Grants per year
Personal profile
Research Interests
Failure of ion channel function results in many human diseases such as Autosomal Polycystic Kidney Disease (ADPKD) and several forms of epilepsy. My labs research directly addresses the molecular and biophysical determinants ion channel disregulation in the disease state. Furthermore, we endeavor to characterize new ion channels and determine their context in cell physiology
Training Experience
| 2015 | Postdoctoral Fellowship, Boston Children's Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pharmacology, University of Washington
… → 2010
Research interests keywords
- Biophysics
- Brain and Nervous System
- Cell Division
- Drug Discovery
- Epilepsy
- Ion Channels
- Kidney
- Molecular Pharmacology
- Neurobiology
- Pain
- Renal Diseases
- Structural Biology
Fingerprint
Dive into the research topics where Paul Gregory DeCaen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Cilia calcium dysregulation in polycystic kidney disease
DeCaen, P. G. (PD/PI), DeCaen, P. G. (PD/PI), Stranger, B. E. (Co-Investigator) & Stranger, B. E. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/22 → 5/31/27
Project: Research project
-
SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L. (PD/PI), Burridge, P. (Other), DeCaen, P. G. (Other), Horvath, C. M. (Other), Kearney, J. A. (Other), Kiskinis, E. (Other), McNally, E. M. (Other), Miller, R. J. (Other), Prakriya, M. (Other), Smith, R. S. (Other), Surmeier Jr, D. J. (Other) & Vanoye, C. G. (Other)
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
-
Kinetic Imaging Plate Reader for Drug Discovery and Biology
George, A. L. (PD/PI), Arispe, L. (Other), Bass, J. (Other), Burridge, P. (Other), DeCaen, P. G. (Other), Gianneschi, N. (Other), Horvath, C. M. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Moskal, J. R. (Other), Penzes, P. (Other), Prakriya, M. (Other), Scheidt, K. A. (Other), Surmeier Jr, D. J. (Other) & Vafabakhsh, R. (Other)
Office of the Director, National Institutes of Health
9/1/21 → 8/31/23
Project: Research project
-
Small Molecule Activators of Polycystin-2 to Treat Autosomal Dominant Polycystic Kidney Disease
DeCaen, P. G. (PD/PI)
3/15/21 → 5/31/22
Project: Research project
-
Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variants
DeCaen, P. G. (PD/PI) & DeCaen, P. G. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/3/19 → 7/31/24
Project: Research project
-
Methods to Assess Neuronal Primary Cilia Electrochemical Signaling
DeCaen, P. G. & Kimura, L. F., Apr 2025, In: Journal of Cellular Physiology. 240, 4, e70034.Research output: Contribution to journal › Article › peer-review
Open Access -
Optimizing a Pipeline for Eukaryotic Ultrastructure
Pappas, V. & DeCaen, P., Jul 24 2024, In: Microscopy and Microanalysis. 30, 2024, p. 753-754 2 p.Research output: Contribution to journal › Conference article › peer-review
-
Energetic landscape of polycystin channel gating
Ng, L. C. T., Harris, B. J., Larmore, M., Ta, M. C., Vien, T. N., Tokars, V. L., Yarov-Yarovoy, V. & DeCaen, P. G., Jul 5 2023, In: EMBO Reports. 24, 7, e56783.Research output: Contribution to journal › Article › peer-review
Open Access -
Polycystin Channel Complexes
Esarte Palomero, O., Larmore, M. & Decaen, P. G., Feb 10 2023, In: Annual review of physiology. 85, p. 425-448 24 p.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
Primary cilia TRP channel regulates hippocampal excitability
Vien, T. N., Ta, M. C., Kimura, L. F., Onay, T. & DeCaen, P. G., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2219686120.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Datasets
-
Full length Wild-Type Open-form Sodium Channel NavMs
Bagnéris, C. (Contributor), Decaen, P. G. (Contributor), Hall, B. A. (Contributor), Naylor, C. E. (Contributor), Clapham, D. E. (Contributor), Kay, C. W. M. (Contributor), Wallace, B. A. (Contributor), Sula, A. (Contributor), Booker, J. (Contributor) & Ng, L. C. T. (Contributor), Protein Data Bank (PDB), Mar 1 2017
DOI: 10.2210/pdb5HVX/pdb, https://www.wwpdb.org/pdb?id=pdb_00005hvx
Dataset
-
Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with N-desmethyltamoxifen (3.2 A resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6Z8C/pdb, https://www.wwpdb.org/pdb?id=pdb_00006z8c
Dataset
-
Crystal structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with 4-hydroxytamoxifen (2.5 Angstrom resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6SXC/pdb, https://www.wwpdb.org/pdb?id=pdb_00006sxc
Dataset
-
Full length Open-form Sodium Channel NavMs I218C
Sula, A. (Contributor), Booker, J. (Contributor), Ng, L. C. T. (Contributor), Naylor, C. E. (Contributor), Decaen, P. G. (Contributor), Wallace, B. A. (Contributor), Bagnéris, C. (Contributor), Hall, B. A. (Contributor), Clapham, D. E. (Contributor) & Kay, C. W. M. (Contributor), Protein Data Bank (PDB), Mar 1 2017
DOI: 10.2210/pdb5HVD/pdb, https://www.wwpdb.org/pdb?id=pdb_00005hvd
Dataset
-
Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) (2.2 Angstrom resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6SX7/pdb, https://www.wwpdb.org/pdb?id=pdb_00006sx7
Dataset