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Personal profile

Research Interests

Failure of ion channel function results in many human diseases such as Autosomal Polycystic Kidney Disease (ADPKD) and several forms of epilepsy. My labs research directly addresses the molecular and biophysical determinants ion channel disregulation in the disease state. Furthermore, we endeavor to characterize new ion channels and determine their context in cell physiology

Training Experience

2015Postdoctoral Fellowship, Boston Children's Hospital

Education/Academic qualification

PhD, University of Washington

… → 2010

Research interests

  • Biophysics
  • Brain and Nervous System
  • Cell Division
  • Drug Discovery
  • Epilepsy
  • Ion Channels
  • Kidney
  • Molecular Pharmacology
  • Neurobiology
  • Pain
  • Renal Diseases
  • Structural Biology

Fingerprint Dive into the research topics where Paul Gregory DeCaen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Voltage-Gated Sodium Channels Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Sodium Channels Medicine & Life Sciences
Ions Medicine & Life Sciences
Cilia Medicine & Life Sciences
TRPP Cation Channels Medicine & Life Sciences
Starch Engineering & Materials Science
Ionic Liquids Chemical Compounds

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Grants 2017 2024

Autosomal Dominant Polycystic Kidney
Cilia
Fingers
Ion Channels
Channelopathies
Cilia
Fingers
Mutation
Autosomal Dominant Polycystic Kidney
Molecular Structure
TRPP Cation Channels
Autosomal Dominant Polycystic Kidney
Cilia
Ion Channels
Electrophysiology
Autosomal Dominant Polycystic Kidney
Cilia
Kidney
Ion Channels
Research

Research Output 2008 2019

  • 1745 Citations
  • 28 Article
  • 1 Chapter
  • 1 Comment/debate

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

Ng, L. C. T., Vien, T. N., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15540-15549 10 p.

Research output: Contribution to journalArticle

Open Access
Ion Channels
TRPP Cation Channels
Transient Receptor Potential Channels
Membranes
Membrane Potentials
20 Citations (Scopus)

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

Liu, X., Vien, T., Duan, J., Sheu, S. H., DeCaen, P. G. & Clapham, D. E., Feb 14 2018, In : eLife. 7, e33183.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Cilia
TRPP Cation Channels
Ion Channels
Ducts
2 Citations (Scopus)

A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel

Tang, C., Zhou, X., Nguyen, P. T., Zhang, Y., Hu, Z., Zhang, C., Yarov-Yarovoy, V., DeCaen, P. G., Liang, S. & Liu, Z., Jul 1 2017, In : FASEB Journal. 31, 7, p. 3167-3178 12 p.

Research output: Contribution to journalArticle

Toxoids
Sodium Channels
Bacillus
Sensors
Electric potential
2 Citations (Scopus)

Choline chloride vs choline ionic liquids for starch thermoplasticization

Decaen, P., Rolland-Sabaté, A., Guilois, S., Jury, V., Allanic, N., Colomines, G., Lourdin, D. & Leroy, E., Dec 1 2017, In : Carbohydrate Polymers. 177, p. 424-432 9 p.

Research output: Contribution to journalArticle

Ionic Liquids
Choline
Starch
Ionic liquids
Plasticizers
5 Citations (Scopus)

On the representative elementary size concept to evaluate the compatibilisation of a plasticised biopolymer blend

Favero, J., Belhabib, S., Guessasma, S., Decaen, P., Reguerre, A. L., Lourdin, D. & Leroy, E., Sep 15 2017, In : Carbohydrate Polymers. 172, p. 120-129 10 p.

Research output: Contribution to journalArticle

Zein
Plasticizers
Biopolymers
Compatibilizers
Choline