Paul F Lindholm

  • 1465 Citations
1986 …2024
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Personal profile

Research Interests

Our clinical laboratory performs tests to evaluate the function of platelets and the plasma hemostatic system for patients with blood clotting disorders. We employ platelet function assays to identify the effects of antiplatelet medications and platelet transfusion on platelet function for patients at risk of bleeding. We find that in patients with acute intracerebral hemorrhage (ICH), reversing anti-platelet medication and increased platelet activity leads to improved clinical outcomes. We also use these assays to identify optimal conditions for safe surgical interventions for patients who have blood clotting disorders or are taking anticoagulants. We are participating in an exciting project to produce platelets from stem cells. The function of these culture-derived platelets is tested to identify optimal culture and storage conditions to obtain a high yield of functional platelets.

Our research laboratory studies the mechanisms by which prostate cancer cells invade surrounding tissues and spread to distant sites in the body. Clinical prostate cancer tissues contain increased numbers of monocytes and macrophages. We have found that human monocyte-lineage cells cross-communicate with prostate cancer cells and this process leads to increased cancer cell invasion. This cross-communication involves cytokines and growth factors including monocyte chemoattractant protein (MCP-1) and increased cancer cell NF-¿B activity. We are investigating how these factors promote cancer cell invasion and metastasis and hope to identify molecular targets that could block prostate cancer progression.

Certifications and Licenses

Blood Banking & Transfusion Medicine
Anatomic Pathology & Clinical Pathology

Training Experience

1988Residency, Univ. of Minnesota Hospital & Clinic

Education/Academic qualification

MD, University of Minnesota

… → 1983

Research interests

  • Cancer Communications
  • Cell Biology
  • Inflammation
  • Pathology
  • Prostate Cancer

Fingerprint Dive into the research topics where Paul F Lindholm is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Human T-lymphotropic virus 1 Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Blood Platelets Medicine & Life Sciences
Cerebral Hemorrhage Medicine & Life Sciences
NF-kappa B Medicine & Life Sciences
Proteins Medicine & Life Sciences
Platelet Transfusion Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2024

Natural History
Phenotype
Comorbidity
Longitudinal Studies
Bronchiectasis
Hydrogels
Microfluidics
Bioreactors
Blood Platelets
Hematopoietic Stem Cells
Adipogenesis
Leptin
Prostatic Neoplasms
Research Personnel
Translational Medical Research
Prostatic Neoplasms
Research Personnel
Translational Medical Research
Advisory Committees
Research
Prostatic Neoplasms
Transcription Factors
Prostate
Research
Quality of Life

Research Output 1986 2019

Thrombosis
Neoplasms
1 Citation (Scopus)
Open Access
Yin-Yang
Thrombosis
Neoplasms
2 Citations (Scopus)

Fibrin and fibrinolysis in cancer

Kwaan, H. C. & Lindholm, P. F., Jan 1 2019, In : Seminars in thrombosis and hemostasis. 45, 4, p. 413-422 10 p.

Research output: Contribution to journalArticle

Fibrinolysis
Fibrin
Neoplasms
Plasminogen Activator Inhibitor 1
Urokinase Plasminogen Activator Receptors

Mixing Studies in Patients with Prolonged Activated Partial Thromboplastin Time or Prothrombin Time

Benzon, H. T., Park, M., McCarthy, R. J., Kendall, M. C. & Lindholm, P. F., Jun 1 2019, In : Anesthesia and analgesia. 128, 6, p. 1089-1096 8 p.

Research output: Contribution to journalArticle

Partial Thromboplastin Time
Prothrombin Time
Lupus Coagulation Inhibitor
Blood Coagulation Factors
Ownership
1 Citation (Scopus)

Thrombosis Risk in Cancer Patients Receiving Red Blood Cell Transfusions

Ramsey, G. E. & Lindholm, P. F., Jan 1 2019, In : Seminars in thrombosis and hemostasis. 45, 6, p. 648-656 9 p.

Research output: Contribution to journalArticle

Erythrocyte Transfusion
Thrombosis
Venous Thromboembolism
Neoplasms
Odds Ratio