• 19606 Citations
1994 …2024
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Personal profile

Education/Academic qualification

PhD, Cornell University

… → 1997

Fingerprint Dive into the research topics where Neil L Kelleher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Mass spectrometry Chemical Compounds
Mass Spectrometry Medicine & Life Sciences
Proteomics Medicine & Life Sciences
Proteins Chemical Compounds
Biosynthesis Chemical Compounds
Peptide Synthases Medicine & Life Sciences
Histones Medicine & Life Sciences
Biological Products Medicine & Life Sciences

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Grants 2010 2024

Amyloid
Alzheimer Disease
Post Translational Protein Processing
Peptides
Data Mining
Mass spectrometry

Proteomics Shared Resource

Kelleher, N. L.

National Cancer Institute

8/10/187/31/23

Project: Research project

Proteomics
Neoplasms
Medicine
Research
Population

Research Output 1994 2019

1 Citation (Scopus)

Accurate estimation of context-dependent false discovery rates in top-down proteomics

LeDuc, R. D., Fellers, R. T., Early, B. P., Greer, J. B., Shams, D. P., Thomas, P. M. & Kelleher, N. L., Jan 1 2019, In : Molecular and Cellular Proteomics. 18, 4, p. 796-805 10 p.

Research output: Contribution to journalArticle

Proteomics
Search Engine
Search engines
Protein Isoforms
Proteins
1 Citation (Scopus)

A comprehensive pipeline for translational top-down proteomics from a single blood draw

Toby, T. K., Fornelli, L., Srzentić, K., DeHart, C. J., Levitsky, J., Friedewald, J. J. & Kelleher, N. L., Jan 1 2019, In : Nature Protocols. 14, 1, p. 119-152 34 p.

Research output: Contribution to journalArticle

Proteomics
Blood
Pipelines
Fractionation
Mass spectrometry
3 Citations (Scopus)

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Histones
Methylation
Lysine

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G. S., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 1 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journalArticle

Pathology
Oligomers
Amyloid
Crosslinking
Alzheimer Disease

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

Donnelly, D. P., Rawlins, C. M., DeHart, C. J., Fornelli, L., Schachner, L. F., Lin, Z., Lippens, J. L., Aluri, K. C., Sarin, R., Chen, B., Lantz, C., Jung, W., Johnson, K. R., Koller, A., Wolff, J. J., Campuzano, I. D. G., Auclair, J. R., Ivanov, A. R., Whitelegge, J. P., Paša-Tolić, L. & 8 others, Chamot-Rooke, J., Danis, P. O., Smith, L. M., Tsybin, Y. O., Loo, J. A., Ge, Y., Kelleher, N. L. & Agar, J. N., Jul 1 2019, In : Nature Methods. 16, 7, p. 587-594 8 p.

Research output: Contribution to journalArticle

Open Access
Benchmarking
Practice Guidelines
Mass spectrometry
Mass Spectrometry
Decision Trees