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Paul Burridge

  • 2944 Citations
20022025
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Personal profile

Research Interests

We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.

Education/Academic qualification

PhD, University of Nottingham, UK

… → 2008

Research interests

  • Adverse Drug Reactions
  • Bioengineering
  • Bioinformatics
  • Breast Cancer
  • Cardiology
  • Drug Discovery
  • Regenerative Medicine
  • Stem Cells
  • Alzheimer's Disease
  • Arrhythmias
  • Atherosclerosis
  • Cardiovascular Diseases

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  • 1 Similar Profiles
Induced Pluripotent Stem Cells Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Pluripotent Stem Cells Medicine & Life Sciences
Stem cells Chemical Compounds
Preclinical Drug Evaluations Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Regenerative Medicine Medicine & Life Sciences
Stem Cells Medicine & Life Sciences

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Grants 2015 2025

Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology

Burridge, P., Carr, J., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.

National Heart, Lung, and Blood Institute

4/15/19 → 3/31/23

Project: Research project

Plasminogen Activator Inhibitor 1
Fibrosis
Mutation
Cardiomyopathies
Cardiac Myocytes

Controlling Doxorubicin Transport to Prevent Cardiotoxicity

Burridge, P.

Northwestern Memorial Hospital

1/1/19 → 12/31/19

Project: Research project

Induced Pluripotent Stem Cells
Cardiac Myocytes
Doxorubicin
Anthracyclines
Clustered Regularly Interspaced Short Palindromic Repeats

Genomic Prediction of Doxorubicin-Induced Cardiotoxicity

Burridge, P.

National Cancer Institute

9/13/18 → 8/31/23

Project: Research project

Doxorubicin
Single Nucleotide Polymorphism
Induced Pluripotent Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
Pediatrics

Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors

Burridge, P.

University of Alabama at Birmingham, National Cancer Institute

9/1/18 → 8/31/25

Project: Research project

Induced Pluripotent Stem Cells
Anthracyclines
Single Nucleotide Polymorphism
Survivors
Clustered Regularly Interspaced Short Palindromic Repeats

Cardiac lymphatic endothelial cells: novel players in cardiomyocyte survival during heart development and repair

Ardehali, H., Burridge, P., McNally, E. M., Quaggin, S. E., Thorp, E. B. & Liu, X.

American Heart Association

7/1/18 → 6/30/21

Project: Research project

Cardiac Myocytes
Induced Pluripotent Stem Cells
Endothelial Cells
Research Design
Mutant Strains Mice

Research Output 2002 2019

2 Citations (Scopus)

Are These Cardiomyocytes? Protocol Development Reveals Impact of Sample Preparation on the Accuracy of Identifying Cardiomyocytes by Flow Cytometry

Waas, M., Weerasekera, R., Kropp, E. M., Romero-Tejeda, M., Poon, E. N., Boheler, K. R., Burridge, P. & Gundry, R. L., Feb 12 2019, In : Stem cell reports. 12, 2, p. 395-410 16 p.

Research output: Contribution to journal › Article

Flow cytometry
Stem cells
Cardiac Myocytes
Flow Cytometry
Troponin
2 Citations (Scopus)

HiPSCs in cardio-oncology: Deciphering the genomics

Pinheiro, E. A., Fetterman, K. A. & Burridge, P., Apr 15 2019, In : Cardiovascular research. 115, 5, p. 935-948 14 p.

Research output: Contribution to journal › Review article

Open Access
Induced Pluripotent Stem Cells
Genomics
Genome-Wide Association Study
Clustered Regularly Interspaced Short Palindromic Repeats
Pharmaceutical Preparations
1 Citation (Scopus)

Late onset heart failure after childhood chemotherapy

Hilfiker-Kleiner, D., Ardehali, H., Fischmeister, R., Burridge, P., Hirsch, E. & Lyon, A. R., Mar 7 2019, In : European heart journal. 40, 10, p. 798-800 3 p.

Research output: Contribution to journal › Article

Open Access
Heart Failure
Drug Therapy

Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Magdy, T. & Burridge, P., Feb 7 2019, In : Cell Stem Cell. 24, 2, p. 203-205 3 p.

Research output: Contribution to journal › Short survey

Coronary Artery Disease
Genotype
Phenotype
Induced Pluripotent Stem Cells
Intergenic DNA

Doxorubicin induces caspase-mediated proteolysis of KV7.1

Strigli, A., Raab, C., Hessler, S., Huth, T., Schuldt, A. J. T., Alzheimer, C., Friedrich, T., Burridge, P., Luedde, M. & Schwake, M., Dec 1 2018, In : Communications Biology. 1, 1, 155.

Research output: Contribution to journal › Article

Open Access
Proteolysis
doxorubicin
caspases
Caspases
proteolysis