Grants per year
Personal profile
Research Interests
We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Stem Cell Biology, PhD, University of Nottingham
… → 2008
Research interests
- Adverse Drug Reactions
- Bioengineering
- Bioinformatics
- Breast Cancer
- Cardiology
- Drug Discovery
- Regenerative Medicine
- Stem Cells
- Alzheimer's Disease
- Arrhythmias
- Atherosclerosis
- Cardiovascular Diseases
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A robotic plate handling system for high content screening and 3D organoid culture
Horvath, C. M., Adli, M., Bulun, S. E., Burridge, P., Chakravarti, D., Duncan, F. E., Horiuchi, D., Kim, J. J., Matei, D. E., Morimoto, R. I., Wainwright, D. A. & Wan, Y.
Office of the Director, National Institutes of Health
9/1/22 → 8/31/23
Project: Research project
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Low Cost, Chemically Defined, GM-Free Animal iPSC Generation, Culture, and Skeletal Muscle Differentiation
2/11/22 → 8/1/23
Project: Research project
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Exploring Novel Treatment Options for Patients with LMNA-Related Cardiomyopathy Using Patient-Specific hiPSCs
1/1/22 → 12/31/23
Project: Research project
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Kinetic Imaging Plate Reader for Drug Discovery and Biology
George, A. L., Arispe, L., Bass, J., Burridge, P., DeCaen, P. G., Gianneschi, N., Horvath, C. M., Kiskinis, E., Klein, W. L., Miller, R. J., Morimoto, R. I., Moskal, J. R., Penzes, P., Prakriya, M., Scheidt, K. A., Surmeier Jr, D. J. & Vafabakhsh, R.
Office of the Director, National Institutes of Health
9/1/21 → 8/31/23
Project: Research project
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Predicting and Preventing Chemotherapy-Induced Cardiotoxicity in African American Children
Burridge, P. & Mohamed, T. M. S.
8/5/21 → 7/31/26
Project: Research project
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A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming
Lyra-Leite, D. M., Gutiérrez-Gutiérrez, Ó., Wang, M., Zhou, Y., Cyganek, L. & Burridge, P. W., Sep 16 2022, In: STAR Protocols. 3, 3, 101560.Research output: Contribution to journal › Review article › peer-review
Open Access -
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility (Nature Genetics, (2022), 54, 3, (232-239), 10.1038/s41588-021-01007-6)
KORA-Study Group & Nantes Referral Center for inherited cardiac arrhythmia, May 2022, In: Nature Genetics. 54, 5, p. 735 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
KORA-Study Group & Nantes Referral Center for inherited cardiac arrhythmia, Mar 1 2022, In: Nature Genetics. 54, 3, p. 232-239 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity
Magdy, T., Jouni, M., Kuo, H. H., Weddle, C. J., Lyra-Leite, D., Fonoudi, H., Romero-Tejeda, M., Gharib, M., Javed, H., Fajardo, G., Ross, C. J. D., Carleton, B. C., Bernstein, D. & Burridge, P. W., Jan 25 2022, In: Circulation. 145, 4, p. 279-294 16 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Pharmacogenomic Screening of Drug Candidates using Patient-Specific hiPSC-Derived Cardiomyocyte High-Throughput Calcium Imaging
Blancard, M., Fetterman, K. A. & Burridge, P. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 241-253 13 p. (Methods in Molecular Biology; vol. 2547).Research output: Chapter in Book/Report/Conference proceeding › Chapter