Grants per year
Personal profile
Research Interests
Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell Physiology, PhD, University of Chicago
… → 1997
Research interests keywords
- Immune System
- Lung Cancer / Chest Cancer
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Collaborations and top research areas from the last five years
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Unveiling Microglial Dynamics: Advanced CRISPR Technologies for Understanding Brain Inflammation
Chandel, N. (Co-PD/PI)
2/1/25 → 7/31/26
Project: Research project
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Phagocyte Crosstalk in the Balance of Inflammation & Cardiac Disease
Thorp, E. B. (PD/PI), Chandel, N. (Co-Investigator), Scott, E. A. (Co-Investigator) & Shah, S. J. (Co-Investigator)
National Heart, Lung, and Blood Institute
2/1/25 → 1/31/32
Project: Research project
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Targeting mitochondria complex I in Parkinson's
Chandel, N. (PD/PI), Davidson, S. (Co-PD/PI) & Kiskinis, E. (Co-PD/PI)
Michael J. Fox Foundation for Parkinson's Research
2/1/25 → 1/31/27
Project: Research project
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Potentiating long-lived antitumor effector CD8+ T cells for TNBC therapy
Zhang, B. (PD/PI), Zhang, B. (PD/PI), Cui, W. (Co-Investigator), Cui, W. (Co-Investigator), Gradishar, W. J. (Co-Investigator), Gradishar, W. J. (Co-Investigator), Chandel, N. (Other), Chandel, N. (Other), Ji, Z. (Other) & Ji, Z. (Other)
U.S. Army Medical Research and Materiel Command
12/15/24 → 12/14/27
Project: Research project
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Compartment-specific manipulation of NAD+ to mitigate post-injury kidney disease.
Kapitsinou, P. (PD/PI) & Chandel, N. (Co-Investigator)
9/30/24 → 8/31/26
Project: Research project
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A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
Eduardo, M. B., Cottone, G., McCloskey, C. W., Liu, S., Palma, F. R., Zappia, M. P., Islam, A. B. M. M. K., Gao, P., Setya, J., Dennis, S., Gao, H., Zhang, Q., Xuei, X., Luo, Y., Locasale, J., Bonini, M. G., Khokha, R., Frolov, M. V., Benevolenskaya, E. V. & Chandel, N. S. & 2 others, , Mar 21 2025, In: Science Advances. 11, 12, eads9182.Research output: Contribution to journal › Article › peer-review
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Distinct Essentiality of the Mitochondrial Respiratory Chain in Proliferating Cells In Vivo
Bosc, C. & Chandel, N. S., Apr 11 2025, In: Annual Review of Cancer Biology. 9, 1, p. 59-77 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models
Cannon, M., Cosantino, A., Tran, L., Chandel, N. S. & Ghoreishi, N., Mar 2025, In: Nutraceuticals. 5, 1, 4.Research output: Contribution to journal › Article › peer-review
Open Access -
Immunomodulatory role of the stem cell circadian clock in muscle repair
Zhu, P., Pfrender, E. M., Steffeck, A. W. T., Reczek, C. R., Zhou, Y., Thakkar, A. V., Gupta, N. R., Kupai, A., Willbanks, A., Lieber, R. L., Roy, I., Chandel, N. S. & Peek, C. B., Mar 7 2025, In: Science Advances. 11, 10, eadq8538.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages
Stoolman, J. S., Grant, R. A., Billingham, L. K., Poor, T. A., Weinberg, S. E., Harding, M. C., Lu, Z., Miska, J., Szibor, M., Budinger, G. R. S. & Chandel, N. S., Jan 24 2025, In: Science Advances. 11, 4, eadu4369.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. S. (Contributor), Schumacker, P. T. (Contributor) & Surmeier, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/records/6949450
Dataset
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Genome wide RNA Sequencing of whole C. elegans RNA
Schieber, M. (Contributor) & Chandel, N. S. (Contributor), Gene Expression Omnibus, Aug 27 2014
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE60825
Dataset
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α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Chandel, N. S. (Creator), Grotmann, C. A. (Creator), Wokosin, D. L. (Creator), Xie, Z. (Creator), Nasiri, E. (Creator), Öertel, W. H. (Contributor) & Dawson, V. L. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7485396.v1, https://springernature.figshare.com/collections/_-Synuclein_pathology_disrupts_mitochondrial_function_in_dopaminergic_and_cholinergic_neurons_at-risk_in_Parkinson_s_disease/7485396/1
Dataset