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Personal profile

Research Interests

Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).

Education/Academic qualification

PhD, University of Chicago

… → 1997

Research interests

  • Immune System
  • Lung Cancer / Chest Cancer

Fingerprint Dive into the research topics where Navdeep Chandel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles
Reactive Oxygen Species Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Hypoxia-Inducible Factor 1 Medicine & Life Sciences
Alveolar Epithelial Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Cell death Chemical Compounds

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Grants 2001 2024

Adaptive Immunity
Mitochondria
Regulatory T-Lymphocytes
T-Lymphocytes
Reactive Oxygen Species
Lung Injury
Stem Cells
Lung
Human Influenza
Epithelial Cells
Allergy and Immunology
Respiration
T-Lymphocytes
Research
Neoplasms
Reactive Oxygen Species
Neoplasms
Mitochondria
Antioxidants
Metformin

Research Output 1993 2019

8 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Metformin
Air Pollution
Electron Transport
Names
Publications

Glucose Metabolism Linked to Antiviral Responses

Stoolman, J. S. & Chandel, N., Jun 27 2019, In : Cell. 178, 1, p. 10-11 2 p.

Research output: Contribution to journalShort survey

Metabolism
Antiviral Agents
Glucose
Interferon Type I
Virus Diseases
2 Citations (Scopus)

Hepatic HKDC1 expression contributes to liver metabolism

Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., Giancola, N., Pervaiz, H., Smith, E. D., Ding, X., Harrison, S., Chandel, N., Becker, T. C., Hay, N., Ardehali, H., Cordoba-Chacon, J. & Layden, B. T., Jan 1 2019, In : Endocrinology. 160, 2, p. 313-330 18 p.

Research output: Contribution to journalArticle

Liver
Hexokinase
Hepatocytes
Glucose
Mitochondrial Dynamics
5 Citations (Scopus)

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

Miska, J. M., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glioblastoma
Immunosuppression
Switches