Paul F Lindholm

  • 1433 Citations
1986 …2018
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Personal profile

Research Interests

Our clinical laboratory performs tests to evaluate the function of platelets and the plasma hemostatic system for patients with blood clotting disorders. We employ platelet function assays to identify the effects of antiplatelet medications and platelet transfusion on platelet function for patients at risk of bleeding. We find that in patients with acute intracerebral hemorrhage (ICH), reversing anti-platelet medication and increased platelet activity leads to improved clinical outcomes. We also use these assays to identify optimal conditions for safe surgical interventions for patients who have blood clotting disorders or are taking anticoagulants. We are participating in an exciting project to produce platelets from stem cells. The function of these culture-derived platelets is tested to identify optimal culture and storage conditions to obtain a high yield of functional platelets.

Our research laboratory studies the mechanisms by which prostate cancer cells invade surrounding tissues and spread to distant sites in the body. Clinical prostate cancer tissues contain increased numbers of monocytes and macrophages. We have found that human monocyte-lineage cells cross-communicate with prostate cancer cells and this process leads to increased cancer cell invasion. This cross-communication involves cytokines and growth factors including monocyte chemoattractant protein (MCP-1) and increased cancer cell NF-¿B activity. We are investigating how these factors promote cancer cell invasion and metastasis and hope to identify molecular targets that could block prostate cancer progression.

Certifications and Licenses

Blood Banking & Transfusion Medicine
Anatomic Pathology & Clinical Pathology

Training Experience

1988Residency, Univ. of Minnesota Hospital & Clinic

Education/Academic qualification

MD, University of Minnesota

… → 1983

Keywords

  • Cancer Communications
  • Cell Biology
  • Inflammation
  • Pathology
  • Prostate Cancer

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Human T-lymphotropic virus 1 Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Blood Platelets Medicine & Life Sciences
Cerebral Hemorrhage Medicine & Life Sciences
NF-kappa B Medicine & Life Sciences
Proteins Medicine & Life Sciences
Platelet Transfusion Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences

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Grants 2001 2017

Hydrogels
Microfluidics
Bioreactors
Blood Platelets
Hematopoietic Stem Cells
Adipogenesis
Leptin
Prostatic Neoplasms
Research Personnel
Translational Medical Research
Prostatic Neoplasms
Research Personnel
Translational Medical Research
Advisory Committees
Research
Prostatic Neoplasms
Transcription Factors
Prostate
Research
Quality of Life

Research Output 1986 2018

Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report

Galvez, C., Abutaleb, A., Iams, W. T., Lindholm, P. F. & Kwaan, H. C., Jun 1 2018, In : Clinical Case Reports. 6, 6, p. 1090-1093 4 p.

Research output: Contribution to journalArticle

Hemolysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin M
B-Lymphocytes
Immunoglobulin G
Thrombocytopenia
Liver Transplantation
Tissue Donors
Antibodies
Liver
4 Citations (Scopus)

Blood bank specimen mislabeling: A college of American pathologists Q-probes study of 41 333 blood bank specimens in 30 institutions

Novis, D. A., Lindholm, P. F., Ramsey, G., Alcorn, K. W., Souers, R. J. & Blond, B., Feb 1 2017, In : Archives of Pathology and Laboratory Medicine. 141, 2, p. 255-259 5 p.

Research output: Contribution to journalArticle

Blood Banks
Blood Grouping and Crossmatching
Laboratory Personnel
Pathologists
Blood Transfusion

A Caucasian JK*A/JK*B woman with Jk(a+b-) red blood cells, anti-Jkb, and a novel JK*B allele c.1038delG

Ramsey, G., Sumugod, R. D., Lindholm, P. F., Zinni, J. G., Keller, J. A., Horn, T. & Keller, M. A., 2016, In : Immunohematology. 32, 3, p. 91-95 5 p.

Research output: Contribution to journalReview article

Erythrocytes
Alleles
Isoantibodies
Exons
Blood Group Antigens
5 Citations (Scopus)

Direct oral anticoagulants: Correlation of laboratory monitoring with safe interventional pain procedures

Benzon, H. T., Lindholm, P. F. & Huntoon, M. A., Jan 1 2016, In : Regional Anesthesia and Pain Medicine. 41, 2, p. 123-124 2 p.

Research output: Contribution to journalEditorial