• 22812 Citations
1970 …2019

Research output per year

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2019

Thomas A. Steitz (1940-2018)

Uhlenbeck, O. C., Feb 1 2019, In : RNA (New York, N.Y.). 25, 2, p. 169-172 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

In vitro selection of DNAs with an increased propensity to form small circles

Rosanio, G., Widom, J. & Uhlenbeck, O. C., Jan 1 2015, In : Biopolymers. 103, 6, p. 303-320 18 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Labeled EF-Tus for rapid kinetic studies of pretranslocation complex formation

Liu, W., Kavaliauskas, D., Schrader, J. M., Poruri, K., Birkedal, V., Goldman, E., Jakubowski, H., Mandecki, W., Uhlenbeck, O. C., Knudsen, C. R., Goldman, Y. E. & Cooperman, B. S., Oct 17 2014, In : ACS chemical biology. 9, 10, p. 2421-2431 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The interface between Escherichia coli elongation factor Tu and aminoacyl-tRNA

Yikilmaz, E., Chapman, S. J., Schrader, J. M. & Uhlenbeck, O. C., Sep 9 2014, In : Biochemistry. 53, 35, p. 5710-5720 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning

Moyle-Heyrman, G., Zaichuk, T., Xi, L., Zhang, Q., Uhlenbeck, O. C., Holmgren, R., Widom, J. & Wang, J. P., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20158-20163 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

TRNA residues evolved to promote translational accuracy

Shepotinovskaya, I. & Uhlenbeck, O. C., Apr 1 2013, In : RNA. 19, 4, p. 510-516 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

Duplex destabilization by four ribosomal DEAD-box proteins

Garcia, I., Albring, M. J. & Uhlenbeck, O. C., Dec 18 2012, In : Biochemistry. 51, 50, p. 10109-10118 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Histidine 66 in Escherichia coli elongation factor Tu selectively stabilizes aminoacyl-tRNAs

Chapman, S. J., Schrader, J. M. & Uhlenbeck, O. C., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1229-1234 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Functional consequences of T-stem mutations in E. coli tRNA ThrUGU in vitro and in vivo

Saks, M. E., Sanderson, L. E., Choi, D. S., Crosby, C. M. & Uhlenbeck, O. C., Jun 1 2011, In : RNA. 17, 6, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Is the sequence-specific binding of aminoacyl-tRNAs by EF-Tu universal among bacteria?

Schrader, J. M. & Uhlenbeck, O. C., Dec 1 2011, In : Nucleic acids research. 39, 22, p. 9746-9758 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tuning the affinity of aminoacyl-tRNA to elongation factor Tu for optimal decoding

Schrader, J. M., Chapman, S. J. & Uhlenbeck, O. C., Mar 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5215-5220 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
2010

Enhanced product stability in the hammerhead ribozyme

Shepotinovskaya, I. & Uhlenbeck, O. C., Jun 1 2010, In : Biochemistry. 49, 21, p. 4494-4500 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit

Sharpe Elles, L. M., Sykes, M. T., Williamson, J. R. & Uhlenbeck, O. C., Nov 16 2009, In : Nucleic acids research. 37, 19, p. 6503-6514 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

A sequence element that tunes Escherichia coli tRNAGGC Ala to ensure accurate decoding

Ledoux, S., Olejniczak, M. & Uhlenbeck, O. C., Apr 1 2009, In : Nature Structural and Molecular Biology. 16, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

RNA biophysics has come of age

Uhlenbeck, O. C., Oct 26 2009, In : Biopolymers. 91, 10, p. 811-814 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Specificity of the ribosomal A site for aminoacyl-tRNAs

Dale, T., Fahlman, R. P., Olejniczak, M. & Uhlenbeck, O. C., Mar 24 2009, In : Nucleic acids research. 37, 4, p. 1202-1210 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Understanding the Sequence Specificity of tRNA Binding to Elongation Factor Tu using tRNA Mutagenesis

Schrader, J. M., Chapman, S. J. & Uhlenbeck, O. C., Mar 13 2009, In : Journal of Molecular Biology. 386, 5, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2008

[3′-32P]-labeling tRNA with nucleotidyltransferase for assaying aminoacylation and peptide bond formation

Ledoux, S. & Uhlenbeck, O. C., Feb 1 2008, In : Methods. 44, 2, p. 74-80 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Catalytic diversity of extended hammerhead ribozymes

Shepotinovskaya, I. V. & Uhlenbeck, O. C., Jul 8 2008, In : Biochemistry. 47, 27, p. 7034-7042 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Different aa-tRNAs Are Selected Uniformly on the Ribosome

Ledoux, S. & Uhlenbeck, O. C., Jul 11 2008, In : Molecular cell. 31, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins

Garcia, I. & Uhlenbeck, O. C., Nov 25 2008, In : Biochemistry. 47, 47, p. 12562-12573 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis

Nelson, J. A. & Uhlenbeck, O. C., Jan 1 2008, In : RNA. 14, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
36 Scopus citations
2007

Directed Mutagenesis Identifies Amino Acid Residues Involved in Elongation Factor Tu Binding to yeast Phe-tRNAPhe

Sanderson, L. E. & Uhlenbeck, O. C., Apr 20 2007, In : Journal of Molecular Biology. 368, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Exploring the specificity of bacterial elongation factor Tu for different tRNAs

Sanderson, L. E. & Uhlenbeck, O. C., May 29 2007, In : Biochemistry. 46, 21, p. 6194-6200 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

The 51-63 base pair of tRNA confers specificity for binding by EF-Tu

Sanderson, L. E. & Uhlenbeck, O. C., Jun 1 2007, In : RNA. 13, 6, p. 835-840 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

