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Personal profile

Research Interests

Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications.

Education/Academic qualification

Bioengineering, PhD, University of Pennsylvania

… → 2012

Bioengineering, Magna Cum Laude, BS, Rice University

… → 2008

Research interests

  • Artificial cells
  • Biomaterials
  • Membrane Biophysics
  • Polymersomes
  • RNA

Fingerprint Dive into the research topics where Neha P. Kamat is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Membranes Chemical Compounds
Artificial Cells Medicine & Life Sciences
RNA Engineering & Materials Science
Peptides Engineering & Materials Science
Phospholipids Engineering & Materials Science
Fatty acids Engineering & Materials Science
Fatty Acids Chemical Compounds
Polymers Chemical Compounds

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Grants 2018 2023

enzyme
membrane
vesicle
lipid
protein
Mechanics
Cell Membrane
Ion Channels
Membranes
Elasticity
Membranes
Sensors
Chemical reactions
Cells
Catalysts

Research Output 2010 2019

  • 643 Citations
  • 18 Article
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Review article

A membrane logic gate to control secretion from vesicles

Hilburger, C. H., Lewis, K. L., Jacobs, M. L. & Kamat, N. P., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Logic gates
Hemolysin Proteins
Membranes
Proteins
Cell-Free System

Controlling Secretion in Artificial Cells with a Membrane and Gate

Hilburger, C. E., Jacobs, M. L., Lewis, K. R., Peruzzi, J. A. & Kamat, N. P., Jun 21 2019, In : ACS synthetic biology. 8, 6, p. 1224-1230 7 p.

Research output: Contribution to journalArticle

Artificial Cells
Membranes
Hemolysin Proteins
Oleic acid
Phospholipids
4 Citations (Scopus)
Open Access
Membrane Proteins
Membranes
Artificial Cells
Protein Folding
Biosensing Techniques
15 Citations (Scopus)

Copying of Mixed-Sequence RNA Templates inside Model Protocells

O'Flaherty, D. K., Kamat, N. P., Mirza, F. N., Li, L., Prywes, N. & Szostak, J. W., Apr 18 2018, In : Journal of the American Chemical Society. 140, 15, p. 5171-5178 8 p.

Research output: Contribution to journalArticle

Artificial Cells
Copying
RNA
Oligomers
Fatty acids
12 Citations (Scopus)

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution

Jin, L., Kamat, N. P., Jena, S. & Szostak, J. W., Apr 12 2018, In : Small. 14, 15, 1704077.

Research output: Contribution to journalArticle

Phospholipids
Fatty acids
Membrane Potentials
Fatty Acids
Membranes