Grants per year
Personal profile
Research Interests
Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications.
Education/Academic qualification
Bioengineering, PhD, University of Pennsylvania
… → 2012
Bioengineering, Magna Cum Laude, BS, Rice University
… → 2008
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Membranes
Chemical Compounds
Artificial Cells
Medicine & Life Sciences
RNA
Engineering & Materials Science
Peptides
Engineering & Materials Science
Fatty acids
Engineering & Materials Science
Polymers
Chemical Compounds
Copying
Chemical Compounds
Fatty Acids
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2018 2023
- 3 Active
A Biophysical Approach to Uncover the Role of Cell Membrane Mechanics in Sensing Mechanical Force
Air Force Office of Scientific Research
1/1/19 → 12/31/21
Project: Research project
Mechanics
Cell Membrane
Membranes
Elasticity
Ion Channels
RoL: EAGER: DESYN-C3 Moving information across synthetic membranes via engineered sensors
12/1/18 → 11/30/20
Project: Research project
Membranes
Sensors
Chemical reactions
Cells
Catalysts
RoL: RAISE: DESYN-C3: A platform for Modular Pseudo-Organelles for Compartmentalization and Control of Pseudo-Cell Processes
Bagheri, N., Ercek, D. T. & Kamat, N. P.
9/15/18 → 8/31/23
Project: Research project
Chassis
Communication
Metabolism
Networks (circuits)
Research Output 2010 2018
Copying of Mixed-Sequence RNA Templates inside Model Protocells
O'Flaherty, D. K., Kamat, N. P., Mirza, F. N., Li, L., Prywes, N. & Szostak, J. W., Apr 18 2018, In : Journal of the American Chemical Society. 140, 15, p. 5171-5178 8 p.Research output: Contribution to journal › Article
Artificial Cells
Copying
RNA
Oligomers
Fatty acids
Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution
Jin, L., Kamat, N. P., Jena, S. & Szostak, J. W., Jan 1 2018, (Accepted/In press) In : Small.Research output: Contribution to journal › Article
Phospholipids
Fatty acids
Membrane Potentials
Fatty Acids
Membranes
Visualizing Tension and Growth in Model Membranes Using Optical Dyes
Boyd, M. A. & Kamat, N. P., Oct 2 2018, In : Biophysical Journal. 115, 7, p. 1307-1315 9 p.Research output: Contribution to journal › Article
Coloring Agents
Membranes
Growth
Surface Tension
Membrane Lipids
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes
Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z. & Szostak, J. W., Dec 28 2016, In : Journal of the American Chemical Society. 138, 51, p. 16669-16676 8 p.Research output: Contribution to journal › Article
Artificial Cells
Acylation
Peptides
Amino acids
RNA
Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication
Jia, T. Z., Fahrenbach, A. C., Kamat, N. P., Adamala, K. P. & Szostak, J. W., Oct 1 2016, In : Nature chemistry. 8, 10, p. 915-921 7 p.Research output: Contribution to journal › Article
RNA
Peptides
Copying
Annealing
Oligoribonucleotides