Grants per year
Personal profile
Research Interests
Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).
Education/Academic qualification
PhD, University of Chicago
… → 1997
Research interests
- Immune System
- Lung Cancer / Chest Cancer
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- 21 Similar Profiles
Reactive Oxygen Species
Medicine & Life Sciences
Mitochondria
Medicine & Life Sciences
Cell Death
Medicine & Life Sciences
Hypoxia-Inducible Factor 1
Medicine & Life Sciences
Alveolar Epithelial Cells
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Oxygen
Medicine & Life Sciences
Cell death
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2001 2024
Mitochondria regulate adaptive immunity
National Institute of Allergy and Infectious Diseases
9/19/19 → 8/31/24
Project: Research project
Adaptive Immunity
Mitochondria
Regulatory T-Lymphocytes
T-Lymphocytes
Reactive Oxygen Species
Mitochondrial regulation of lung development, injury and repair
7/1/19 → 6/30/22
Project: Research project
Lung Injury
Stem Cells
Lung
Human Influenza
Epithelial Cells
The Robert H. Lurie Comprehensive Cancer Center
Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L. & Woloschak, G. E.
8/10/18 → 7/31/23
Project: Research project
Neoplasms
Medicine
Research
Population
Mitochondrial respiration in CD8 T cell mediated immune responses to solid tumors
10/1/17 → 9/30/20
Project: Research project
Allergy and Immunology
Respiration
T-Lymphocytes
Research
Neoplasms
Mitochondrial metabolism and ROS regulate cancer
Budinger, G. S., Chandel, N. & Cheng, C.
6/1/16 → 5/31/23
Project: Research project
Reactive Oxygen Species
Neoplasms
Mitochondria
Antioxidants
Metformin
Research Output 1993 2019
8
Citations
(Scopus)
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5Research output: Contribution to journal › Article
Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD
Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))
Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, , Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.Research output: Contribution to journal › Comment/debate
Metformin
Air Pollution
Electron Transport
Names
Publications
Glucose Metabolism Linked to Antiviral Responses
Stoolman, J. S. & Chandel, N., Jun 27 2019, In : Cell. 178, 1, p. 10-11 2 p.Research output: Contribution to journal › Short survey
Metabolism
Antiviral Agents
Glucose
Interferon Type I
Virus Diseases
2
Citations
(Scopus)
Hepatic HKDC1 expression contributes to liver metabolism
Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., Giancola, N., Pervaiz, H., Smith, E. D., Ding, X., Harrison, S., Chandel, N., Becker, T. C., Hay, N., Ardehali, H., Cordoba-Chacon, J. & Layden, B. T., Jan 1 2019, In : Endocrinology. 160, 2, p. 313-330 18 p.Research output: Contribution to journal › Article
Liver
Hexokinase
Hepatocytes
Glucose
Mitochondrial Dynamics
5
Citations
(Scopus)
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J. M., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4Research output: Contribution to journal › Article
Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glioblastoma
Immunosuppression
Switches