• 3203 Citations
19992022

Research output per year

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Research Output

2019

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

11 Scopus citations

CDK4/6 and diffuse intrinsic pontine glioma - Evaluate at diagnosis?

Becher, O. J., Jun 1 2019, In : EBioMedicine. 44, p. 16-17 2 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Martinez-Velez, N., Marigil, M., García-Moure, M., Gonzalez-Huarriz, M., Aristu, J. J., Ramos-García, L. I., Tejada, S., Díez-Valle, R., Patiño-García, A., Becher, O. J., Gomez-Manzano, C., Fueyo, J. & Alonso, M. M., Apr 29 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

HDAC inhibitors to the rescue in sonic hedgehog medulloblastoma

Becher, O. J., Sep 6 2019, In : Neuro-oncology. 21, 9, p. 1091-1092 2 p.

Research output: Contribution to journalEditorial

Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas

Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, Hashizume, R., Broniscer, A., Pollack, I. F. & Agnihotri, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.

Research output: Contribution to journalArticle

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

Martínez-Vélez, N., Garcia-Moure, M., Marigil, M., González-Huarriz, M., Puigdelloses, M., Gallego Pérez-Larraya, J., Zalacaín, M., Marrodán, L., Varela-Guruceaga, M., Laspidea, V., Aristu, J. J., Ramos, L. I., Tejada-Solís, S., Díez-Valle, R., Jones, C., Mackay, A., Martínez-Climent, J. A., García-Barchino, M. J., Raabe, E., Monje, M. & 10 others, Becher, O. J., Junier, M. P., El-Habr, E. A., Chneiweiss, H., Aldave, G., Jiang, H., Fueyo, J., Patiño-García, A., Gomez-Manzano, C. & Alonso, M. M., May 28 2019, In : Nature communications. 10, 1, 2235.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

Hoeman, C., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

Research output: Contribution to journalReview article

4 Scopus citations

T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity

Harward, S., Harrison Farber, S., Malinzak, M., Becher, O. J. & Thompson, E. M., Mar 1 2018, In : Child's Nervous System. 34, 3, p. 449-455 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma

Kushner, B. H., Cheung, N. K. V., Modak, S., Becher, O. J., Basu, E. M., Roberts, S. S., Kramer, K. & Dunkel, I. J., Jan 15 2017, In : International Journal of Cancer. 140, 2, p. 480-484 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors

Becher, O. J., Gilheeney, S. W., Khakoo, Y., Lyden, D. C., Haque, S., De Braganca, K. C., Kolesar, J. M., Huse, J. T., Modak, S., Wexler, L. H., Kramer, K., Spasojevic, I. & Dunkel, I. J., Jul 1 2017, In : Pediatric Blood and Cancer. 64, 7, e26409.

Research output: Contribution to journalArticle

16 Scopus citations

A phase i study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors

Becher, O. J., Millard, N. E., Modak, S., Kushner, B. H., Haque, S., Spasojevic, I., Trippett, T. M., Gilheeney, S. W., Khakoo, Y., Lyden, D. C., De Braganca, K. C., Kolesar, J. M., Huse, J. T., Kramer, K., Cheung, N. K. V. & Dunkel, I. J., Jun 1 2017, In : PLoS One. 12, 6, e0178593.

Research output: Contribution to journalArticle

7 Scopus citations

Histone H3.3K27M represses p16 to accelerate gliomagenesis in a murine model of DIPG

Cordero, F. J., Huang, Z., Grenier, C., He, X., Hu, G., McLendon, R. E., Murphy, S. K., Hashizume, R. & Becher, O. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1243-1254 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pediatric high-grade glioma: Biologically and clinically in need of new thinking

Jones, C., Karajannis, M. A., Jones, D. T. W., Kieran, M. W., Monje, M., Baker, S. J., Becher, O. J., Cho, Y. J., Gupta, N., Hawkins, C., Hargrave, D., Haas-Kogan, D. A., Jabado, N., Li, X. N., Mueller, S., Nicolaides, T., Packer, R. J., Persson, A. I., Phillips, J. J., Simonds, E. F. & 4 others, Stafford, J. M., Tang, Y., Pfister, S. M. & Weiss, W. A., Jan 1 2017, In : Neuro-oncology. 19, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Pre-clinical study of panobinostat in xenograft and genetically engineered murine diffuse intrinsic pontine glioma models

Hennika, T., Hu, G., Olaciregui, N. G., Barton, K. L., Ehteda, A., Chitranjan, A., Chang, C., Gifford, A. J., Tsoli, M., Ziegler, D. S., Carcaboso, A. M. & Becher, O. J., Jan 2017, In : PloS one. 12, 1, e0169485.

