• 2944 Citations
1990 …2021

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Article
2018
2 Scopus citations

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

Thurman, A. R., Schwartz, J. L., Brache, V., Clark, M. R., McCormick, T., Chandra, N., Marzinke, M. A., Stanczyk, F. Z., Dezzutti, C. S., Hillier, S. L., Herold, B. C., Fichorova, R., Asin, S. N., Rollenhagen, C., Weiner, D., Kiser, P. & Doncel, G. F., Jun 2018, In : PloS one. 13, 6, e0199778.

Research output: Contribution to journalArticle

14 Scopus citations
2017

A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates

Su, J. T., Teller, R. S., Srinivasan, P., Zhang, J., Martin, A., Sung, S., Smith, J. M. & Kiser, P. F., Oct 1 2017, In : Pharmaceutical Research. 34, 10, p. 2163-2171 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Long-term direct visualization of passively transferred fluorophore-conjugated antibodies

Schneider, J. R., Carias, A. M., Bastian, A. R., Cianci, G. C., Kiser, P. F., Veazey, R. S. & Hope, T. J., Nov 2017, In : Journal of Immunological Methods. 450, p. 66-72 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men

Greene, G. J., Swann, G., Fought, A. J., Carballo-Diéguez, A., Hope, T. J., Kiser, P. F., Mustanski, B. & D’Aquila, R. T., May 1 2017, In : AIDS and behavior. 21, 5, p. 1336-1349 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Repeated administration of high-dose depot medroxyprogesterone acetate does not alter SHIVSF 162p3 viral kinetics and tenofovir pharmacokinetics when delivered via intravaginal rings

Srinivasan, P., Zhang, J., Dinh, C. T., Teller, R. S., McNicholl, J. M., Kiser, P. F., Herold, B. C. & Smith, J. M., Aug 2017, In : Journal of Medical Primatology. 46, 4, p. 129-136 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring

Keller, M. J., Mesquita, P. M., Marzinke, M. A., Teller, R., Espinoza, L., Atrio, J. M., Lo, Y., Frank, B., Srinivasan, S., Fredricks, D. N., Rabe, L., Anderson, P. L., Hendrix, C. W., Kiser, P. F. & Herold, B. C., Mar 13 2016, In : AIDS. 30, 5, p. 743-751 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release

Teller, R. S., Malaspina, D. C., Rastogi, R., Clark, J. T., Szleifer, I. G. & Kiser, P., Feb 28 2016, In : Journal of Controlled Release. 224, p. 176-183 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differential mechanisms of tenofovir and tenofovir disoproxil fumarate cellular transport and implications for topical preexposure prophylaxis

Taneva, E., Crooker, K., Park, S. H., Su, J. T., Ott, A., Cheshenko, N., Szleifer, I., Kiser, P. F., Frank, B., Mesquita, P. M. M. & Herold, B. C., Mar 2016, In : Antimicrobial agents and chemotherapy. 60, 3, p. 1667-1675 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Engineering and characterization of simplified vaginal and seminal fluid simulants

Rastogi, R., Su, J., Mahalingam, A., Clark, J., Sung, S., Hope, T. J. & Kiser, P., Apr 1 2016, In : Contraception. 93, 4, p. 337-346 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16

Gunn, B. M., Shansab, M., Schneider, J. R., Bastian, A. R., Fahrbach, K. M., SmithIV, A. D., Mahan, A. E., Karim, M. M., Licht, A. F., Zvonar, I., Tedesco, J., Anderson, M. R., Chapel, A., Suscovich, T. J., Malaspina, D. C., Streeck, H., Walker, B. D., Kim, A., Lauer, G., Altfeld, M. & 6 others, Pillai, S., Szleifer, I., Kelleher, N. L., Kiser, P. F., Hope, T. J. & Alter, G., Nov 1 2016, In : Mucosal Immunology. 9, 6, p. 1549-1558 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract

Carias, A. M., Allen, S. A., Fought, A. J., Kotnik Halavaty, K., Anderson, M. R., Jimenez, M. L., McRaven, M. D., Gioia, C. J., Henning, T. R., Kersh, E. N., Smith, J. M., Pereira, L. E., Butler, K., McNicholl, S. J. M., Hendry, R. M., Kiser, P. F., Veazey, R. S. & Hope, T. J., Sep 2016, In : PLoS pathogens. 12, 9, e1005885.

Research output: Contribution to journalArticle

9 Scopus citations

Perceptibility and the "choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design

Guthrie, K. M., Dunsiger, S., Vargas, S. E., Fava, J. L., Shaw, J. G., Rosen, R. K., Kiser, P. F., Kojic, E. M., Friend, D. R. & Katz, D. F., Nov 1 2016, In : AIDS research and human retroviruses. 32, 10-11, p. 1022-1030 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission

Ugaonkar, S. R., Clark, J. T., English, L. B., Johnson, T. J., Buckheit, K. W., Bahde, R. J., Appella, D. H., Buckheit, R. W. & Kiser, P., Oct 1 2015, In : Journal of Pharmaceutical Sciences. 104, 10, p. 3426-3439 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures

Smith, J. M., Srinivasan, P., Teller, R. S., Lo, Y., Dinh, C. T., Kiser, P. F. & Herold, B. C., Jan 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 68, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

The promise of intravaginal rings for prevention: User perceptions of biomechanical properties and implications for prevention product development

Guthrie, K. M., Vargas, S., Shaw, J. G., Rosen, R. K., Van Den Berg, J. J., Kiser, P., Buckheit, K., Bregman, D., Thompson, L., Jensen, K., Johnson, T. & Buckheit, R. W., Dec 1 2015, In : PloS one. 10, 12, e0145642.

Research output: Contribution to journalArticle

15 Scopus citations

The vaginal acquisition and dissemination of HIV-1 infection in a novel transgenic mouse model is facilitated by coinfection with herpes simplex virus 2 and is inhibited by microbicide treatment

Seay, K., Khajoueinejad, N., Zheng, J. H., Kiser, P., Ochsenbauer, C., Kappes, J. C., Herold, B. & Goldstein, H., Jan 1 2015, In : Journal of virology. 89, 18, p. 9559-9570 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: Relating user sensory perceptions and experiences to formulation properties

Morrow, K. M., Fava, J. L., Rosen, R. K., Vargas, S., Shaw, J. G., Kojic, E. M., Kiser, P. F., Friend, D. R., Katz, D. F., Barosso, C., Higgins, M., Wallace, J., Thompson, L., Bregman, D., Van Den Berg, J., Jensen, K., Dunsiger, S., Panameño, A., Colleran, C., Salomon, L. & 12 others, Covahey, C., Mayer, K. H., Dang, D., Frontiero, V., Panther, L., Peters, J., Geonnotti, A., Henderson, M., Lai, B., Clark, M., Tuitupou, A. & Fabian, J., Jan 1 2014, In : AIDS Research and Human Retroviruses. 30, 1, p. 78-91 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy

Clark, J. T., Clark, M. R., Shelke, N. B., Johnson, T. J., Smith, E. M., Andreasen, A. K., Nebeker, J. S., Fabian, J., Friend, D. R. & Kiser, P. F., Mar 5 2014, In : PloS one. 9, 3, e88509.

Research output: Contribution to journalArticle

52 Scopus citations

Intravaginal flux controlled pump for sustained release of macromolecules

Teller, R. S., Rastogi, R., Johnson, T. J., Blair, M. J., Hitchcock, R. W. & Kiser, P. F., May 2 2014, In : Pharmaceutical Research. 31, 9, p. 2344-2353 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Srinivasan, P., Dinh, C., Zhang, J., Pau, C. P., Mcnicholl, J. M., Lo, Y., Herold, B. C., Teller, R., Kiser, P. & Smith, J. M., Oct 1 2014, In : Journal of Medical Primatology. 43, 5, p. 364-369 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

"set it and forget it": Women's perceptions and opinions of long-acting topical vaginal gels

Van Den Berg, J. J., Rosen, R. K., Bregman, D. E., Thompson, L. A., Jensen, K. M., Kiser, P. F., Katz, D. F., Buckheit, K., Buckheit, R. W. & Morrow, K. M., May 2014, In : AIDS and behavior. 18, 5, p. 862-870 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Vaginally delivered tenofovir disoproxil fumarate provides greater protection than tenofovir against genital herpes in a murine model of efficacy and safety

Nixon, B., Jandl, T., Teller, R. S., Taneva, E., Wang, Y., Nagaraja, U., Kiser, P. F. & Herold, B. C., Feb 1 2014, In : Antimicrobial agents and chemotherapy. 58, 2, p. 1153-1160 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement

Shukair, S. A., Allen, S. A., Cianci, G. C., Stieh, D. J., Anderson, M. R., Baig, S. M., Gioia, C. J., Spongberg, E. J., Kauffman, S. M., McRaven, M. D., Lakougna, H. Y., Hammond, C., Kiser, P. F. & Hope, T. J., Mar 1 2013, In : Mucosal Immunology. 6, 2, p. 427-434 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

Smith, J. M., Rastogi, R., Teller, R. S., Srinivasan, P., Mesquita, P. M. M., Nagaraja, U., McNicholl, J. M., Hendry, R. M., Dinh, C. T., Martin, A., Herold, B. C. & Kiser, P. F., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16145-16150 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties

Mesquita, P. M. M., Srinivasan, P., Johnson, T. J., Rastogi, R., Evans-Strickfaden, T., Kay, M. S., Buckheit, K. W., Buckheit, R. W., Smith, J. M., Kiser, P. F. & Herold, B. C., Oct 24 2013, In : Retrovirology. 10, 1, 113.

Research output: Contribution to journalArticle

19 Scopus citations

Osmotic pump tablets for delivery of antiretrovirals to the vaginal mucosa

Rastogi, R., Teller, R. S., Mesquita, P. M. M., Herold, B. C. & Kiser, P. F., Sep 19 2013, In : Antiviral Research. 100, 1, p. 255-258 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis

Johnson, T. J., Clark, M. R., Albright, T. H., Nebeker, J. S., Tuitupou, A. L., Clark, J. T., Fabian, J., McCabe, R. T., Chandra, N., Doncel, G. F., Friend, D. R. & Kiser, P. F., Dec 1 2012, In : Antimicrobial Agents and Chemotherapy. 56, 12, p. 6272-6283 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781

Clark, M. R., Johnson, T. J., McCabe, R. T., Clark, J. T., Tuitupou, A., Elgendy, H., Friend, D. R. & Kiser, P. F., Jan 1 2012, In : Journal of Pharmaceutical Sciences. 101, 2, p. 576-587 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Design of tenofovir-UC781 combination microbicide vaginal gels

Kiser, P. F., Mahalingam, A., Fabian, J., Smith, E., Damian, F. R., Peters, J. J., Katz, D. F., Elgendy, H., Clark, M. R. & Friend, D. R., Jan 1 2012, In : Journal of Pharmaceutical Sciences. 101, 5, p. 1852-1864 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Development of a combination microbicide gel formulation containing IQP-0528 and tenofovir for the prevention of HIV infection

Ham, A. S., Ugaonkar, S. R., Shi, L., Buckheit, K. W., Lakougna, H., Nagaraja, U., Gwozdz, G., Goldman, L., Kiser, P. F. & Buckheit, R. W., Apr 2012, In : Journal of Pharmaceutical Sciences. 101, 4, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection

Mesquita, P. M. M., Rastogi, R., Segarra, T. J., Teller, R. S., Merna Torres, N., Huber, A. M., Kiser, P. F. & Herold, B. C., Jul 1 2012, In : Journal of Antimicrobial Chemotherapy. 67, 7, p. 1730-1738 9 p., dks097.

Research output: Contribution to journalArticle

66 Scopus citations

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir

Clark, J. T., Johnson, T. J., Clark, M. R., Nebeker, J. S., Fabian, J., Tuitupou, A. L., Ponnapalli, S., Smith, E. M., Friend, D. R. & Kiser, P. F., Oct 28 2012, In : Journal of Controlled Release. 163, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings

Johnson, T. J., Srinivasan, P., Albright, T. H., Watson-Buckheit, K., Rabe, L., Martin, A., Pau, C. P., Hendry, R. M., Otten, R., McNicholl, J., Buckheit, R., Smith, J. & Kiser, P. F., Mar 1 2012, In : Antimicrobial agents and chemotherapy. 56, 3, p. 1291-1299 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2011

Activity and safety of synthetic lectins based on benzoboroxole- functionalized polymers for inhibition of HIV entry

Mahalingam, A., Geonnotti, A. R., Balzarini, J. & Kiser, P. F., Dec 5 2011, In : Molecular Pharmaceutics. 8, 6, p. 2465-2475 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine

Kaur, M., Gupta, K. M., Poursaid, A. E., Karra, P., Mahalingam, A., Aliyar, H. A. & Kiser, P. F., Jun 1 2011, In : Drug Delivery and Translational Research. 1, 3, p. 223-237 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles

Clark, M. R., Aliyar, H. A., Lee, C. W., Jay, J. I., Gupta, K. M., Watson, K. M., Stewart, R. J., Buckheit, R. W. & Kiser, P. F., Jul 15 2011, In : International Journal of Pharmaceutics. 413, 1-2, p. 10-18 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system

Mahalingam, A., Jay, J. I., Langheinrich, K., Shukair, S., McRaven, M. D., Rohan, L. C., Herold, B. C., Hope, T. J. & Kiser, P. F., Nov 1 2011, In : Biomaterials. 32, 33, p. 8343-8355 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: A comparison of polymer matrices

Clark, M. R., Kiser, P. F., Loxley, A., McConville, C., Malcolm, R. K. & Friend, D. R., Jun 1 2011, In : Drug Delivery and Translational Research. 1, 3, p. 238-246 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Unequal stoichiometry between crosslinking moieties affects the properties of transient networks formed by dynamic covalent crosslinks

Jay, J. I., Langheinrich, K., Hanson, M. C., Mahalingam, A. & Kiser, P. F., Jun 21 2011, In : Soft Matter. 7, 12, p. 5826-5835 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1

Mahalingam, A., Simmons, A. P., Ugaonkar, S. R., Watson, K. M., Dezzutti, C. S., Rohan, L. C., Buckheit, R. W. & Kiser, P. F., Apr 1 2011, In : Antimicrobial agents and chemotherapy. 55, 4, p. 1650-1660 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
2010

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions

Damian, F., Fabian, J., Friend, D. R. & Kiser, P. F., Aug 1 2010, In : International Journal of Pharmaceutics. 396, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Design of a semisolid vaginal microbicide gel by relating composition to properties and performance

Mahalingam, A., Smith, E., Fabian, J., Damian, F. R., Peters, J. J., Clark, M. R., Friend, D. R., Katz, D. F. & Kiser, P. F., Nov 1 2010, In : Pharmaceutical Research. 27, 11, p. 2478-2491 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors

Jay, J. I., Lai, B. E., Myszka, D. G., Mahalingam, A., Langheinrich, K., Katz, D. F. & Kiser, P. F., Feb 1 2010, In : Molecular Pharmaceutics. 7, 1, p. 116-129 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir

Johnson, T. J., Gupta, K. M., Fabian, J., Albright, T. H. & Kiser, P. F., Feb 19 2010, In : European Journal of Pharmaceutical Sciences. 39, 4, p. 203-212 10 p.

Research output: Contribution to journalArticle

115 Scopus citations
2009

In situ crosslinked hydrogels formed using Cu(I)-free Huisgen cycloaddition reaction

Clark, M. & Kiser, P., Oct 1 2009, In : Polymer International. 58, 10, p. 1190-1195 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of viscoelasticity and HIV transport as a function of pH in a reversibly crosslinked hydrogel

Jay, J. I., Shukair, S., Langheinrich, K., Hanson, M. C., Cianci, G. C., Johnson, T. J., Clark, M. R., Hope, T. J. & Kiser, P. F., Sep 23 2009, In : Advanced Functional Materials. 19, 18, p. 2969-2977 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Chemorheology of phenylboronate-salicylhydroxamate cross-linked hydrogel networks with a sulfonated polymer backbone

Roberts, M. C., Mahalingam, A., Hanson, M. C. & Kiser, P. F., Nov 25 2008, In : Macromolecules. 41, 22, p. 8832-8840 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Measuring macrodiffusion coefficients in microbicide hydrogels via postphotoactivation scanning

Geonnotti, A. R., Furlow, M. J., Wu, T., DeSoto, M. G., Henderson, M. H., Kiser, P. F. & Katz, D. F., Feb 1 2008, In : Biomacromolecules. 9, 2, p. 748-751 4 p.

Research output: Contribution to journalArticle

9 Scopus citations