• 3287 Citations
19992022

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Article
2020

ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma

Tsvankin, V., Hashizume, R., Katagi, H., Herndon, J. E., Lascola, C., Venkatraman, T. N., Picard, D., Burrus, B., Becher, O. J. & Thompson, E. M., May 1 2020, In : Neurosurgery. 86, 5, p. 742-751 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

12 Scopus citations

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Martinez-Velez, N., Marigil, M., García-Moure, M., Gonzalez-Huarriz, M., Aristu, J. J., Ramos-García, L. I., Tejada, S., Díez-Valle, R., Patiño-García, A., Becher, O. J., Gomez-Manzano, C., Fueyo, J. & Alonso, M. M., Apr 29 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas

Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, Hashizume, R., Broniscer, A., Pollack, I. F. & Agnihotri, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.

Research output: Contribution to journalArticle

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

Martínez-Vélez, N., Garcia-Moure, M., Marigil, M., González-Huarriz, M., Puigdelloses, M., Gallego Pérez-Larraya, J., Zalacaín, M., Marrodán, L., Varela-Guruceaga, M., Laspidea, V., Aristu, J. J., Ramos, L. I., Tejada-Solís, S., Díez-Valle, R., Jones, C., Mackay, A., Martínez-Climent, J. A., García-Barchino, M. J., Raabe, E., Monje, M. & 10 others, Becher, O. J., Junier, M. P., El-Habr, E. A., Chneiweiss, H., Aldave, G., Jiang, H., Fueyo, J., Patiño-García, A., Gomez-Manzano, C. & Alonso, M. M., May 28 2019, In : Nature communications. 10, 1, 2235.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity

Harward, S., Harrison Farber, S., Malinzak, M., Becher, O. J. & Thompson, E. M., Mar 1 2018, In : Child's Nervous System. 34, 3, p. 449-455 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma

Kushner, B. H., Cheung, N. K. V., Modak, S., Becher, O. J., Basu, E. M., Roberts, S. S., Kramer, K. & Dunkel, I. J., Jan 15 2017, In : International Journal of Cancer. 140, 2, p. 480-484 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors

Becher, O. J., Gilheeney, S. W., Khakoo, Y., Lyden, D. C., Haque, S., De Braganca, K. C., Kolesar, J. M., Huse, J. T., Modak, S., Wexler, L. H., Kramer, K., Spasojevic, I. & Dunkel, I. J., Jul 1 2017, In : Pediatric Blood and Cancer. 64, 7, e26409.

Research output: Contribution to journalArticle

17 Scopus citations

A phase i study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors

Becher, O. J., Millard, N. E., Modak, S., Kushner, B. H., Haque, S., Spasojevic, I., Trippett, T. M., Gilheeney, S. W., Khakoo, Y., Lyden, D. C., De Braganca, K. C., Kolesar, J. M., Huse, J. T., Kramer, K., Cheung, N. K. V. & Dunkel, I. J., Jun 1 2017, In : PLoS One. 12, 6, e0178593.

Research output: Contribution to journalArticle

9 Scopus citations

Histone H3.3K27M represses p16 to accelerate gliomagenesis in a murine model of DIPG

Cordero, F. J., Huang, Z., Grenier, C., He, X., Hu, G., McLendon, R. E., Murphy, S. K., Hashizume, R. & Becher, O. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1243-1254 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pediatric high-grade glioma: Biologically and clinically in need of new thinking

Jones, C., Karajannis, M. A., Jones, D. T. W., Kieran, M. W., Monje, M., Baker, S. J., Becher, O. J., Cho, Y. J., Gupta, N., Hawkins, C., Hargrave, D., Haas-Kogan, D. A., Jabado, N., Li, X. N., Mueller, S., Nicolaides, T., Packer, R. J., Persson, A. I., Phillips, J. J., Simonds, E. F. & 4 others, Stafford, J. M., Tang, Y., Pfister, S. M. & Weiss, W. A., Jan 1 2017, In : Neuro-oncology. 19, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Pre-clinical study of panobinostat in xenograft and genetically engineered murine diffuse intrinsic pontine glioma models

Hennika, T., Hu, G., Olaciregui, N. G., Barton, K. L., Ehteda, A., Chitranjan, A., Chang, C., Gifford, A. J., Tsoli, M., Ziegler, D. S., Carcaboso, A. M. & Becher, O. J., Jan 2017, In : PloS one. 12, 1, e0169485.

