Grants per year
Personal profile
Research Interests
We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Stem Cell Biology, PhD, University of Nottingham
… → 2008
Research interests keywords
- Adverse Drug Reactions
- Bioengineering
- Bioinformatics
- Breast Cancer
- Cardiology
- Drug Discovery
- Regenerative Medicine
- Stem Cells
- Alzheimer's Disease
- Arrhythmias
- Atherosclerosis
- Cardiovascular Diseases
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cardiac Organoid Models of Hypoplastic Left Heart Syndrome
Additional Ventures Foundation
11/1/22 → 10/31/25
Project: Research project
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Molecular and cellular characterization of essential human genes.
National Human Genome Research Institute
9/22/22 → 6/30/27
Project: Research project
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Dr. Paul Burridge's Subproject
National Human Genome Research Institute
9/22/22 → 6/30/27
Project: Research project
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Exploring Novel Treatment Options for Patients with LMNA-Related Cardiomyopathy Using Patient-Specific hiPSCs
1/1/22 → 12/31/23
Project: Research project
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Predicting and Preventing Chemotherapy-Induced Cardiotoxicity in African American Children
Burridge, P., Fonoudi, H. & Mohamed, T. M. S.
8/5/21 → 7/31/26
Project: Research project
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A novel transcription factor combination for direct reprogramming to a spontaneously contracting human cardiomyocyte-like state
Romero-Tejeda, M., Fonoudi, H., Weddle, C. J., DeKeyser, J. M., Lenny, B., Fetterman, K. A., Magdy, T., Sapkota, Y., Epting, C. L. & Burridge, P. W., Sep 2023, In: Journal of Molecular and Cellular Cardiology. 182, p. 30-43 14 p.Research output: Contribution to journal › Article › peer-review
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Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors
Wang, X., Singh, P., Zhou, L., Sharafeldin, N., Landier, W., Hageman, L., Burridge, P., Yasui, Y., Sapkota, Y., Blanco, J. G., Oeffinger, K. C., Hudson, M. M., Chow, E. J., Armenian, S. H., Neglia, J. P., Ritchey, A. K., Hawkins, D. S., Ginsberg, J. P., Robison, L. L., Armstrong, G. T., & 1 others, Mar 20 2023, In: Journal of Clinical Oncology. 41, 9, p. 1758-1769 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A COG-ALTE03N1 Report
Singh, P., Crossman, D. K., Zhou, L., Wang, X., Sharafeldin, N., Hageman, L., Blanco, J. G., Burridge, P. W., Armenian, S. H., Balis, F. M., Hawkins, D. S., Keller, F. G., Hudson, M. M., Neglia, J. P., Ritchey, A. K., Ginsberg, J. P., Landier, W. & Bhatia, S., Jun 2023, In: JACC: CardioOncology. 5, 3, p. 392-401 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nutritional requirements of human induced pluripotent stem cells
Lyra-Leite, D. M., Copley, R. R., Freeman, P. P., Pongpamorn, P., Shah, D., McKenna, D. E., Lenny, B., Pinheiro, E. A., Weddle, C. J., Gharib, M., Javed, H., Fonoudi, H., Sapkota, Y. & Burridge, P. W., Jun 13 2023, In: Stem cell reports. 18, 6, p. 1371-1387 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Novel Locus on 6p21.2 for Cancer Treatment-Induced Cardiac Dysfunction among Childhood Cancer Survivors
Sapkota, Y., Ehrhardt, M. J., Qin, N., Wang, Z., Liu, Q., Qiu, W., Shelton, K., Shao, Y., Plyler, E., Mulder, H. L., Easton, J., Michael, J. R., Burridge, P. W., Wang, X., Wilson, C. L., Jefferies, J. L., Chow, E. J., Oeffinger, K. C., Morton, L. M., Li, C., & 8 others, Aug 1 2022, In: Journal of the National Cancer Institute. 114, 8, p. 1109-1116 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Transcriptomic analysis of inter- and intra-patient variation in human iPSC cardiomyocytes: Platform for precision medicine to predict drug toxicity
Matsa, E. (Contributor), Burridge, P. (Contributor), Yu, K. (Contributor), Shao, N. (Contributor) & Wu, J. C. (Contributor), Gene Expression Omnibus, 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83668
Dataset