The Kelleher Group is comprised of three main sub-groups: Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin. They have been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology. More specifically, Prof. Kelleher’s team pursues the biosynthesis and discovery of polyketides and non-ribosomally produced peptides from soil bacteria and are leading the way to use intact proteins directly (no proteases like trypsin) as the primary unit of measurement in proteomics to efficiently detect their post-translational modifications.