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Navdeep Chandel

  • 29191 Citations
1993 …2024

Research output per year

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Personal profile

Research Interests

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).

Education/Academic qualification

PhD, The University of Chicago

… → 1997

Research interests

  • Immune System
  • Lung Cancer / Chest Cancer

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Grants

Regulation of de novo purine synthesis by the MAPK/ERK pathway

Ben-Sahra, I. & Chandel, N.

National Institute of General Medical Sciences

1/1/20 → 12/31/24

Project: Research project

    • Mitochondria regulate adaptive immunity

    Chandel, N.

    National Institute of Allergy and Infectious Diseases

    9/19/19 → 8/31/24

    Project: Research project

    • Mitochondrial regulation of lung development, injury and repair

    Chandel, N.

    Francis Family Foundation

    7/1/19 → 6/30/22

    Project: Research project

    • The Robert H. Lurie Comprehensive Cancer Center

    Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L. & Woloschak, G. E.

    National Cancer Institute

    8/10/18 → 7/31/23

    Project: Research project

    • Mitochondrial respiration in CD8 T cell mediated immune responses to solid tumors

    Chandel, N.

    Cancer Research Institute

    10/1/17 → 9/30/20

    Project: Research project

    • Research Output

    FIH-1 engages novel binding partners to positively influence epithelial proliferation via p63

    Kaplan, N., Dong, Y., Wang, S., Yang, W., Park, J. K., Wang, J., Fiolek, E., Perez White, B., Chandel, N. S., Peng, H. & Lavker, R. M., Jan 1 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 525-539 15 p.

    Research output: Contribution to journal › Article

    Open Access

    • Mitochondrial TCA cycle metabolites control physiology and disease

    Martínez-Reyes, I. & Chandel, N. S., Dec 1 2020, In : Nature communications. 11, 1, 102.

    Research output: Contribution to journal › Review article

    Open Access
    • 2 Scopus citations

    We need to talk about the Warburg effect

    DeBerardinis, R. J. & Chandel, N. S., Jan 1 2020, (Accepted/In press) In : Nature Metabolism.

    Research output: Contribution to journal › Comment/debate

    Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

    Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

    Research output: Contribution to journal › Article

    • 20 Scopus citations

    Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

    Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

    Research output: Contribution to journal › Comment/debate