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Personal profile

Research Interests

My laboratory uses genetic mouse modeling tools to study Diffuse Intrinsic Pontine Glioma (DIPG), an incurable brain cancer that arises in children. Our three aims are to develop improved DIPG mouse models, to study the mechanism of novel oncogenes implicated in DIPG pathogenesis (e.g., H3K27M, ACVR1/ALK2), and to evaluate novel therapeutics

My academic focus is research to identify effective treatments for children with brain tumors, particularly DIPG (Diffuse Intrinsic Pontine Glioma). I am also interested in mentoring the next generation of physician-scientists or scientists who have similar interests.

To provide the scientific rationale for improved clinical trials for children with brain tumors, particularly pediatric high-grade gliomas

Training Experience

2003Residency, Children's National Medical Center
2006Fellowship, New York Presbyterian Hospital
2007Fellowship, New York Presbyterian Hospital

Education/Academic qualification

MD, Johns Hopkins University

… → 2000

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Genetics
  • Epigenetics
  • Pediatrics

Fingerprint Dive into the research topics where Oren Josh Becher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
Glioma Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Brain Stem Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Histones Medicine & Life Sciences

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Grants 2017 2022

Glioma
Dissection
Brain Neoplasms
Neoplasms
Growth
Bone Morphogenetic Proteins
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Mutation
Type I Activin Receptors

Research Output 1999 2019

4 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations
1 Citation (Scopus)

CDK4/6 and diffuse intrinsic pontine glioma - Evaluate at diagnosis?

Becher, O. J., Jun 1 2019, In : EBioMedicine. 44, p. 16-17 2 p.

Research output: Contribution to journalComment/debate

Open Access
Glioma

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Martinez-Velez, N., Marigil, M., García-Moure, M., Gonzalez-Huarriz, M., Aristu, J. J., Ramos-García, L. I., Tejada, S., Díez-Valle, R., Patiño-García, A., Becher, O. J., Gomez-Manzano, C., Fueyo, J. & Alonso, M. M., Apr 29 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Radiotherapy
Pediatrics
Neoplasms
Therapeutics

HDAC inhibitors to the rescue in sonic hedgehog medulloblastoma

Becher, O. J., Sep 6 2019, In : Neuro-oncology. 21, 9, p. 1091-1092 2 p.

Research output: Contribution to journalEditorial

Medulloblastoma
Histone Deacetylase Inhibitors

Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas

Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, Hashizume, R., Broniscer, A., Pollack, I. F. & Agnihotri, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Therapeutics
Brain Stem Neoplasms
Proto-Oncogenes