Oren Josh Becher

  • 2785 Citations
19992022
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Personal profile

Research Interests

To provide the scientific rationale for improved clinical trials for children with brain tumors, particularly pediatric high-grade gliomas

My academic focus is research to identify effective treatments for children with brain tumors, particularly DIPG (Diffuse Intrinsic Pontine Glioma). I am also interested in mentoring the next generation of physician-scientists or scientists who have similar interests.

My laboratory uses genetic mouse modeling tools to study Diffuse Intrinsic Pontine Glioma (DIPG), an incurable brain cancer that arises in children. Our three aims are to develop improved DIPG mouse models, to study the mechanism of novel oncogenes implicated in DIPG pathogenesis (e.g., H3K27M, ACVR1/ALK2), and to evaluate novel therapeutics

Training Experience

2003Residency, Children's National Medical Center
2006Fellowship, New York Presbyterian Hospital
2007Fellowship, New York Presbyterian Hospital

Education/Academic qualification

MD, Johns Hopkins University

… → 2000

Keywords

  • Brain Cancer / Nervous System Cancer
  • Cancer Genetics
  • Epigenetics
  • Pediatrics

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  • 19 Similar Profiles
Glioma Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Brain Stem Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Heterografts Medicine & Life Sciences

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Grants 2017 2022

Glioma
Dissection
Brain Neoplasms
Neoplasms
Growth
Bone Morphogenetic Proteins
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Mutation
Type I Activin Receptors
Ataxia Telangiectasia
Glioma
Clinical Trials
Brain Stem Neoplasms
Radiotherapy
Glioma
Histones
Dissection
Mutation
Bone Morphogenetic Protein Receptors

Research Output 1999 2019

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations
1 Citation (Scopus)

CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

Research output: Contribution to journalReview article

Glioma
Gene Transfer Techniques
Manuscripts
Standard of Care
Brain Neoplasms
1 Citation (Scopus)

T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity

Harward, S., Harrison Farber, S., Malinzak, M., Becher, O. J. & Thompson, E. M., Mar 1 2018, In : Child's Nervous System. 34, 3, p. 449-455 7 p.

Research output: Contribution to journalArticle

Glioma
Convection
Corpus Callosum
Neoplasms
Catheters
13 Citations (Scopus)

A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma

Kushner, B. H., Cheung, N. K. V., Modak, S., Becher, O. J., Basu, E. M., Roberts, S. S., Kramer, K. & Dunkel, I. J., Jan 15 2017, In : International Journal of Cancer. 140, 2, p. 480-484 5 p.

Research output: Contribution to journalArticle

Neuroblastoma
Disease-Free Survival
Salvage Therapy
perifosine
Survivors
11 Citations (Scopus)

A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors

Becher, O. J., Gilheeney, S. W., Khakoo, Y., Lyden, D. C., Haque, S., De Braganca, K. C., Kolesar, J. M., Huse, J. T., Modak, S., Wexler, L. H., Kramer, K., Spasojevic, I. & Dunkel, I. J., Jul 1 2017, In : Pediatric Blood and Cancer. 64, 7, e26409.

Research output: Contribution to journalArticle

Glioma
Pediatrics
Neoplasms
Medulloblastoma
Pharmacokinetics