
Hepatocytes
Glucose
Mitochondrial Dynamics

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

Miska, J., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4

Research output: Contribution to journal › Article

Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glioblastoma
Immunosuppression
Switches

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 1, eaat0456.

Research output: Contribution to journal › Article

Glioblastoma
Glycine Hydroxymethyltransferase
Carbon
Methionine
Activity Cycles