Grants per year
Personal profile
Research Interests
Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.
Training Experience
| 1989 | Postdoctoral Fellowship, University of Michigan |
Education/Academic qualification
PhD, University of Washington
… → 1986
Keywords
- Bacterial Pathogenesis
- Bacteriology
- Cellular Microbiology
- Genetics: Microbial
- Infectious Diseases: Bacteria
- Microbiology
- Pneumonia
- Prokaryotic Cells
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Legionella pneumophila
Medicine & Life Sciences
Legionella
Medicine & Life Sciences
Legionnaires' Disease
Medicine & Life Sciences
Macrophages
Medicine & Life Sciences
Infection
Medicine & Life Sciences
Iron
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Siderophores
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2003 2022
Reassessing Legionella pneumophila Recognition during Intracellular Infection of Human Macrophages
National Institute of Allergy and Infectious Diseases
11/15/18 → 10/31/20
Project: Research project
Legionella pneumophila
Macrophages
Infection
Legionnaires' Disease
Toll-Like Receptors
Siderophores of Legionella pneumophila
National Institute of Allergy and Infectious Diseases
7/23/18 → 6/30/22
Project: Research project
Siderophores
Legionella pneumophila
Iron
Legionnaires' Disease
Aptitude
Immunology and Molecular Pathogenesis Training Program
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Allergy and Immunology
Education
Microbiology
Students
Research
Defining the Siderophore of Stenotrophomonas maltophilia, an Emerging, Multi-Drug Resistant Pathogen
National Institute of Allergy and Infectious Diseases
7/20/17 → 6/30/19
Project: Research project
Stenotrophomonas maltophilia
Siderophores
Pharmaceutical Preparations
Enterobactin
Pneumonia
The non-canonical role of the CRISPR Cas2 nuclease in infection by Legionella pneumophila
National Institute of Allergy and Infectious Diseases
1/1/17 → 12/31/18
Project: Research project
Clustered Regularly Interspaced Short Palindromic Repeats
Legionnaires' Disease
Legionella pneumophila
Amoeba
CRISPR-Cas Systems
Research Output 1983 2018
Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas
White, R. C., Gunderson, F. F., Tyson, J. Y., Richardson, K. H., Portlock, T. J., Garnett, J. A. & Cianciotto, N. P., Mar 1 2018, In : mBio. 9, 2, e00528-18.Research output: Contribution to journal › Article
Legionnaires' Disease
Acyltransferases
Aminopeptidases
Amoeba
Acanthamoeba castellanii
Expanding role of type II secretion in bacterial pathogenesis and beyond
Cianciotto, N. P. & White, R. C., May 1 2017, In : Infection and immunity. 85, 5, e00014-17.Research output: Contribution to journal › Article
Legionella pneumophila
Bacteria
Proteins
Xylella
Erwinia amylovora
Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin
Nas, M. Y. & Cianciotto, N. P., Nov 1 2017, In : Microbiology (United Kingdom). 163, 11, p. 1590-1603 14 p., 000545.Research output: Contribution to journal › Article
Enterobactin
Stenotrophomonas maltophilia
Siderophores
Iron
Growth
Stenotrophomonas maltophilia serine protease StmPr1 induces matrilysis, anoikis, and protease-activated receptor 2 activation in human lung epithelial cells
DuMont, A. L. & Cianciotto, N. P., Jan 1 2017, In : Infection and immunity. 85, 12, e00544-17.Research output: Contribution to journal › Article
Anoikis
PAR-2 Receptor
Stenotrophomonas maltophilia
Serine Proteases
Epithelial Cells
The type II secretion system of Legionella pneumophila dampens the MyD88 and Toll-like receptor 2 signaling pathway in infected human macrophages
Mallama, C. A., McCoy-Simandle, K. & Cianciotto, N. P., Apr 1 2017, In : Infection and Immunity. 85, 4, e00897-16.Research output: Contribution to journal › Article
Toll-Like Receptor 2
Legionella pneumophila
Macrophages
Infection
Interleukin-6