Patrick Casey Seed

  • 3419 Citations
19952020

Research output per year

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Personal profile

Research Interests

Patrick C. Seed, MD, Ph.D., is Associate Chief Research Officer for Basic Sciences at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. He is a Professor of Pediatrics and Microbiology & Immunology at Northwestern University Feinberg School of Medicine, and Division Head and Attending Physician in Lurie Children’s Division of Infectious Diseases. Dr. Seed’s lab aims to translate molecular knowledge of microbial/microbiome genetics, physiology, and pathogenesis into diagnostics and treatments for a broad range of pediatric diseases. He joined Lurie Children’s in October 2016 from Duke University, where he served as an Associate Professor of Pediatrics, Molecular Genetics and Microbiology and Surgery. Dr. Seed was also an Attending Physician in pediatric infectious diseases at Duke University Medicine Center. He received his medical degree and doctorate from the University of Rochester School of Medicine and completed his residency in pediatrics at the University of Michigan Hospital. Dr. Seed completed his fellowship in pediatric infectious diseases and postdoctoral training at Washington University School of Medicine/St. Louis Children’s Hospital.

The Seed Research Group broadly studies the interactions of mammals and microbes to understand how microbial communities alter health and disease and how pathogenic microbes emerge from those communities to cause specific infections of the urinary tract, blood, and central nervous system. Our work combines clinical human studies, conventional and germ-free animal models, molecular genetics, immunology, biochemistry, structural biology, high-dimensional data computational analysis, and a number of complementary 'omics technologies including genomics, metagenomics, transcriptomics, metatranscriptomics, and metabolomics to understand complex systems. We use the lessons learned from these molecular studies to design new diagnostics and therapeutics.

Dr. Seed provides clinical consultation and expertise for a variety of complex pediatric infectious diseases including infections of children with multidrug-resistant infections, compromised immune systems, and organ and stem cell transplantation.

Education/Academic qualification

MD, University of Rochester

… → 1998

PhD, University of Rochester

… → 1996

Research interests

  • Bladder and Urinary Tract
  • Cellular Microbiology
  • Infectious Diseases in Children
  • Microbial Pathogenesis
  • Microbiology
  • Microbiome
  • Microbiota

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Grants

Research Output

  • 3419 Citations
  • 62 Article
  • 6 Review article
  • 4 Comment/debate
  • 1 Short survey

Correction: Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria (ACS Infectious Diseases (2018)4:6(1019-1029)DOI: 10.1021/acsinfecdis.8b00037)

Zaengle-Barone, J. M., Jackson, A. C., Besse, D. M., Becken, B., Arshad, M., Seed, P. C. & Franz, K. J., Apr 10 2020, In : ACS Infectious Diseases. 6, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access
  • Long-term stability of microbiome diversity and composition in fecal samples stored in eNAT medium

    Young, R. R., Jenkins, K., Araujo-Perez, F., Seed, P. C. & Kelly, M. S., Jul 1 2020, In : MicrobiologyOpen. 9, 7, e1046.

    Research output: Contribution to journalArticle

    Open Access
  • The gut of healthy infants in the community as a reservoir of esbl and carbapenemase- producing bacteria

    Saleem, A. F., Allana, A., Hale, L., Diaz, A., Salinas, R., Salinas, C., Qureshi, S. M., Hotwani, A., Rahman, N., Khan, A., Zaidi, A. K., Seed, P. C. & Arshad, M., Jun 2020, In : Antibiotics. 9, 6, 286.

    Research output: Contribution to journalArticle

    Open Access
  • Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

    Qi, C., Hountras, P., Pickens, C. O., Walter, J. M., Kruser, J. M., Singer, B. D., Seed, P., Green, S. J. & Wunderink, R. G., Jul 2019, In : Journal of medical microbiology. 68, 7, p. 996-1002 7 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations