Grants per year
Personal profile
Research Interests
Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.
Training Experience
| 1989 | Postdoctoral Fellowship, University of Michigan |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, MicroImmunology, University of Washington
… → 1986
Research interests keywords
- Bacterial Pathogenesis
- Bacteriology
- Cellular Microbiology
- Genetics: Microbial
- Infectious Diseases: Bacteria
- Microbiology
- Pneumonia
- Prokaryotic Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Deciphering how the Cas2 ribonuclease non-canonically controls Legionella pneumophila thermal tolerance and virulence
Cianciotto, N. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
7/8/24 → 5/31/26
Project: Research project
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Immunology and Molecular Pathogenesis Training Program
Cianciotto, N. P. (PD/PI) & Thorp, E. B. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/1/23 → 8/31/28
Project: Research project
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Rethinking Legionella pneumophila type IV pili and their roles in intracellular infection
Cianciotto, N. P. (PD/PI) & Cianciotto, N. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
6/13/23 → 5/31/25
Project: Research project
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Mucinases as Emerging Players in Legionella pneumophila Pathogenesis
Cianciotto, N. P. (PD/PI) & Cianciotto, N. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
2/1/23 → 1/31/25
Project: Research project
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Stenotrophomonas maltophilia TfcA and TfcB: Antibacterial T4SS effectors from an emerging human pathogen
Cianciotto, N. P. (PD/PI) & Cianciotto, N. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
1/17/23 → 12/31/24
Project: Research project
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Bactericidal effectors of the Stenotrophomonas maltophilia type IV secretion system: functional definition of the nuclease TfdA and structural determination of TfcB
Cobe, B. L., Dey, S., Minasov, G., Inniss, N., Satchell, K. J. F. & Cianciotto, N. P., Jul 2024, In: mBio. 15, 7Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans
Rehman, S., Antonovic, A. K., McIntire, I. E., Zheng, H., Cleaver, L., Baczynska, M., Adams, C. O., Portlock, T., Richardson, K., Shaw, R., Oregioni, A., Mastroianni, G., Whittaker, S. B. M., Kelly, G., Lorenz, C. D., Fornili, A., Cianciotto, N. P. & Garnett, J. A., Dec 2024, In: Nature communications. 15, 1, 4912.Research output: Contribution to journal › Article › peer-review
Open Access -
Complete Genome Sequence of Legionella cardiaca Strain H63T, Isolated from a Case of Native Valve Endocarditis
Lopez, A. E., Mayoral, J. & Cianciotto, N. P., Jul 2023, In: Microbiology Resource Announcements. 12, 7Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Lopez, A. E., Grigoryeva, L. S., Barajas, A. & Cianciottoa, N. P., Aug 2023, In: Infection and immunity. 91, 8Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection
Campbell, J. A. & Cianciotto, N. P., Oct 2022, In: Infection and immunity. 90, 10Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Datasets
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Solution structure of Legionella pneumophila NttA
Portlock, T. J. (Contributor), Tyson, J. Y. (Contributor), Dantu, S. C. (Contributor), Rehman, S. (Contributor), White, R. C. (Contributor), McIntire, I. E. (Contributor), Sewell, L. (Contributor), Richardson, K. (Contributor), Shaw, R. (Contributor), Pandini, A. (Contributor), Cianciotto, N. P. (Contributor) & Garnett, J. A. (Contributor), Protein Data Bank (PDB), Jul 22 2020
DOI: 10.2210/pdb6XTT/pdb, https://www.wwpdb.org/pdb?id=pdb_00006xtt
Dataset
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Crystal structure of the Legionella pneumophila ChiA C-terminal domain
Rehman, S. (Contributor), Grigoryeva, L. S. (Contributor), Richardson, K. H. (Contributor), Corsini, P. (Contributor), White, R. C. (Contributor), Shaw, R. (Contributor), Portlock, T. J. (Contributor), Dorgan, B. (Contributor), Zanjani, Z. S. (Contributor), Fornili, A. (Contributor), Cianciotto, N. P. (Contributor) & Garnett, J. A. (Contributor), Protein Data Bank (PDB), Apr 22 2020
DOI: 10.2210/pdb6S2X/pdb, https://www.wwpdb.org/pdb?id=pdb_00006s2x
Dataset
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Crystal structure of the Legionella pneumophila type II secretion system substrate NttC
Portlock, T. J. (Contributor), Tyson, J. Y. (Contributor), Dantu, S. C. (Contributor), Rehman, S. (Contributor), White, R. C. (Contributor), McIntire, I. E. (Contributor), Sewell, L. (Contributor), Richardson, K. (Contributor), Shaw, R. (Contributor), Pandini, A. (Contributor), Cianciotto, N. P. (Contributor) & Garnett, J. A. (Contributor), Protein Data Bank (PDB), May 20 2020
DOI: 10.2210/pdb6SJT/pdb, https://www.wwpdb.org/pdb?id=pdb_00006sjt
Dataset
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Crystal structure of the Legionella pneumoppila LapA
White, R. C. (Contributor), Gunderson, F. F. (Contributor), Tyson, J. Y. (Contributor), Richardson, K. H. (Contributor), Portlock, T. J. (Contributor), Garnett, J. A. (Contributor) & Cianciotto, N. P. (Contributor), Protein Data Bank (PDB), Apr 4 2018
DOI: 10.2210/pdb6ESL/pdb, https://www.wwpdb.org/pdb?id=pdb_00006esl
Dataset
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Crystal structure of the Legionella pneumophila type II secretion system substrate NttE
Portlock, T. J. (Contributor), Tyson, J. Y. (Contributor), Dantu, S. C. (Contributor), Rehman, S. (Contributor), White, R. C. (Contributor), McIntire, I. E. (Contributor), Sewell, L. (Contributor), Richardson, K. (Contributor), Shaw, R. (Contributor), Pandini, A. (Contributor), Cianciotto, N. P. (Contributor) & Garnett, J. A. (Contributor), Protein Data Bank (PDB), May 20 2020
DOI: 10.2210/pdb6SKW/pdb, https://www.wwpdb.org/pdb?id=pdb_00006skw
Dataset