• 21275 Citations
1994 …2025

Research output per year

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Personal profile

Research Interests

The Kelleher Group is comprised of three main sub-groups: Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin. They have been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology. More specifically, Prof. Kelleher’s team pursues the biosynthesis and discovery of polyketides and non-ribosomally produced peptides from soil bacteria and are leading the way to use intact proteins directly (no proteases like trypsin) as the primary unit of measurement in proteomics to efficiently detect their post-translational modifications.

Education/Academic qualification

PhD, Cornell University

… → 1997

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Grants

  • Research Output

    A computational framework to explore large-scale biosynthetic diversity

    Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In : Nature Chemical Biology. 16, 1, p. 60-68 9 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Accurate estimation of context-dependent false discovery rates in top-down proteomics

    LeDuc, R. D., Fellers, R. T., Early, B. P., Greer, J. B., Shams, D. P., Thomas, P. M. & Kelleher, N. L., Jan 1 2019, In : Molecular and Cellular Proteomics. 18, 4, p. 796-805 10 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    A comprehensive pipeline for translational top-down proteomics from a single blood draw

    Toby, T. K., Fornelli, L., Srzentić, K., DeHart, C. J., Levitsky, J., Friedewald, J. & Kelleher, N. L., Jan 1 2019, In : Nature Protocols. 14, 1, p. 119-152 34 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    A five-level classification system for proteoform identifications

    Smith, L. M., Thomas, P. M., Shortreed, M. R., Schaffer, L. V., Fellers, R. T., LeDuc, R. D., Tucholski, T., Ge, Y., Agar, J. N., Anderson, L. C., Chamot-Rooke, J., Gault, J., Loo, J. A., Paša-Tolić, L., Robinson, C. V., Schlüter, H., Tsybin, Y. O., Vilaseca, M., Vizcaíno, J. A., Danis, P. O. & 1 others, Kelleher, N. L., Oct 1 2019, In : Nature Methods. 16, 10, p. 939-940 2 p.

    Research output: Contribution to journalLetter

    3 Scopus citations