Research output: Contribution to journalArticle

40 Scopus citations

Tumor-Specific Mutations in Gliomas and their Implications for Immunotherapy

Pirozzi, C. J., Carpenter, A. B., Hennika, T., Becher, O. J. & Yan, H., Mar 2 2017, Translational Immunotherapy of Brain Tumors. Sampson, J. (ed.). Elsevier Inc, p. 83-107 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor

Wells, E., Kambhampati, M., Damsker, J. M., Gordish-Dressman, H., Yadavilli, S., Becher, O. J., Gittens, J., Stampar, M., Packer, R. J. & Nazarian, J., Jan 1 2017, In : Oncotarget. 8, 6, p. 9366-9374 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

ABCG2 and ABCB1 limit the efficacy of dasatinib in a PDGF-B-driven brainstem glioma model

Mittapalli, R. K., Chung, A. H., Parrish, K. E., Crabtree, D., Halvorson, K. G., Hu, G., Elmquist, W. F. & Becher, O. J., May 2016, In : Molecular cancer therapeutics. 15, 5, p. 819-829 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells

Misuraca, K. L., Hu, G., Barton, K. L., Chung, A. & Becher, O. J., Jan 1 2016, In : Neoplasia. 18, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Diffuse intrinsic pontine glioma: Time for cautious optimism

Hennika, T. & Becher, O. J., Oct 1 2016, In : Journal of child neurology. 31, 12, p. 1377-1385 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetics of glioma

Hansen, L. J., Diplas, B. H., Becher, O. & Yan, H., Mar 31 2016, The Duke Glioma Handbook: Pathology, Diagnosis, and Management. Cambridge University Press, p. 1-23 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Pediatric neuro-oncology: Time to go molecular

Becher, O. J., May 15 2016, In : ONCOLOGY (United States). 30, 5

Research output: Contribution to journalArticle

Pediatric Neuro-Oncology: Time to Go Molecular

Becher, O. J., May 1 2016, In : Oncology (Williston Park, N.Y.). 30, 5, p. 424-425 2 p.

Research output: Contribution to journalComment/debate

Tumor location, but not H3.3K27M, significantly influences the blood–brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma

Subashi, E., Cordero, F. J., Halvorson, K. G., Qi, Y., Nouls, J. C., Becher, O. J. & Johnson, G. A., Jan 1 2016, In : Journal of Neuro-Oncology. 126, 2, p. 243-251 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

Research output: Contribution to journalArticle

29 Scopus citations

Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay

Becher, O. J. & Holland, E. C., Dec 14 2015, In : Cancer Cell. 28, 6, p. 679-680 2 p.

Research output: Contribution to journalShort survey

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Shen, Y., Li, J., Nitta, M., Futalan, D., Steed, T., Treiber, J. M., Taich, Z., Stevens, D., Wykosky, J., Chen, H. Z., Carter, B. S., Becher, O. J., Kennedy, R., Esashi, F., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K., Desai, A. & Chen, C. C., Jan 1 2015, In : Oncotarget. 6, 14, p. 11751-11767 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pre-clinical models of diffuse intrinsic pontine glioma

Misuraca, K. L., Cordero, F. J. & Becher, O. J., Jan 1 2015, In : Frontiers in Oncology. 5, JUL, 172.

Research output: Contribution to journalReview article

18 Scopus citations

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

Yadavilli, S., Scafidi, J., Becher, O. J., Saratsis, A. M., Hiner, R. L., Kambhampati, M., Mariarita, S., MacDonald, T. J., Codispoti, K. E., Magge, S. N., Jaiswal, J. K., Packer, R. J. & Nazarian, J., Jan 1 2015, In : Oncotarget. 6, 14, p. 12141-12155 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology

Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.

Research output: Contribution to journalReview article

30 Scopus citations

For pediatric glioma, leave no histone unturned

Becher, O. J. & Wechsler-Reya, R. J., Dec 19 2014, In : Science. 346, 6216, p. 1458-1459 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Castelo-Branco, P. & 32 others, Mangerel, J., Tabori, U., Ho, K. C., Huang, A., Taylor, K. R., Mackay, A., Bendel, A. E., Nazarian, J., Fangusaro, J. R., Karajannis, M. A., Zagzag, D., Foreman, N. K., Donson, A., Hegert, J. V., Smith, A., Chan, J., Lafay-Cousin, L., Dunn, S., Hukin, J., Dunham, C., Scheinemann, K., Michaud, J., Zelcer, S., Ramsay, D., Cain, J., Brennan, C., Souweidane, M. M., Jones, C., Allis, C. D., Brudno, M., Becher, O. & Hawkins, C., May 2014, In : Nature Genetics. 46, 5, p. 451-456 6 p.

Research output: Contribution to journalArticle

275 Scopus citations

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications

Buczkowicz, P., Bartels, U., Bouffet, E., Becher, O. & Hawkins, C., Jan 1 2014, In : Acta Neuropathologica. 128, 4, p. 573-581 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge

Sturm, D., Bender, S., Jones, D. T. W., Lichter, P., Grill, J., Becher, O., Hawkins, C., Majewski, J., Jones, C., Costello, J. F., Iavarone, A., Aldape, K., Brennan, C. W., Jabado, N. & Pfister, S. M., Feb 1 2014, In : Nature Reviews Cancer. 14, 2, p. 92-107 16 p.

