Pamela J Focia

  • 1958 Citations
19952020

Research output per year

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Research Output

  • 1958 Citations
  • 38 Article
  • 2 Comment/debate
2020

DNA-Directed Protein Packing within Single Crystals

Winegar, P. H., Hayes, O. G., McMillan, J. R., Figg, C. A., Focia, P. J. & Mirkin, C. A., Apr 9 2020, In : Chem. 6, 4, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Klosowiak, J. L., Park, S., Smith, K. P., French, M. E., Focia, P. J., Freymann, D. M. & Rice, S. E., Sep 8 2016, In : Scientific reports. 6, 33019.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Structures of KcsA in complex with symmetrical quaternary ammonium compounds reveal a hydrophobic binding site

Lenaeus, M. J., Burdette, D., Wagner, T., Focia, P. J. & Gross, A., Aug 19 2014, In : Biochemistry. 53, 32, p. 5365-5373 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

Klosowiak, J. L., Focia, P. J., Chakravarthy, S., Landahl, E. C., Freymann, D. M. & Rice, S. E., Nov 1 2013, In : EMBO Reports. 14, 11, p. 968-974 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge)

Freymann, D. M., Nakamura, Y., Focia, P. J., Sakai, R. & Swanson, G. T., Sep 1 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 9, p. 1163-1174 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules

Liu, H., Focia, P. J. & He, X., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 797-805 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Electron spin-echo envelope modulation (ESEEM) reveals water and phosphate interactions with the KcsA potassium channel

Cieslak, J. A., Focia, P. J. & Gross, A., Feb 23 2010, In : Biochemistry. 49, 7, p. 1486-1494 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

Liu, H., Juo, Z. S., Shim, A. H. R., Focia, P. J., Chen, X., Garcia, K. C. & He, X., Sep 3 2010, In : Cell. 142, 5, p. 749-761 13 p.

Research output: Contribution to journalArticle

93 Scopus citations

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Shim, A. H. R., Liu, H., Focia, P. J., Chen, X., Lin, P. C. & He, X., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11307-11312 6 p.

Research output: Contribution to journalArticle

97 Scopus citations
2008

Cu(I) recognition via cation-π and methionine interactions in CusF

Xue, Y., Davis, A. V., Balakrishnan, G., Stasser, J. P., Staehlin, B. M., Focia, P., Spiro, T. G., Penner-Hahn, J. E. & O'Halloran, T. V., Feb 2008, In : Nature Chemical Biology. 4, 2, p. 107-109 3 p.

Research output: Contribution to journalArticle

164 Scopus citations

Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh

Ramirez, U. D., Focia, P. J. & Freymann, D. M., Sep 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 10, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions

Chen, X., Liu, H., Shim, A. H. R., Focia, P. J. & He, X., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
54 Scopus citations
2007

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases

Liu, H., Chen, X., Focia, P. J. & He, X., Feb 7 2007, In : EMBO Journal. 26, 3, p. 891-901 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

X-ray structure of the T. aquaticus Ftsy:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases

Gawronski-Salerno, J., Coon V, J. S., Focia, P. J. & Freymann, D. M., Mar 1 2007, In : Proteins: Structure, Function and Genetics. 66, 4, p. 984-995 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site

Focia, P. J., Gawronski-Salerno, J., Coon V, J. S. & Freymann, D. M., Jul 14 2006, In : Journal of Molecular Biology. 360, 3, p. 631-643 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2005

Structural basis of TEA blockade in a model potassium channel

Lenaeus, M. J., Vamvouka, M., Focia, P. J. & Gross, A., May 1 2005, In : Nature Structural and Molecular Biology. 12, 5, p. 454-459 6 p.

Research output: Contribution to journalArticle

105 Scopus citations
2004

Heterodimeric GTPase Core of the SRP Targeting Complex

Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A. & Freymann, D. M., Jan 16 2004, In : Science. 303, 5656, p. 373-377 5 p.

Research output: Contribution to journalArticle

204 Scopus citations

Interactions at the Dimer Interface Influence the Relative Efficiencies for Purine Nucleotide Synthesis and Pyrophosphorolysis in a Phosphoribosyltransferase

Canyuk, B., Medrano, F. J., Wenck, M. A., Focia, P. J., Eakin, A. E. & Craig, S. P., Jan 23 2004, In : Journal of Molecular Biology. 335, 4, p. 905-921 17 p.

