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Personal profile

Research Interests

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).

Education/Academic qualification

PhD, University of Chicago

… → 1997

Research interests

  • Immune System
  • Lung Cancer / Chest Cancer

Fingerprint Dive into the research topics where Navdeep Chandel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles
Reactive Oxygen Species Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Hypoxia-Inducible Factor 1 Medicine & Life Sciences
Alveolar Epithelial Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Cell death Chemical Compounds

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Grants 2001 2024

MAP Kinase Signaling System
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Adaptive Immunity
Regulatory T-Lymphocytes
Reactive Oxygen Species
Lung Injury
Stem Cells
Human Influenza
Epithelial Cells
Allergy and Immunology

Research Output 1993 2019

14 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

Electron Transport
Fatty Acids

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Air Pollution
Electron Transport

Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

Bueno, M. J., Jimenez-Renard, V., Samino, S., Capellades, J., Junza, A., López-Rodríguez, M. L., Garcia-Carceles, J., Lopez-Fabuel, I., Bolaños, J. P., Chandel, N. S., Yanes, O., Colomer, R. & Quintela-Fandino, M., Dec 1 2019, In : Nature communications. 10, 1, 5011.

Research output: Contribution to journalArticle

Open Access
Fatty Acid Synthases
fatty acids

Glucose Metabolism Linked to Antiviral Responses

Stoolman, J. S. & Chandel, N., Jun 27 2019, In : Cell. 178, 1, p. 10-11 2 p.

Research output: Contribution to journalShort survey

Antiviral Agents
Interferon Type I
Virus Diseases
3 Citations (Scopus)

Hepatic HKDC1 expression contributes to liver metabolism

Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., Giancola, N., Pervaiz, H., Smith, E. D., Ding, X., Harrison, S., Chandel, N. S., Becker, T. C., Hay, N., Ardehali, H., Cordoba-Chacon, J. & Layden, B. T., Jan 1 2019, In : Endocrinology. 160, 2, p. 313-330 18 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics