Nobuo Horikoshi

  • 2709 Citations
1986 …2019
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Personal profile

Education/Academic qualification

PhD, University of Tokyo

… → 1989

Fingerprint Dive into the research topics where Nobuo Horikoshi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
DNA Damage Medicine & Life Sciences
Ionizing Radiation Medicine & Life Sciences
DNA Repair Medicine & Life Sciences
Double-Stranded DNA Breaks Medicine & Life Sciences
Proteins Medicine & Life Sciences
Recombinational DNA Repair Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Adenovirus E1A Proteins Medicine & Life Sciences

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Grants 2017 2018

Research Output 1986 2019

1 Citation (Scopus)

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D. R., Dec 1 2019, In : Nature communications. 10, 1, 2399.

Research output: Contribution to journalArticle

Open Access
acetylation
Acetylation
Detoxification
inorganic peroxides
lysine

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase

Horikoshi, N., Sharma, D., Leonard, F., Pandita, R. K., Charaka, V. K., Hambarde, S., Horikoshi, N. T., Gaur Khaitan, P., Chakraborty, S., Cote, J., Godin, B., Hunt, C. R. & Pandita, T. K., Dec 1 2019, In : Communications Biology. 2, 1, 253.

Research output: Contribution to journalArticle

Open Access
Euchromatin
Recombinational DNA Repair
homologous recombination
DNA repair
S Phase
13 Citations (Scopus)

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C., Spitz, D. R. & Gius, D. R., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3682-3691 10 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Neoplasms
Therapeutics
Electron Transport
NADP
1 Citation (Scopus)

Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice

Quan, S., Principe, D. R., Dean, A. E., Park, S. H., Grippo, P. J., Gius, D. R. & Horikoshi, N., Dec 1 2018, In : Scientific reports. 8, 1, 16501.

Research output: Contribution to journalArticle

Ceruletide
Pancreatitis
Phenotype
Mutation
Pancreas
2 Citations (Scopus)

A multifaceted role for MOF histone modifying factor in genome maintenance

Mujoo, K., Hunt, C. R., Horikoshi, N. & Pandita, T. K., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 177-180 4 p.

Research output: Contribution to journalReview article

Histones
Maintenance
Genome
Ataxia Telangiectasia
DNA Repair