Grants per year
Personal profile
Research Interests
The primary focus of the Kiser research group is developing and translating new drug delivery technologies for the prevention and treatment of HIV infection. We are particularly interested in new antiviral agents and drug delivery systems to intercept sexually transmitted viruses at the point of interaction with the genital mucosa and the first target cells infected in the mucosa. Our methods include synthetic polymer chemistry, pharmaceutical chemistry, modeling drug transport, and using these results in drug delivery system design and prototyping. We perform preclinical toxicity efficacy evaluations in cell, tissue, and animal models; conduct antiviral assays and drug transport assays; and produce devices using a variety of pharmaceutical manufacturing technologies. Our projects range from new materials discovery that could lead to next generation mucosally active antiviral agents and mucosal vaccines, to the development of new assays to evaluate HIV prevention technologies, to sustained delivery system projects for antiviral, anti-infectives and contraceptive agents. The lab is funded by the NIH (NIAD), the Bill and Melinda Gates Foundation and USAID.
Education/Academic qualification
Mechanical Engineering and Materials Science, PhD, Duke University
… → 1999
MS, University of Wisconsin-Milwaukee
… → 1989
Chemistry and Philosophy, BS, University of Wisconsin-Madison
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Network
Grants
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POS Core and subcontracts to EVMS and UNC-Chapel Hill
Kiser, P., Kiser, P. & Hope, T. J.
National Institute of Allergy and Infectious Diseases
7/7/15 → 6/30/21
Project: Research project
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SRS-3 Core
National Institute of Allergy and Infectious Diseases
7/7/15 → 6/30/21
Project: Research project
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Sustained Long Acting Prevention Against HIV Program Operation
Fought, A. J., Hammond, C., Kiser, P., Komanduri, S., Murphy, R. L., Rademaker, A. W., Taiwo, B. O. & Hope, T. J.
National Institute of Allergy and Infectious Diseases
7/7/15 → 6/30/21
Project: Research project
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Identification of new LAT-1 transporter substrates for drug delivery
University of Nebraska at Kearney, National Institute of Neurological Disorders and Stroke
9/18/17 → 8/31/19
Project: Research project
Research Output
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Design and Testing of a Cabotegravir Implant for HIV Prevention
Karunakaran, D., Simpson, S. M., Su, J. T., Bryndza-Tfaily, E., Hope, T. J., Veazey, R., Dobek, G., Qiu, J., Watrous, D., Sung, S., Chacon, J. E. & Kiser, P. F., Feb 10 2021, In: Journal of Controlled Release. 330, p. 658-668 11 p.Research output: Contribution to journal › Article › peer-review
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A subcutaneous implant of tenofovir alafenamide fumarate causes local inflammation and tissue necrosis in rabbits and macaques
Su, J. T., Simpson, S. M., Sung, S., Tfaily, E. B., Veazey, R., Marzinke, M., Qiu, J., Watrous, D., Widanapathirana, L., Pearson, E., Peet, M. M., Karunakaran, D., Grasperge, B., Dobek, G., Cain, C. M., Hope, T. & Kiser, P. F., 2020, In: Antimicrobial agents and chemotherapy. 64, 3, e01893.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Design of a Drug-Eluting Subcutaneous Implant of the Antiretroviral Tenofovir Alafenamide Fumarate
Simpson, S. M., Widanapathirana, L., Su, J. T., Sung, S., Watrous, D., Qiu, J., Pearson, E., Evanoff, A., Karunakaran, D., Chacon, J. E. & Kiser, P. F., Apr 1 2020, In: Pharmaceutical Research. 37, 4, 83.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
A subcutaneous implant of tenofovir alafenamide fumarate causes local inflammation and tissue necrosis in rabbits and macaques
Su, J. T., Simpson, S. M., Sung, S., Tfaily, E. B., Veazey, R., Marzinke, M., Qiu, J., Watrous, D., Widanapathirana, L., Pearson, E., Melissa Peet, M., Karunakaran, D., Grasperge, B., Dobek, G., Cain, C. M., Hope, T. & Kiser, P. F., Sep 19 2019, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
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Qualitative consumer research on acceptance of long-acting pre-exposure prophylaxis products among men having sex with men and medical practitioners in the United States
Calder, B. J., Schieffer, R. J., Bryndza Tfaily, E., D'Aquila, R., Greene, G. J., Carballo-Diéguez, A., Giguere, R., Kiser, P. F. & Hope, T. J., Oct 2018, In: AIDS research and human retroviruses. 34, 10, p. 849-856 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations