Oren Josh Becher

  • 2879 Citations
19992022
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Personal profile

Research Interests

My laboratory uses genetic mouse modeling tools to study Diffuse Intrinsic Pontine Glioma (DIPG), an incurable brain cancer that arises in children. Our three aims are to develop improved DIPG mouse models, to study the mechanism of novel oncogenes implicated in DIPG pathogenesis (e.g., H3K27M, ACVR1/ALK2), and to evaluate novel therapeutics

My academic focus is research to identify effective treatments for children with brain tumors, particularly DIPG (Diffuse Intrinsic Pontine Glioma). I am also interested in mentoring the next generation of physician-scientists or scientists who have similar interests.

To provide the scientific rationale for improved clinical trials for children with brain tumors, particularly pediatric high-grade gliomas

Training Experience

2003Residency, Children's National Medical Center
2006Fellowship, New York Presbyterian Hospital
2007Fellowship, New York Presbyterian Hospital

Education/Academic qualification

MD, Johns Hopkins University

… → 2000

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Genetics
  • Epigenetics
  • Pediatrics

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  • 20 Similar Profiles
Glioma Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Brain Stem Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Heterografts Medicine & Life Sciences

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Grants 2017 2022

Glioma
Dissection
Brain Neoplasms
Neoplasms
Growth
Ataxia Telangiectasia
Glioma
Clinical Trials
Brain Stem Neoplasms
Radiotherapy
Glioma
Histones
Dissection
Mutation
Bone Morphogenetic Protein Receptors

Research Output 1999 2019

3 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations
1 Citation (Scopus)

CDK4/6 and diffuse intrinsic pontine glioma - Evaluate at diagnosis?

Becher, O. J., Jun 1 2019, In : EBioMedicine. 44, p. 16-17 2 p.

Research output: Contribution to journalComment/debate

Open Access
Glioma

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Martinez-Velez, N., Marigil, M., García-Moure, M., Gonzalez-Huarriz, M., Aristu, J. J., Ramos-García, L. I., Tejada, S., Díez-Valle, R., Patiño-García, A., Becher, O. J., Gomez-Manzano, C., Fueyo, J. & Alonso, M. M., Apr 29 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Radiotherapy
Pediatrics
Neoplasms
Therapeutics

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

Martínez-Vélez, N., Garcia-Moure, M., Marigil, M., González-Huarriz, M., Puigdelloses, M., Gallego Pérez-Larraya, J., Zalacaín, M., Marrodán, L., Varela-Guruceaga, M., Laspidea, V., Aristu, J. J., Ramos, L. I., Tejada-Solís, S., Díez-Valle, R., Jones, C., Mackay, A., Martínez-Climent, J. A., García-Barchino, M. J., Raabe, E., Monje, M. & 10 othersBecher, O. J., Junier, M. P., El-Habr, E. A., Chneiweiss, H., Aldave, G., Jiang, H., Fueyo, J., Patiño-García, A., Gomez-Manzano, C. & Alonso, M. M., Dec 1 2019, In : Nature communications. 10, 1, 2235.

Research output: Contribution to journalArticle

Open Access
Oncolytic Viruses
Pediatrics
viruses
Viruses
Glioma
1 Citation (Scopus)

CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

Research output: Contribution to journalReview article

Glioma
Gene Transfer Techniques
Manuscripts
Standard of Care
Brain Neoplasms