• 1694 Citations
20122020

Research output per year

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Personal profile

Research Interests

The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri- dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. To address these questions we use high-throughput molecular and cell biology techniques like ChIP-Seq, RNA-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c. in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help us design and test targeted therapies in preclinical models of leukemia.

Training Experience

2015Postdoctoral Fellowship, New York University

Education/Academic qualification

PhD, National and Kapodistrian University of Athens

… → 2009

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Chromatin
  • Gene Regulation
  • Molecular Genetics

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Grants

  • Research Output

    • 1694 Citations
    • 21 Article
    • 5 Review article
    • 1 Comment/debate
    • 1 Short survey

    Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies

    Gutierrez-Diaz, B. T., Gu, W. & Ntziachristos, P., Apr 2020, In : Trends in Immunology. 41, 4, p. 327-340 14 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    iAMPlified gene expression offers new insights in B cell precursor leukemia subtype

    Ntziachristos, P., Feb 23 2020, In : Leukemia and Lymphoma. 61, 3, p. 501-503 3 p.

    Research output: Contribution to journalComment/debate

    Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

    Kloetgen, A., Thandapani, P., Ntziachristos, P., Ghebrechristos, Y., Nomikou, S., Lazaris, C., Chen, X., Hu, H., Bakogianni, S., Wang, J., Fu, Y., Boccalatte, F., Zhong, H., Paietta, E., Trimarchi, T., Zhu, Y., Van Vlierberghe, P., Inghirami, G. G., Lionnet, T., Aifantis, I. & 1 others, Tsirigos, A., Apr 1 2020, In : Nature Genetics. 52, 4, p. 388-400 13 p.

    Research output: Contribution to journalArticle

  • Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

    Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., Shulman, G. I., Goldberg, I. J. & Drosatos, K., Sep 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 9, p. 2125-2137 13 p.

    Research output: Contribution to journalArticle

  • Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease

    Rawat, R., Starczynowski, D. T. & Ntziachristos, P., Jun 2019, In : Current Opinion in Cell Biology. 58, p. 85-94 10 p.

    Research output: Contribution to journalReview article

  • 7 Scopus citations