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Neha P. Kamat

  • 679 Citations
20102023

Research output per year

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Personal profile

Research Interests

Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications.

Education/Academic qualification

Bioengineering, PhD, University of Pennsylvania

… → 2012

Bioengineering, Magna Cum Laude, BS, Rice University

… → 2008

Research interests

  • Artificial cells
  • Biomaterials
  • Membrane Biophysics
  • Polymersomes
  • RNA

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Grants

Fatty acids in cellular membranes nonspecifically impact cardiovascular function though Piezo1 activity

Kamat, N. P.

American Heart Association

1/1/20 → 12/31/21

Project: Research project

    • Collaborative Research: EAGER: Uncovering the role of Golgi organization on function

    Kamat, N. P.

    National Science Foundation

    8/15/19 → 7/31/21

    Project: Research project

    • A Biophysical Approach to Uncover the Role of Cell Membrane Mechanics in Sensing Mechanical Force

    Kamat, N. P.

    Air Force Office of Scientific Research

    1/1/19 → 12/31/21

    Project: Research project

    • RoL: EAGER: DESYN-C3 Moving information across synthetic membranes via engineered sensors

    Kamat, N. P. & Leonard, J. N.

    National Science Foundation

    12/1/18 → 11/30/20

    Project: Research project

    • RoL: RAISE: DESYN-C3: A platform for Modular Pseudo-Organelles for Compartmentalization and Control of Pseudo-Cell Processes

    Bagheri, N., Ercek, D. T. & Kamat, N. P.

    National Science Foundation

    9/15/18 → 8/31/23

    Project: Research project

    • Research Output

    • 679 Citations
    • 19 Article
    • 1 Conference contribution
    • 1 Comment/debate
    • 1 Review article

    A membrane logic gate to control secretion from vesicles

    Hilburger, C. H., Lewis, K. L., Jacobs, M. L. & Kamat, N. P., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    • Barcoding Biological Reactions with DNA-Functionalized Vesicles

    Peruzzi, J. A., Jacobs, M. L., Vu, T. Q., Wang, K. S. & Kamat, N. P., Dec 16 2019, In : Angewandte Chemie - International Edition. 58, 51, p. 18683-18690 8 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Controlling Secretion in Artificial Cells with a Membrane and Gate

    Hilburger, C. E., Jacobs, M. L., Lewis, K. R., Peruzzi, J. A. & Kamat, N. P., Jun 21 2019, In : ACS synthetic biology. 8, 6, p. 1224-1230 7 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Diblock copolymers enhance folding of a mechanosensitive membrane protein during cell-free expression

    Jacobs, M. L., Boyd, M. A. & Kamat, N. P., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4031-4036 6 p.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Copying of Mixed-Sequence RNA Templates inside Model Protocells

    O'Flaherty, D. K., Kamat, N. P., Mirza, F. N., Li, L., Prywes, N. & Szostak, J. W., Apr 18 2018, In : Journal of the American Chemical Society. 140, 15, p. 5171-5178 8 p.

    Research output: Contribution to journal › Article

    • 22 Scopus citations