• 5085 Citations
1983 …2022
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Personal profile

Research Interests

Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.

Training Experience

1989Postdoctoral Fellowship, University of Michigan

Education/Academic qualification

PhD, University of Washington

… → 1986

Research interests

  • Bacterial Pathogenesis
  • Bacteriology
  • Cellular Microbiology
  • Genetics: Microbial
  • Infectious Diseases: Bacteria
  • Microbiology
  • Pneumonia
  • Prokaryotic Cells

Fingerprint Dive into the research topics where Nicholas P Cianciotto is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Legionella pneumophila Medicine & Life Sciences
Legionella Medicine & Life Sciences
Legionnaires' Disease Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Infection Medicine & Life Sciences
Iron Medicine & Life Sciences
Siderophores Medicine & Life Sciences
Genes Medicine & Life Sciences

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Grants 2003 2022

Legionella pneumophila
Macrophages
Infection
Legionnaires' Disease
Toll-Like Receptors
Siderophores
Legionella pneumophila
Iron
Legionnaires' Disease
Aptitude
Allergy and Immunology
Education
Microbiology
Students
Research
Stenotrophomonas maltophilia
Siderophores
Pharmaceutical Preparations
Enterobactin
Pneumonia

Research Output 1983 2019

Analysis of iron requirements and siderophore production

Burnside, D. M. & Cianciotto, N. P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 3-19 17 p. (Methods in Molecular Biology; vol. 1921).

Research output: Chapter in Book/Report/Conference proceedingChapter

Siderophores
Legionella pneumophila
Iron
Anions
Chromatography
1 Citation (Scopus)
Open Access
Legionella pneumophila
Legionella
Genomics
Mimiviridae
Legionnaires' Disease
1 Citation (Scopus)
Stenotrophomonas maltophilia
Pseudomonas aeruginosa
Apoptosis
Bacteria
Lung
2 Citations (Scopus)

Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas

White, R. C., Gunderson, F. F., Tyson, J. Y., Richardson, K. H., Portlock, T. J., Garnett, J. A. & Cianciotto, N. P., Mar 1 2018, In : mBio. 9, 2, e00528-18.

Research output: Contribution to journalArticle

Legionnaires' Disease
Acyltransferases
Aminopeptidases
Amoeba
Acanthamoeba castellanii
31 Citations (Scopus)

Expanding role of type II secretion in bacterial pathogenesis and beyond

Cianciotto, N. P. & White, R. C., May 1 2017, In : Infection and immunity. 85, 5, e00014-17.

Research output: Contribution to journalArticle

Legionella pneumophila
Bacteria
Proteins
Xylella
Erwinia amylovora