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Personal profile

Research Interests

Failure of ion channel function results in many human diseases such as Autosomal Polycystic Kidney Disease (ADPKD) and several forms of epilepsy. My labs research directly addresses the molecular and biophysical determinants ion channel disregulation in the disease state. Furthermore, we endeavor to characterize new ion channels and determine their context in cell physiology

Training Experience

2015Postdoctoral Fellowship, Boston Children's Hospital

Education/Academic qualification

PhD, University of Washington

… → 2010

Research interests

  • Biophysics
  • Brain and Nervous System
  • Cell Division
  • Drug Discovery
  • Epilepsy
  • Ion Channels
  • Kidney
  • Molecular Pharmacology
  • Neurobiology
  • Pain
  • Renal Diseases
  • Structural Biology

Fingerprint Dive into the research topics where Paul Gregory DeCaen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Voltage-Gated Sodium Channels Medicine & Life Sciences
Sodium Channels Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Ions Medicine & Life Sciences
Cilia Medicine & Life Sciences
Starch Engineering & Materials Science
TRPP Cation Channels Medicine & Life Sciences
Ionic Liquids Chemical Compounds

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Grants 2017 2024

Autosomal Dominant Polycystic Kidney
Cilia
Fingers
Ion Channels
Channelopathies
Cilia
Fingers
Mutation
Autosomal Dominant Polycystic Kidney
Molecular Structure
TRPP Cation Channels
Autosomal Dominant Polycystic Kidney
Cilia
Ion Channels
Electrophysiology
Autosomal Dominant Polycystic Kidney
Cilia
Fingers
Ion Channels
Channelopathies

Research Output 2008 2020

  • 1905 Citations
  • 30 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Short survey

Influence of ionic plasticizers on the processing and viscosity of starch melts

Decaen, P., Rolland-Sabaté, A., Colomines, G., Guilois, S., Lourdin, D., Della Valle, G. & Leroy, E., Feb 15 2020, In : Carbohydrate Polymers. 230, 115591.

Research output: Contribution to journalArticle

Plasticizers
Starch
Choline
Viscosity
Chlorides

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

Ng, L. C. T., Vien, T. N., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15540-15549 10 p.

Research output: Contribution to journalArticle

Open Access
Ion Channels
TRPP Cation Channels
Transient Receptor Potential Channels
Membranes
Membrane Potentials

The Sodium Channel Voltage Sensor Slides to Rest

Yarov-Yarovoy, V. & DeCaen, P., Oct 2019, In : Trends in Pharmacological Sciences. 40, 10, p. 718-720 3 p.

Research output: Contribution to journalShort survey

Voltage-Gated Sodium Channels
Molecular Conformation
Sodium Channels
Action Potentials
Conformations

Valproic acid interactions with the NavMs voltage-gated sodium channel

Zanatta, G., Sula, A., Miles, A. J., Ng, L. C. T., Torella, R., Pryde, D. C., DeCaen, P. G. & Wallace, B. A., Dec 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26549-26554 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Valproic Acid
Anticonvulsants
Sodium Channels
Hot Temperature
32 Citations (Scopus)

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

Liu, X., Vien, T., Duan, J., Sheu, S. H., DeCaen, P. G. & Clapham, D. E., Feb 14 2018, In : eLife. 7, e33183.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Cilia
TRPP Cation Channels
Ion Channels
Ducts