Grants per year
Personal profile
Research Interests
Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.
Training Experience
1989 | Postdoctoral Fellowship, University of Michigan |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, MicroImmunology, University of Washington
… → 1986
Research interests keywords
- Bacterial Pathogenesis
- Bacteriology
- Cellular Microbiology
- Genetics: Microbial
- Infectious Diseases: Bacteria
- Microbiology
- Pneumonia
- Prokaryotic Cells
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Collaborations and top research areas from the last five years
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Immunology and Molecular Pathogenesis Training Program
Cianciotto, N. P. & Thorp, E. B.
National Institute of Allergy and Infectious Diseases
9/1/23 → 8/31/28
Project: Research project
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Rethinking Legionella pneumophila type IV pili and their roles in intracellular infection
National Institute of Allergy and Infectious Diseases
6/13/23 → 5/31/25
Project: Research project
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Mucinases as Emerging Players in Legionella pneumophila Pathogenesis
Cianciotto, N. P. & Cianciotto, N. P.
National Institute of Allergy and Infectious Diseases
2/1/23 → 1/31/25
Project: Research project
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Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Lopez, A. E., Grigoryeva, L. S., Barajas, A. & Cianciotto, N. P., Aug 16 2023, In: Infection and immunity. 91, 8, p. e0007223Research output: Contribution to journal › Article › peer-review
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Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection
Campbell, J. A. & Cianciotto, N. P., Oct 2022, In: Infection and immunity. 90, 10Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Assay for assessing mucin binding to bacteria and bacterial proteins
Grigoryeva, L. S., Rehman, S., White, R. C., Garnett, J. A. & Cianciotto, N. P., Mar 5 2021, In: Bio-protocol. 11, 5, e3933.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Effectors of the stenotrophomonas maltophilia type IV secretion system mediate killing of clinical isolates of pseudomonas aeruginosa
Nas, M. Y., Gabell, J. & Cianciotto, N. P., Jun 2021, In: mBio. 12, 3, e01502-21.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor
Grigoryeva, L. S. & Cianciotto, N. P., Jul 2021, In: PLoS pathogens. 17, July, e1009781.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations