• 4852 Citations
1983 …2022
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Personal profile

Research Interests

Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.

Training Experience

1989Postdoctoral Fellowship, University of Michigan

Education/Academic qualification

PhD, University of Washington

… → 1986

Keywords

  • Bacterial Pathogenesis
  • Bacteriology
  • Cellular Microbiology
  • Genetics: Microbial
  • Infectious Diseases: Bacteria
  • Microbiology
  • Pneumonia
  • Prokaryotic Cells

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Legionella pneumophila Medicine & Life Sciences
Legionella Medicine & Life Sciences
Legionnaires' Disease Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Infection Medicine & Life Sciences
Iron Medicine & Life Sciences
Genes Medicine & Life Sciences
Siderophores Medicine & Life Sciences

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Grants 2003 2022

Legionella pneumophila
Macrophages
Infection
Legionnaires' Disease
Toll-Like Receptors
Siderophores
Legionella pneumophila
Iron
Legionnaires' Disease
Aptitude
Allergy and Immunology
Education
Microbiology
Students
Research
Stenotrophomonas maltophilia
Siderophores
Pharmaceutical Preparations
Enterobactin
Pneumonia
Clustered Regularly Interspaced Short Palindromic Repeats
Legionnaires' Disease
Legionella pneumophila
Amoeba
CRISPR-Cas Systems

Research Output 1983 2018

Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas

White, R. C., Gunderson, F. F., Tyson, J. Y., Richardson, K. H., Portlock, T. J., Garnett, J. A. & Cianciotto, N. P., Mar 1 2018, In : mBio. 9, 2, e00528-18.

Research output: Contribution to journalArticle

Legionnaires' Disease
Acyltransferases
Aminopeptidases
Amoeba
Acanthamoeba castellanii
16 Citations

Expanding role of type II secretion in bacterial pathogenesis and beyond

Cianciotto, N. P. & White, R. C., May 1 2017, In : Infection and immunity. 85, 5, e00014-17.

Research output: Contribution to journalArticle

Legionella pneumophila
Bacteria
Proteins
Xylella
Erwinia amylovora
1 Citations

Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin

Nas, M. Y. & Cianciotto, N. P., Nov 1 2017, In : Microbiology (United Kingdom). 163, 11, p. 1590-1603 14 p., 000545.

Research output: Contribution to journalArticle

Enterobactin
Stenotrophomonas maltophilia
Siderophores
Iron
Growth
4 Citations
Anoikis
PAR-2 Receptor
Stenotrophomonas maltophilia
Serine Proteases
Epithelial Cells
10 Citations

The type II secretion system of Legionella pneumophila dampens the MyD88 and Toll-like receptor 2 signaling pathway in infected human macrophages

Mallama, C. A., McCoy-Simandle, K. & Cianciotto, N. P., Apr 1 2017, In : Infection and Immunity. 85, 4, e00897-16.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Legionella pneumophila
Macrophages
Infection
Interleukin-6