Alanine scanning of MS2 coat protein reveals protein-phosphate contacts involved in thermodynamic hot spots

Hobson, D. & Uhlenbeck, O. C., Feb 24 2006, In : Journal of Molecular Biology. 356, 3, p. 613-624 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Quantitative analysis of deoxynucleotide substitutions in the codon-anticodon helix

Fahlman, R. P., Olejniczak, M. & Uhlenbeck, O. C., Feb 3 2006, In : Journal of Molecular Biology. 355, 5, p. 887-892 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold

Wang, S., Hu, Y., Overgaard, M. T., Karginov, F. V., Uhlenbeck, O. C. & McKay, D. B., Jun 1 2006, In : RNA. 12, 6, p. 959-967 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

tRNA residues that have coevolved with their anticodon to ensure uniform and accurate codon recognition

Olejniczak, M. & Uhlenbeck, O. C., Aug 1 2006, In : Biochimie. 88, 8, p. 943-950 8 p.

Research output: Contribution to journalArticle

45 Scopus citations
2005

Amino acid specificity in translation

Dale, T. & Uhlenbeck, O. C., Dec 2005, In : Trends in Biochemical Sciences. 30, 12, p. 659-665 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Binding of misacylated tRNAs to the ribosomal a site

Dale, T. & Uhlenbeck, O. C., Nov 1 2005, In : RNA. 11, 11, p. 1610-1615 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Escherichia coli DbpA Is a 3′ → 5′ RNA helicase

Diges, C. M. & Uhlenbeck, O. C., May 31 2005, In : Biochemistry. 44, 21, p. 7903-7911 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants

Nelson, J. A., Shepotinovskaya, I. & Uhlenbeck, O. C., Nov 8 2005, In : Biochemistry. 44, 44, p. 14577-14585 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Idiosyncratic tuning of tRNAs to achieve uniform ribosome binding

Olejniczak, M., Dale, T., Fahlman, R. P. & Uhlenbeck, O. C., Sep 1 2005, In : Nature Structural and Molecular Biology. 12, 9, p. 788-793 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Predicting the binding affinities of misacylated tRNAs for Thermus thermophilus EF-Tu·GTP

Asahara, H. & Uhlenbeck, O. C., Aug 23 2005, In : Biochemistry. 44, 33, p. 11254-11261 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

YxiN is a modular protein combining a DExD/H core and a specific RNA-binding domain

Karginov, F. V., Caruthers, J. M., Hu, Y. X., McKay, D. B. & Uhlenbeck, O. C., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35499-35505 7 p.

Research output: Contribution to journalArticle

53 Scopus citations
2004

Contribution of the esterified amino acid to the binding of aminoacylated tRNAs to the ribosomal P- and A-sites

Fahlman, R. P. & Uhlenbeck, O. C., Jun 15 2004, In : Biochemistry. 43, 23, p. 7575-7583 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Interaction of Escherichia coli DbpA with 23S rRNA in different functional states of the enzyme

Karginov, F. V. & Uhlenbeck, O. C., Aug 16 2004, In : Nucleic acids research. 32, 10, p. 3028-3032 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

The affinity of elongation factor Tu for an aminoacyl-tRNA is modulated by the esterified amino acid

Dale, T., Sanderson, L. E. & Uhlenbeck, O. C., May 25 2004, In : Biochemistry. 43, 20, p. 6159-6166 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites

Fahlman, R. P., Dale, T. & Uhlenbeck, O. C., Dec 3 2004, In : Molecular cell. 16, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle

75 Scopus citations
2002

Cooperative binding of ATP and RNA substrates to the DEAD/H protein DbpA

Polach, K. J. & Uhlenbeck, O. C., Mar 19 2002, In : Biochemistry. 41, 11, p. 3693-3702 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent cross-links

Blount, K. F. & Uhlenbeck, O. C., May 28 2002, In : Biochemistry. 41, 21, p. 6834-6841 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Modulation of tRNAAla identity by inorganic pyrophosphatase

Wolfson, A. D. & Uhlenbeck, O. C., Apr 30 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 9, p. 5965-5970 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Steric interference modification of the hammerhead ribozyme

Blount, K. F., Grover, N. L., Mokler, V., Beigelman, L. & Uhlenbeck, O. C., Sep 1 2002, In : Chemistry and Biology. 9, 9, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

The carboxy-terminal domain of the DExD/H protein YxiN is sufficient to confer specificity for 23 S rRNA

Kossen, K., Karginov, F. V. & Uhlenbeck, O. C., Jan 1 2002, In : Journal of Molecular Biology. 324, 4, p. 625-636 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

The hammerhead ribozyme

Blount, K. F. & Uhlenbeck, O. C., Nov 1 2002, In : Biochemical Society transactions. 30, 6, p. 1119-1122 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

The tRNA specificity of Thermus thermophilus EF-Tu

Asahara, H. & Uhlenbeck, O. C., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3499-3504 6 p.

Research output: Contribution to journalArticle

81 Scopus citations
2001

A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase

Stage-Zimmermann, T. K. & Uhlenbeck, O. C., Oct 14 2001, In : Nature Structural Biology. 8, 10, p. 863-867 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization

Sherlin, L. D., Bullock, T. L., Nissan, T. A., Perona, J. J., Lariviere, F. J., Uhlenbeck, O. C. & Scaringe, S. A., Dec 3 2001, In : RNA. 7, 11, p. 1671-1678 8 p.

Research output: Contribution to journalArticle

94 Scopus citations