Research output: Contribution to journalArticle

46 Scopus citations

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor

Wells, E., Kambhampati, M., Damsker, J. M., Gordish-Dressman, H., Yadavilli, S., Becher, O. J., Gittens, J., Stampar, M., Packer, R. J. & Nazarian, J., Jan 1 2017, In : Oncotarget. 8, 6, p. 9366-9374 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

ABCG2 and ABCB1 limit the efficacy of dasatinib in a PDGF-B-driven brainstem glioma model

Mittapalli, R. K., Chung, A. H., Parrish, K. E., Crabtree, D., Halvorson, K. G., Hu, G., Elmquist, W. F. & Becher, O. J., May 2016, In : Molecular cancer therapeutics. 15, 5, p. 819-829 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells

Misuraca, K. L., Hu, G., Barton, K. L., Chung, A. & Becher, O. J., Jan 1 2016, In : Neoplasia. 18, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Diffuse intrinsic pontine glioma: Time for cautious optimism

Hennika, T. & Becher, O. J., Oct 1 2016, In : Journal of child neurology. 31, 12, p. 1377-1385 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pediatric neuro-oncology: Time to go molecular

Becher, O. J., May 15 2016, In : ONCOLOGY (United States). 30, 5

Research output: Contribution to journalArticle

Tumor location, but not H3.3K27M, significantly influences the blood–brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma

Subashi, E., Cordero, F. J., Halvorson, K. G., Qi, Y., Nouls, J. C., Becher, O. J. & Johnson, G. A., Jan 1 2016, In : Journal of Neuro-Oncology. 126, 2, p. 243-251 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

Research output: Contribution to journalArticle

29 Scopus citations

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Shen, Y., Li, J., Nitta, M., Futalan, D., Steed, T., Treiber, J. M., Taich, Z., Stevens, D., Wykosky, J., Chen, H. Z., Carter, B. S., Becher, O. J., Kennedy, R., Esashi, F., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K., Desai, A. & Chen, C. C., Jan 1 2015, In : Oncotarget. 6, 14, p. 11751-11767 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

Yadavilli, S., Scafidi, J., Becher, O. J., Saratsis, A. M., Hiner, R. L., Kambhampati, M., Mariarita, S., MacDonald, T. J., Codispoti, K. E., Magge, S. N., Jaiswal, J. K., Packer, R. J. & Nazarian, J., Jan 1 2015, In : Oncotarget. 6, 14, p. 12141-12155 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Castelo-Branco, P. & 32 others, Mangerel, J., Tabori, U., Ho, K. C., Huang, A., Taylor, K. R., Mackay, A., Bendel, A. E., Nazarian, J., Fangusaro, J. R., Karajannis, M. A., Zagzag, D., Foreman, N. K., Donson, A., Hegert, J. V., Smith, A., Chan, J., Lafay-Cousin, L., Dunn, S., Hukin, J., Dunham, C., Scheinemann, K., Michaud, J., Zelcer, S., Ramsay, D., Cain, J., Brennan, C., Souweidane, M. M., Jones, C., Allis, C. D., Brudno, M., Becher, O. & Hawkins, C., May 2014, In : Nature Genetics. 46, 5, p. 451-456 6 p.

Research output: Contribution to journalArticle

281 Scopus citations

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications

Buczkowicz, P., Bartels, U., Bouffet, E., Becher, O. & Hawkins, C., Jan 1 2014, In : Acta Neuropathologica. 128, 4, p. 573-581 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma

Misuraca, K. L., Barton, K. L., Chung, A., Diaz, A. K., Conway, S. J., Corcoran, D. L., Baker, S. J. & Becher, O. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 134.

Research output: Contribution to journalArticle

16 Scopus citations

Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma

Becher, O. J. & Holland, E. C., Jan 1 2014, In : EMBO Journal. 33, 18, p. 1984-1986 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma

Buczkowicz, P., Zarghooni, M., Bartels, U., Morrison, A., Misuraca, K. L., Chan, T., Bouffet, E., Huang, A., Becher, O. & Hawkins, C., May 1 2013, In : Brain Pathology. 23, 3, p. 244-253 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J. & Allis, C. D., May 17 2013, In : Science. 340, 6134, p. 857-861 5 p.

Research output: Contribution to journalArticle

570 Scopus citations

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

Barton, K. L., Misuraca, K., Cordero, F., Dobrikova, E., Min, H. D., Gromeier, M., Kirsch, D. G. & Becher, O. J., Oct 2 2013, In : PloS one. 8, 10, e77639.

