Grants per year
Personal profile
Research Interests
Our laboratory studies Legionella pneumophila, the bacterial agent of Legionnaires' Disease pneumonia and Pontiac Fever. Research efforts include understanding the protein secretion systems and iron acquisition pathways that contribute to the organism's ability to infect host cells and the lung. Our laboratory has also identified a new species of Legionella (L. cardiaca) that is linked to heart infection. Finally, we study Stenotrophomonas maltophilia and Klebsiella pneumonia, highly antibiotic resistant bacteria that are increasingly associated with human infections.
Training Experience
| 1989 | Postdoctoral Fellowship, University of Michigan |
Education/Academic qualification
PhD, University of Washington
… → 1986
Research interests
- Bacterial Pathogenesis
- Bacteriology
- Cellular Microbiology
- Genetics: Microbial
- Infectious Diseases: Bacteria
- Microbiology
- Pneumonia
- Prokaryotic Cells
Fingerprint Dive into the research topics where Nicholas P Cianciotto is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Legionella pneumophila
Medicine & Life Sciences
Legionella
Medicine & Life Sciences
Legionnaires' Disease
Medicine & Life Sciences
Macrophages
Medicine & Life Sciences
Infection
Medicine & Life Sciences
Iron
Medicine & Life Sciences
Siderophores
Medicine & Life Sciences
Amoeba
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2003 2022
Stenotrophomonas Maltophilia Type IV Secretion: Modulator of Both Host-Cell Apoptosis and Interbacterial Killing
National Institute of Allergy and Infectious Diseases
2/13/19 → 1/31/21
Project: Research project
Stenotrophomonas maltophilia
Apoptosis
Bacteria
Lung
Genome
Reassessing Legionella pneumophila Recognition during Intracellular Infection of Human Macrophages
National Institute of Allergy and Infectious Diseases
11/15/18 → 10/31/20
Project: Research project
Legionella pneumophila
Macrophages
Infection
Legionnaires' Disease
Toll-Like Receptors
Siderophores of Legionella pneumophila
National Institute of Allergy and Infectious Diseases
7/23/18 → 6/30/22
Project: Research project
Siderophores
Legionella pneumophila
Iron
Legionnaires' Disease
Aptitude
Immunology and Molecular Pathogenesis Training Program
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Allergy and Immunology
Education
Microbiology
Students
Research
Defining the Siderophore of Stenotrophomonas maltophilia, an Emerging, Multi-Drug Resistant Pathogen
National Institute of Allergy and Infectious Diseases
7/20/17 → 6/30/20
Project: Research project
Stenotrophomonas maltophilia
Siderophores
Pharmaceutical Preparations
Enterobactin
Pneumonia
Research Output 1983 2019
Analysis of iron requirements and siderophore production
Burnside, D. M. & Cianciotto, N. P., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 3-19 17 p. (Methods in Molecular Biology; vol. 1921).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Siderophores
Legionella pneumophila
Iron
Anions
Chromatography
4
Citations
(Scopus)
Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: The Legionella type II secretion paradigm
White, R. C. & Cianciotto, N. P., Jul 1 2019, In : Microbial Genomics. 5, 6, p. 1-30 30 p.Research output: Contribution to journal › Article
Open Access
Legionella pneumophila
Legionella
Genomics
Mimiviridae
Legionnaires' Disease
1
Citation
(Scopus)
Stenotrophomonas maltophilia encodes a VirB/VirD4 type IV secretion system that modulates apoptosis in human cells and promotes competition against heterologous bacteria, including Pseudomonas aeruginosa
Nas, M. Y., White, R. C., DuMont, A. L., Lopez, A. E. & Cianciottoa, N. P., Sep 1 2019, In : Infection and immunity. 87, 9, e00457-19.Research output: Contribution to journal › Article
Stenotrophomonas maltophilia
Pseudomonas aeruginosa
Apoptosis
Bacteria
Lung
Type II secretion promotes bacterial growth within the Legionella-containing vacuole in infected amoebae
White, R. C., Truchan, H. K., Zheng, H., Tyson, J. Y. & Cianciotto, N. P., Jan 1 2019, In : Infection and immunity. 87, 11, e00374-19.Research output: Contribution to journal › Article
Legionella
Amoeba
Vacuoles
Legionella pneumophila
Growth
4
Citations
(Scopus)
Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas
White, R. C., Gunderson, F. F., Tyson, J. Y., Richardson, K. H., Portlock, T. J., Garnett, J. A. & Cianciotto, N. P., Mar 1 2018, In : mBio. 9, 2, e00528-18.Research output: Contribution to journal › Article
Legionnaires' Disease
Acyltransferases
Aminopeptidases
Amoeba
Acanthamoeba castellanii