Research output: Contribution to journalArticle

27 Scopus citations

Novel Protein and Mg2+ Configurations in the Mg2+GDP Complex of the SRP GTPase Ffh

Focia, P. J., Alam, H., Lu, T., Ramirez, U. D. & Freymann, D. M., Feb 1 2004, In : Proteins: Structure, Function and Genetics. 54, 2, p. 222-230 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2003

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

Velentza, A. V., Wainwright, M., Zasadzki, M., Mirzoeva, S., Schumacher, A. M., Haiech, J., Focia, P. J., Egli, M. & Watterson, D. M., Oct 20 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3465-3470 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY

Shepotinovskaya, I. V., Focia, P. J. & Freymann, D. M., Oct 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 10, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nanomolar inhibitors of AmpC β-lactamase

Morandi, F., Caselli, E., Morandi, S., Focia, P. J., Blázquez, J., Shoichet, B. K. & Prati, F., Jan 22 2003, In : Journal of the American Chemical Society. 125, 3, p. 685-695 11 p.

Research output: Contribution to journalArticle

101 Scopus citations
2002
1 Scopus citations

Structural basis for mobility in the 1.1 Å crystal structure of the NG domain of Thermus aquaticus Ffh

Ramirez, U. D., Minasov, G., Focia, P. J., Stroud, R. M., Walter, P., Kuhn, P. & Freymann, D. M., Jan 1 2002, In : Journal of Molecular Biology. 320, 4, p. 783-799 17 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structural milestones in the reaction pathway of an amide hydrolase: Substrate, acyl, and product complexes of cephalothin with AmpC β-lactamase

Beadle, B. M., Trehan, I., Focia, P. J. & Shoichet, B. K., Mar 26 2002, In : Structure. 10, 3, p. 413-424 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
2001

Structures of ceftazidime and its transition-state analogue in complex with AmpC β-lactamase: Implications for resistance mutations and inhibitor design

Powers, R. A., Caselli, E., Focia, P. J., Prati, F. & Shoichet, B. K., Aug 7 2001, In : Biochemistry. 40, 31, p. 9207-9214 8 p.

Research output: Contribution to journalArticle

92 Scopus citations
19 Scopus citations
2000

Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi

Freymann, D. M., Wenck, M. A., Engel, J. C., Feng, J., Focia, P. J., Eakin, A. E. & Craig, S. P., Jan 1 2000, In : Chemistry and Biology. 7, 12, p. 957-968 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
1999

Erratum: Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding (Protein Science (1999) 8:5 (1023-1031))

Balendiran, G. K., Molina, J. A., Xu, Y., Torres-Martinez, J., Stevens, R., Focia, P. J., Eakin, A. E., Sacchettini, J. C. & Craig, S. P., Dec 1 1999, In : Protein Science. 8, 12, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding

Balendiran, G. K., Molina, J. A., Xu, Y., Torres-Martinez, J., Stevens, R., Focia, P. J., Eakin, A. E., Sacchettini, J. C. & Craig, S. P., Jan 1 1999, In : Protein Science. 8, 5, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
1998

A 1.4 Å Crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi

Focia, P. J., Craig, S. P., Nieves-Alicea, R., Fletterick, R. J. & Eakin, A. E., Oct 27 1998, In : Biochemistry. 37, 43, p. 15066-15075 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Approaching the transition state in the crystal structure of a phosphoribosyltransferase

Focia, P. J., Craig, S. P. & Eakin, A. E., Dec 8 1998, In : Biochemistry. 37, 49, p. 17120-17127 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
6 Scopus citations
1997

Crystallographic studies of parasite hgprtases pamela

Focia, J., Somoza, J. R. & Freymann, D. M., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: Crystallization and inhibition studies with purine analogs

Eakin, A. E., Guerra, A., Focia, P. J., Torres-Martinez, J. & Craig, S. P., Aug 1 1997, In : Antimicrobial agents and chemotherapy. 41, 8, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
6 Scopus citations

The crystal structure of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) from trypanosoma cruzi

Eakin, A. E., Focia, P. J., Nieves-Alicea, R., Craig, S. P. & Fletterick, R. J., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

1996

Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus

Somoza, J. R., Chin, M. S., Focia, P. J., Wang, C. C. & Fletterick, R. J., Jun 4 1996, In : Biochemistry. 35, 22, p. 7032-7040 9 p.

Research output: Contribution to journalArticle

102 Scopus citations
1995

Identification of the Active Sites of Human and Schistosomal Hypoxanthine-Guanine Phosphoribosyltransferases by GMP-2’,3'-dialdehyde Affinity Labeling

Kanaani, J., Maltby, D., Focia, P. & Wang, C. C., Jan 1 1995, In : Biochemistry. 34, 46, p. 14987-14996 10 p.

Research output: Contribution to journalArticle

14 Scopus citations