Grants per year
Personal profile
Research Interests
Failure of ion channel function results in many human diseases such as Autosomal Polycystic Kidney Disease (ADPKD) and several forms of epilepsy. My labs research directly addresses the molecular and biophysical determinants ion channel disregulation in the disease state. Furthermore, we endeavor to characterize new ion channels and determine their context in cell physiology
Training Experience
| 2015 | Postdoctoral Fellowship, Boston Children's Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pharmacology, University of Washington
… → 2010
Research interests keywords
- Biophysics
- Brain and Nervous System
- Cell Division
- Drug Discovery
- Epilepsy
- Ion Channels
- Kidney
- Molecular Pharmacology
- Neurobiology
- Pain
- Renal Diseases
- Structural Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L., Burridge, P., DeCaen, P. G., Horvath, C. M., Kearney, J. A., Kiskinis, E., McNally, E. M., Miller, R. J., Prakriya, M., Smith, R. S., Surmeier Jr, D. J. & Vanoye, C. G.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Cilia calcium dysregulation in polycystic kidney disease
DeCaen, P. G., DeCaen, P. G., Stranger, B. E. & Stranger, B. E.
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/22 → 5/31/27
Project: Research project
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Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variants
National Institute of Diabetes and Digestive and Kidney Diseases
9/3/19 → 7/31/24
Project: Research project
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Kinetic Imaging Plate Reader for Drug Discovery and Biology
George, A. L., Arispe, L., Bass, J., Burridge, P., DeCaen, P. G., Gianneschi, N., Horvath, C. M., Kiskinis, E., Klein, W. L., Miller, R. J., Morimoto, R. I., Moskal, J. R., Penzes, P., Prakriya, M., Scheidt, K. A., Surmeier Jr, D. J. & Vafabakhsh, R.
Office of the Director, National Institutes of Health
9/1/21 → 8/31/23
Project: Research project
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Small Molecule Activators of Polycystin-2 to Treat Autosomal Dominant Polycystic Kidney Disease
3/15/21 → 5/31/22
Project: Research project
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Energetic landscape of polycystin channel gating
Ng, L. C. T., Harris, B. J., Larmore, M., Ta, M. C., Vien, T. N., Tokars, V. L., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 5 2023, In: EMBO Reports. 24, 7, e56783.Research output: Contribution to journal › Article › peer-review
Open Access -
Polycystin Channel Complexes
Esarte Palomero, O., Larmore, M. & Decaen, P. G., Feb 10 2023, In: Annual review of physiology. 85, p. 425-448 24 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Primary cilia TRP channel regulates hippocampal excitability
Vien, T. N., Ta, M. C., Kimura, L. F., Onay, T. & DeCaen, P. G., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2219686120.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain
McCollum, M. M., Larmore, M., Ishihara, S., Ng, L. C. T., Kimura, L. F., Guadarrama, E., Ta, M. C., Vien, T. N., Frost, G. B., Scheidt, K. A., Miller, R. E. & DeCaen, P. G., Aug 23 2022, In: Cell reports. 40, 8, 111248.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A tamoxifen receptor within a voltage-gated sodium channel
Sula, A., Hollingworth, D., Ng, L. C. T., Larmore, M., DeCaen, P. G. & Wallace, B. A., Mar 18 2021, In: Molecular cell. 81, 6, p. 1160-1169.e5Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations
Datasets
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5T4D : Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703
Shen, P. S. (Contributor), Yang, X. (Contributor), DeCaen, P. G. (Contributor), Liu, X. (Contributor), Bulkley, D. (Contributor), Clapham, D. E. (Contributor) & Cao, E. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb5t4d/pdb, https://www.rcsb.org/structure/5T4D
Dataset