• 21654 Citations
1994 …2020

Research output per year

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Personal profile

Research Interests

The Kelleher Group is comprised of three main sub-groups: Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin. They have been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology. More specifically, Prof. Kelleher’s team pursues the biosynthesis and discovery of polyketides and non-ribosomally produced peptides from soil bacteria and are leading the way to use intact proteins directly (no proteases like trypsin) as the primary unit of measurement in proteomics to efficiently detect their post-translational modifications.

Education/Academic qualification

PhD, Cornell University

… → 1997

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  • Research Output

    A computational framework to explore large-scale biosynthetic diversity

    Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In : Nature Chemical Biology. 16, 1, p. 60-68 9 p.

    Research output: Contribution to journalArticle

  • 22 Scopus citations

    A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain simian immunodeficiency virus epitope specificities

    Schneider, J. R., Shen, X., Orlandi, C., Nyanhete, T., Sawant, S., Carias, A. M., Smith, A. D., Kelleher, N. L., Veazey, R. S., Lewis, G. K., Tomaras, G. D. & Hope, T. J., Mar 1 2020, In : Journal of virology. 94, 5, e01246-19.

    Research output: Contribution to journalArticle

  • A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

    Zhu, W., Doubleday, P. F., Catlin, D. S., Weerawarna, P. M., Butrin, A., Shen, S., Wawrzak, Z., Kelleher, N. L., Liu, D. & Silverman, R. B., Mar 11 2020, In : Journal of the American Chemical Society. 142, 10, p. 4892-4903 12 p.

    Research output: Contribution to journalArticle

  • Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

    Montaser, R. & Kelleher, N. L., May 15 2020, In : ACS chemical biology. 15, 5, p. 1134-1140 7 p.

    Research output: Contribution to journalArticle

  • Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

    Doubleday, P. F., Fornelli, L. & Kelleher, N. L., Feb 7 2020, In : Journal of Proteome Research. 19, 2, p. 938-948 11 p.

    Research output: Contribution to journalArticle