Neha P. Kamat

  • 536 Citations
20102023
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Personal profile

Research Interests

Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications.

Education/Academic qualification

Bioengineering, PhD, University of Pennsylvania

… → 2012

Bioengineering, Magna Cum Laude, BS, Rice University

… → 2008

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Membranes Chemical Compounds
Artificial Cells Medicine & Life Sciences
RNA Engineering & Materials Science
Peptides Engineering & Materials Science
Fatty acids Engineering & Materials Science
Polymers Chemical Compounds
Copying Chemical Compounds
Fatty Acids Chemical Compounds

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Grants 2018 2023

Research Output 2010 2018

  • 536 Citations
  • 16 Article
  • 1 Comment/debate
  • 1 Review article
2 Citations

Copying of Mixed-Sequence RNA Templates inside Model Protocells

O'Flaherty, D. K., Kamat, N. P., Mirza, F. N., Li, L., Prywes, N. & Szostak, J. W., Apr 18 2018, In : Journal of the American Chemical Society. 140, 15, p. 5171-5178 8 p.

Research output: Contribution to journalArticle

Artificial Cells
Copying
RNA
Oligomers
Fatty acids

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution

Jin, L., Kamat, N. P., Jena, S. & Szostak, J. W., Jan 1 2018, (Accepted/In press) In : Small.

Research output: Contribution to journalArticle

Phospholipids
Fatty acids
Membrane Potentials
Fatty Acids
Membranes

Visualizing Tension and Growth in Model Membranes Using Optical Dyes

Boyd, M. A. & Kamat, N. P., Jan 1 2018, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

Coloring Agents
Membranes
Growth
Surface Tension
Membrane Lipids
10 Citations

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes

Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z. & Szostak, J. W., Dec 28 2016, In : Journal of the American Chemical Society. 138, 51, p. 16669-16676 8 p.

Research output: Contribution to journalArticle

Artificial Cells
Acylation
Peptides
Amino acids
RNA
15 Citations

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication

Jia, T. Z., Fahrenbach, A. C., Kamat, N. P., Adamala, K. P. & Szostak, J. W., Oct 1 2016, In : Nature chemistry. 8, 10, p. 915-921 7 p.

Research output: Contribution to journalArticle

RNA
Peptides
Copying
Annealing
Oligoribonucleotides