Paul F Lindholm

Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
1986 …2024

Research activity per year

Personal profile

Research Interests

Our clinical laboratory performs tests to evaluate the function of platelets and the plasma hemostatic system for patients with blood clotting disorders. We employ platelet function assays to identify the effects of antiplatelet medications and platelet transfusion on platelet function for patients at risk of bleeding. We find that in patients with acute intracerebral hemorrhage (ICH), reversing anti-platelet medication and increased platelet activity leads to improved clinical outcomes. We also use these assays to identify optimal conditions for safe surgical interventions for patients who have blood clotting disorders or are taking anticoagulants. We are participating in an exciting project to produce platelets from stem cells. The function of these culture-derived platelets is tested to identify optimal culture and storage conditions to obtain a high yield of functional platelets.

Our research laboratory studies the mechanisms by which prostate cancer cells invade surrounding tissues and spread to distant sites in the body. Clinical prostate cancer tissues contain increased numbers of monocytes and macrophages. We have found that human monocyte-lineage cells cross-communicate with prostate cancer cells and this process leads to increased cancer cell invasion. This cross-communication involves cytokines and growth factors including monocyte chemoattractant protein (MCP-1) and increased cancer cell NF-¿B activity. We are investigating how these factors promote cancer cell invasion and metastasis and hope to identify molecular targets that could block prostate cancer progression.

Certifications and Licenses

Blood Banking & Transfusion Medicine
Anatomic Pathology & Clinical Pathology

Training Experience

1988Residency, Univ. of Minnesota Hospital & Clinic

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Medicine, MD, University of Minnesota

… → 1983

Research interests keywords

  • Cancer Communications
  • Cell Biology
  • Inflammation
  • Pathology
  • Prostate Cancer


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