Research output: Contribution to journalArticle

70 Scopus citations
2011

Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma

Polkinghorn, W. R., Dunkel, I. J., Souweidane, M. M., Khakoo, Y., Lyden, D. C., Gilheeney, S. W., Becher, O. J., Budnick, A. S. & Wolden, S. L., Nov 1 2011, In : International Journal of Radiation Oncology Biology Physics. 81, 3

Research output: Contribution to journalArticle

38 Scopus citations

Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-Deficient PDGF-driven murine glioblastoma

Pitter, K. L., Galbán, C. J., Galbán, S., Saeed-Tehrani, O., Li, F., Charles, N., Bradbury, M. S., Becher, O. J., Chenevert, T. L., Rehemtulla, A., Ross, B. D., Holland, E. C. & Hambardzumyan, D., Feb 2 2011, In : PloS one. 6, 1, e14545.

Research output: Contribution to journalArticle

59 Scopus citations

Reirradiation for recurrent medulloblastoma

Bakst, R. L., Dunkel, I. J., Gilheeney, S., Khakoo, Y., Becher, O., Souweidane, M. M. & Wolden, S. L., Nov 1 2011, In : Cancer. 117, 21, p. 4977-4982 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Heterozygosity for Ptenpromotes Tumorigenesis in a Mouse Model of Medulloblastoma

Castellino, R. C., Barwick, B. G., Schniederjan, M., Buss, M. C., Becher, O., Hambardzumyan, D., Macdonald, T. J., Brat, D. J. & Durden, D. L., Sep 17 2010, In : PloS one. 5, 5, e10849.

Research output: Contribution to journalArticle

33 Scopus citations

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

Becher, O. J., Hambardzumyan, D., Walker, T. R., Helmy, K., Nazarian, J., Albrecht, S., Hiner, R. L., Gall, S., Huse, J. T., Jabado, N., MacDonald, T. J. & Holland, E. C., Mar 15 2010, In : Cancer Research. 70, 6, p. 2548-2557 10 p.

Research output: Contribution to journalArticle

101 Scopus citations
2009

Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis

Becher, O. J., Souweidane, M., Lavi, E., Kramer, K., Lis, E., Marghoob, A. A. & Khakoo, Y., Jan 1 2009, In : Pediatric Dermatology. 26, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modeling adult gliomas using RCAS/t-va technology

Hambardzumyan, D., Amankulor, N. M., Helmy, K. Y., Becher, O. J. & Holland, E. C., Jun 2009, In : Translational Oncology. 2, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

Amankulor, N. M., Hambardzumyan, D., Pyonteck, S. M., Becher, O. J., Joyce, J. A. & Holland, E. C., Aug 19 2009, In : Journal of Neuroscience. 29, 33, p. 10299-10308 10 p.

Research output: Contribution to journalArticle

133 Scopus citations
2008

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

Becher, O. J., Hambardzumyan, D., Fomchenko, E. I., Momota, H., Mainwaring, L., Bleau, A. M., Katz, A. M., Edgar, M., Kenney, A. M., Cordon-Cardo, C., Blasberg, R. G. & Holland, E. C., Apr 1 2008, In : Cancer Research. 68, 7, p. 2241-2249 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK

Becher, O. J., Peterson, K. M., Khatua, S., Santi, M. R. & MacDonald, T. J., Oct 15 2008, In : Journal of Child Neurology. 23, 10, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

Hambardzumyan, D., Becher, O. J., Rosenblum, M. K., Pandolfi, P. P., Manova-Todorova, K. & Holland, E. C., Feb 15 2008, In : Genes and Development. 22, 4, p. 436-448 13 p.

Research output: Contribution to journalArticle

344 Scopus citations
2006

Medulloblastoma: Therapy and biologic considerations

Gershon, T. R. & Becher, O. J., May 1 2006, In : Current neurology and neuroscience reports. 6, 3, p. 200-206 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

Reasons for pediatrician nonadherence to asthma guidelines

Cabana, M. D., Rand, C. S., Becher, O. J. & Rubin, H. R., Jan 1 2001, In : Archives of Pediatrics and Adolescent Medicine. 155, 9, p. 1057-1062 6 p.

Research output: Contribution to journalArticle

216 Scopus citations
2000

Histiocytoid cardiomyopathy presenting with Wolff-Parkinson-White syndrome

Cabana, M. D., Becher, O. & Smith, A., May 31 2000, In : Heart. 83, 1, p. 98-99 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
1999

Patellofemoral complications after total knee arthroplasty: a comparison of Modular Porous-Coated Anatomic with Duracon prostheses.

Mont, M. A., Becher, O. J., Lee, C. W., LaPorte, D. M. & Hungerford, D. S., Apr 1999, In : American journal of orthopedics (Belle Mead, N.J.). 28, 4, p. 241-247 7 p.

Research output: Contribution to journalArticle

2 Scopus citations