Grants per year
Personal profile
Research Interests
We use human induced pluripotent stem cells (hiPSCs) to understand the role of the genome in influencing drug efficacy and side effects as well as complex disease traits. We are also interested in pluripotency, differentiation methods, cardiac regenerative medicine, direct reprogramming, long QT syndrome, atrial fibrillation, peripheral artery disease, and hiPSC models of cancer. Along with the hiPSC model, we use a combination of whole genome sequencing, automation and robotics, high-throughput drug screening, high-content imaging, and electrophysiological testing.
Education/Academic qualification
PhD, University of Nottingham, UK
… → 2008
Keywords
- Adverse Drug Reactions
- Bioengineering
- Bioinformatics
- Breast Cancer
- Cardiology
- Drug Discovery
- Regenerative Medicine
- Stem Cells
- Alzheimer's Disease
- Arrhythmias
- Atherosclerosis
- Cardiovascular Diseases
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2015 2025
Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Burridge, P., Carr, J., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
Plasminogen Activator Inhibitor 1
Fibrosis
Mutation
Cardiomyopathies
Cardiac Myocytes
Doxorubicin
Single Nucleotide Polymorphism
Induced Pluripotent Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
Pediatrics
Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors
University of Alabama at Birmingham, National Cancer Institute
9/1/18 → 8/31/25
Project: Research project
Induced Pluripotent Stem Cells
Anthracyclines
Single Nucleotide Polymorphism
Survivors
Clustered Regularly Interspaced Short Palindromic Repeats
Validation of Genomic Hits Predicting Doxorubicin-Induced Cardiotoxicity
7/1/18 → 6/30/21
Project: Research project
Doxorubicin
Single Nucleotide Polymorphism
Induced Pluripotent Stem Cells
Quantitative Trait Loci
Cardiac Myocytes
Cardiac lymphatic endothelial cells: novel players in cardiomyocyte survival during heart development and repair
Ardehali, H., Burridge, P., McNally, E. M., Quaggin, S. E., Thorp, E. B. & Liu, X.
7/1/18 → 6/30/21
Project: Research project
Cardiac Myocytes
Induced Pluripotent Stem Cells
Endothelial Cells
Research Design
Mutant Strains Mice
Research Output 2002 2019
Are These Cardiomyocytes? Protocol Development Reveals Impact of Sample Preparation on the Accuracy of Identifying Cardiomyocytes by Flow Cytometry
Waas, M., Weerasekera, R., Kropp, E. M., Romero-Tejeda, M., Poon, E. N., Boheler, K. R., Burridge, P. & Gundry, R. L., Feb 12 2019, In : Stem cell reports. 12, 2, p. 395-410 16 p.Research output: Contribution to journal › Article
Flow cytometry
Stem cells
Cardiac Myocytes
Flow Cytometry
Troponin
hiPSCs in cardio-oncology: deciphering the genomics
Pinheiro, E. A., Fetterman, K. A. & Burridge, P., Apr 15 2019, In : Cardiovascular research. 115, 5, p. 935-948 14 p.Research output: Contribution to journal › Article
Open Access
Induced Pluripotent Stem Cells
Genomics
Genome-Wide Association Study
Clustered Regularly Interspaced Short Palindromic Repeats
Pharmaceutical Preparations
Late onset heart failure after childhood chemotherapy
Hilfiker-Kleiner, D., Ardehali, H., Fischmeister, R., Burridge, P., Hirsch, E. & Lyon, A. R., Mar 7 2019, In : European heart journal. 40, 10, p. 798-800 3 p.Research output: Contribution to journal › Article
Open Access
Heart Failure
Drug Therapy
Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease
Magdy, T. & Burridge, P., Feb 7 2019, In : Cell Stem Cell. 24, 2, p. 203-205 3 p.Research output: Contribution to journal › Short survey
Coronary Artery Disease
Genotype
Phenotype
Induced Pluripotent Stem Cells
Intergenic DNA
8
Citations
(Scopus)
Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems
Magdy, T., Schuldt, A. J. T., Wu, J. C., Bernstein, D. & Burridge, P., Jan 6 2018, In : Annual Review of Pharmacology and Toxicology. 58, p. 83-103 21 p.Research output: Contribution to journal › Review article
Induced Pluripotent Stem Cells
Stem cells
Preclinical Drug Evaluations
Pharmaceutical Preparations
Screening