Research output: Contribution to journalReview article

276 Scopus citations

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma

Misuraca, K. L., Barton, K. L., Chung, A., Diaz, A. K., Conway, S. J., Corcoran, D. L., Baker, S. J. & Becher, O. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 134.

Research output: Contribution to journalArticle

14 Scopus citations

Pediatric High-Grade Gliomas and DIPG

Becher, OJ., Barton, K., Halvorson, K. & McLendon, R., 2014, Molecular Pathology of Nervous System Tumors. Karajannis, M. & Zagzag, D. (eds.). New York: Springer New York, p. 95-104

Research output: Chapter in Book/Report/Conference proceedingChapter

Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma

Becher, O. J. & Holland, E. C., Jan 1 2014, In : EMBO Journal. 33, 18, p. 1984-1986 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma

Buczkowicz, P., Zarghooni, M., Bartels, U., Morrison, A., Misuraca, K. L., Chan, T., Bouffet, E., Huang, A., Becher, O. & Hawkins, C., May 1 2013, In : Brain Pathology. 23, 3, p. 244-253 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J. & Allis, C. D., May 17 2013, In : Science. 340, 6134, p. 857-861 5 p.

Research output: Contribution to journalArticle

554 Scopus citations

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

Barton, K. L., Misuraca, K., Cordero, F., Dobrikova, E., Min, H. D., Gromeier, M., Kirsch, D. G. & Becher, O. J., Oct 2 2013, In : PloS one. 8, 10, e77639.

Research output: Contribution to journalArticle

68 Scopus citations
2011

Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma

Polkinghorn, W. R., Dunkel, I. J., Souweidane, M. M., Khakoo, Y., Lyden, D. C., Gilheeney, S. W., Becher, O. J., Budnick, A. S. & Wolden, S. L., Nov 1 2011, In : International Journal of Radiation Oncology Biology Physics. 81, 3

Research output: Contribution to journalArticle

38 Scopus citations

Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-Deficient PDGF-driven murine glioblastoma

Pitter, K. L., Galbán, C. J., Galbán, S., Saeed-Tehrani, O., Li, F., Charles, N., Bradbury, M. S., Becher, O. J., Chenevert, T. L., Rehemtulla, A., Ross, B. D., Holland, E. C. & Hambardzumyan, D., Feb 2 2011, In : PloS one. 6, 1, e14545.

Research output: Contribution to journalArticle

58 Scopus citations

Reirradiation for recurrent medulloblastoma

Bakst, R. L., Dunkel, I. J., Gilheeney, S., Khakoo, Y., Becher, O., Souweidane, M. M. & Wolden, S. L., Nov 1 2011, In : Cancer. 117, 21, p. 4977-4982 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Evidence for and against regional differences in neural stem and progenitor cells of the CNS

Becher, O. J. & Holland, E. C., Oct 15 2010, In : Genes and Development. 24, 20, p. 2233-2238 6 p.

Research output: Contribution to journalReview article

6 Scopus citations

Heterozygosity for Ptenpromotes Tumorigenesis in a Mouse Model of Medulloblastoma

Castellino, R. C., Barwick, B. G., Schniederjan, M., Buss, M. C., Becher, O., Hambardzumyan, D., Macdonald, T. J., Brat, D. J. & Durden, D. L., Sep 17 2010, In : PloS one. 5, 5, e10849.

Research output: Contribution to journalArticle

33 Scopus citations

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

Becher, O. J., Hambardzumyan, D., Walker, T. R., Helmy, K., Nazarian, J., Albrecht, S., Hiner, R. L., Gall, S., Huse, J. T., Jabado, N., MacDonald, T. J. & Holland, E. C., Mar 15 2010, In : Cancer Research. 70, 6, p. 2548-2557 10 p.

Research output: Contribution to journalArticle

101 Scopus citations
2009

Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis

Becher, O. J., Souweidane, M., Lavi, E., Kramer, K., Lis, E., Marghoob, A. A. & Khakoo, Y., Jan 1 2009, In : Pediatric Dermatology. 26, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modeling adult gliomas using RCAS/t-va technology

Hambardzumyan, D., Amankulor, N. M., Helmy, K. Y., Becher, O. J. & Holland, E. C., Jun 2009, In : Translational Oncology. 2, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

131 Scopus citations

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

Amankulor, N. M., Hambardzumyan, D., Pyonteck, S. M., Becher, O. J., Joyce, J. A. & Holland, E. C., Aug 19 2009, In : Journal of Neuroscience. 29, 33, p. 10299-10308 10 p.

Research output: Contribution to journalArticle

130 Scopus citations
2008

Cancer stem cells and survival pathways

Hambardzumyan, D., Becher, O. J. & Holland, E. C., May 15 2008, In : Cell Cycle. 7, 10, p. 1371-1378 8 p.

Research output: Contribution to journalReview article

92 Scopus citations