Grants per year
Personal profile
Research Interests
The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri- dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. To address these questions we use high-throughput molecular and cell biology techniques like ChIP-Seq, RNA-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c. in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help us design and test targeted therapies in preclinical models of leukemia.
Training Experience
2015 | Postdoctoral Fellowship, New York University |
Education/Academic qualification
PhD, National and Kapodistrian University of Athens
… → 2009
Research interests
- Blood Cancer (leukemia and lymphomas)
- Chromatin
- Gene Regulation
- Molecular Genetics
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Grants
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Therapeutic targeting of demethylation-deubiquitination axis in acute leukemia
4/1/20 → 3/31/25
Project: Research project
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Transcriptional Control of Cellular Survival and Proliferation in KSHV-transformed B Cells
Bartom, E. T., Gottwein, E. & Ntziachristos, P.
3/1/20 → 3/31/25
Project: Research project
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EFRI-CEE: Epigenetic Cell Reprogramming In Situ: A Novel Tool for Regenerative Engineering
Ameer, G. A., Backman, V., Ntziachristos, P., Subramanian, H. & Taflove, A.
9/1/18 → 8/31/22
Project: Research project
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Delineating the Pro-oncogenic Role of Deubiquitination in High-Risk Acute Lymphoblastic Leukemia
6/1/18 → 5/31/21
Project: Research project
Research Output
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C., Wang, Z., Han, C., Safgren, S. L., Helmin, K. A., Adelman, E. R., Serafin, V., Basso, G., Eagen, K. P., Gaspar-Maia, A., Figueroa, M. E., Singer, B. D., Ratan, A., Ntziachristos, P. & Zang, C., Sep 15 2020, In: Genome biology. 21, 1, 247.Research output: Contribution to journal › Article › peer-review
Open Access -
Determinants and role of chromatin organization in acute leukemia
Fang, C., Rao, S., Crispino, J. D. & Ntziachristos, P., Oct 1 2020, In: Leukemia. 34, 10, p. 2561-2575 15 p.Research output: Contribution to journal › Review article › peer-review
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Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies
Gutierrez-Diaz, B. T., Gu, W. & Ntziachristos, P., Apr 2020, In: Trends in Immunology. 41, 4, p. 327-340 14 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
iAMPlified gene expression offers new insights in B cell precursor leukemia subtype
Ntziachristos, P., Feb 23 2020, In: Leukemia and Lymphoma. 61, 3, p. 501-503 3 p.Research output: Contribution to journal › Comment/debate › peer-review
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Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
Kloetgen, A., Thandapani, P., Ntziachristos, P., Ghebrechristos, Y., Nomikou, S., Lazaris, C., Chen, X., Hu, H., Bakogianni, S., Wang, J., Fu, Y., Boccalatte, F., Zhong, H., Paietta, E., Trimarchi, T., Zhu, Y., Van Vlierberghe, P., Inghirami, G. G., Lionnet, T., Aifantis, I. & 1 others, , Apr 1 2020, In: Nature Genetics. 52, 4, p. 388-400 13 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations