• 2960 Citations
1990 …2020

Research output per year

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Personal profile

Research Interests

The primary focus of the Kiser research group is developing and translating new drug delivery technologies for the prevention and treatment of HIV infection. We are particularly interested in new antiviral agents and drug delivery systems to intercept sexually transmitted viruses at the point of interaction with the genital mucosa and the first target cells infected in the mucosa. Our methods include synthetic polymer chemistry, pharmaceutical chemistry, modeling drug transport, and using these results in drug delivery system design and prototyping. We perform preclinical toxicity efficacy evaluations in cell, tissue, and animal models; conduct antiviral assays and drug transport assays; and produce devices using a variety of pharmaceutical manufacturing technologies. Our projects range from new materials discovery that could lead to next generation mucosally active antiviral agents and mucosal vaccines, to the development of new assays to evaluate HIV prevention technologies, to sustained delivery system projects for antiviral, anti-infectives and contraceptive agents. The lab is funded by the NIH (NIAD), the Bill and Melinda Gates Foundation and USAID.

Education/Academic qualification

Mechanical Engineering and Materials Science, PhD, Duke University

… → 1999

MS, University of Wisconsin-Milwaukee

… → 1989

Chemistry and Philosophy, BS, University of Wisconsin-Madison

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Grants

  • Research Output

    A subcutaneous implant of tenofovir alafenamide fumarate causes local inflammation and tissue necrosis in rabbits and macaques

    Su, J. T., Simpson, S. M., Sung, S., Tfaily, E. B., Veazey, R., Marzinke, M., Qiu, J., Watrous, D., Widanapathirana, L., Pearson, E., Peet, M. M., Karunakaran, D., Grasperge, B., Dobek, G., Cain, C. M., Hope, T. & Kiser, P. F., Jan 1 2020, In : Antimicrobial agents and chemotherapy. 64, 3, e01893.

    Research output: Contribution to journalArticle

    Open Access
  • Design of a Drug-Eluting Subcutaneous Implant of the Antiretroviral Tenofovir Alafenamide Fumarate

    Simpson, S. M., Widanapathirana, L., Su, J. T., Sung, S., Watrous, D., Qiu, J., Pearson, E., Evanoff, A., Karunakaran, D., Chacon, J. E. & Kiser, P. F., Apr 1 2020, In : Pharmaceutical Research. 37, 4, 83.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

    Thurman, A. R., Schwartz, J. L., Brache, V., Clark, M. R., McCormick, T., Chandra, N., Marzinke, M. A., Stanczyk, F. Z., Dezzutti, C. S., Hillier, S. L., Herold, B. C., Fichorova, R., Asin, S. N., Rollenhagen, C., Weiner, D., Kiser, P. & Doncel, G. F., Jun 2018, In : PloS one. 13, 6, e0199778.

    Research output: Contribution to journalArticle

  • 15 Scopus citations

    A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates

    Su, J. T., Teller, R. S., Srinivasan, P., Zhang, J., Martin, A., Sung, S., Smith, J. M. & Kiser, P. F., Oct 1 2017, In : Pharmaceutical Research. 34, 10, p. 2163-2171 9 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations