Grants per year
Personal profile
Research Interests
We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Stem Cell Biology, PhD, University of Nottingham
… → 2008
Research interests keywords
- Adverse Drug Reactions
- Bioengineering
- Bioinformatics
- Breast Cancer
- Cardiology
- Drug Discovery
- Regenerative Medicine
- Stem Cells
- Alzheimer's Disease
- Arrhythmias
- Atherosclerosis
- Cardiovascular Diseases
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans
Vaughan, D. E. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Burridge, P. (Co-Investigator), Cuda, C. M. (Co-Investigator), Eren, M. (Co-Investigator), Ghosh, A. K. (Co-Investigator), Hayes, M. G. (Co-Investigator), Kelleher, N. L. (Co-Investigator), Khan, S. S. (Co-Investigator), Stoeger, T. (Co-Investigator), Wilsbacher, L. D. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/1/24 → 12/31/30
Project: Research project
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Cardiac Organoid Models of Hypoplastic Left Heart Syndrome
Burridge, P. (PD/PI), Burridge, P. (PD/PI), Fonoudi, H. (Other) & Fonoudi, H. (Other)
Additional Ventures Foundation
11/1/22 → 10/31/25
Project: Research project
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Molecular and cellular characterization of essential human genes.
Adli, M. (PD/PI), Adli, M. (PD/PI), Burridge, P. (PD/PI), Burridge, P. (PD/PI) & Yue, F. (PD/PI)
National Human Genome Research Institute
9/22/22 → 6/30/27
Project: Research project
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Predicting and Preventing Chemotherapy-Induced Cardiotoxicity in African American Children
Burridge, P. (PD/PI), Burridge, P. (PD/PI), Fonoudi, H. (Other) & Mohamed, T. M. S. (Other)
8/5/21 → 7/31/26
Project: Research project
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George, A. L. (PD/PI), Abdulkadir, S. A. (Other), Ardehali, H. (Other), Arora, R. K. (Other), Burridge, P. (Other), Kearney, J. A. (Other), McNally, E. M. (Other), Schiltz, G. E. (Other), Silverman, R. B. (Other), Watterson, D. M. (Other) & Wilsbacher, L. D. (Other)
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project
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Anthracycline Toxicity: Light at the End of the Tunnel?
Cejas, R. B., Petrykey, K., Sapkota, Y. & Burridge, P. W., Jan 23 2024, In: Annual Review of Pharmacology and Toxicology. 64, p. 115-134 20 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Functional Validation of Doxorubicin-Induced Cardiotoxicity-Related Genes
Fonoudi, H., Jouni, M., Cejas, R. B., Magdy, T., Blancard, M., Ge, N., Shah, D. A., Lyra-Leite, D. M., Neupane, A., Gharib, M., Jiang, Z., Sapkota, Y. & Burridge, P. W., Feb 2024, In: JACC: CardioOncology. 6, 1, p. 38-50 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Independent compartmentalization of functional, metabolic, and transcriptional maturation of hiPSC-derived cardiomyocytes
Fetterman, K. A., Blancard, M., Lyra-Leite, D. M., Vanoye, C. G., Fonoudi, H., Jouni, M., DeKeyser, J. M. L., Lenny, B., Sapkota, Y., George, A. L. & Burridge, P. W., May 28 2024, In: Cell reports. 43, 5, 114160.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nilotinib-induced alterations in endothelial cell function recapitulate clinical vascular phenotypes independent of ABL1
Pinheiro, E. A., DeKeyser, J. M., Lenny, B., Sapkota, Y. & Burridge, P. W., Dec 2024, In: Scientific reports. 14, 1, 7123.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Physiological stress improves stem cell modeling of dystrophic cardiomyopathy
Fullenkamp, D. E., Willis, A. B., Curtin, J. L., Amaral, A. P., Dittloff, K. T., Harris, S. I., Chychula, I. A., Holgren, C. W., Burridge, P. W., Russell, B., Demonbreun, A. R. & McNally, E. M., Jun 2024, In: DMM Disease Models and Mechanisms. 17, 6, dmm050487.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Transcriptomic analysis of inter- and intra-patient variation in human iPSC cardiomyocytes: Platform for precision medicine to predict drug toxicity
Matsa, E. (Contributor), Burridge, P. W. (Contributor), Yu, K.-H. (Contributor), Shao, N. (Contributor) & Wu, J. C. (Contributor), Gene Expression Omnibus, Jun 23 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83668
Dataset