• 1490 Citations
20122022
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Personal profile

Research Interests

The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri- dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. To address these questions we use high-throughput molecular and cell biology techniques like ChIP-Seq, RNA-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c. in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help us design and test targeted therapies in preclinical models of leukemia.

Training Experience

2015Postdoctoral Fellowship, New York University

Education/Academic qualification

PhD, University of Athens

… → 2009

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Chromatin
  • Gene Regulation
  • Molecular Genetics

Fingerprint Dive into the research topics where Panagiotis Ntziachristos is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 16 Similar Profiles
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Genes Chemical Compounds
T-cells Chemical Compounds
Chromatin Medicine & Life Sciences
Cell Differentiation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2015 2022

Chromatin
Aptitude
Eukaryotic Cells
Technology
Regeneration
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Ataxia Telangiectasia
Ubiquitin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Damage
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Drug Resistance
Drug Therapy
Therapeutics

Research Output 2012 2019

  • 1490 Citations
  • 20 Article
  • 4 Review article
  • 1 Short survey

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., Shulman, G. I., Goldberg, I. J. & Drosatos, K., Sep 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 9, p. 2125-2137 13 p.

Research output: Contribution to journalArticle

White Adipose Tissue
Cardiac Myocytes
Body Weight
Peroxisome Proliferator-Activated Receptors
Obesity
1 Citation (Scopus)

Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease

Rawat, R., Starczynowski, D. T. & Ntziachristos, P., Jun 1 2019, In : Current Opinion in Cell Biology. 58, p. 85-94 10 p.

Research output: Contribution to journalReview article

Ubiquitin-Specific Proteases
Post Translational Protein Processing
Ubiquitin
Sumoylation
Protein Stability

PHF6: It is written in the stem cells

Ntziachristos, P., Jun 6 2019, In : Blood. 133, 23, p. 2461-2462 2 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Fingers
Stem Cells
Hematopoietic Stem Cells
Ablation
7 Citations (Scopus)

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 others, Goosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Specific Proteases
T-Cell Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromatin
20 Citations (Scopus)

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

Epigenomics
Tumors
Methyltransferases
Histones
Mutation