Paul F Lindholm

  • 1547 Citations
1986 …2020

Research output per year

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Personal profile

Research Interests

Our clinical laboratory performs tests to evaluate the function of platelets and the plasma hemostatic system for patients with blood clotting disorders. We employ platelet function assays to identify the effects of antiplatelet medications and platelet transfusion on platelet function for patients at risk of bleeding. We find that in patients with acute intracerebral hemorrhage (ICH), reversing anti-platelet medication and increased platelet activity leads to improved clinical outcomes. We also use these assays to identify optimal conditions for safe surgical interventions for patients who have blood clotting disorders or are taking anticoagulants. We are participating in an exciting project to produce platelets from stem cells. The function of these culture-derived platelets is tested to identify optimal culture and storage conditions to obtain a high yield of functional platelets.

Our research laboratory studies the mechanisms by which prostate cancer cells invade surrounding tissues and spread to distant sites in the body. Clinical prostate cancer tissues contain increased numbers of monocytes and macrophages. We have found that human monocyte-lineage cells cross-communicate with prostate cancer cells and this process leads to increased cancer cell invasion. This cross-communication involves cytokines and growth factors including monocyte chemoattractant protein (MCP-1) and increased cancer cell NF-¿B activity. We are investigating how these factors promote cancer cell invasion and metastasis and hope to identify molecular targets that could block prostate cancer progression.

Certifications and Licenses

Blood Banking & Transfusion Medicine
Anatomic Pathology & Clinical Pathology

Training Experience

1988Residency, Univ. of Minnesota Hospital & Clinic

Education/Academic qualification

MD, University of Minnesota Twin Cities

… → 1983

Research interests

  • Cancer Communications
  • Cell Biology
  • Inflammation
  • Pathology
  • Prostate Cancer

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Grants

  • Research Output

    Blood transfusion utilization in hospitalized COVID-19 patients

    Barriteau, C. M., Bochey, P., Lindholm, P. F., Hartman, K., Sumugod, R. & Ramsey, G., 2020, (Accepted/In press) In : Transfusion.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Fibrin and fibrinolysis in cancer

    Kwaan, H. C. & Lindholm, P. F., Jan 1 2019, In : Seminars in thrombosis and hemostasis. 45, 4, p. 413-422 10 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Mixing Studies in Patients with Prolonged Activated Partial Thromboplastin Time or Prothrombin Time

    Benzon, H. T., Park, M., McCarthy, R. J., Kendall, M. C. & Lindholm, P. F., Jun 1 2019, In : Anesthesia and analgesia. 128, 6, p. 1089-1096 8 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations