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Personal profile

Research Interests

Failure of ion channel function results in many human diseases such as Autosomal Polycystic Kidney Disease (ADPKD) and several forms of epilepsy. My labs research directly addresses the molecular and biophysical determinants ion channel disregulation in the disease state. Furthermore, we endeavor to characterize new ion channels and determine their context in cell physiology

Training Experience

2015Postdoctoral Fellowship, Boston Children's Hospital

Education/Academic qualification

PhD, University of Washington

… → 2010

Research interests

  • Biophysics
  • Brain and Nervous System
  • Cell Division
  • Drug Discovery
  • Epilepsy
  • Ion Channels
  • Kidney
  • Molecular Pharmacology
  • Neurobiology
  • Pain
  • Renal Diseases
  • Structural Biology

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Grants

  • Research Output

    • 2039 Citations
    • 32 Article
    • 1 Chapter
    • 1 Comment/debate
    • 1 Short survey

    Influence of ionic plasticizers on the processing and viscosity of starch melts

    Decaen, P., Rolland-Sabaté, A., Colomines, G., Guilois, S., Lourdin, D., Della Valle, G. & Leroy, E., Feb 15 2020, In : Carbohydrate Polymers. 230, 115591.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain

    Vien, T. N., Wang, J., Ng, L. C. T., Cao, E. & DeCaen, P. G., May 12 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 19, p. 10329-10338 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Structure and function of polycystin channels in primary cilia

    Ta, C. M., Vien, T. N., Ng, L. C. T. & DeCaen, P. G., Aug 2020, In : Cellular Signalling. 72, 109626.

    Research output: Contribution to journalArticle

    Open Access
  • Opening TRPP2 (PKD2L1) requires the transfer of gating charges

    Ng, L. C. T., Vien, T. N., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15540-15549 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    The Sodium Channel Voltage Sensor Slides to Rest

    Yarov-Yarovoy, V. & DeCaen, P., Oct 2019, In : Trends in Pharmacological Sciences. 40, 10, p. 718-720 3 p.

    Research output: Contribution to journalShort survey

  • 1 Scopus citations