Patrick Casey Seed

  • 3242 Citations
1995 …2022

Research output per year

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Personal profile

Research Interests

Patrick C. Seed, MD, Ph.D., is Associate Chief Research Officer for Basic Sciences at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. He is a Professor of Pediatrics and Microbiology & Immunology at Northwestern University Feinberg School of Medicine, and Division Head and Attending Physician in Lurie Children’s Division of Infectious Diseases. Dr. Seed’s lab aims to translate molecular knowledge of microbial/microbiome genetics, physiology, and pathogenesis into diagnostics and treatments for a broad range of pediatric diseases. He joined Lurie Children’s in October 2016 from Duke University, where he served as an Associate Professor of Pediatrics, Molecular Genetics and Microbiology and Surgery. Dr. Seed was also an Attending Physician in pediatric infectious diseases at Duke University Medicine Center. He received his medical degree and doctorate from the University of Rochester School of Medicine and completed his residency in pediatrics at the University of Michigan Hospital. Dr. Seed completed his fellowship in pediatric infectious diseases and postdoctoral training at Washington University School of Medicine/St. Louis Children’s Hospital.

The Seed Research Group broadly studies the interactions of mammals and microbes to understand how microbial communities alter health and disease and how pathogenic microbes emerge from those communities to cause specific infections of the urinary tract, blood, and central nervous system. Our work combines clinical human studies, conventional and germ-free animal models, molecular genetics, immunology, biochemistry, structural biology, high-dimensional data computational analysis, and a number of complementary 'omics technologies including genomics, metagenomics, transcriptomics, metatranscriptomics, and metabolomics to understand complex systems. We use the lessons learned from these molecular studies to design new diagnostics and therapeutics.

Dr. Seed provides clinical consultation and expertise for a variety of complex pediatric infectious diseases including infections of children with multidrug-resistant infections, compromised immune systems, and organ and stem cell transplantation.

Education/Academic qualification

MD, University of Rochester

… → 1998

PhD, University of Rochester

… → 1996

Research interests

  • Bladder and Urinary Tract
  • Cellular Microbiology
  • Infectious Diseases in Children
  • Microbial Pathogenesis
  • Microbiology
  • Microbiome
  • Microbiota

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Grants

Research Output

  • 3242 Citations
  • 60 Article
  • 6 Review article
  • 3 Comment/debate
  • 1 Short survey
  • Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

    Qi, C., Hountras, P., Pickens, C. O., Walter, J. M., Kruser, J. M., Singer, B. D., Seed, P., Green, S. J. & Wunderink, R. G., Jul 2019, In : Journal of medical microbiology. 68, 7, p. 996-1002 7 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

    Younge, N. E., Newgard, C. B., Cotten, C. M., Goldberg, R. N., Muehlbauer, M. J., Bain, J. R., Stevens, R. D., O’Connell, T. M., Rawls, J. F., Seed, P. C. & Ashley, P. L., Dec 1 2019, In : Scientific reports. 9, 1, 8167.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Fetal exposure to the maternal microbiota in humans and mice

    Younge, N., McCann, J. R., Ballard, J., Plunkett, C., Akhtar, S., Araújo-Pérez, F., Murtha, A., Brandon, D. & Seed, P. C., Jan 1 2019, In : JCI Insight. 4, 19, e127806.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients

    Kelly, M. S., Ward, D. V., Severyn, C. J., Arshad, M., Heston, S. M., Jenkins, K., Martin, P. L., McGill, L., Stokhuyzen, A., Bhattarai, S. K., Bucci, V. & Seed, P. C., Nov 2019, In : Biology of Blood and Marrow Transplantation. 25, 11, p. 2274-2280 7 p.

    Research output: Contribution to journalArticle