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Paul Burridge

  • 3279 Citations
20022025

Research output per year

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Personal profile

Research Interests

We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.

Education/Academic qualification

PhD, University of Nottingham

… → 2008

Research interests

  • Adverse Drug Reactions
  • Bioengineering
  • Bioinformatics
  • Breast Cancer
  • Cardiology
  • Drug Discovery
  • Regenerative Medicine
  • Stem Cells
  • Alzheimer's Disease
  • Arrhythmias
  • Atherosclerosis
  • Cardiovascular Diseases

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Grants

A Patient-Specific hiPSC Model of Nilotinib-Induced Peripheral Artery Disease Pharmacogenomics

Burridge, P.

National Institutes of Health

2/21/20 → 2/20/21

Project: Research project

    • Subproject for Institution # SP0053781

    Burridge, P.

    Leducq Foundation

    1/1/20 → 12/31/24

    Project: Research project

    • A Patient-Specific hiPSC Model of Nilotinib-Induced Peripheral Artery Disease Pharmacogenomics

    Burridge, P. & Quaggin, S. E.

    American Heart Association

    1/1/20 → 12/31/21

    Project: Research project

    • Project 2

    Burridge, P., George Jr, A. L. & Potet, F.

    American Heart Association

    7/1/19 → 6/30/23

    Project: Research project

    Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology

    Burridge, P., Carr, J., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.

    National Heart, Lung, and Blood Institute

    4/15/19 → 3/31/23

    Project: Research project

    • Research Output

    Are These Cardiomyocytes? Protocol Development Reveals Impact of Sample Preparation on the Accuracy of Identifying Cardiomyocytes by Flow Cytometry

    Waas, M., Weerasekera, R., Kropp, E. M., Romero-Tejeda, M., Poon, E. N., Boheler, K. R., Burridge, P. W. & Gundry, R. L., Feb 12 2019, In : Stem cell reports. 12, 2, p. 395-410 16 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Genetic Mosaicism in Calmodulinopathy

    Wren, L. M., Jiménez-Jáimez, J., Al-Ghamdi, S., Al-Aama, J. Y., Bdeir, A., Al-Hassnan, Z. N., Kuan, J. L., Foo, R. Y., Potet, F., Johnson, C. N., Aziz, M. C., Carvill, G. L., Kaski, J. P., Crotti, L., Perin, F., Monserrat, L., Burridge, P. W., Schwartz, P. J., Chazin, W. J., Bhuiyan, Z. A. & 1 others, George, A. L., Sep 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 9, p. 375-385 11 p., e002581.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    HiPSCs in cardio-oncology: Deciphering the genomics

    Pinheiro, E. A., Fetterman, K. A. & Burridge, P. W., Apr 15 2019, In : Cardiovascular research. 115, 5, p. 935-948 14 p.

    Research output: Contribution to journal › Review article

    Open Access
    • 3 Scopus citations

    Late onset heart failure after childhood chemotherapy

    Hilfiker-Kleiner, D., Ardehali, H., Fischmeister, R., Burridge, P., Hirsch, E. & Lyon, A. R., Mar 7 2019, In : European heart journal. 40, 10, p. 798-800 3 p.

    Research output: Contribution to journal › Article

    Open Access
    1 Scopus citations

    Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

    Magdy, T. & Burridge, P. W., Feb 7 2019, In : Cell stem cell. 24, 2, p. 203-205 3 p.

    Research output: Contribution to journal › Short survey